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Author : R. F. Adams
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (173 download)
Download or read book Rapid Drug Analysis in Biological Samples by Gas Chromatography written by R. F. Adams and published by . This book was released on 1973 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rabi A. Musah
Publisher : Humana Press
ISBN 13 : 9781493985784
Total Pages : 231 pages
Book Rating : 4.9/5 (857 download)
Download or read book Analysis of Drugs of Abuse written by Rabi A. Musah and published by Humana Press. This book was released on 2018-07-05 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants. Chapters guide readers through the application of color tests, light microscopy-based particle imaging, GC-MS, Raman spectroscopy, capillary electrophoresis, ultra-high performance LC-tandem MS, DART-MS, MALDI-mass spectrometry imaging, LC-MS/MS and HPLC-ESI-MS/MS to the analysis of abused drugs in wastewater, hair, urine and plant-derived materials, among other matrices. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Analysis of Drugs of Abuse aims to ensure successful results in the further study of this vital field.
Author : Joseph Chamberlain
Publisher : CRC Press
ISBN 13 : 1351411446
Total Pages : 368 pages
Book Rating : 4.3/5 (514 download)
Download or read book The Analysis of Drugs in Biological Fluids written by Joseph Chamberlain and published by CRC Press. This book was released on 2018-02-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition focuses on a variety of techniques available for the analysis of drugs in biological fluids. Over 150 figures and tables help to describe the latest advances and give examples of their applications. Current chiral analysis methods as well as discussions on the impact of chirality are described. Practical aspects of bioanalytical work, including many examples of laboratory problems not often reported in the scientific literature, are examined in depth.
Author : Robert Shipman
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (862 download)
Download or read book Forensic Drug Identification by Gas Chromatography - Infrared Spectroscopy written by Robert Shipman and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary goal of the forensic drug examiner is the unequivocal identification of any controlled substance present in a drug exhibit. Most forensic laboratories routinely employ Gas Chromatography/ Mass Spectrometry (GC/MS) as the preferred method for this examination. The technique provides a rapid, semi-automated analysis of the sample and typically yields sufficient information to identify the compounds in question. However, the application of GC/MS for drug analysis does have its limitations. Certain drugs yield minimal mass spectral fragmentation patterns using electron impact MS, while other compounds, such as some diastereomers and positional isomers, are not readily differentiated technique to mass spectroscopy. Infrared spectroscopy (IR, meaning FTIR) provides an alternate technique to mass spectroscopy for the identification of organic compounds. Recent improvements in the hyphenated technique, Gas Chromatography/Infrared Spectroscopy (GC/IR) may provide a simple alternative or supplemental approach to GC/MS for identification of certain compounds. A newly introduced instrument collects GC effluent on a liquid nitrogen cooled, IR transparent window that allows the direct analysis of the deposited solid material. This technique is superior to the IR light pipe in sensitivity, IR spectral quality, and allows direct comparison of the collected spectra to existing IR databases. Our research developed procedures and protocols for the analysis of drugs and determined the benefits and limitations of this technology. The research focused on the routine identification of commonly encountered drugs, designer drugs, closely related drug isomers, as well as the fundamentals of the gas chromatography and infrared systems. Statement of purpose: The research was undertaken to develop this technology into a viable technique for the forensic community. The instrument was studied for repeatability, sensitivity, and selectivity while optimizing for analysis of a wide range of drug samples. Based upon this work the instrument proved to be a powerful forensic tool providing complimentary data to GC/MS. Acceptable levels of sensitivity, linearity, and reproducibility were achieved using the GC split-less injection mode. Concern about cross contamination of samples on the collection disk were dispelled as the deposited GC vapor produced solid "tracks" that were unique to each sample and appropriately documented by the instrument. Analytical methods were developed for the routine analyses of drugs and synthetic cannabinoids. Through these studies the instrument was verified for casework analysis and is presently in operational use in our laboratory. Software limitations hindered research progress, although software and hardware upgrades were made by the vendor (Spectra Analysis) some of which were driven by feedback provided by staff at the Vermont Forensic Laboratory (VFL).
Author : Rodger L. Foltz
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (327 download)
Download or read book GC/MS Assays for Abused Drugs in Body Fluids written by Rodger L. Foltz and published by . This book was released on 1980 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
ISBN 13 : 1588297802
Total Pages : 441 pages
Book Rating : 4.5/5 (882 download)
Download or read book Handbook of Drug Monitoring Methods written by Amitava Dasgupta and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.
Author : Teresa Kowalska
Publisher : CRC Press
ISBN 13 : 1315313162
Total Pages : 478 pages
Book Rating : 4.3/5 (153 download)
Download or read book Chromatographic Techniques in the Forensic Analysis of Designer Drugs written by Teresa Kowalska and published by CRC Press. This book was released on 2018-01-31 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.
Author : Rajeev Jain
Publisher : CRC Press
ISBN 13 : 1000473740
Total Pages : 268 pages
Book Rating : 4.0/5 (4 download)
Download or read book Microextraction Techniques in Analytical Toxicology written by Rajeev Jain and published by CRC Press. This book was released on 2021-12-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microextraction Techniques in Analytical Toxicology provides the information readers need to include about cutting-edge sample preparation techniques into their everyday analytical practice, including comprehensive information about principles and state-of-the-art microextraction sample preparation techniques for the analysis of drugs and poisons in biological specimens, especially in forensic and clinical settings. This book also focuses on theoretical discussions of solid-based and liquid-based microextraction techniques, their method development, validation, and applications. A detailed compilation of analytical protocols based on published microextraction procedures to aid in method development, synthesis, and the application of green solvents (ionic liquids and deep eutectic solvents) and new sorbents, such as molecularly imprinted polymers, and their application in microextraction techniques are also covered. Features: Provides a systematic review of microextraction techniques applied in analytical toxicology A comprehensive guide for the practical implementation of microextraction techniques in forensic, clinical, and analytical laboratories Contains figures and tables for easy understanding and quick adaptation of the parameters of microextraction techniques Fundamentals, development, and applications of microextraction techniques as a sample preparation procedure are discussed in detail Extremely useful for the researchers and academicians engaged in analytical method development using microextraction techniques This book appeals to a wide readership of forensic, clinical, and analytical toxicologists, as well as academicians and researchers. Written by eminent scientists and leading experts on sample preparation techniques, this book serves as a desk reference for routine laboratory analysis and as an indispensable teaching tool in the classroom for graduate and Ph.D. students.
Author : Adriaan Albertyn Scheepers Marais
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (956 download)
Download or read book Applications of Extractive-derivatization Sample Preparation in a Clinical Toxicology Laboratory Setting written by Adriaan Albertyn Scheepers Marais and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The metabolism of absorbed xenobiotic compounds in humans results in a mixture of target compounds applicable for analysis, trapped in complex biological matrices. Gas chromatography-mass spectrometry (GC-MS) is a powerful analytical technique that has been successfully applied in the analysis of volatile and semi-volatile compounds from complex biological samples. This is due to the ability of GC-MS to separate different sample constituents at trace levels while providing accurate molecular structural information for the resolved compounds. The complexity of biological specimens and their largely aqueous nature, combined with the physicochemical properties of target analytes resulting from metabolism, greatly precludes direct analysis of biosamples by GC-MS. Traditionally, highly laborious and time consuming sample preparation procedures are performed to isolate and chemically alter target analytes to attain suitable amenity for the detection system. Furthermore, routine analytical procedures in clinical toxicology laboratories are signified by short specimen turn-around times. The commonplace use of GC-MS in modern-day laboratories still suffer from prolonged turn-around times that result from both sample preparation steps and lengthy instrumental analysis. Simplified and cost-effective analytical procedures capable of extracting multiple analytes, with divergent functional groups, from biological matrices in a timely manner are therefore required. To address this issue, this work describes the development of validated extractive-derivatization methods combined with fast GC-MS analysis for expedient and accurate quantitation of different analytes in occupational monitoring and workplace drug testing. Extractive alkylation of acidic analytes phenol, o-cresol, mandelic acid, hippuric acid, and (o-, m-, p- ) methylhippuric acid for simultaneous urinary bio-monitoring of occupational exposure to benzene, toluene, ethylbenzene, and xylene, respectively, is performed. Extractive acylation for simultaneous urinary confirmation of basic analytes amphetamine, methamphetamine, norephedrine, methcathinone, ephedrine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), methylenedioxyethylamphetamine (MDEA) and N-methyl-1-(3,4 methylenedioxyphenyl)-2-butanamine (MBDB) in workplace drug testing is performed. The successful combination of abovementioned techniques alongside fast GC-MS allows increased sample throughput and decreased turn-around time for routine analysis while maintaining bioanalytical quantitative criteria, as required in a clinical toxicology laboratory setting.
Author : Benjamin J. Gudzinowicz
Publisher :
ISBN 13 : 9780835760140
Total Pages : 571 pages
Book Rating : 4.7/5 (61 download)
Download or read book Analysis of Drugs and Metabolites by Gas Chromatography written by Benjamin J. Gudzinowicz and published by . This book was released on 1980-01-01 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Per O. Edlund
Publisher :
ISBN 13 : 9789155416638
Total Pages : 38 pages
Book Rating : 4.4/5 (166 download)
Download or read book Trace Analysis of Drugs, Catecholamines and Their Metabolites in Biological Samples by Gas- and Liquid Chromatography written by Per O. Edlund and published by . This book was released on 1985 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : B. J. Gudzinowicz
Publisher :
ISBN 13 : 9780783700328
Total Pages : 507 pages
Book Rating : 4.7/5 (3 download)
Download or read book Analysis of Drugs and Metabolites by Gas Chromatography written by B. J. Gudzinowicz and published by . This book was released on 1977 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : AF. Hernández
Publisher :
ISBN 13 :
Total Pages : 7 pages
Book Rating : 4.:/5 (125 download)
Download or read book Application of the Combined Use of HPLC/Diode Array Detection and Capillary GC/Nitrogen Phosphorus Detection for the Rapid Analysis of Illicit Heroin and Cocaine Samples written by AF. Hernández and published by . This book was released on 1992 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: A method using a combination of high-performance liquid chromatography and diode array detection (HPLC/DAD) with a methanol/perchlorate buffer pH 2.5 mobile phase and reverse phase C-18 column and capillary gas chromatography with nitrogen phosphorus detection (GC/NPD) has been developed for the rapid, sensitive and accurate analysis of illicit samples of heroin or cocaine. Retention times and UV-spectra were used for the identification of various adulterants and synthetic by-products in street samples. This method is compared with gas-chromatography/mass spectrometry (GC/MS) Forty street samples were analyzed by both methods. It is concluded that the combined use of HPLC/DAD and GC/NPD as a routine analytical procedure for the analysis of illicit samples could be a good alternative to GC/MS for forensic purposes. It is due to their high accessibility and the possibility to perform simultaneously qualitative and quantitative analysis.
Author : Lukasz Komsta
Publisher : CRC Press
ISBN 13 : 1466507152
Total Pages : 1070 pages
Book Rating : 4.4/5 (665 download)
Download or read book Thin Layer Chromatography in Drug Analysis written by Lukasz Komsta and published by CRC Press. This book was released on 2013-12-20 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separation and analysis of chiral substances. The text addresses the newest advances in TLC instrumentation, two-dimensional TLC, quantification by slit scanning densitometry and image analysis, statistical processing of data, and various detection and identification methods. It also describes the use of TLC for solving a key issue in the drug market—the presence of substandard and counterfeit pharmaceutical products. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups. Each chapter contains an introduction about the structures and medicinal actions of the described substances and a literature review of their TLC analysis. A useful resource for chromatographers, pharmacists, analytical chemists, students, and R&D, clinical, and forensic laboratories, this book can be utilized as a manual, reference, and teaching source.
Author : Benjamin J. Gudzinowicz
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (632 download)
Download or read book Analysis of Drugs and Metabolites by Gas Chromatography-mass Spectrometry written by Benjamin J. Gudzinowicz and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Adrianna Coty
Publisher :
ISBN 13 : 9781681172620
Total Pages : 290 pages
Book Rating : 4.1/5 (726 download)
Download or read book Applications of Gas Chromatography written by Adrianna Coty and published by . This book was released on 2016-04-01 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas chromatography is a term used to describe the group of analytical separation techniques used to analyze volatile substances in the gas phase. In gas chromatography, the components of a sample are dissolved in a solvent and vaporized in order to separate the analyses by distributing the sample between two phases: a stationary phase and a mobile phase. The mobile phase is a chemically inert gas that serves to carry the molecules of the analyze through the heated column. Gas chromatography is one of the sole forms of chromatography that does not utilize the mobile phase for interacting with the analyze. The stationary phase is either a solid adsorbent, termed gas-solid chromatography (GSC), or a liquid on an inert support, termed gas-liquid chromatography (GLC). Helium remains the most commonly used carrier gas in about 90% of instruments although hydrogen is preferred for improved separations. This inert gas goes through a glass column packed with silica that is coated with a liquid. Materials that are less soluble in the liquid will increase the result faster than the material with greater solubility. The purpose of this book entitled Applications of Gas Chromatography is to provide a better understanding on its separation and measurement techniques and its application. Since chromatography techniques are separating and analyzing methods, this book will help other researchers and young scientists to choose a suitable chromatography technique. Furthermore, this book illustrates the newest challenges in this area. This valuable book aims to provide a connection between various chromatography techniques and different processes.
Author : Benjamin J. Gudzinowicz
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (5 download)
Download or read book Analysis of Drugs and Metabolites by Gas Chromatography written by Benjamin J. Gudzinowicz and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
