Rational Design And Synthesis Of Mesoporous Silica Nanostructure Based Drug Delivery Systems

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Rational Design and Synthesis of Mesoporous Silica Nanostructure-based Drug Delivery Systems

Author : Lauren Chlebanowski
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Rational Design and Synthesis of Mesoporous Silica Nanostructure-based Drug Delivery Systems by : Lauren Chlebanowski

Download or read book Rational Design and Synthesis of Mesoporous Silica Nanostructure-based Drug Delivery Systems written by Lauren Chlebanowski and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the most threatening diseases in the world, cancer and multi-drug resistant bacteria infections are two of the most serious. Mesoporous silica nanoparticles or nanostructures (MSNs) provide nanovesicles for transporting anti-cancer or anti-microbial drugs. The MSNs can easily be functionalized with gatekeepers to ensure that these drugs are released when and where they are needed. It is known that membrane disruption is more difficult for bacteria to gain resistance. For this reason, a small surfactant library was designed with potential of having significant activity toward both gram-positive and gram-negative bacteria. Once the surfactants were synthesized, they were characterized using NMR, IR, and mass spectroscopy. Their activity was then tested against Micrococcus luteus and Methicillin Resistant-Staphylococcus aureus. The surfactants with best activity were then successfully incorporated into MSN structures. Benzalkonium chloride (BAC), a commercially available antiseptic, had the lowest minimum inhibitory concentration (MIC) of the surfactants tested, thus making it the best candidate for use in the proof of study for the designed delivery system. The MSN-based system for treatment of bacterial infections consisted of BAC loaded, amine functionalized MSNs anchored to a vancomycin gatekeeper via a protease cleavable peptide linker. The peptide was designed to have two cleavage positions by proteases for optimal cleaving. Vancomycin was chosen for its bulky size and activity toward bacteria. The system designed for treatment of cancer was focused on the non-specific nature of the therapeutic peptide SA-D-K6L9-AS. The peptide needed to be "gift-wrapped" and sent to the exact location of the tumor to minimize systemic toxicity. The proposed system for this was to use MSNs built directly around a self-assembling version of D-K6L9, then embedding iron oxide nanoparticles on the surface of the MSN, and finally enveloping the MSN in a lipid membrane. The drug would be released when the iron oxide particles were heated via radio-wave mediated hyperthermia. As proof of concept, MSNs built around a rhodamine-B labeled, self-assembling version of D-K6L9 were used and tested against GL26 (glioma), B16F10 (melanoma), and NSC (neural stem cells) cell lines, both with and without the gatekeeping system. The outcome was as anticipated, the gatekeeper kept the peptide inside and the cell viabilities remained high. The next steps of these projects will be to continue in-vitro testing before moving on to mouse model studies. The MSNs in both projects were characterized using DLS, Zeta potential, TGA, and TEM. Overall, the proposed MSN-based drug delivery systems appear to exhibit promising potential for new approaches towards treatment of both antibiotic resistance and cancer.

Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems

Download Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems PDF Online Free

Author : Yu Chen
Publisher : Springer
ISBN 13 : 3662486229
Total Pages : 100 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems by : Yu Chen

Download or read book Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems written by Yu Chen and published by Springer. This book was released on 2015-10-14 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.

Nanotechnology and Drug Delivery, Volume One

Author : José L. Arias
Publisher : CRC Press
ISBN 13 : 1466599480
Total Pages : 378 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Nanotechnology and Drug Delivery, Volume One by : José L. Arias

Download or read book Nanotechnology and Drug Delivery, Volume One written by José L. Arias and published by CRC Press. This book was released on 2014-08-04 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatfo

Silica-coated Magnetic Nanoparticles

Author : Mariela A. Agotegaray
Publisher : Springer
ISBN 13 : 3319501585
Total Pages : 93 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Silica-coated Magnetic Nanoparticles by : Mariela A. Agotegaray

Download or read book Silica-coated Magnetic Nanoparticles written by Mariela A. Agotegaray and published by Springer. This book was released on 2017-01-04 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.

Advances in Nanotechnology-Based Drug Delivery Systems

Author : Anupam Das Talukdar
Publisher : Elsevier
ISBN 13 : 0323904149
Total Pages : 672 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advances in Nanotechnology-Based Drug Delivery Systems by : Anupam Das Talukdar

Download or read book Advances in Nanotechnology-Based Drug Delivery Systems written by Anupam Das Talukdar and published by Elsevier. This book was released on 2022-06-06 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more

Drug Delivery Approaches and Nanosystems, Two-Volume Set

Author : Raj K. Keservani
Publisher : CRC Press
ISBN 13 : 1351839357
Total Pages : 858 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Drug Delivery Approaches and Nanosystems, Two-Volume Set by : Raj K. Keservani

Download or read book Drug Delivery Approaches and Nanosystems, Two-Volume Set written by Raj K. Keservani and published by CRC Press. This book was released on 2020-02-10 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new two-volume set, Drug Delivery Approaches and Nanosystems, Volume 1: Novel Drug Carriers and Volume 2: Drug Targeting Aspects of Nanotechnology presents a comprehensive look at the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is due to the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. These volumes address that gap. Volume 1 addresses the ubiquitous applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques, while Volume 2 focuses on drug targeting aspects of nanotechnology. Together they provide a thorough review of the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. These two volumes will provide a plethora of real-world information for the application of drug delivery approaches via nanotechnology that will be valuable to scientists and researchers as well as faculty and students. The volumes are available separately or together as a set.

Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications

Author : Wei Chen
Publisher :
ISBN 13 :
Total Pages : 263 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications by : Wei Chen

Download or read book Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications written by Wei Chen and published by . This book was released on 2019 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional mesoporous silica nanoparticles (MSNs) have aroused much attention during the past decades for drug delivery and bioimaging applications because of their intrinsic properties including extremely high surface area, large pore volume, tunable pore diameter, easy surface modification, and high biocompatibility. Even though MSNs have these preeminent properties, rendering this unique nanostructure a promising nanocarrier for biomedical applications, several hurdles still challenge the fields of drug delivery and bioimaging when using MSNs as the nanocarries: (i) high loading and high release amounts of water-insoluble drugs delivered to the site of diseases; (ii) precise control of the dosage of drugs delivered to the site of diseases using non-invasive external stimuli; and (iii) construction of MSNs-based shortwave infrared optical imaging contrast agents as an innovative tool for bioimaging and cancer diagnostics. Therefore, this dissertation primarily focuses on the development of innovative strategies that solve these unmet needs and that advance the research in the field of biomedical applications using MSNs as the nanocarriers. In this dissertation, first of all, we review the research work, which mainly focuses on the design and synthesis of multifunctional MSNs and nanomachines for biomedical applications in Accounts of Chemical Research. A wide variety of nanomachines responsive to the different stimuli (pH, redox, enzyme, heat, light, and/or magnetic field) are discussed in this Account. Additionally, we develop a facile strategy for MSNs delivery and release of the water-insoluble drug clofazimine (CFZ), which is used to treat multidrug-resistant tuberculosis. The strategy employs a companion molecule as a chaperone to improve both the loading of CFZ into the pores of MSNs and its subsequent release, thus enabling both high loading and high release of this water-insoluble drug by MSNs. In vitro treatment of macrophages infected with Mycobacterium tuberculosis with the optimized CFZ-loaded MSNs killed the bacteria in the cells in a dose-dependent manner. These studies demonstrate a highly efficient method for loading nanoparticles with water-insoluble drug molecules and the efficacy of the nanoparticles in delivering drugs into eukaryotic cells in aqueous media. Additionally, we used a noninvasive alternating magnetic field (AMF) to stimulate and control the dosage of drug release from MSNs. Noninvasive stimuli-responsive drug delivery using AMF in conjunction with superparamagnetic nanoparticles also offers the potential for the spatial and temporal control of drug release. In vitro studies showed that the death of pancreatic cancer cells treated by drug-loaded nanoparticles was controlled by different lengths of AMF exposure time due to different amounts of drug released from the carriers. Finally, to develop a new shortwave infrared (SWIR) optical imaging contrast agent which has a higher tissue penetration depth, we demonstrate that J-aggregates of near infrared (NIR) fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The use of J-aggregates stabilized in HMSNs as SWIR imaging agents has the potential to overcome the stability, toxicity, and brightness challenges of contrast agents for this compelling region of the electromagnetic spectrum. Collectively, in this dissertation, we explore and develop innovative strategies to load and deliver high amounts of water-insoluble drugs; control the dosage of anticancer drugs released from MSNs triggered by an AMF; and establish a new SWIR optical imaging contrast agent based on the superior carriers - MSNs.

Drug Delivery Approaches and Nanosystems, Volume 1

Author : Raj K. Keservani
Publisher : CRC Press
ISBN 13 : 1351846698
Total Pages : 268 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Drug Delivery Approaches and Nanosystems, Volume 1 by : Raj K. Keservani

Download or read book Drug Delivery Approaches and Nanosystems, Volume 1 written by Raj K. Keservani and published by CRC Press. This book was released on 2017-11-15 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the first of the two-volume Drug Delivery Approaches and Nanosystems series, presents a full picture of the state-of-the-art research and development in drug delivery systems using nanotechnology and its applications. It addresses the ever-expanding application of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. This volume addresses that gap. This volume presents 12 chapters that provide information about the preparation and characterization of nanocomposite materials used in drug delivery systems; advanced research of carbon nanotubes, nanocomposite materials, and polymer-clay, ceramics, and silicate glass-based nanocomposites; and the functionality of graphene nanocomposites. The book also provides detailed information on the application of nanotechnology in drug delivery systems in health care systems and medicine. The book describes how nanostructures are synthesized and draws attention to wide variety of nanostructures available for biological research and treatment applications. This valuable volume provides a wealth of information that will be valuable to scientists and researchers, faculty, and students. Volume 2 of the two-volume series is subtitled Drug Targeting Aspects of Nanotechnology. The volumes are available separately or as a set.

Drug Delivery Systems

Author : Pieter Stroeve
Publisher : World Scientific
ISBN 13 : 9813201061
Total Pages : 391 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Drug Delivery Systems by : Pieter Stroeve

Download or read book Drug Delivery Systems written by Pieter Stroeve and published by World Scientific. This book was released on 2017-11-27 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility.The book provides a comprehensive overview of the recent developments on 'smart' targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book.

Drug Delivery Using Nanomaterials

Author : Yasser Shahzad
Publisher : CRC Press
ISBN 13 : 1000529495
Total Pages : 360 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Drug Delivery Using Nanomaterials by : Yasser Shahzad

Download or read book Drug Delivery Using Nanomaterials written by Yasser Shahzad and published by CRC Press. This book was released on 2022-01-18 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.

Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release

Author : Giri Supratim
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659516733
Total Pages : 84 pages
Book Rating : 4.5/5 (167 download)

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Book Synopsis Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release by : Giri Supratim

Download or read book Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release written by Giri Supratim and published by LAP Lambert Academic Publishing. This book was released on 2014-01 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is one of the key technologies of twenty first century. It involves engineering with materials that have size dimension in nanometer range. As important biological entities like virus, pores of biological membranes, proteins, etc also share their sizes in the nanometer ranges; there has been an extensive application of nanotechnology in biology and biomedicine. Nanomaterial based drug delivery offers one of the most useful techniques to administer therapeutics in living cells and tissues. Mesoporous silica nanomaterials act as excellent hosts to store and deliver guest molecules. In this book, research topics on the development of mesoporous silica nanomaterials as a stimuli responsive and controlled release delivery agents have been discussed. Magnetic nanoparticles were utilized for targeting the drug delivery assembly to a site of interest and induce stimuli responsive drug release in 'proof of principle' studies. The work described in this book is expected to provide a rational approach towards designing targeted and stimuli responsive smart drug delivery systems.

Nanostructures for Drug Delivery

Author : Ecaterina Andronescu
Publisher : Elsevier
ISBN 13 : 0323461492
Total Pages : 1026 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanostructures for Drug Delivery by : Ecaterina Andronescu

Download or read book Nanostructures for Drug Delivery written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-03-24 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial

Drug Delivery Approaches and Nanosystems, Volume 2

Author : Raj K. Keservani
Publisher : CRC Press
ISBN 13 : 1351846663
Total Pages : 248 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Drug Delivery Approaches and Nanosystems, Volume 2 by : Raj K. Keservani

Download or read book Drug Delivery Approaches and Nanosystems, Volume 2 written by Raj K. Keservani and published by CRC Press. This book was released on 2017-11-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.

Nanoparticle Therapeutics

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128209186
Total Pages : 674 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanoparticle Therapeutics by : Prashant Kesharwani

Download or read book Nanoparticle Therapeutics written by Prashant Kesharwani and published by Academic Press. This book was released on 2021-11-06 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states. This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful. Brings together the novel applications of nanotechnology in biological fields Explores perspectives on technologies through highly organized tables, illustrative figures and flow charts Addresses key multidisciplinary challenges faced by nanotechnologists to foster collaboration among biologists, chemists, physicists, engineers and clinicians

Nano- and Microscale Drug Delivery Systems

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0323527280
Total Pages : 516 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Nano- and Microscale Drug Delivery Systems by : Alexandru Mihai Grumezescu

Download or read book Nano- and Microscale Drug Delivery Systems written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-03-27 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems. Shows how micro- and nanomaterials can be engineered to create more effective drug delivery systems Summarizes current nanotechnology research in the field of drug delivery systems Explores the pros and cons of using particular nanomaterials as therapeutic agents Serves as a valuable reference for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems

Nanotechnology and Drug Delivery, Volume One

Author : José L. Arias
Publisher : CRC Press
ISBN 13 : 1466599472
Total Pages : 382 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Nanotechnology and Drug Delivery, Volume One by : José L. Arias

Download or read book Nanotechnology and Drug Delivery, Volume One written by José L. Arias and published by CRC Press. This book was released on 2014-08-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

Design and Development of New Nanocarriers

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0128136286
Total Pages : 769 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Design and Development of New Nanocarriers by : Alexandru Mihai Grumezescu

Download or read book Design and Development of New Nanocarriers written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-11-30 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry