Regulation And Transcriptional Role Of Crtc1 During Activity In Neurons

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The Transcriptional Regulation of Memory

Author : Benedict C. Albensi
Publisher : Frontiers Media SA
ISBN 13 : 2889198650
Total Pages : 118 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The Transcriptional Regulation of Memory by : Benedict C. Albensi

Download or read book The Transcriptional Regulation of Memory written by Benedict C. Albensi and published by Frontiers Media SA. This book was released on 2016-09-06 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage. The formation of short-term (across minutes) memory is mediated by local changes in synapses, while long-term (across hours to days) memory storage is associated with activation of transcription and synthesis of proteins that modify synaptic function. Transcription factors, which can either repress or activate transcription, play a vital role in driving protein synthesis underlying synaptic plasticity and memory, whereby protein synthesis provides the necessary building blocks to accommodate structural changes at the synapse that foster memory formation. Recent data implicate several families of transcription factors that appear critically important in the regulation of memory. In this Topic we will focus on the families of transcription factors thus far found to be critically involved in synaptic plasticity and memory formation. These include cAMP response element binding protein (CREB), Rel/nuclear factor B (Rel/NFB), CCAAT enhancer binding protein (C/EBP), and early growth response factor (Egr). In recent years, numerous studies have implicated epigenetic mechanisms, changes in gene activity and expression that occur without alteration in gene sequence, in the memory consolidation process. DNA methylation and chromatin remodeling are critically involved in learning and memory, supporting a role of epigenetic mechanisms. Here we provide more evidence of the importance of DNA methylation, histone posttranslational modifications and the role of histone acetylation and HDAC inhibitors in above mentioned processes.

Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II

Download Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II PDF Online Free

Author : Estela Maris Muñoz
Publisher : Frontiers Media SA
ISBN 13 : 2832533817
Total Pages : 169 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II by : Estela Maris Muñoz

Download or read book Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II written by Estela Maris Muñoz and published by Frontiers Media SA. This book was released on 2023-10-03 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: A finely tuned regulation of gene expression is essential for shaping the nervous system and for maintaining its homeostasis throughout life. Disruptions in gene regulation can impact brain development and physiology in ways that contribute to diverse pathologies. The master orchestrators of gene activity in the nucleus are transcription factors, proteins that recognize and bind to specific DNA motifs in regulatory regions and drive changes in gene expression. Transcription factors act with the help of other co-factor proteins, including components of the Mediator complex, histone modifying enzymes, chromatin modelers, and DNA methylases. In addition, transcription factor activity in the nervous system can be modulated by extracellular signals, including growth factors, hormones, neuropeptides and neurotransmitters that activate specific receptors and intracellular transduction pathways. An in-depth understanding of the mechanisms of transcription regulation is needed in order to better describe how each element, from genes to cells, defines and maintains identities and functionalities in the healthy and diseased brain. This Research Topic is oriented to developing an integrative view about transcription regulation within the nervous system, focusing on developmental and homeostatic processes, dysregulation in functionality and expression levels and consequent associated pathologies such as neurodevelopmental disorders, brain tumors, and neurodegenerative diseases. Transcription regulation investigations will specifically focus on transcription factors that belong to the bHLH (e.g. NeuroD), homeobox (e.g. Islet, Pax, Rax, and Lhx) and CREB families, and on their roles over defined nervous system areas: cerebral cortex, thalamic and hypothalamic areas, interacting with the developing brain.

Chromatin Signaling and Neurological Disorders

Author :
Publisher : Academic Press
ISBN 13 : 0128137975
Total Pages : 380 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chromatin Signaling and Neurological Disorders by :

Download or read book Chromatin Signaling and Neurological Disorders written by and published by Academic Press. This book was released on 2019-05-24 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. - Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more - Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics - Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Issues in Neuroscience Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464963614
Total Pages : 3143 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in Neuroscience Research and Application: 2011 Edition by :

Download or read book Issues in Neuroscience Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 3143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Plastic Brain

Author : Rommy von Bernhardi
Publisher : Springer
ISBN 13 : 3319628178
Total Pages : 281 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis The Plastic Brain by : Rommy von Bernhardi

Download or read book The Plastic Brain written by Rommy von Bernhardi and published by Springer. This book was released on 2017-10-26 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the many factors that can influence brain plasticity throughout the lifespan. Addresses perinatal plasticity, functional state plasticity, injury-induced plasticity, and stressor-induced plasticity. Because it looks at so many aspects of the field, this volume will serve as a great resource for students as well as researchers interested in expanding their knowledge. The volume comes out as an integrated view based in the expertise of Ibero American neuroscientists working in the field.

Neurobiology of TRP Channels

Author : Tamara Luti Rosenbaum Emir
Publisher : CRC Press
ISBN 13 : 1498755267
Total Pages : 327 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Neurobiology of TRP Channels by : Tamara Luti Rosenbaum Emir

Download or read book Neurobiology of TRP Channels written by Tamara Luti Rosenbaum Emir and published by CRC Press. This book was released on 2017-08-09 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels. Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology. Features: • Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins. • Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes. • Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance. • Features several full color illustrations to allow the reader better comprehension of TRP channels. A volume in the Frontiers in Neuroscience series

The Genetics of Circadian Rhythms

Author :
Publisher : Academic Press
ISBN 13 : 0123876982
Total Pages : 269 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis The Genetics of Circadian Rhythms by :

Download or read book The Genetics of Circadian Rhythms written by and published by Academic Press. This book was released on 2011-09-16 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest volume in Advances in Genetics covers the genetics of Circadian rhythms. With an international group of authors this volume is the latest offering in this widely praised series.

Striatal Signaling: Two Decades of Progress

Author : Emmanuel Valjent
Publisher : Frontiers E-books
ISBN 13 : 2889190706
Total Pages : 216 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Striatal Signaling: Two Decades of Progress by : Emmanuel Valjent

Download or read book Striatal Signaling: Two Decades of Progress written by Emmanuel Valjent and published by Frontiers E-books. This book was released on with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic aims to highlight and cover recent understanding on striatal signaling pathways, which are activated by a variety of therapeutic agents or drugs of abuse in physiological and pathological context. The recent development of different mouse models allowing the identification of specific cell types and neuronal circuits in which a given signaling pathway is activated in various physiological and pathological conditions provides essential information and allowed to untangle the complexity of study signal transduction in the brain in vivo.

Transcriptional Gene Regulation in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128123400
Total Pages : 256 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Transcriptional Gene Regulation in Health and Disease by :

Download or read book Transcriptional Gene Regulation in Health and Disease written by and published by Academic Press. This book was released on 2018-01-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists drawn from international sources - Offers a wide range of perspectives on specific subjects

The Neuron in Context

Author : Vanessa Lux
Publisher : Springer Nature
ISBN 13 : 3031552296
Total Pages : 193 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis The Neuron in Context by : Vanessa Lux

Download or read book The Neuron in Context written by Vanessa Lux and published by Springer Nature. This book was released on with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Towards a Theoretical Neuroscience: from Cell Chemistry to Cognition

Author : L Andrew Coward
Publisher : Springer Science & Business Media
ISBN 13 : 940077107X
Total Pages : 526 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Towards a Theoretical Neuroscience: from Cell Chemistry to Cognition by : L Andrew Coward

Download or read book Towards a Theoretical Neuroscience: from Cell Chemistry to Cognition written by L Andrew Coward and published by Springer Science & Business Media. This book was released on 2013-08-23 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book explains how to understand cognition in terms of brain anatomy, physiology and chemistry, using an approach adapted from techniques for understanding complex electronic systems. These techniques create hierarchies of information process based descriptions on different levels of detail, where higher levels contain less information and can therefore describe complete cognitive phenomena, but are more approximate. The nature of the approximations are well understood, and more approximate higher level descriptions can therefore be mapped to more precise detailed descriptions of any part of a phenomenon as required. Cognitive phenomena, the anatomy and connectivity of major brain structures, neuron physiology, and cellular chemistry are reviewed. Various cognitive tasks are described in terms of information processes performed by different major anatomical structures. These higher level descriptions are selectively mapped to more detailed physiological and chemical levels.

Cellular Migration and Formation of Neuronal Connections

Author :
Publisher : Academic Press
ISBN 13 : 0123973473
Total Pages : 1081 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Cellular Migration and Formation of Neuronal Connections by :

Download or read book Cellular Migration and Formation of Neuronal Connections written by and published by Academic Press. This book was released on 2013-05-06 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity

Learning and Memory: A Comprehensive Reference

Author :
Publisher : Academic Press
ISBN 13 : 0128052910
Total Pages : 2517 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Learning and Memory: A Comprehensive Reference by :

Download or read book Learning and Memory: A Comprehensive Reference written by and published by Academic Press. This book was released on 2017-07-07 with total page 2517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learning and Memory: A Comprehensive Reference, Second Edition, Four Volume Set is the authoritative resource for scientists and students interested in all facets of learning and memory. This updated edition includes chapters that reflect the state-of-the-art of research in this area. Coverage of sleep and memory has been significantly expanded, while neuromodulators in memory processing, neurogenesis and epigenetics are also covered in greater detail. New chapters have been included to reflect the massive increase in research into working memory and the educational relevance of memory research. No other reference work covers so wide a territory and in so much depth. Provides the most comprehensive and authoritative resource available on the study of learning and memory and its mechanisms Incorporates the expertise of over 150 outstanding investigators in the field, providing a ‘one-stop’ resource of reputable information from world-leading scholars with easy cross-referencing of related articles to promote understanding and further research Includes further reading for each chapter that helps readers continue their research Includes a glossary of key terms that is helpful for users who are unfamiliar with neuroscience terminology

Cyclin Dependent Kinase 5 (Cdk5)

Author : Nancy Y. Ip
Publisher : Springer Science & Business Media
ISBN 13 : 0387788875
Total Pages : 326 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Cyclin Dependent Kinase 5 (Cdk5) by : Nancy Y. Ip

Download or read book Cyclin Dependent Kinase 5 (Cdk5) written by Nancy Y. Ip and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Pharmacoepigenetics

Author : Ramón Cacabelos
Publisher : Academic Press
ISBN 13 : 0128139404
Total Pages : 986 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Pharmacoepigenetics by : Ramón Cacabelos

Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2019-06-04 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

The Fragile X Syndrome

Author : Kay E. Davies
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Fragile X Syndrome by : Kay E. Davies

Download or read book The Fragile X Syndrome written by Kay E. Davies and published by Oxford University Press, USA. This book was released on 1989 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book is an up-to-date review of the clinical, epidemiological, and cytogenetic aspects of the fragile X (Martin-Bell) syndrome--the most common genetic cause of mental retardation after Down syndrome. The book includes the latest research findings concerning diagnosis on the basis of the appearance of a fragile site in cultured lymphocytes. It assumes little prior knowledge of the subject, and provides a clearly written, easy-to-understand discussion previously unavailable in a single reference source. The book will be of special interest to molecular biologists, cytogeneticists, medical geneticists, and clinicians and other professionals working with the mentally handicapped.

Memory Mechanisms In Health And Disease: Mechanistic Basis Of Memory

Author : Karl Peter Giese
Publisher : World Scientific
ISBN 13 : 9814458147
Total Pages : 461 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Memory Mechanisms In Health And Disease: Mechanistic Basis Of Memory by : Karl Peter Giese

Download or read book Memory Mechanisms In Health And Disease: Mechanistic Basis Of Memory written by Karl Peter Giese and published by World Scientific. This book was released on 2012-06-07 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally, the impact of contemporary memory research for psychiatry is illustrated.