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Download or read book Regulation of Gene Expression During Lymphocyte Activation written by and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1468459430
Total Pages : 254 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation III written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.
Author : John C. Cambier
Publisher : CRC Press
ISBN 13 : 135108691X
Total Pages : 404 pages
Book Rating : 4.3/5 (51 download)
Download or read book B-Lymphocyte Differentiation written by John C. Cambier and published by CRC Press. This book was released on 2018-01-18 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the mechanisms of transmembrane signal transduction during B-Cell Activation, the Regulation of Gene Expression during B-Cell Differentiation, Anti-immunoglobulin antibody induction of B-Lymphocyte activation and differentiation in vivo and in vitro, Helper signals in B-Lymphocyte differentiation, Growth and differentiation of b-cell clones in vitro, B-Cell tumors as models of lymphocyte differentiation, and Memory b-cell activation, differentiation, and isotype switching.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1468453238
Total Pages : 333 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.
Author : S. Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1475758030
Total Pages : 145 pages
Book Rating : 4.4/5 (757 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation II written by S. Gupta and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ac ti vati on of Iymphocytes by physiologie ligands has become a central area of study for immunologists. Furthermore, Iymphocytes offer many advantages for the study of general aspects of receptor-mediated cellular activation. For these reasons, research on the cellular and molecular aspects of the activation of Iymphocytes by antigens, antigen analogues, Iymphokines and other growth factors has expanded enormously in the last several years. Aseries of conferences, "The International Conferences on Lymphocyte Activation", has been initiated to meet the growing need for a forum for the discussion of the topics that are included within the area of Iymphocyte activation. This volume represents the proceedings of the Second International Conference on Lymphocyte Activation and Immune Regulation, held on February 18-20, 1988 at Newport Beach, California. The proceedings comprise four major sections. The first deals with the T cell receptors and T cell activation. It includes a model for the T cell receptor interaction with a complex of MHC plus antigen, structure of y c'i T cell receptor and their distinct isotypic forms, the role of zeta chain in the expression and structure of T cell receptors and its role in transmembrane signalling. The use of somatic cell mutants in the study of signal transduction function of the T cell antigen receptors and the early and late steps of signal transduction via a / ß T cell antigen receptors are discussed.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 146150757X
Total Pages : 212 pages
Book Rating : 4.4/5 (615 download)
Download or read book Lymphocyte Activation and Immune Regulation IX written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented. Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans. Novel methods of visualization of immune cells and immune systems are reviewed in Section III.
Author : Jeffrey Scott Riegel
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (33 download)
Download or read book Induction of T Cell Activation Gene Expression in Thymocyte Subsets written by Jeffrey Scott Riegel and published by . This book was released on 1990 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cornelis Murre
Publisher : Springer Science & Business Media
ISBN 13 : 3642241026
Total Pages : 197 pages
Book Rating : 4.6/5 (422 download)
Download or read book Epigenetic Regulation of Lymphocyte Development written by Cornelis Murre and published by Springer Science & Business Media. This book was released on 2012-01-13 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1489909877
Total Pages : 261 pages
Book Rating : 4.4/5 (899 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation V written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signaling through antigen receptor initiates a complex series of events resulting in the activation of genes that regulate the development, proliferation and differentiation of lymphocytes. During the past few years, rapid progress has been made in understanding the molecular basis of signaling pathways mediated by antigen and cytokine receptors. These pathways involve protein tyrosine kinases which are coupled to downstream regulatory molecules, including small guanine nucleotide binding proteins (e. g. p21'OS), serine threonine kinases (e. g. , members of the ERK family), and a large group of transcription factors. More recently, there have been breakthroughs in elucidating the genetic defects underlying three X-linked primary immunodeficiency diseases in humans. This volume surveys aspects of these rapidly developing areas of research. The book is divided into 5 different sections. Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways. The role of accessory molecules in the regulation of signaling by the B cell antigen receptor is also considered. Section II adopts a similar approach to the analysis of the antigen receptor on T lymphocytes. The importance of specialized signaling motifs in the CD3 polypeptides, mechanisms whereby these motifs may interact with the lymphocyte-specific protein tyrosine kinases, and the downstream consequences of these interactions are reviewed. In addition, the role of antigen-induced apoptosis in the generation of immunological tolerance is discussed.
Author :
Publisher : CSHL Press
ISBN 13 : 0879695692
Total Pages : 621 pages
Book Rating : 4.8/5 (796 download)
Download or read book Signaling and Gene Expression in the Immune System written by and published by CSHL Press. This book was released on 1999 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke immunity. The debate ranges over biochemistry, physiology, molecular genetics, as well as classical cellular immunology. Input came from over 70 of the world's leading investigators.
Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)
Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author : John Bertrand Gurdon
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.3/5 (91 download)
Download or read book Gene Expression During Cell Differentiation written by John Bertrand Gurdon and published by . This book was released on 1973 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 0387241809
Total Pages : 160 pages
Book Rating : 4.3/5 (872 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation X written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is edited by Dr. Sudhir Gupta, internationally recognized expert in Immunology, Professor of Medicine, Pathology, Microbiology and Molecular Genetics. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.
Author : Katie Podshivalova
Publisher :
ISBN 13 :
Total Pages : 530 pages
Book Rating : 4.:/5 (9 download)
Download or read book Small Non-coding RNAs and Regulation of Gene Expression During CD4 T Cell Activation written by Katie Podshivalova and published by . This book was released on 2014 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Activation of CD4 T cells by antigen is critical for initiation of the adaptive immune response and is accompanied by extensive changes in expression of protein-coding and non-coding genes, including hundreds of microRNAs - small non-coding RNAs that post-transcriptionally inhibit gene expression. However, the functions of most activation-associated microRNAs remain unknown, and it is poorly understood which signaling pathways regulate their biogenesis. Activation of naïve CD4 T cells utlimately leads to the formation of memory CD4 T cells, which produce more rapid and robust responses than naïve cells upon re-exposure to antigen. This is important for protective immunity, but also poses clinical problems. Activation of memory CD4 T cells reduces allograft survival in transplant patients, despite administration of immunosuppressive drugs. How different immunosuppressive drugs affect naïve and memory CD4 T cell activation and gene expression has not been addressed. It is also unknown whether differences between naïve and memory responses are programmed at the level of gene expression regulation by microRNAs. Here, I identify microRNAs regulated by the mechanistic target of ramycin (mTOR) pathway during CD4 T cell activation and show that miR-150 amplifies the effects of mTOR signaling by targeting multiple cell cycle genes. These results help better understand how rapid proliferation of activated CD4 T cells is achieved through regulation of gene expression by microRNAs. I also show that immuosuppressant drugs that target mTOR and calcineurin have different effects on activation and gene expression in naïve and memory CD4 T cells. Furthermore, I determine microRNA and protein-coding gene changes that occur during activation of naïve and memory CD4 T cells and computationally predict that microRNAs help memory cells achieve faster proliferation and more diverse effector functions. Finally, I identify a novel class of small RNAs in CD4 T cells that originate from a specific class of larger non-coding RNAs and that are differently expressed with activation in both naïve and memory cells. In total, this work helps better define gene expression changes that underlie CD4 T cell activation and the role played by small non-coding RNAs in this process.
Author : Luca Mariani
Publisher : Logos Verlag Berlin GmbH
ISBN 13 : 3832530037
Total Pages : 176 pages
Book Rating : 4.8/5 (325 download)
Download or read book Stochastic Regulation of the Interleukin-4 Gene written by Luca Mariani and published by Logos Verlag Berlin GmbH. This book was released on 2012-07-25 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the expression variability of highly regulated genes in multi-cellular organisms through a multidisciplinary approach combining quantitative measurements and mathematical modeling. For this purpose, the cytokine gene Interleukin-4 (IL-4) in murine type-2 (Th2) lymphocytes was chosen as prototypical model system of an inducible gene regulated at the epigenetic and transductional level. As many cytokines, IL-4 is expressed in a probabilistic manner, but the underlying molecular mechanisms behind this phenomenon are still unresolved. Through an iterative process of quantitative measurements and mathematical analysis, the author develops a computational model able to predict several system properties. The model indicates that the heterogeneity in IL-4 expression results from a rate-limiting chromatin opening during antigenic stimulation. The rate of inactivation of the promoter is slow (on the order of a cell cycle), which increases the probability of subsequent IL-4 stimulation in the same cells. As a consequence, a previously unknown short-term memory for IL-4 induction is tested and verified experimentally. The multidisciplinary approach presented here will be hopefully useful for investigating other genes highly regulated at the epigenetic level and shows the potential of system biology in revealing new properties of complex processes.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1461533961
Total Pages : 199 pages
Book Rating : 4.4/5 (615 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation IV written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined.
