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Quick Guide To The Cytochrome P450 System
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Author :Paul R. Ortiz de Montellano Publisher :Springer Science & Business Media ISBN 13 :0387274472 Total Pages :702 pages Book Rating :4.3/5 (872 download)
Book Synopsis Cytochrome P450 by : Paul R. Ortiz de Montellano
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Book Synopsis Human Drug Metabolism by : Michael D. Coleman
Download or read book Human Drug Metabolism written by Michael D. Coleman and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher
Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Book Synopsis Clinical Manual of Drug Interaction Principles for Medical Practice by : Gary H. Wynn
Download or read book Clinical Manual of Drug Interaction Principles for Medical Practice written by Gary H. Wynn and published by American Psychiatric Pub. This book was released on 2009-06-03 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population patterns in the U.S. have amplified this trend, with aging baby boomers swelling the patient pool and demanding treatment with medications advertised on television and in print. Fortunately, drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. With this new edition, the book has evolved from "Concise Guide" to "Clinical Manual" and offers the expanded coverage and features healthcare providers need to keep up with this critical field. The book is well organized, with major sections on metabolism; cytochrome P450 enzymes; drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. In the section on P450 enzymes, each chapter addresses what the individual enzyme does and where, its polymorphisms, and drugs that inhibit or induce activity. Each chapter also includes extensive references and study cases to help the reader understand and contextualize the information. A number of additional features enhance the book's scope and utility: The book boasts the very latest information in the area of drug metabolism, transport, and interaction. The chapter on P-glycoprotein (a drug transporter) was expanded from the last edition to include a broader array of transport mechanisms. The highest ethical standard was adhered to in the development of this volume, which was not supported in any way by pharmaceutical makers or distributors. All eight contributors to this excellent resource are experts in the fields they have addressed, and clinicians can trust that the information contained in the Manual reflects the very latest research. This exceptionally practical manual is essential to maintaining the highest standard of care.
Book Synopsis Lange Smart Charts: Pharmacology by : Catherine Pelletier
Download or read book Lange Smart Charts: Pharmacology written by Catherine Pelletier and published by McGraw-Hill Education / Medical. This book was released on 2003-03-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized by drug group, this book presents a complete review of pharmacology in an innovative format. Composed entirely of tables and diagrams, this book facilitates comparison and clarifies relationships among drugs in terms of interactions, pharmacokinetics, uses, and side effects. Each chapter begins with an outline of the drug class discussed, followed by a list of key terms.
Book Synopsis The Medicinal Chemist's Guide to Solving ADMET Challenges by : Patrick Schnider
Download or read book The Medicinal Chemist's Guide to Solving ADMET Challenges written by Patrick Schnider and published by Royal Society of Chemistry. This book was released on 2021-08-20 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Medicinal Chemist’s Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist’s Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.
Book Synopsis Pocket Guide to Emergent and Serious Adverse Events in Psychopharmacology by : Richard Balon, M.D.
Download or read book Pocket Guide to Emergent and Serious Adverse Events in Psychopharmacology written by Richard Balon, M.D. and published by American Psychiatric Pub. This book was released on 2023-03-30 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Flow Cytometry by : Alice Longobardi Givan
Download or read book Flow Cytometry written by Alice Longobardi Givan and published by John Wiley & Sons. This book was released on 2013-04-10 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow cytometry continually amazes scientists with its ever-expanding utility. Advances in flow cytometry have opened new directions in theoretical science, clinical diagnosis, and medical practice. The new edition of Flow Cytometry: First Principles provides a thorough update of this now classic text, reflecting innovations in the field while outlining the fundamental elements of instrumentation, sample preparation, and data analysis. Flow Cytometry: First Principles, Second Edition explains the basic principles of flow cytometry, surveying its primary scientific and clinical applications and highlighting state-of-the-art techniques at the frontiers of research. This edition contains extensive revisions of all chapters, including new discussions on fluorochrome and laser options for multicolor analysis, an additionalsection on apoptosis in the chapter on DNA, and new chapters onintracellular protein staining and cell sorting, including high-speed sorting and alternative sorting methods, as well as traditional technology. This essential resource: Assumes no prior knowledge of flow cytometry Progresses with an informal, engaging lecture style from simpleto more complex concepts Offers a clear introduction to new vocabulary, principles of instrumentation, and strategies for data analysis Emphasizes the theory relevant to all flow cytometry, with examples from a variety of clinical and scientific fields Flow Cytometry: First Principles, Second Edition provides scientists, clinicians, technologists, and students with the knowledge necessary for beginning the practice of flow cytometry and for understanding related literature.
Book Synopsis The Dentist's Quick Guide to Medical Conditions by : Mea A. Weinberg
Download or read book The Dentist's Quick Guide to Medical Conditions written by Mea A. Weinberg and published by John Wiley & Sons. This book was released on 2015-04-15 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: With increasing numbers of dental patients being elderly or having medical conditions, it is important for the dentist to understand how these conditions may impact dental treatment. The Dentist’s Quick Guide to Medical Conditions presents the relevant information dentists need—symptoms, diagnostic tests, medications prescribed, and dental management—for each disease and condition. Chapters will focus on each major bodily system, including respiratory, cardiovascular, hematologic, endocrine, gastrointestinal, immune, nervous, reproductive, and urinary, as well as chapters on the liver, kidneys, skin, and psychological conditions. Appendices list guidelines for antibiotic prophylaxis, additional conditions requiring antibiotics, and a quick list of diagnostic tests.
Book Synopsis Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism by : Aparajita Dey
Download or read book Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism written by Aparajita Dey and published by Springer Science & Business Media. This book was released on 2013-02-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
Book Synopsis User's Guide to Detoxification by : Shari Lieberman
Download or read book User's Guide to Detoxification written by Shari Lieberman and published by James J. Gormley. This book was released on 2005 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: We live in a toxic world - and there's no escaping it. But each of us can take steps to enhance our body's ability to detoxify pollutants, synthetic hormones, and cancer causing chemicals. The Benefits? A healthier life with a lower risk of developing debilitating diseases. This User's Guide focuses on specific supplements, including herbs and vitamin-like substances, that help protect your body protect itself.
Book Synopsis Frequently Prescribed Medications by : Michael Mancano
Download or read book Frequently Prescribed Medications written by Michael Mancano and published by Jones & Bartlett Learning. This book was released on 2010-11-12 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health Sciences & Professions
Book Synopsis A Short Guide to Clinical Pharmacokinetics by : Krishnaveni Manubolu
Download or read book A Short Guide to Clinical Pharmacokinetics written by Krishnaveni Manubolu and published by Springer Nature. This book was released on with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 by : Eugene G. Hrycay
Download or read book Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 written by Eugene G. Hrycay and published by Springer. This book was released on 2015-05-22 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Book Synopsis 2021 Lippincott Pocket Drug Guide for Nurses by : Rebecca Tucker
Download or read book 2021 Lippincott Pocket Drug Guide for Nurses written by Rebecca Tucker and published by Independently Published. This book was released on 2021-09-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: he 2021 Lippincott Pocket Drug Guide for Nurses provides current, vital drug information in a nutshell. This handy pocket guide by Rebecca Tucker gives essential information on over 4,200 medications, including 38 generic drugs newly approved by the FDA, in an easy-access A-to-Z format. The drug monographs include generic and trade names, drug classes, pregnancy risk category and controlled substance schedule, black box warnings, indications & dosages, dose adjustments, adverse effects, drug interactions, nursing considerations, and patient teaching. A special section following the A-to-Z drugs provides essential Patient Safety information. Appendices cover topical and ophthalmic medications, laxatives, combination products, contraceptives, biological agents (vaccines), and more.
Book Synopsis Pharmacology in 7 Days for Medical Students by : Fazal-I-Akbar Danish
Download or read book Pharmacology in 7 Days for Medical Students written by Fazal-I-Akbar Danish and published by CRC Press. This book was released on 2018-05-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacological knowledge among medical students can have a very short 'half life': students often fail not because they have failed to study, but because they have been unable to retain key knowledge and reproduce it in an exam setting. This book takes an alternative route to the conventional approach of comprehensively exploring each individual drug and its features: not only can such an approach overwhelm and make knowledge retention difficult, but the current exam format makes questions structured in this way unlikely anyway. Instead of aiming to be completely comprehensive, it examines drugs systematically by classifications, mechanisms of action, therapeutic uses and side effects, enabling students to gain the distilled, functional grasp of pharmacology that their exams actually demand quickly and clearly.
Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
