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Author : Dan Gusfield
Publisher : Association for Computing Machinery (ACM)
ISBN 13 : 9781581137552
Total Pages : 376 pages
Book Rating : 4.1/5 (375 download)
Download or read book RECOMB 2004 written by Dan Gusfield and published by Association for Computing Machinery (ACM). This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Webb Miller
Publisher :
ISBN 13 : 9781581136357
Total Pages : 356 pages
Book Rating : 4.1/5 (363 download)
Download or read book RECOMB 2003 written by Webb Miller and published by . This book was released on 2003 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: We study haplotype reconstruction under the Mendelian law of inheritance and the minimum recombination principleon pedigree data. We prove that the problem of finding a mini-mum-recombinant haplotype configuration (MRHC) is in general NP-hard. This is the first complexity result concerning the problem to our knowledge. An iterative algorithm based on blocks of consecutive resolved marker loci (called block-extension) is proposed. It is very efficient and can be used for large pedigrees with a large number of markers, especially for those data sets requiring few recombinants (or recombination events). A polynomial-time exact algorithm for haplotype reconstruction without recombinants is also presented. This algorithm first identifies all the necessary constraints based on the Mendelian law and the zero recombinant assumption, and represents them using a system of linear equations over the cyclic group Z2. By using a simple method based on Gaussian elimination, we could obtain all possible feasible haplotype configurations. We have tested the block-extension algorithm on simulated data generated on three pedigree structures. The results show that the algorithm performs very well on both multi-allelic and biallelic data, especially when the number of recombinants is small.
Author : Marylyn D. Ritchie
Publisher : Springer Science & Business Media
ISBN 13 : 3642122108
Total Pages : 259 pages
Book Rating : 4.6/5 (421 download)
Download or read book Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics written by Marylyn D. Ritchie and published by Springer Science & Business Media. This book was released on 2010-03-25 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ?eld of bioinformatics has two main objectives: the creation and main- nance of biological databases, and the discovery of knowledge from life sciences datainordertounravelthemysteriesofbiologicalfunction,leadingtonewdrugs andtherapiesforhumandisease. Life sciencesdatacomeinthe formofbiological sequences, structures, pathways, or literature. One major aspect of discovering biological knowledge is to search, predict, or model speci'c information in a given dataset in order to generate new interesting knowledge. Computer science methods such as evolutionary computation, machine learning, and data mining all have a great deal to o'er the ?eld of bioinformatics. The goal of the 8th - ropean Conference on Evolutionary Computation, Machine Learning, and Data Mining in Bioinformatics (EvoBIO 2010) was to bring together experts in these ?elds in order to discuss new and novel methods for tackling complex biological problems. The 8th EvoBIO conference was held in Istanbul, Turkey during April 7-9, 2010attheIstanbulTechnicalUniversity. EvoBIO2010washeldjointlywiththe 13th European Conference on Genetic Programming (EuroGP 2010), the 10th European Conference on Evolutionary Computation in Combinatorial Opti- sation (EvoCOP 2010), and the conference on the applications of evolutionary computation,EvoApplications. Collectively,the conferences areorganizedunder the name Evo* (www. evostar. org). EvoBIO, held annually as a workshop since 2003, became a conference in 2007 and it is now the premiere European event for those interested in the interface between evolutionary computation, machine learning, data mining, bioinformatics, and computational biology.
Author : Andrés Aguilera
Publisher : Springer Science & Business Media
ISBN 13 : 3540710213
Total Pages : 536 pages
Book Rating : 4.5/5 (47 download)
Download or read book Molecular Genetics of Recombination written by Andrés Aguilera and published by Springer Science & Business Media. This book was released on 2007-04-24 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.
Author : Gary Benson
Publisher : Springer
ISBN 13 : 3540397639
Total Pages : 539 pages
Book Rating : 4.5/5 (43 download)
Download or read book Algorithms in Bioinformatics written by Gary Benson and published by Springer. This book was released on 2003-12-08 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the Third International Workshop on Algorithms in Bioinformatics, WABI 2003, held in Budapest, Hungary, in September 2003. The 36 revised full papers presented were carefully reviewed and selected from 78 submissions. The papers are organized in topical sections on comparative genomics, database searching, gene finding and expression, genome mapping, pattern and motif discovery, phylogenetic analysis, polymorphism, protein structure, sequence alignment, and string algorithms.
Author : Deepti Yadav
Publisher : Elsevier
ISBN 13 : 032398584X
Total Pages : 307 pages
Book Rating : 4.3/5 (239 download)
Download or read book Fundamentals of Recombinant Protein Production, Purification and Characterization written by Deepti Yadav and published by Elsevier. This book was released on 2024-09-27 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Recombinant Protein Production, Purification and Characterization is organized into nine chapters in a logical fashion that cover an introduction to recombinant proteins and expression in different host expression systems, extraction, purification and analysis of proteins. This important reference features protocols, along with the advantages and disadvantage of each expression hosts and characterization technique (presented in tabular format) and offers detailed coverage of all aspects of protein production and processing (upstream and downstream processing) in one place. Finally, the book ends with different characterization techniques. Production of recombinant proteins for biotechnological and therapeutic applications at a large scale is an essential need of mankind. With the huge application potential of therapeutic and industrial proteins, there has been increasing demand for effective and efficient bioprocessing strategies. Recent progress around recombinant DNA technologies and bioprocessing strategies has paved the way for efficient production of recombinant proteins. Important factors such as insolubility and cost of production need to be considered for large scale production of these recombinant proteins. Includes step-by-step reproducible protocols while also providing updated information on the rationale and latest developments in expression systems Can also be used as a handbook for protein expression and purification as expression systems and chromatographic methods are explained in detail Consists of notes on troubleshooting from the eminent researchers in the field Provides comprehensive information on protein production, purification and characterization in a single volume Describes different purification methods for comparatively difficult to obtain proteins Brings the topics of recombinant protein expression, purification and characterization together, thereby making it the first resource on how to solve problems with respect to upstream and downstream processing of heterologous proteins
Author : Jeffrey J. Clare
Publisher : John Wiley & Sons
ISBN 13 : 3527607935
Total Pages : 302 pages
Book Rating : 4.5/5 (276 download)
Download or read book Expression and Analysis of Recombinant Ion Channels written by Jeffrey J. Clare and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap created over the past five years, during which many new techniques have entered the market, this book is directed at both the new and the experienced ion channel researcher wishing to learn more about the considerations and methods for studying recombinant ion channels. These latest developments are covered here for the first time, contributed by editors and authors working for major pharmaceutical companies and who routinely apply these techniques in their daily work. The first three chapters cover the use of the Xenopus oocyte expression system for structure-function studies, from basic approaches for manipulating ion channel cDNAs to more specialized but powerful techniques. This is followed by reviews of strategies and methodologies available for expressing channels in mammalian cells and for their analysis by patch-clamp electrophysiology. Chapters 6 to 8 review the latest methodologies for ion channel drug discovery, including high throughput screening using fluorescence and luminescence, as well as automated planar array electrophysiology. The remaining two chapters focus on approaches for determining ion channel crystal structures and on computational approaches to understanding channel mechanisms at atomic resolution. Rather than provide detailed protocols, indicated by references in each chapter, the authors provide a comprehensive and easily accessible overview of the techniques involved, reviewing underlying principles and providing working guidelines as well as an understanding of the key theoretical and practical considerations associated with each topic. In each case, this practical advice is illustrated by real life examples, taken either from the author's own experience or from key examples in the literature, providing valuable practical hints not found elsewhere. The result is a compendium of practical ion channel information that will prove a valuable resource to academic and industrial workers alike.
Author : Mohammad Resa Nowrousian
Publisher : Springer Science & Business Media
ISBN 13 : 3211694595
Total Pages : 866 pages
Book Rating : 4.2/5 (116 download)
Download or read book Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology written by Mohammad Resa Nowrousian and published by Springer Science & Business Media. This book was released on 2010-06-14 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anemia, a frequent complication of cancer and its treatments, produces unwanted symptoms and significantly impairs metabolic and physiologic functions, as well as patients' activity, quality of life and even life expectancy. In its new Second Edition, this book presents current knowledge on anemia in cancer and its treatment with Recombinant Human Erythropoietin (rhEPO). Expanded, updated and newly added chapters describe scientific and clinical aspects of anemia, and give diagnostic and therapeutic recommendations on use of rhEPO. This is an essential source of information for radiotherapists, medical oncologists, hematologists, internists, pediatricians, surgeons, specialists in transfusion and laboratory medicine, and pharmacologists.
Author : Gerd Gellissen
Publisher : John Wiley & Sons
ISBN 13 : 3527604413
Total Pages : 429 pages
Book Rating : 4.5/5 (276 download)
Download or read book Production of Recombinant Proteins written by Gerd Gellissen and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the choices of microbial and eukaryotic expression systems for production of recombinant proteins are many, most researchers in academic and industrial settings do not have ready access to pertinent biological and technical information since it is normally scattered throughout the scientific literature. This book closes the gap by providing information on the general biology of the host organism, a description of the expression platform, a methodological section -- with strains, genetic elements, vectors and special methods, where applicable -- as well as examples of proteins produced with the respective platform. The systems thus described are well balanced by the inclusion of three prokaryotes (two Gram-negatives and one Gram-positive), four yeasts, two filamentous fungi and two higher eukaryotic cell systems -- mammalian and plant cells. Throughout, the book provides valuable practical and theoretical information on the criteria and schemes for selecting the appropriate expression platform, the possibility and practicality of a universal expression vector, and on comparative industrial-scale fermentation, with the production of a recombinant Hepatitis B vaccine chosen as an industrial example. With a foreword by Herbert P. Schweizer, Colorado State University, USA: "As a whole, this book is a valuable and overdue resource for a varied audience. It is a practical guide for academic and industrial researchers who are confronted with the design of the most suitable expression platform for their favorite protein for technical or pharmaceutical purposes. In addition, the book is also a valuable study resource for professors and students in the fields of applied biology and biotechnology."
Author : Fumio Hanaoka
Publisher : Springer
ISBN 13 : 443155873X
Total Pages : 548 pages
Book Rating : 4.4/5 (315 download)
Download or read book DNA Replication, Recombination, and Repair written by Fumio Hanaoka and published by Springer. This book was released on 2016-01-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Author : Richard Egel
Publisher : Springer Science & Business Media
ISBN 13 : 3540753737
Total Pages : 375 pages
Book Rating : 4.5/5 (47 download)
Download or read book Recombination and Meiosis written by Richard Egel and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating volume addresses the processes and mechanisms taking place in the cell during meiosis and recombination. It covers multicellular eukaryotes such as Drosophila, Arabidopsis, mice and humans. Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II – reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over.
Author : Melvyn Little
Publisher : Cambridge University Press
ISBN 13 : 0521887321
Total Pages : 445 pages
Book Rating : 4.5/5 (218 download)
Download or read book Recombinant Antibodies for Immunotherapy written by Melvyn Little and published by Cambridge University Press. This book was released on 2009-07-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.
Author : Kerstin Kurzhals
Publisher : Springer Nature
ISBN 13 : 3658356669
Total Pages : 355 pages
Book Rating : 4.6/5 (583 download)
Download or read book Resource Recombination in Firms from a Dynamic Capability Perspective written by Kerstin Kurzhals and published by Springer Nature. This book was released on 2021-11-17 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elaborates the concept of Resource Recombination in firms from a Dynamic Capability perspective. With the investigation of the role of Dynamic Capabilities in the process of innovation generation through Resource Recombination, this research addresses some existing shortcomings in the Dynamic Capability literature, where there is a crucial need to better understand the interrelationship between Dynamic Capabilities, the firm`s resource base, and innovation through Resource Recombinations. This research contributes to the resource and competence based research by developing and empirically testing a conceptual model of factors influencing Resource Recombination in firms. The principal aim of this research is to bring clarity to the notion of Dynamic Capabilities, their role and effects towards building Resource Recombinations in firms.
Author : Eduardo A. Ceccarelli
Publisher : Frontiers E-books
ISBN 13 : 2889192946
Total Pages : 103 pages
Book Rating : 4.8/5 (891 download)
Download or read book Recombinant protein expression in microbial systems written by Eduardo A. Ceccarelli and published by Frontiers E-books. This book was released on 2014-10-02 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of recombinant DNA technology, expressing heterologous proteins in microorganisms rapidly became the method of choice for their production at laboratory and industrial scale. Bacteria, yeasts and other hosts can be grown to high biomass levels efficiently and inexpensively. Obtaining high yields of recombinant proteins from this material was only feasible thanks to constant research on microbial genetics and physiology that led to novel strains, plasmids and cultivation strategies. Despite the spectacular expansion of the field, there is still much room for progress. Improving the levels of expression and the solubility of a recombinant protein can be quite challenging. Accumulation of the product in the cell can lead to stress responses which affect cell growth. Buildup of insoluble and biologically inactive aggregates (inclusion bodies) lowers the yield of production. This is particularly true for obtaining membrane proteins or high-molecular weight and multi-domain proteins. Also, obtaining eukaryotic proteins in a prokaryotic background (for example, plant or animal proteins in bacteria) results in a product that lack post-translational modifications, often required for functionality. Changing to a eukaryotic host (yeasts or filamentous fungi) may not be a proper solution since the pattern of sugar modifications is different than in higher eukaryotes. Still, many advances in the last couple of decades have provided to researchers a wide variety of strategies to maximize the production of their recombinant protein of choice. Everything starts with the careful selection of the host. Be it bacteria or yeast, a broad list of strains is available for overcoming codon use bias, incorrect disulfide bond formation, protein toxicity and lack of post-translational modifications. Also, a huge catalog of plasmids allows choosing for different fusion partners for improving solubility, protein secretion, chaperone co-expression, antibiotic resistance and promoter strength. Next, controlling culture conditions like temperature, inducer and media composition can bolster recombinant protein production. With this Research Topic, we aim to provide an encyclopedic account of the existing approaches to the expression of recombinant proteins in microorganisms, highlight recent discoveries and analyze the future prospects of this exciting and ever-growing field.
Author : Steven L. Guberman
Publisher : Springer Science & Business Media
ISBN 13 : 1461500834
Total Pages : 467 pages
Book Rating : 4.4/5 (615 download)
Download or read book Dissociative Recombination of Molecular Ions with Electrons written by Steven L. Guberman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dissociative Recombination of Molecular Ions with Electrons is a comprehensive collection of refereed papers describing the latest developments in dissociative recombination research. The papers are written by the leading researchers in the field. The topics covered include the use of microwave afterglows, merged beams and storage rings to measure rate coefficients and to identify the products and their yields. The molecules studied range in size from the smallest, H2+, to bovine insulin ions. The theoretical papers cover the important role of Rydberg states and the use of wave packets and quantum defect theory to deduce cross sections, rate constants and quantum yields. Several theoretical and experimental papers address the controversial topic of H3+ dissociative recombination and its importance in the interstellar medium. Dissociative recombination studies of other molecular ions in the interstellar medium and in cometary and planetary atmospheres are covered. Ionization is an important competitive process to dissociative recombination and its competition with predissociation and its role in the reverse process of the association of neutral species is presented. Dissociative attachment, in which an electron attaches to a neutral molecule, has many similarities to dissociative recombination. The topics covered include the accurate calculation of electron affinities, attachment to molecules, clusters, and to species absorbed on solid surfaces and electron scattering by a molecular anion.
Author : Pierre Ferrier
Publisher : Springer Science & Business Media
ISBN 13 : 1441902961
Total Pages : 216 pages
Book Rating : 4.4/5 (419 download)
Download or read book V(D)J Recombination written by Pierre Ferrier and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.
Author : Hujun Yin
Publisher : Springer
ISBN 13 : 3642326390
Total Pages : 882 pages
Book Rating : 4.6/5 (423 download)
Download or read book Intelligent Data Engineering and Automated Learning -- IDEAL 2012 written by Hujun Yin and published by Springer. This book was released on 2012-08-01 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 13th International Conference on Intelligent Data Engineering and Automated Learning, IDEAL 2012, held in Natal, Brazil, in August 2012. The 100 revised full papers presented were carefully reviewed and selected from more than 200 submissions for inclusion in the book and present the latest theoretical advances and real-world applications in computational intelligence.
