Real Time Monitoring Of Cancer Cell Metabolism For Drug Testing

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Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

Author : Hamed Alborzinia
Publisher :
ISBN 13 : 9783658101626
Total Pages : pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing by : Hamed Alborzinia

Download or read book Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing written by Hamed Alborzinia and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion. Contents Drug Screening with New Perspectives Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip Anticancer Agents - Effects Measured in Real Time Metabolism of Cancer Cells Target Groups Researchers and students in the fields of biotechnology and pharmacy The Author Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Real-time monitoring of cancer cell metabolism upon drug treatment and other forms of metabolic manipulation

Author : Hamed Alborzinia
Publisher :
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.:/5 (778 download)

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Book Synopsis Real-time monitoring of cancer cell metabolism upon drug treatment and other forms of metabolic manipulation by : Hamed Alborzinia

Download or read book Real-time monitoring of cancer cell metabolism upon drug treatment and other forms of metabolic manipulation written by Hamed Alborzinia and published by . This book was released on 2011 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

Author : Hamed Alborzinia
Publisher : Springer
ISBN 13 : 365810161X
Total Pages : 160 pages
Book Rating : 4.6/5 (581 download)

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Book Synopsis Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing by : Hamed Alborzinia

Download or read book Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing written by Hamed Alborzinia and published by Springer. This book was released on 2015-06-03 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

Chemosensitivity

Author : Rosalyn D. Blumenthal
Publisher : Humana Press
ISBN 13 : 9781588295866
Total Pages : 442 pages
Book Rating : 4.2/5 (958 download)

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Book Synopsis Chemosensitivity by : Rosalyn D. Blumenthal

Download or read book Chemosensitivity written by Rosalyn D. Blumenthal and published by Humana Press. This book was released on 2005-02-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.

Nanostructures for Novel Therapy

Author : Denisa Ficai
Publisher : Elsevier
ISBN 13 : 0323461484
Total Pages : 908 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanostructures for Novel Therapy by : Denisa Ficai

Download or read book Nanostructures for Novel Therapy written by Denisa Ficai and published by Elsevier. This book was released on 2017-02-25 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability. - Outlines how the characteristics of nanostructures made from different materials gives particular properties that can be successfully used in therapeutics - Compares the properties of different nanostructures, allowing medicinal chemists and engineers to select which are most appropriate for their needs - Highlights new uses of nanostructures within the therapeutic field, enabling the discovery of new, more effective drugs

New Insights into Cell Culture Technology

Author : Sivakumar Joghi Thatha Gowder
Publisher : BoD – Books on Demand
ISBN 13 : 9535131338
Total Pages : 204 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis New Insights into Cell Culture Technology by : Sivakumar Joghi Thatha Gowder

Download or read book New Insights into Cell Culture Technology written by Sivakumar Joghi Thatha Gowder and published by BoD – Books on Demand. This book was released on 2017-05-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "New Insights into Cell Culture Technology" focuses on many advanced methods and techniques concerned with cell culture. The contributing authors have discussed various developments in cell culture methods, the application of insect cells for the efficient production of heterologous proteins, the expansion of human mesenchymal stromal cells for different clinical applications, the remote sensing of cell culture experiments and concepts for the development of cell culture bioprocess, continuous production of retroviral pseudotype vectors, and the production of oncolytic measles virus vectors for cancer therapy. This book is an original contribution of experts from different parts of the globe, and the in-depth information will be a significant resource for students, scientists, and physicians who are directly dealing with cells.["Culture" is essential for human life and also the life of a cell. - Sivakumar Gowder]

Microfluidic Devices for Biomedical Applications

Author : Xiujun (James) Li
Publisher : Woodhead Publishing
ISBN 13 : 0128227559
Total Pages : 724 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Microfluidic Devices for Biomedical Applications by : Xiujun (James) Li

Download or read book Microfluidic Devices for Biomedical Applications written by Xiujun (James) Li and published by Woodhead Publishing. This book was released on 2021-08-05 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. - Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores a wide range of medical applications - Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies - Details applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and its role in developing tissue scaffolds, and stem cell engineering

Tumor Suppressor Genes

Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
ISBN 13 : 1592593291
Total Pages : 657 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Tumor Suppressor Genes by : Wafik S. El-Deiry

Download or read book Tumor Suppressor Genes written by Wafik S. El-Deiry and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.

Encyclopedia of Interfacial Chemistry

Author :
Publisher : Elsevier
ISBN 13 : 0128098945
Total Pages : 5276 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Encyclopedia of Interfacial Chemistry by :

Download or read book Encyclopedia of Interfacial Chemistry written by and published by Elsevier. This book was released on 2018-03-29 with total page 5276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry, Seven Volume Set summarizes current, fundamental knowledge of interfacial chemistry, bringing readers the latest developments in the field. As the chemical and physical properties and processes at solid and liquid interfaces are the scientific basis of so many technologies which enhance our lives and create new opportunities, its important to highlight how these technologies enable the design and optimization of functional materials for heterogeneous and electro-catalysts in food production, pollution control, energy conversion and storage, medical applications requiring biocompatibility, drug delivery, and more. This book provides an interdisciplinary view that lies at the intersection of these fields. Presents fundamental knowledge of interfacial chemistry, surface science and electrochemistry and provides cutting-edge research from academics and practitioners across various fields and global regions

Human Organs-on-a-Chip Technology

Author : P.V. Mohanan
Publisher : Elsevier
ISBN 13 : 0443137838
Total Pages : 632 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Human Organs-on-a-Chip Technology by : P.V. Mohanan

Download or read book Human Organs-on-a-Chip Technology written by P.V. Mohanan and published by Elsevier. This book was released on 2024-06-18 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Organs-on-a-Chip Technology focuses on the technology advancement from "organ-on-a-chip to "multi organs-on-a-chip to the newest stage of "human organs-on-a-chip. Chapters investigate the design, simulation studies, device development and application of microfluidic systems. They also offer expert perspectives on the development of an alternative test system in the biological evaluation of drugs, cosmetics, chemicals, medical devices and many others. Lastly, the book addresses issues related to the development of microfluidic devices and alternative test systems in biological and biomedical research. - Explores organs-on-a-chip technology, from the basics, to advanced developments and existing challenges and recent research trends and applications - Reviews every aspect of microfluidic devices, including biological evaluation and targeted delivery - Includes the latest information on regulatory updates

Aggregation-Induced Emission

Author : Youhong Tang
Publisher : Springer Nature
ISBN 13 : 3030899330
Total Pages : 389 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Aggregation-Induced Emission by : Youhong Tang

Download or read book Aggregation-Induced Emission written by Youhong Tang and published by Springer Nature. This book was released on 2021-11-05 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Aggregation-Induced Emission In Electrochemiluminescence: Advances and Perspectives" is available open access under a CC BY 4.0 License via link.springer.com.

AACR 2022 Proceedings: Part A Online-Only and April 10

Author : American Association for Cancer Research
Publisher : CTI Meeting Technology
ISBN 13 : 1005372799
Total Pages : 2287 pages
Book Rating : 4.0/5 (53 download)

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Book Synopsis AACR 2022 Proceedings: Part A Online-Only and April 10 by : American Association for Cancer Research

Download or read book AACR 2022 Proceedings: Part A Online-Only and April 10 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2022-05-09 with total page 2287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.

14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics

Author : Alexei Katashev
Publisher : Springer Science & Business Media
ISBN 13 : 354069367X
Total Pages : 662 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics by : Alexei Katashev

Download or read book 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics written by Alexei Katashev and published by Springer Science & Business Media. This book was released on 2008-07-30 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: 14th Nordic – Baltic Conference on Biomedical Engineering and Medical Physics – NBC-2008 – brought together scientists not only from the Nordic – Baltic region, but from the entire world. This volume presents the Proceedings of this international conference, jointly organized by the Latvian Medical Engineering and Physics Society, Riga Technical University and University of Latvia in close cooperation with International Federation of Medical and Biological Engineering (IFMBE) The topics covered by the Conference Proceedings include: Biomaterials and Tissue Engineering; Biomechanics, Artificial Organs, Implants and Rehabilitation; Biomedical Instrumentation and Measurements, Biosensors and Transducers; Biomedical Optics and Lasers; Healthcare Management, Education and Training; Information Technology to Health; Medical Imaging, Telemedicine and E-Health; Medical Physics; Micro- and Nanoobjects, Nanostructured Systems, Biophysics

Microfluidics for Cells and Other Organisms

Author : Danny van Noort
Publisher : MDPI
ISBN 13 : 3039215620
Total Pages : 200 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Microfluidics for Cells and Other Organisms by : Danny van Noort

Download or read book Microfluidics for Cells and Other Organisms written by Danny van Noort and published by MDPI. This book was released on 2019-10-23 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.

Chemical Warfare Agents

Author : Brian J. Lukey
Publisher : CRC Press
ISBN 13 : 0429632967
Total Pages : 826 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Chemical Warfare Agents by : Brian J. Lukey

Download or read book Chemical Warfare Agents written by Brian J. Lukey and published by CRC Press. This book was released on 2019-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11, 2001. The second edition titled, Chemical Warfare Agents: Pharmacology, Toxicology, and Therapeutics, included new epidemiological and clinical studies of exposed or potentially exposed populations; new treatment concepts and products; improved organization of the national response apparatus addressing the potential for CWA terrorism; and improved diagnostic tests that enable rapid diagnosis and treatment. Since the second edition, the chemical warfare agent community has worked hard to advance research for protection and treatment and develop/improve response approaches for individuals and definitive care. Consequently, in addition to updating previous chapters, Chemical Warfare Agents: Biomedical and Psychological Effects, Medical Countermeasures, and Emergency Response, Third Edition features several new chapters that address the Syrian War, chemical destruction, the Organisation for the Prohibition of Chemical Weapons, biomarkers for chemical warfare agent exposure, field sensors, aircraft decontamination, lung/human on a chip, chemical warfare response decision making, and other research advancements. Features: Describes the newest medical interventions, and the latest technologies deployed in the field, as well as developments in the international response to CW usage highlighting recent events in the Middle East Discusses the latest in organizational/interagency partitioning in terms of responsibilities for emergency response, not just in the United States but at the international level—whether prevention, mitigation, medical care, reclamation, or medico-legal aspects of such response Contains the most current research from bench-level experts The third edition contains the most up-to-date and comprehensive coverage of the question of chemical warfare agent employment on the battlefield or in terrorism. Edited by workers that have been in the field for 35+ years, it remains faithful to the scientific "constants," while evaluating and crediting the advances by the industry that have made us safer.

Metabolism in Cancer

Author : Thorsten Cramer
Publisher : Springer
ISBN 13 : 3319421182
Total Pages : 272 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Metabolism in Cancer by : Thorsten Cramer

Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Microfluidic Cell Culture Systems

Author : Jeffrey T Borenstein
Publisher : Elsevier
ISBN 13 : 0128136723
Total Pages : 398 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Microfluidic Cell Culture Systems by : Jeffrey T Borenstein

Download or read book Microfluidic Cell Culture Systems written by Jeffrey T Borenstein and published by Elsevier. This book was released on 2018-09-12 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. - Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. - Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. - Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.