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Regulation Of Cytokines Gene Activation In Virus Infected Cells By Interferon Regulatory Factor 3
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Book Synopsis Regulation of Cytokines Gene Activation in Virus Infected Cells by Interferon Regulatory Factor 3 by : Christophe Heylbroeck
Download or read book Regulation of Cytokines Gene Activation in Virus Infected Cells by Interferon Regulatory Factor 3 written by Christophe Heylbroeck and published by . This book was released on 1999 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biological DNA Sensor by : Ken Ishii
Download or read book Biological DNA Sensor written by Ken Ishii and published by Academic Press. This book was released on 2013-10-30 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Interferon Regularoty Factor-3 Activation in Adenovirus Infection by : Koralee Chaisson
Download or read book Interferon Regularoty Factor-3 Activation in Adenovirus Infection written by Koralee Chaisson and published by . This book was released on 2007 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Interferon Regulatory Factor-3 in Innate Immunity by : Lorena Navarro
Download or read book The Role of Interferon Regulatory Factor-3 in Innate Immunity written by Lorena Navarro and published by . This book was released on 2002 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion, volume II by : Chenhe Su
Download or read book Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion, volume II written by Chenhe Su and published by Frontiers Media SA. This book was released on 2024-01-18 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is the second volume of the “Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion”. Please see the first volume here. The innate immune system is crucial to defend against viruses or other pathogenic microbes in the early phases of infection. The response starts with detecting evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Following the detection of specific viral PAMPs, PRRs trigger the activation of intracellular signaling cascades, ultimately leading to the induction of type I interferons (IFNs), pro-inflammatory cytokines, and antiviral genes through the activation of interferon regulatory factor 3 (IRF3) and IRF7. Antiviral pathways need to be tightly regulated to ensure successful antiviral defenses and avoid aberrant or dysregulation of host immune signaling. We believe that the Research Topic will give updated insights into the dynamic fields of PAMPs sensing in antiviral innate immunity and viral immune evasion. We hope it will serve the purpose of encouraging new research. This Research Topic will provide an overall picture of antiviral innate immune sensing signal pathways, regulation, and viral immune evasion. We welcome the submission of Original Research, Review, Mini-Review, Hypothesis and Theory, and Perspective articles that cover, but are not limited to, the following subtopics:
Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Book Synopsis Measuring Immunity by : Michael T. Lotze
Download or read book Measuring Immunity written by Michael T. Lotze and published by Elsevier. This book was released on 2011-05-04 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology. * Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity* Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques * Includes basic science foundations as well as the approaches currently applied
Book Synopsis Interferons and Other Regulatory Cytokines by : E. M. DeMaeyer
Download or read book Interferons and Other Regulatory Cytokines written by E. M. DeMaeyer and published by Wiley-Interscience. This book was released on 1988 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a presentation of the state-of-knowledge of interferons (IFNs) providing a synthetic overview of the role and significance of IFNs in health and disease. Treatment is placed in a broad biological context including much up-to-date background information on the different systems (eg oncogenes or T cell function) that are under the influence of IFNs. This approach makes the book accessible to those not directly involved in IFN research. Coverage also includes other cytokines, such as tumor necrosis factor alpha and beta, and the various interleukins.
Book Synopsis Regulation of Interferon Regulatory Factor 1 by Protein Inhibitor of Activated STAT 3 by : Danyang Xu
Download or read book Regulation of Interferon Regulatory Factor 1 by Protein Inhibitor of Activated STAT 3 written by Danyang Xu and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncolytic viruses exploit tumor-specific cellular changes for selective replication, inducing cancer cell death. Our previous research showed that Ras/mitogen-activated protein kinase kinase (MEK) downregulation of interferon regulatory factor 1 (IRF1) is a major mechanism underlying viral oncolysis. Protein inhibitor of activated STAT 3 (PIAS3) is known as the E3 ligase of IRF1 sumoylation. The objective of this study was to identify if, and how, PIAS3 modulates cellular sensitivity to oncolytic viruses via regulation of IRF1. By conducting co-immunoprecipitation, I found that IRF1 has no direct interaction with PIAS3 found within HT1080 cells. However, CRISPR knockdown of PIAS3 increases IRF1 expression as well as transcription of IRF1-responsive anti-viral genes. Furthermore, PIAS3 knockdown HT1080 cells were equally sensitive to viral infection as their parent HT1080 cells. Together, these results demonstrate that PIAS3 does not directly interact with IRF1 but regulates expression and transcriptional activity of IRF1. Moreover, as CRISPR knockdown of PIAS3 did not change cellular sensitivity to viral infection, IRF1 modulation via PIAS3 does not play very critical roles in host innate antiviral responses.
Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer
Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Book Synopsis Viral Gastroenteritis by : Shunzo Chiba
Download or read book Viral Gastroenteritis written by Shunzo Chiba and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.
Book Synopsis Beyond Innate Immunity by : Nancy Fares-Frederickson
Download or read book Beyond Innate Immunity written by Nancy Fares-Frederickson and published by . This book was released on 2016 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon regulatory factor 3 (IRF3) is a transcription factor found in the cytoplasm of most nucleated cells. Upon pathogen detection by pattern recognition receptors, IRF3 becomes activated and translocates to the nucleus where it mediates the production of type I interferon (IFN) and IFN-stimulated genes. The collective actions of these genes induce an antimicrobial state within infected and neighboring cells, allowing for pathogen clearance. Whereas the type I IFN system has been studied extensively in the context of pathogen responses, it has more recently become appreciated for its role in immune cell modulation. In this report we discuss novel findings highlighting the involvement of the type I IFN system--with a focus on IRF3--in T cell development, activation, differentiation, and cytokine production. Using a combination of in vitro assays and in vivo disease models, we demonstrate that IRF3 is a positive regulator of lL-17 and IFN-[gamma] in CD4+ T cells. We show that IRF3-deficient CD4+ T cells have impaired production of the pro-inflammatory cytokines IL-17 and IFN-[gamma], and are unable to induce disease in the T cell transfer model of colitis. Unexpectedly, we observed IRF3 nuclear translocation in activated T cells. To our knowledge, this is the first description of IRF3 activation following T cell receptor stimulation. These results, which are the focus of chapter 1, reveal a previously unappreciated role for IRF3 in CD4+ T cell responses and extend its role beyond the innate immune response to pathogens. Additionally, we show that type I IFN limits T cell production of IL-2--a cytokine required for T cell activation and expansion--by indirectly altering histone modifications in the IL-2 promoter to retain the locus in an inaccessible configuration. These results, which are the focus of chapter 2, help explain why type I IFN has been an effective treatment for multiple sclerosis--a T cell-mediated autoimmune condition.
Book Synopsis Fields Virology: Emerging Viruses by : Peter M. Howley
Download or read book Fields Virology: Emerging Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2020-02-11 with total page 2597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.
Book Synopsis Investigating the Role of Interferon Regulatory Factor 3 in Response to Genotoxic Stress by : Adam Davidson
Download or read book Investigating the Role of Interferon Regulatory Factor 3 in Response to Genotoxic Stress written by Adam Davidson and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon regulatory factor 3 (IRF3) plays an important role in activating the innate immune response in a variety of conditions, including viral infection. As well as regulating the immune response to viruses, IRF3 is involved in regulating cellular functions including apoptosis. Apoptosis and the inflammatory response to viral infection are very different; therefore, it is obvious that IRF3 plays dramatically different roles in the cell depending on the conditions. We previously identified a non-activating phosphorylation of IRF3 in response to adenovirus (Ad) in which Serine-173 is phosphorylated. In addition to Ad infection, IRF3- S173 is phosphorylated in response to genotoxic stresses including ultraviolet (UV) irradiation and etoposide. In this study, I show that this phosphorylation event is involved in a variety of processes including protein stability, cell survival and IRF3 regulation. Thus, phosphorylation of IRF3-S173 is a novel and important event in a complex regulatory pathway of an integral protein.
Book Synopsis Virus Dynamics : Mathematical Principles of Immunology and Virology by : Martin Nowak
Download or read book Virus Dynamics : Mathematical Principles of Immunology and Virology written by Martin Nowak and published by Oxford University Press, UK. This book was released on 2000-11-23 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature
Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail
