Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Radical Cyclization Approach To A Chemoenzymatic Synthesis Of Morphine full books in PDF, epub, and Kindle. Read online Radical Cyclization Approach To A Chemoenzymatic Synthesis Of Morphine ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Michele R. Stabile
Publisher :
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.:/5 (331 download)
Download or read book Radical Cyclization Approach to a Chemoenzymatic Synthesis of Morphine written by Michele R. Stabile and published by . This book was released on 1995 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Denice M. Spero
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.:/5 (29 download)
Download or read book A Radical Cyclization Approach to the Synthesis of Morphine and Synthetic Approaches to Trialkoxyphthalic Acid Derivatives written by Denice M. Spero and published by . This book was released on 1988 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kevin J. Finn
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)
Download or read book Applications of Dihydroarenediols to Chemoenzymatic Synthesis written by Kevin J. Finn and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The present studies describe, as a primary goal, our recent progess toward the synthesis of morphine alkaloids from aromatic precursors. Model substrates were synthesized which allowed investigation into Diels-Alder, radical cascade, and palladium-catalyzed bond-forming reactions as possible routes to the morphine alkaloid skeleton. As a secondary objective, three separate series of aromatic substrates were subjected to whole-cell oxidation with Escherichia coli JM 109 (pDTG601), a recombinant organism over-expressing the enzyme toluene dioxygenase. Included in this study were bromothioanisoles, dibromobenzenes, and cyclopropylbenzene derivatives. The products of oxidation were characterized by chemical conversion to known intermediates. The synthetic utility of one of these bacterial metabolites, derived from oxidation of o-dibromobenezene, was demonstrated by chemical conversion to (-)conduritol E.
Author : Demosthenes Fokas
Publisher :
ISBN 13 :
Total Pages : 450 pages
Book Rating : 4.:/5 (314 download)
Download or read book The Tandem Radical Cyclization Synthesis of Morphine Alkaloids written by Demosthenes Fokas and published by . This book was released on 1993 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carlos David Gonzalez
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.:/5 (433 download)
Download or read book A Chemoenzymatic Approach to Morphine and Other Oxygenated Alkaloids, Total Synthesis of Narciclasine written by Carlos David Gonzalez and published by . This book was released on 1999 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mariia Makarova
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)
Download or read book Chemoenzymatic Total Synthesis of Ent-Oxycodone written by Mariia Makarova and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the approach towards chemoenzymatic total synthesis of ent-dihydroisocodeine and chemoenzymatic total synthesis of ent-oxycodone as well as the development of a new method for the preparation of rearranged allylic isocyanates. The synthesis of ent-dihydroisocodeine started from phenethyl acetate and included a microbial oxidation of phenethyl acetate by E. coli JM109 (pDTG601A), a Mitsunobu reaction to the couple A- and C-rings, Heck cyclization to construct the E-ring and Henry reaction to introduce the nitrogen functionality as key steps. The construction of the B-ring proved to be challenging and neither radical cyclization nor attempts to perform photochemistry or nucleophilic opening of an epoxide gave any positive results. The chemoenzymatic total synthesis of ent-oxycodone was accomplished starting from phenethyl acetate in 23 steps. The tricyclic intermediate was furnished in the same manner as described above. The olefin to ketone conversion and a double Henry reaction allowed the construction of the B-ring. Unfortunately, it was established that the resulting hydroxyl group at C14 and amino group at C9 were of the undesired trans stereochemistry. To complete the morphine skeleton the transformation of the side chain at C13 to an N-methyl-p-toluenesufonamide via Mitsunobu reaction as well as the elimination of the amino group at C9 via formation of an N-oxide were performed. Subsequent radical cyclization of the side chain at the C9 position formed the last D-ring. The silyl ether deprotection followed by oxidation provided ent-oxycodone. The other approach to construct the D-ring was based on the formation of a lactone and the elimination of the amino group via an N-oxide. The nitrogen functionality was reinstalled using sodium azide and was accompanied by the introduction of the C10 hydroxyl group. Reduction of the azide and subsequent formation of the amide allowed access to the core skeleton of the target compound. The removal of the C10 hydroxyl group accomplished the synthesis. The last project involved the development of a new method for the preparation of rearranged allylic isocyanates from allylic alcohols using 1-cyano-4-dimethylaminopyridinium as the source of electrophilic cyanide. Experimental and spectral data are provided for all the compounds.
Author : Ahindra Nag
Publisher : CRC Press
ISBN 13 : 1000545105
Total Pages : 370 pages
Book Rating : 4.0/5 (5 download)
Download or read book Greener Synthesis of Organic Compounds written by Ahindra Nag and published by CRC Press. This book was released on 2022-05-30 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an interdisciplinary, integrative overview of environmental problem-solving using mild reaction conditions, green reagents, waste free and energy efficient synthesis in both industry and academic world. Discussions include a broad, integrated perspective on sustainability, integrated risk, multi-scale changes and impacts taking place within ecosystems worldwide. Features: This book serves as a reference book for scientific investigators who need to do greener synthesis of organic compounds, drugs and natural products under mild reaction condition using green reagents, eco-friendly catalysts and benign reaction mediums over traditional synthetic processes which is a key driving force of scientists. Greener synthesis of multiple value-added heterocycles opens up a new horizon towards the organic catalysis and for this purpose, development of natural resources acts as an effective catalyst. Using environmentally friendly reaction medium e.g. ACC, WETSA, WEBSA have been used for the synthesis of some crucial heterocyclic scaffolds such as bisenols and 2-amino-4H-pyrans, tetraketones, pyrans, and biaryls. This book can also be used as a textbook for graduate and post graduate level courses for students. Furthermore, the problems with answers in book will add better understanding for students.
Author : Christopher T. Walsh
Publisher : Royal Society of Chemistry
ISBN 13 : 1788010760
Total Pages : 787 pages
Book Rating : 4.7/5 (88 download)
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Author :
Publisher :
ISBN 13 :
Total Pages : 848 pages
Book Rating : 4.F/5 ( download)
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 012820138X
Total Pages : 568 pages
Book Rating : 4.1/5 (282 download)
Download or read book Flavin-Dependent Enzymes: Mechanisms, Structures and Applications written by and published by Academic Press. This book was released on 2020-09-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes, Volume 47, highlights new advances in the field, with this new volume presenting interesting chapters on The Multipurpose Family of Oxidases, Vanillyl alcohol oxidase, Choline oxidases, Aryl alcohol oxidase, D- and L-amino acid oxidases, Sugar oxidases, Phenolic Compounds hydroxylases, Baeyer-Villiger Monooxygenases, Flavin-dependent halogenases, Flavin-dependent dehalogenases, Styrene Monooxygenases, Bacterial luciferases, Cellobiose Dehydrogenases, Prenylated flavoenzymes, Ene-reductases, Flavoenzymes in Biocatalysis. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series
Author : Herbert Waldmann
Publisher : John Wiley & Sons
ISBN 13 : 3527620451
Total Pages : 420 pages
Book Rating : 4.5/5 (276 download)
Download or read book Organic Synthesis Highlights II written by Herbert Waldmann and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like its predecessor, Organic Synthesis Highlights II surveys recent accomplishments and current trends in synthetic organic chemistry. Part I describes new methods and reagents including asymmetric carbon-carbon bond formation with metallocenes and with enzymes, via temporary silicon connections, and by means of carbohydrate complexes. Part II describes landmarks in the synthesis of natural products and surveys synthetic strategies to different classes of natural products. The forty essays in this volume bear witness to the creativity and talent which have led to the recent advances in the field. Both advanced students and researchers active in the field will welcome this as a source of ideas and inspiration.
Author :
Publisher :
ISBN 13 :
Total Pages : 896 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2002 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hans-Josef Altenbach
Publisher : John Wiley & Sons
ISBN 13 : 3527621393
Total Pages : 424 pages
Book Rating : 4.5/5 (276 download)
Download or read book Organic Synthesis Highlights written by Hans-Josef Altenbach and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unusual collection of 49 essays gives an overview of the trends and accomplishments of synthetic organic chemistry in recent years. Unique in its approach, it deals with almost every aspect of modern synthesis. The first part of the book describes methods and reagents, with particular emphasis on rapidly developing organometallic and biooriented procedures. In the second part, these tools are applied to the syntheses of interesting target compounds and natural compounds with remarkable physiological properties. Mechanistic discussions and retrosynthetic analyses are included. More than 1000 up-to-date references help the reader to pursue the topics highlighted here. This book gives both the active researcher and the advanced student insight into the competitive atmosphere, creativity, and resourcefulness so characteristic of organic synthesis today.
Author : Hans-Joachim Knoelker
Publisher : Springer Science & Business Media
ISBN 13 : 3642255280
Total Pages : 268 pages
Book Rating : 4.6/5 (422 download)
Download or read book Alkaloid Synthesis written by Hans-Joachim Knoelker and published by Springer Science & Business Media. This book was released on 2012-01-13 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Author : Alexandros L. Zografos
Publisher : John Wiley & Sons
ISBN 13 : 1118751736
Total Pages : 585 pages
Book Rating : 4.1/5 (187 download)
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Author : J.D. Phillipson
Publisher : Springer Science & Business Media
ISBN 13 : 3642701280
Total Pages : 315 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Chemistry and Biology of Isoquinoline Alkaloids written by J.D. Phillipson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isoquinolines form one of the largest groups of plant alkaloids and they in clude a number of valuable clinical agents such as codeine, morphine, eme tine and tubocurarine. Research into different aspects of isoquinolines con tinues in profusion, attracting the talents of botanists, chemists, bioche mists, analysts, pharmacists and pharmacologists. Many of these aspects are of an interdisciplinary nature, and in April 1984, The Phytochemical Society of Europe arranged a 3-day symposium on The Chemistry and Bi ology of Isoquinoline Alkaloids in order to provide a forum for scientists of differing disciplines who are united by a common interest in this one class of natural product. Each chapter in this volume is based on a lecture given at this symposium. Attempts have been made to make the aims and objectives, experimental findings and conclusions reached, intelligible to scientists of differing backgrounds. The introductory chapter, which is mainly based on a historical discus sion, stresses that plants containing isoquinolines have proved to be both a boon and a curse to mankind. The Opium Poppy, Papaver somniferum, produces the medicinally used alkaloids morphine, codeine, noscapine and papaverine whilst it also continues to provide drugs of abuse, particularly morphine and its readily prepared O,O-diacetyl derivative, heroin. Numer ous other alkaloids have been isolated from other members of the Papaver acea, and a knowledge of their presence and distribution within the various species has proved a useful adjunct to systematic botanical studies.
Author : Marco Brito-Arias
Publisher : Springer Nature
ISBN 13 : 3030978540
Total Pages : 543 pages
Book Rating : 4.0/5 (39 download)
Download or read book Synthesis and Characterization of Glycosides written by Marco Brito-Arias and published by Springer Nature. This book was released on 2022-04-22 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates. Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control. A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
