Quantitative Aspects Of Chemical Pharmacology

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Quantitative Aspects of Chemical Pharmacology

Author : R.B. Barlow
Publisher : Springer Science & Business Media
ISBN 13 : 1468483323
Total Pages : 257 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Quantitative Aspects of Chemical Pharmacology by : R.B. Barlow

Download or read book Quantitative Aspects of Chemical Pharmacology written by R.B. Barlow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers together chemical ideas which are important for understanding how drugs act and how new drugs may be developed. Students meet some of these ideas in courses in chemistry, biochemistry and pharmacology but in my experience they find it difficult to put together information often acquired in different years and from different departments; they need it set out in a book. I believe also that it helps if they can see how these ideas may be applied to numerical problems so I have included examples (with answers), many of which are taken from research work. These should therefore provide a chance for the student both to test his or her own understanding and to see the sort of results which form the bricks of which any experimental science is made. In all the problems the arithmetic takes less than ten minutes with a small calculator which has exponential functions and logarithms.

Quantitative Aspects of Chemical Pharmacology

Author : Richard Bawden Barlow
Publisher : Springer
ISBN 13 : 9780856648922
Total Pages : 250 pages
Book Rating : 4.6/5 (489 download)

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Book Synopsis Quantitative Aspects of Chemical Pharmacology by : Richard Bawden Barlow

Download or read book Quantitative Aspects of Chemical Pharmacology written by Richard Bawden Barlow and published by Springer. This book was released on 1980 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quantitative Calculations in Pharmaceutical Practice and Research

Author : Themistoklēs P. Chatzēiōannou
Publisher : VCH Publishers
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Quantitative Calculations in Pharmaceutical Practice and Research by : Themistoklēs P. Chatzēiōannou

Download or read book Quantitative Calculations in Pharmaceutical Practice and Research written by Themistoklēs P. Chatzēiōannou and published by VCH Publishers. This book was released on 1993 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical handbook aims at familiarizing students and scientists with the most common calculations encountered in the pharmaceutical sciences. It consolidates theoretical knowledge by applying it to the solution of real problems. Each chapter provides a short introduction of the relevant theory and includes equations to aid the comprehension of the theoretical principle. The text includes 220 solved examples and 250 problems and answers. Annotation copyright by Book News, Inc., Portland, OR

Quantitative Structure-Activity Relationships of Drugs

Author : John Topliss
Publisher : Elsevier
ISBN 13 : 0323146872
Total Pages : 535 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Quantitative Structure-Activity Relationships of Drugs by : John Topliss

Download or read book Quantitative Structure-Activity Relationships of Drugs written by John Topliss and published by Elsevier. This book was released on 2012-12-02 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity relationship (QSAR) methodologies in different drug therapeutic areas and discusses the results in terms of their contribution to medicinal chemistry. After briefly describing the developments in QSAR research, this 12-chapter volume goes on discussing the contributions of QSAR methodology in elucidating drug action and rational development of drugs against bacterial, fungal, viral, and other parasitic infections of man. Other chapters explore the mode of action and QSAR of antitumor, cardiovascular, antiallergic, antiulcer, antiarthritic, and nonsteroidal antiinflammatory drugs (NSAID) agents. The discussion then shifts to the pharmacologic effects and QSAR analysis of central nervous system agents, steroids, and other hormones. A chapter examines the major chemicals affecting insects and mites, with particular emphasis on the parameters of binding correlation and reactivity for insect and mite enzymes. The concluding chapters cover the limitations of the QSAR approach in the quantitative treatment of drug absorption, distribution, and metabolism. This volume is of great value to medicinal chemists, scientists, and researchers.

Basic Pharmacology

Author : Maria A. Hernandez, Ph.D.
Publisher : CRC Press
ISBN 13 : 1351988654
Total Pages : 400 pages
Book Rating : 4.3/5 (519 download)

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Book Synopsis Basic Pharmacology by : Maria A. Hernandez, Ph.D.

Download or read book Basic Pharmacology written by Maria A. Hernandez, Ph.D. and published by CRC Press. This book was released on 2017-07-12 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.

Pharmacometrics

Author : Ene I. Ette
Publisher : John Wiley & Sons
ISBN 13 : 1118679512
Total Pages : 1236 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Pharmacometrics by : Ene I. Ette

Download or read book Pharmacometrics written by Ene I. Ette and published by John Wiley & Sons. This book was released on 2013-03-14 with total page 1236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

Chemical Structure–Biological Activity Relationships: Quantitative Approaches

Author : F. Darvas
Publisher : Elsevier
ISBN 13 : 1483147851
Total Pages : 401 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Chemical Structure–Biological Activity Relationships: Quantitative Approaches by : F. Darvas

Download or read book Chemical Structure–Biological Activity Relationships: Quantitative Approaches written by F. Darvas and published by Elsevier. This book was released on 2013-10-22 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about the QSAR research conducted in East-European countries. This volume contains 38 presentations organized into six sections. Several lecturers deal with ""real prediction"" cases, i.e. activity estimation prior to the synthesis of the compounds. A particularly abundant section is devoted to the question of how the receptor models can be built up by means of QSAR calculations. Other sections present mathematical models and algorithms which could be applied to improve further the effectiveness of QSAR calculations. As another unique feature, a separate section treats the quantitative aspects of peptide structure-activity relationships—a field seemingly backward despite its evident importance. Hydrophobicity and its influence on biological potency along with the relationship of steric properties and biological activity are also discussed.

Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis

Author : J. Clemmesen
Publisher : Springer
ISBN 13 : 9783642673894
Total Pages : 0 pages
Book Rating : 4.6/5 (738 download)

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Book Synopsis Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis by : J. Clemmesen

Download or read book Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis written by J. Clemmesen and published by Springer. This book was released on 1980 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment

Author : Roy, Kunal
Publisher : IGI Global
ISBN 13 : 1466681373
Total Pages : 727 pages
Book Rating : 4.4/5 (666 download)

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Book Synopsis Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment by : Roy, Kunal

Download or read book Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment written by Roy, Kunal and published by IGI Global. This book was released on 2015-02-28 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Drug Design Strategies

Author : David J. Livingstone
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731667
Total Pages : 517 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Drug Design Strategies by : David J. Livingstone

Download or read book Drug Design Strategies written by David J. Livingstone and published by Royal Society of Chemistry. This book was released on 2012 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative fashion (ie: numerical analysis to enable robust predictions to be made). Each chapter includes a brief review of the topic showing the historical development of.

Introduction to Neuropharmacology

Author : Philip B. Bradley
Publisher : Butterworth-Heinemann
ISBN 13 : 1483183688
Total Pages : 362 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Introduction to Neuropharmacology by : Philip B. Bradley

Download or read book Introduction to Neuropharmacology written by Philip B. Bradley and published by Butterworth-Heinemann. This book was released on 2014-04-24 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Neuropharmacology presents the action of drugs as it relates to nervous system. It discusses the purposes into which drugs are use (e.g. as contraceptives and anti-riot agents). It addresses the differences between physiology and pharmacology. Some of the topics covered in the book are the factors affecting responses to drugs; properties of drugs; the kinetics of drug-receptor interactions; dose-response relationship; the principles of synaptic transmission; criteria for synaptic transmitters; somatic motor system; drugs affecting neuromuscular transmission; and drugs which act post-synaptically. The venoms and toxins that affect neuromuscular transmission are covered. The subdivisions of the autonomic nervous system are discussed. The text describes the autonomic ganglion stimulants. A study of the drugs mimicking parasympathetic stimulation is presented. A chapter is devoted to the drugs with antagonist actions on adrenoceptors. Another section focuses on the clinical uses of local anaesthetic drugs and the neurotransmitters in the central nervous system. The book can provide useful information to dentists, doctors, pharmacists, neurologists, students, and researchers.

Pharmaceutical Chemistry

Author : Christine Bladon
Publisher : John Wiley & Sons
ISBN 13 : 9780471496373
Total Pages : 240 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Pharmaceutical Chemistry by : Christine Bladon

Download or read book Pharmaceutical Chemistry written by Christine Bladon and published by John Wiley & Sons. This book was released on 2002-04-03 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a broad introduction to the growing field, this book explores the way in which peptides, proteins, nucleic acids and carbohydrates used therapeutically. With help of numerous illustrations, it covers both the compounds and how therapeutics exert their influence throuhg an understanding of biological processes. * Includes the latest developments in the field * Covers the various strategies behind the development and production of a range of key clinically useful compounds * Focuses on the concepts and ideas of why compounds are developed as pharmaceuticals * Provides many examples and problems Invaluable to all students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology. Will also be of interest to researchers and professionals needing a concise, up-to-date account of this subject.

Quantum Pharmacology

Author : W. G. Richards
Publisher : Elsevier
ISBN 13 : 1483163679
Total Pages : 288 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Quantum Pharmacology by : W. G. Richards

Download or read book Quantum Pharmacology written by W. G. Richards and published by Elsevier. This book was released on 2013-10-22 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantum Pharmacology, Second Edition discusses molecular pharmacology, molecular quantum mechanics, and the applications of theory to experiment. The book reviews molecular and quantitative pharmacology, as well as acetylcholines, catecholamines, and histamines. The text also discusses the central nervous system in relation to monoamines, acetylcholines, amino acids, and peptides. The book explains wave functions and orbitals, secular equations, matrix elements, and self-consistent molecular orbitals. One way to improve wave functions as a result of a self-consistent field or as an approximate calculation, is to permit different configurations to interact. Linear mixing will lead to improved wave functions. The investigator can compute wave functions and energies of molecules for any set of nuclear coordinates. Quantum chemical calculations treat conformation as similar with geometry; calculations are performed for a series of positions in one part of a molecule relative to another. The investigator can then compare the energies found in each position. The book points out that calculations of conformational internal energy surfaces for flexible pharmacological molecules treating the molecule or ion as isolated in space fit in with observed results of crystallographic experiments. The text is suitable for pharmacologists, and scientists involved in molecular pharmacology, medicinal chemistry, and quantum chemistry.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1456 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

An Introduction to Chemical Pharmacology

Author : Hugh McGuigan
Publisher :
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis An Introduction to Chemical Pharmacology by : Hugh McGuigan

Download or read book An Introduction to Chemical Pharmacology written by Hugh McGuigan and published by . This book was released on 1921 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1442 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery

Author : Gus R. Rosania
Publisher : Humana
ISBN 13 : 9781071612491
Total Pages : 453 pages
Book Rating : 4.6/5 (124 download)

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Book Synopsis Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery by : Gus R. Rosania

Download or read book Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery written by Gus R. Rosania and published by Humana. This book was released on 2021-07-12 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologics and other macromolecules, including peptide therapeutics, cyclotides, antibodies, as well as nanoparticles, thus creating a comprehensive treatise that approaches cellular pharmacokinetics from the different perspectives of pharmaceutical scientists, chemical biologists, medicinal chemists, and protein engineers dealing with very different chemical agents spanning a wide range of sizes, physicochemical properties, and targeting mechanisms. Written for the Methods in Pharmacology and Toxicology series, chapters provide the kind of key detail and expert implementation advice that leads to excellent results in the lab. Synthetic biologists, biophysicists, and bioengineers are amongst the long list of scientists who could benefit from reading this book or from using it as a textbook. Authoritative and practical, Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery builds on a long history of drug development and the adding of quantitative methods at the cellular scale in order to inspire new approaches to drug development that are better able to take advantage of phenomena such as soluble-to-insoluble phase transitions or bispecific targeting, which could ultimately be exploited for the development of more effective drug delivery systems and therapeutic agents.