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Author : Amit Mehndiratta
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (885 download)
Download or read book Quantitative Measurements of Cerebral Hemodynamics Using Magnetic Resonance Imaging written by Amit Mehndiratta and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. P. Schadé
Publisher :
ISBN 13 : 9780444409522
Total Pages : 438 pages
Book Rating : 4.4/5 (95 download)
Download or read book Progress in Brain Research written by J. P. Schadé and published by . This book was released on 1963 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Leonardo A. Rivera
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)
Download or read book MRI Methods for Cerebrovascular Hemodynamics Assessment written by Leonardo A. Rivera and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracranial vascular hemodynamics and vascular architecture are modified in a wide array of diseases, including tumors, stroke, and varying forms of dementia. Non-invasive methods capable of quantitatively assessing cerebrovascular disease are highly desirable. Magnetic resonance imaging (MRI) enables non-invasive quantitative assessment of cerebral hemodynamics and structure. Within this framework, the work in this thesis describes and applies innovative approaches to characterize hemodynamics in the cerebral vasculature using quantitative MRI. Additionally, these methods are validated and exhibited in-vivo. To assess vascular hemodynamics in relatively large arteries and veins a 4D flow MRI approach was used. This method enables both volumetric angiographic and quantitative assessment of blood flow velocities in a single acquisition with full volumetric coverage and sub millimeter resolution. 4D flow MRI was applied to healthy and pathological populations of individuals including: healthy younger and older adults, Alzheimer's disease (AD), mild cognitively impaired (MCI) and dural arteriovenous fistula (DAVF) patients. Targeted blood flow derived measurements, such as blood flow rates, pulsatility and resistivity, area, flow directionality, and pressure gradients were quantified. To assess small vessels and brain parenchyma tissue hemodynamics T1 and T2* mapping techniques were explored using ferumoxytol enhanced MRI. In addition, time-resolved T2* ferumoxytol enhanced MRI was implemented. With these approaches small vessel pulsatility and cerebral blood volume (CBV) were successfully characterized in gray and white matter tissues in a cohort of healthy volunteers.
Author : Matthias Johannes Paulus Osch
Publisher :
ISBN 13 : 9789039331729
Total Pages : 178 pages
Book Rating : 4.3/5 (317 download)
Download or read book Evaluation of Cerebral Hemodynamics by Quantitative Perfusion MRI written by Matthias Johannes Paulus Osch and published by . This book was released on 2002 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Reswanul Kabir Khan
Publisher :
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (883 download)
Download or read book Hemodynamic Measurements and Modeling for Functional Magnetic Resonance Imaging written by Reswanul Kabir Khan and published by . This book was released on 2014 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: In imaging, short wavelength (high-frequency) particles scattered from targets typically yield greater spatial resolutions than longer wavelengths. X-Rays, for example are typically within 2 orders of magnitude of a nanometer wavelength to achieve desired resolutions for medical imaging. Although better for imaging, this poses a health risk for subjects as ionizing radiation and this limits its use. Functional Magnetic Resonance Imaging (fMRI) avoids this issue by using radiation of much larger wavelengths, 4.8 m (62.5 MHz), that are relatively harmless. Instead of scattering, these photons are used to excite protons between spin-states in an external magnetic field. Magnetization relaxation rates and dephasing as a function of space and time are then measured to reconstruct images. This dissertation develops experimental methods to understand and interpret the biophysical underpinnings of fMRI in terms of blood flow and oxygen concentration changes. In neuroscience, fMRI may be used to deduce brain activity. Brain activity is a general term related to neuronal firing rate, which metabolizes oxygen. Deoxygenated blood increases proton spin dephasing. This is the physical mechanism that ultimately yields contrast in the fMRI signal. This is known as Blood-Oxygen Level Dependent (BOLD) contrast. A critical piece of information in this process, hemodynamics, is the dynamics of cerebral (brain) oxygen concentrations in relation to blood flow. The hemodynamics of BOLD contrast fMRI and its relation to brain activity is vital. In this dissertation, I have classified hemodynamic data as a function of space and time in cerebral cortex as well as testing a rudimentary hemodynamic model. I have taken fMRI measurements in three human subjects to identify spatial and temporal hemodynamic trends in brain. Furthermore, I've analyzed laser-speckle imaging in three subjects to identify spatiotemporal trends in blood speed. The final portion of this dissertation relates developments of a hemodynamic model of BOLD.
Author : Jeffrey Neil Stout
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.:/5 (13 download)
Download or read book MRI Based Cerebral Oxygenation Measures in Humans written by Jeffrey Neil Stout and published by . This book was released on 2018 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI based cerebral oxygenation measures could enable brain-centered clinical care and improve understanding of brain energy use throughout human development. We made technical improvements to two MR oxygenation imaging techniques, and explored the concordance between various methods to quantify the cerebral metabolic rate of oxygen consumption (CMRO2 ) and other aspects of cerebral metabolism in neonates with congenital heart disease (CHD). Using a turbo gradient spin echo readout we reduced the scan time of the existing QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) technique for measurements of global oxygen extraction fraction by eightfold while improving robustness to physiological noise and motion. We also corrected the effect of residual cerebrospinal fluid signal on transverse relaxation time quantification. The detected change in oxygen extraction fraction in the visual cortex during visual stimulation, demonstrated the technique's suitability for absolute quantitative functional MRI experiments. T2-Relaxation Under Spin Tagging (TRUST) has been used in several studies, including one with neonates, to quantify blood oxygen saturation. We investigated how involuntary subject motion affects quantification by incorporating volume navigators into TRUST to monitor motion during scans. We demonstrated that motion causes an upward bias in venous oxygen saturation quantification. Finally, we used TRUST and phase contrast MRI to measure CMRO2 in neonates with congenital heart disease (CHD) and explored the link between CMRO2 and other aspects of metabolism examined by MR spectroscopic imaging. We found a relationship between cerebral oxygenation and lactate and glutathione concentrations in white matter. We also sought to extend the reach of absolute MRI-based quantification by comparing it to bedside near infrared spectroscopy-based measurements. We found good agreement between oxygenation measurements, but no agreement between cerebral blood flow measurements, suggesting that hemodynamics vary more rapidly than oxygenation. Robust MR-based oxygenation imaging would improve clinical care and our understanding of how abnormal oxygen delivery affects brain development. Seeking a complete picture of cerebral metabolism throughout development, future work will perfect techniques to monitor cerebral hemodynamics, oxygenation and metabolism from midgestation to old age.
Author : Aldo Rescigno
Publisher : Springer
ISBN 13 :
Total Pages : 292 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cerebral Blood Flow written by Aldo Rescigno and published by Springer. This book was released on 1988 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advanced Study Institute on "Cerebral Blood Flow: Mathematical Models, Instrumentation, and Imaging Techniques" was held in L'Aquila, Italy, June 2-13, 1986. Contributions to this program were received from the University of L'Aquila, Consiglio Nazionale delle Ricerche, Siemens Elettra S.p.A., and Bracco S.p.A. Recent studies of the cerebral blood circulation have lagged behind analysis of other parameters such as glucose utilization, transmitter distribution, and precursors. This Advanced Study Institute tried to fill this gap by analyzing in detail different physical techniques such as Autoradiography (including Double-Tracer Auto radiography and highly specific tracers as Iodoantipyrine, Micro spheres), Single Photon Emission Computed Tomography, Nuclear Magnetic Resonance. Each method was analyzed in regards to its precision, resolution, response time. A considerable part of this Institute was devoted to the mathematics of CBF measurement, in its two aspects, i.e. the modeling of the underlying kinetic system and the statistical analysis of the data. The modeling methods proposed included the development of a differential algebra whereby the differential and integral equations involved could be solved by simple algebraic methods, including graph theoretical ones; the statistical methods proposed included the illustration of different parametrizations of possible use in the interpretation of experimental results.
Author : Denis Peruzzo
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (955 download)
Download or read book Quantification of Cerebral Hemodynamics from Dynamic Susceptibility Contrast-magnetic Resonance Imaging Technique written by Denis Peruzzo and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jean Chen
Publisher : Humana
ISBN 13 : 9781071617625
Total Pages : 218 pages
Book Rating : 4.6/5 (176 download)
Download or read book Cerebrovascular Reactivity written by Jean Chen and published by Humana. This book was released on 2021-11-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.
Author : Karthikeyan Kuppusamy
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (378 download)
Download or read book Assessment of Brain Function and Hemodynamics Using Magnetic Resonance Imaging written by Karthikeyan Kuppusamy and published by . This book was released on 1997 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Francesca Zanderigo
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (955 download)
Download or read book Assessment of Cerebral Hemodynamics by Deconvolution with Dynamic Susceptibility Contrast-magnetic Resonance Imaging written by Francesca Zanderigo and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernice Erland Hoppel
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (281 download)
Download or read book Measurement of Regional Oxygenation and Cerebral Hemodynamics Using Rapid MRI written by Bernice Erland Hoppel and published by . This book was released on 1993 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Adam Martin Winchell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (973 download)
Download or read book Implementation and Assessment of Novel Functional Hemodynamic MRI Measurements in the Brain for Evaluation of Disease and Treatment written by Adam Martin Winchell and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The characterization and quantification of cerebral hemodynamics can provide critical biological information of current physiology. Divergent hemodynamic processes can provide integral knowledge into different pathophysiologies and aid in the diagnosis and evaluation of treatment. A variety of different magnetic resonance (MR) imaging techniques were implemented to quantify cerebral hemodynamics in a diverse set of neurological conditions. The first study investigated the association of blood flow and blood volume of a diffuse intrinsic pontine glioma tumor by arterial spin labeling (ASL) and dynamic susceptibility weighted contrast MR as a predictive marker of survival. Higher tumor blood flow and maintenance of higher blood flow was associated with longer progression free survival. In the following study, ASL was used to evaluate the association of resting state perfusion and neurocognitive impairment in long-term survivors of pediatric acute lymphoblastic leukemia and Hodgkin lymphoma. Systematic differences in resting state perfusion and neurocognitive performance was observed between the cancer survivor groups. In the last few studies, a variety of different MR techniques were implemented to investigate the hemodynamic properties of Sickle cell disease (SCD). Susceptibility weighed imaging (SWI) was used to investigate difference in the cerebral venous vascular system integrity between SCD patients and healthy controls. A segmentation procedure was introduced to quantify the normalized visible venous volume (NVVV). The study showed that SCD effects SWI venous conspicuity by having a lower NVVV with a global isointense venous contrast. A follow-up study improved the accuracy of the NVVV quantification by removing hypointese arterial vessel contamination. This new segmentation framework combined information from SWI and MR angiography. In the final study, intracranial blood velocity measurements made by MRI and transcranial Doppler ultrasound were compared in a cohort of SCD patients. Excessive intracranial blood velocity is a clinical indicator of elevated stroke risk in SCD patients. Blood velocities correlated well between the different modalities, however, MR systematically underestimated the blood velocity. The ability to noninvasively image, quantify, and monitor biological processed represents a powerful diagnostic toolkit for physiological evaluation. Characterizing cerebral hemodynamics only represents a small but vital tool for the future of medicine.
Author : Minoru Tomita
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cerebral Hyperemia and Ischemia, from the Standpoint of Cerebral Blood Volume written by Minoru Tomita and published by . This book was released on 1988 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joni Oja
Publisher :
ISBN 13 : 9789517817370
Total Pages : 84 pages
Book Rating : 4.8/5 (173 download)
Download or read book In Vivo Determination of Cerebral Hemodynamics and Bioergetics Using Spin-echo Magnetic Resonance Imaging written by Joni Oja and published by . This book was released on 1999 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Cerebral Blood Flow Measurements Using Stable Xenon/CT written by and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin Smith
Publisher : Oxford University Press
ISBN 13 : 0198739559
Total Pages : 457 pages
Book Rating : 4.1/5 (987 download)
Download or read book Oxford Textbook of Neurocritical Care written by Martin Smith and published by Oxford University Press. This book was released on 2016 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Neurocritical Care provides an authoritative and up-to-date summary of the scientific basis, clinical techniques and management guidelines in this exciting clinical discipline. Authored by an international team of expert practitioners this textbook reflects world-wide practice.
