Red Blood Cell Aging

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Red Blood Cell Aging

Author : Antonio De Flora
Publisher : Springer Science & Business Media
ISBN 13 : 1468459856
Total Pages : 365 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Red Blood Cell Aging by : Antonio De Flora

Download or read book Red Blood Cell Aging written by Antonio De Flora and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.

Regulation of red cell life-span, erythropoiesis, senescence and clearance

Author : Lars Kaestner
Publisher : Frontiers E-books
ISBN 13 : 2889193489
Total Pages : 118 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Regulation of red cell life-span, erythropoiesis, senescence and clearance by : Lars Kaestner

Download or read book Regulation of red cell life-span, erythropoiesis, senescence and clearance written by Lars Kaestner and published by Frontiers E-books. This book was released on 2014-12-03 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Red Blood Cell Aggregation

Author : Oguz Baskurt
Publisher : CRC Press
ISBN 13 : 1439841810
Total Pages : 310 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Red Blood Cell Aggregation by : Oguz Baskurt

Download or read book Red Blood Cell Aggregation written by Oguz Baskurt and published by CRC Press. This book was released on 2011-09-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this real

Blood Cells, Rheology and Aging

Author : Dieter Platt
Publisher : Springer
ISBN 13 :
Total Pages : 242 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Blood Cells, Rheology and Aging by : Dieter Platt

Download or read book Blood Cells, Rheology and Aging written by Dieter Platt and published by Springer. This book was released on 1988 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the third Erlangen-Nuremberg symposium on experimental geronto logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co agulation is a typical thrombophilic tendency with aging.

Influence of Oxygen Toxicity on the Rate of Red Cell Aging

Author : D. Danon
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Influence of Oxygen Toxicity on the Rate of Red Cell Aging by : D. Danon

Download or read book Influence of Oxygen Toxicity on the Rate of Red Cell Aging written by D. Danon and published by . This book was released on 1967 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Red Cell Membrane Transport in Health and Disease

Author : Ingolf Bernhardt
Publisher : Springer Science & Business Media
ISBN 13 : 3662051818
Total Pages : 761 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Red Cell Membrane Transport in Health and Disease by : Ingolf Bernhardt

Download or read book Red Cell Membrane Transport in Health and Disease written by Ingolf Bernhardt and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: 51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Cellular and Molecular Aspects of Aging

Author : John Wallace Eaton
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cellular and Molecular Aspects of Aging by : John Wallace Eaton

Download or read book Cellular and Molecular Aspects of Aging written by John Wallace Eaton and published by . This book was released on 1985 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

RealAge

Author : Michael F. Roizen
Publisher : Harper Collins
ISBN 13 : 0061957720
Total Pages : 530 pages
Book Rating : 4.0/5 (619 download)

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Book Synopsis RealAge by : Michael F. Roizen

Download or read book RealAge written by Michael F. Roizen and published by Harper Collins. This book was released on 2010-11-16 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is aging? Aging is not a mysterious metaphysical phenomenon. Aging happens in the particulars. Your arteries become clogged. Your arthritis flares up. Age is not just a chronological measurement; it's the rate at which the primary internal guardians of health--your cardiovascular and immune systems--decline. While your chronological age is fixed, your biological age may be years older--or younger--depending on a combination of factors. RealAge offers a revolutionary, systematic program that calculates the aging effect of more than 100 different health behaviors--ranging from diet and medication to stress control and chronic smoking--and enables you to assess your own biological age. Most important, it shows you how to design a specific path to improving or reversing your own aging trajectory. Developed by Dr. Michael F. Roizen, chair of anesthesia and critical care at the University of Chicago and preventive gerontologist, along with four other scientists, the RealAge program is based on cutting-edge scientific research. Dr. Roizen and his team have pored over 25,000 medical studies, evaluating what they tell us about aging and what they tell us about the prevention of aging.In RealAge, they present the complete results of their analysis for the first time. Each chapter covers a broad health topic--for example, how the right vitamins and supplements, exercise, or diet can be used to control how your genes affect you--and calculates the RealAge advantage you will gain by adopting a specific behavior. Charts, fact sheets, and tests give you specific choices to make and describe benefits to be gained so you can measure your success. Suggested behavior changes are rated in order of difficulty so you can decide whether the result is worth the effort. Ultimately, this program is about maintaining your health. The better condition you are in, the better prepared you will be to fight the factors that age you. RealAge demonstrates that you can have more control over the aging process. It makes science simple and its promise is irresistible: You may live as young at seventy as you did at forty-four. Remeber your high school reunion? Even though everyone was the same chronological age, people no longer looked the same. Some wore the years well, staying young and exuberant despite the passage of time, whereas others looked as if they had aged ten years more than everyone else--and probably had. Did you know that: Financial stress can make your RealAge two to thirty-two years older? The difference between having the ideal blood pressure 115/76--and high blood pressure--higher than 140/90--can make a RealAge difference of more than twenty years? A tablet of aspirin a day can make your RealAge 1.9 years younger? Flossing daily and seeing a dentist and dental hygienist every six months can make your RealAge 6.4 years younger? In RealAge you will discover many other easy-to-institute Age Reduction Strategies that will enable you to live longer and younger.

Transfusion Medicine and Scientific Developments

Author : A.W.M.M. Koopman-van Gemert
Publisher : BoD – Books on Demand
ISBN 13 : 9535133195
Total Pages : 130 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Transfusion Medicine and Scientific Developments by : A.W.M.M. Koopman-van Gemert

Download or read book Transfusion Medicine and Scientific Developments written by A.W.M.M. Koopman-van Gemert and published by BoD – Books on Demand. This book was released on 2017-07-05 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transfusion Medicine and Scientific Developments focuses on unknown aspects of blood cells and transfusion practice. Blood transfusion medicine has become a sophisticated and specialized field of medicine. Some aspects will be discussed in this book. The book has been divided into three sections. The first section includes chapters describing the immunological and coagulation-assisting functions of red blood cells and methods to measure their life span. The second section discusses the role of platelets in inflammatory processes. The third section reviews functional dose of RBC transfusions and transfusion practice in various clinical settings.

Anatomy & Physiology

Author : Lindsay Biga
Publisher :
ISBN 13 : 9781955101158
Total Pages : pages
Book Rating : 4.1/5 (11 download)

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Book Synopsis Anatomy & Physiology by : Lindsay Biga

Download or read book Anatomy & Physiology written by Lindsay Biga and published by . This book was released on 2019-09-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A version of the OpenStax text

Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Author : Franck Mauvais-Jarvis
Publisher : Springer
ISBN 13 : 3319701789
Total Pages : 627 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity by : Franck Mauvais-Jarvis

Download or read book Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity written by Franck Mauvais-Jarvis and published by Springer. This book was released on 2017-12-08 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Lipid metabolism in mammals

Author : Fred Snyder
Publisher : Springer Science & Business Media
ISBN 13 : 1468428322
Total Pages : 415 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Lipid metabolism in mammals by : Fred Snyder

Download or read book Lipid metabolism in mammals written by Fred Snyder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade we have witnessed a vast expansion in our knowl edge of lipid metabolism, especially for mammalian tissues. One obvious conclusion arising from these studies is that no single overall scheme of lipid metabolism can be classed as distinctly characteristic of all mamma lian organs. Although certain synthetic and degradative lipid pathways are similar in a variety of organs, I have been impressed by the notable exceptions. I was motivated to organize this work on Lipid Metabolism in Mammals because of the lack of a single reference source containing a comparative organ approach to lipid metabolism in mammals that empha sizes the uniqueness of pathways in the various organs of the body. Because of the escalation in lipid research, I also feel strongly that there is an urgent need for an updated concise account of this field. The group of authors for the chapters in the two volumes of Lipid Metabolism in Mammals were selected for their expertise and personal experience with the lipid metabolism of the organs or blood constituents that are the subjects of the chapters. Sufficient leeway has been given each author to approach the subject matter from a personal viewpoint. How ever, the overall direction of each chapter has been slanted to emphasize the similarities and differences in lipid metabolism among organ systems. The introductory chapter on general pathways provides a convenient refer ence to illustrations of specific reaction sequences that are well established and that occur in a number of organs.

Encyclopedia of Aging and Public Health

Author : Sana Loue
Publisher : Springer Science & Business Media
ISBN 13 : 0387337539
Total Pages : 852 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Encyclopedia of Aging and Public Health by : Sana Loue

Download or read book Encyclopedia of Aging and Public Health written by Sana Loue and published by Springer Science & Business Media. This book was released on 2008-01-16 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Americans are living longer, and the elder population is growing larger. To meet the ongoing need for quality information on elder health, the Encyclopedia of Aging and Public Health combines multiple perspectives to offer readers a more accurate and complete picture of the aging process. The book takes a biopsychosocial approach to the complexities of its subject. In-depth introductory chapters include coverage on a historical and demographic overview of aging in America, a guide to biological changes accompanying aging, an analysis of the diversity of the U.S. elder population, legal issues commonly affecting older adults, and the ethics of using cognitively impaired elders in research. From there, over 425 entries cover the gamut of topics, trends, diseases, and phenomena: -Specific populations, including ethnic minorities, custodial grandparents, and centenarians -Core medical conditions associated with aging, from cardiac and pulmonary diseases to Parkinson’s and Alzheimer’s -Mental and emotional disorders -Drugs/vitamins/alternative medicine -Disorders of the eyes, feet, and skin -Insomnia and sleep disorders; malnutrition and eating disorders -Sexual and gender-related concerns -And a broad array of social and political issues, including access to care, abuse/neglect, veterans’ affairs, and assisted suicide Entries on not-quite-elders’ concerns (e.g., midlife crisis, menopause) are featured as well. And all chapters and entries include references and resource lists. The Encyclopedia has been developed for maximum utility to clinicians, social workers, researchers, and public health professionals working with older adults. Its multidisciplinary coverage and scope of topics make this volume an invaluable reference for academic and public libraries.

The Red Cell Life-Cycle From Erythropoiesis to Clearance

Author : Lars Kaestner
Publisher : Frontiers Media SA
ISBN 13 : 2889457028
Total Pages : 238 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The Red Cell Life-Cycle From Erythropoiesis to Clearance by : Lars Kaestner

Download or read book The Red Cell Life-Cycle From Erythropoiesis to Clearance written by Lars Kaestner and published by Frontiers Media SA. This book was released on 2019-02-05 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eBook ‘The red cell life-cycle from erythropoiesis to clearance’ continues the discussion of questions like: What are the changes associated with red blood cell maturation, adulthood and senescence? What are the determinants of red blood cell life span and clearance? What are the mechanisms in control of red blood cell mass in healthy humans and patients with various forms of anaemia? Can red blood cells be 'trained' to provide the body with more oxygen during endurance exercises? What are the markers of circulating red blood cell senescence and in cells during storage and transfusion? And what can be learned from various species that developed advanced adaptations to maintain oxygen delivery under stress conditions such as exercising to the limit, diving or living in anaerobic aquatic habitats or at high altitude? Within the approximately 120 days (or 40 in a mouse, or 150-170 in a horse) life span of 'healthy' red blood cells, many cellular properties change leading to aged mixed cell populations in the circulation. Red blood cells seem to be genetically terminated by the time they become red blood cells and the contributions of this eBook increase the understanding of this process. There are surprisingly versatile remodeling processes happening during the red blood cell life span. Numerous disorders are associated with the premature onset of the 'ageing process' of red blood cells. Furthermore, in vitro ageing and/or modifications as well as the slowing down of the modifications is an important issue in transfusion medicine. Many of the molecular mechanisms behind such effects are elucidated in this eBook.

Blood Cells, Rheology, and Aging

Author : Dieter Platt
Publisher :
ISBN 13 : 9783642717918
Total Pages : 236 pages
Book Rating : 4.7/5 (179 download)

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Book Synopsis Blood Cells, Rheology, and Aging by : Dieter Platt

Download or read book Blood Cells, Rheology, and Aging written by Dieter Platt and published by . This book was released on 1987-12-11 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume on experimental gerontology deals with the effects of aging on blood cells and rheology. Since gerontology is an interdisciplinary science, numerous experts engaged in various disciplines present their up-to-date results related to aging. The detailed accounts compiled in this book will augment the knowledge of red cells, immunology, receptors, blood coagulation, and rheology. The volume provides a valuable basis for future scientific work in gerontological research.

Rossi's Principles of Transfusion Medicine

Author : Toby L. Simon
Publisher : John Wiley & Sons
ISBN 13 : 1119012996
Total Pages : 754 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Rossi's Principles of Transfusion Medicine by : Toby L. Simon

Download or read book Rossi's Principles of Transfusion Medicine written by Toby L. Simon and published by John Wiley & Sons. This book was released on 2016-05-23 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references

Handbook of Hemorheology and Hemodynamics

Author : O.K. Baskurt
Publisher : IOS Press
ISBN 13 : 1607502631
Total Pages : 468 pages
Book Rating : 4.6/5 (75 download)

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Book Synopsis Handbook of Hemorheology and Hemodynamics by : O.K. Baskurt

Download or read book Handbook of Hemorheology and Hemodynamics written by O.K. Baskurt and published by IOS Press. This book was released on 2007-10-03 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication primarily focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements and blood vessel walls, and on the microvascular aspects of hemodynamics. Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics. Sections of the Handbook include History of Hemorheology; Hemorheology, covering basic aspects, blood composition, blood rheology, cell mechanics, pathophysiology, methods and comparative studies; Hemodynamics, covering basic principles, microcirculation, in vivo effects, endothelium and methods; and Clinical Aspects of Hemorheology, covering hyperviscosity, clinical significance and treatment. The goal is to foster greater interchange between workers in the fields so as to promote collaborative efforts and, hopefully, improved health. In selecting topics for this handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics. Hemorheology and hemodynamics are closely related, the former dealing with all aspects of the flow and interactions of the individual blood cells mostly studied in vitro, the latter with the in vivo relationships among vessel architecture, driving pressure, flow rate and shear stress. The linkage between the in vitro and in vivo research described in the book will be of interest to both basic science and clinical investigators. The editors of the handbook have each been active in the fields of bio- and hemorheology for many years, and have published extensively. They have successfully achieved their objective to publish a well-written and well-edited handbook that will be valuable for researchers and students in the field.