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Author : Cheng-Chi Chao
Publisher :
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.:/5 (835 download)
Download or read book Regulation of Adhesion Molecule Expression on Murine T Lymphocytes written by Cheng-Chi Chao and published by . This book was released on 1995 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1461533961
Total Pages : 199 pages
Book Rating : 4.4/5 (615 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation IV written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined.
Author : Alf Hamann
Publisher : CRC Press
ISBN 13 : 9789057022289
Total Pages : 268 pages
Book Rating : 4.0/5 (222 download)
Download or read book Adhesion Molecules and Chemokines in Lymphocyte Trafficking written by Alf Hamann and published by CRC Press. This book was released on 1998-01-26 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes the latest research in the field, with particular emphasis on molecular mechanisms involved in lymphocyte traffic, for scientists, clinicians, and students. Subjects include the role of homing to mucosal tissue, adhesion molecules, and chemokines in regulation of lymphocyte and leukocyte migration, roles of integrins in the interactions of lymphocytes with intestinal mucosa, lymphocyte trafficking through the central nervous system, and implications for tumor immunotherapy. Includes bandw drawings. Annotation copyrighted by Book News, Inc., Portland, OR
Author : Peter E. Lipsky
Publisher : Springer Science & Business Media
ISBN 13 : 1461392667
Total Pages : 411 pages
Book Rating : 4.4/5 (613 download)
Download or read book Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion written by Peter E. Lipsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 9780306443121
Total Pages : 226 pages
Book Rating : 4.4/5 (431 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation IV written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 1992 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 23 papers from an international conference in Newport Beach, California, February 1992, immunologists and molecular biologists focus on the role interactions among the cells play in lymphocyte activation and immune regulation. The general topics are cell receptors and T-cell activation; T-cell de
Author : Dominique Dunon
Publisher : Springer Science & Business Media
ISBN 13 : 3642782531
Total Pages : 255 pages
Book Rating : 4.6/5 (427 download)
Download or read book Adhesion in Leukocyte Homing and Differentiation written by Dominique Dunon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Microbiology and Immunology was planned in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held at the Basel Institute for Immunology in November 1992, and many of the workshop speakers have contributed to it. Cell adhesion is one of the most dynamic fields of biological research and presented in this book is the current knowledge on the structure and function of the major families of cell adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. Complex interactions between the members of these families mediate diverse adhesion functions, including leukocyte-leukocyte interactions, lymphocyte homing, inflammation, and lymphocyte-stromal cell interaction during hematopoiesis. A great deal of emphasis is placed on the regulatory elements that control the expression and function of adhesion molecules. Cytokines not only induce the expression of certain adhesion molecules, but may also modify their functional status. For instance, the integrins exist in either an inactive nonfunctional form or an active functional form, and a number of intracellular or extracellular stimuli modify integrin function. This is particularly important during leukocyte binding to endothelium and transendothelial migration, which proceeds through a cascade of adhesion events. Although cell adhesion molecules play an important role in many processes, this book concentrates on their role within the immune system. A number of chapters discuss the migration of lymphocytes between hematopoietic organs such as the thymus, lymph nodes, Peyer's patches, and spleen.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Gerold Schuler
Publisher : CRC Press
ISBN 13 : 9780849356469
Total Pages : 336 pages
Book Rating : 4.3/5 (564 download)
Download or read book Epidermal Langerhans Cells written by Gerold Schuler and published by CRC Press. This book was released on 1990-12-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.
Author : Susan A. Lancaster
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (296 download)
Download or read book Regulation of THY-1 Expression by CAMP in Murine T Lymphocytes written by Susan A. Lancaster and published by . This book was released on 1993 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wolfgang Siess
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.3/5 (91 download)
Download or read book Adhesion Molecules and Cell Signaling written by Wolfgang Siess and published by Raven Press (ID). This book was released on 1995 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041656
Total Pages : 99 pages
Book Rating : 4.6/5 (15 download)
Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author : Miyuki Azuma
Publisher : Springer Nature
ISBN 13 : 9813297174
Total Pages : 326 pages
Book Rating : 4.8/5 (132 download)
Download or read book Co-signal Molecules in T Cell Activation written by Miyuki Azuma and published by Springer Nature. This book was released on 2019-11-22 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Author : Pierre Vantourout
Publisher : Frontiers Media SA
ISBN 13 : 2889459918
Total Pages : 165 pages
Book Rating : 4.8/5 (894 download)
Download or read book Molecular Determinants of γδ T Cell Selection, Maintenance and Function written by Pierre Vantourout and published by Frontiers Media SA. This book was released on 2019-08-29 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : B. Kyewski
Publisher : Springer Science & Business Media
ISBN 13 : 3540277021
Total Pages : 331 pages
Book Rating : 4.5/5 (42 download)
Download or read book CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential written by B. Kyewski and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
Author : A. Neil Barclay
Publisher : Elsevier
ISBN 13 : 0080535437
Total Pages : 626 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Leucocyte Antigen Factsbook written by A. Neil Barclay and published by Elsevier. This book was released on 1997-06-22 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists. Key Features* Completely up-to-date* Revised and expanded to include over 70 new entries* More than 200 entries in total, plus additional introductory material* New structural data* New nomenclature for CD and related molecules covered
