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Providing Pharmacological Access To The Brain
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Book Synopsis Providing Pharmacological Access to the Brain by : Thomas R. Flanagan
Download or read book Providing Pharmacological Access to the Brain written by Thomas R. Flanagan and published by Academic Press. This book was released on 2013-10-22 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.Highlights* Polymeric, cellular, and molecular drug delivery* Neuropharmacology* Blood-brain barrier* Central nervous system
Book Synopsis Drugs, Addiction, and the Brain by : George F. Koob
Download or read book Drugs, Addiction, and the Brain written by George F. Koob and published by Academic Press. This book was released on 2014-07-12 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. - Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle - Actual data figures from original sources illustrating key concepts and findings - Introduction to basic neuropharmacology terms and concepts - Introduction to numerous animal models used to study diverse aspects of drug use. - Thorough review of extant work on the neurobiology of addiction
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309486483 Total Pages :175 pages Book Rating :4.3/5 (94 download)
Book Synopsis Medications for Opioid Use Disorder Save Lives by : National Academies of Sciences, Engineering, and Medicine
Download or read book Medications for Opioid Use Disorder Save Lives written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-06-16 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Book Synopsis Caffeine for the Sustainment of Mental Task Performance by : Institute of Medicine
Download or read book Caffeine for the Sustainment of Mental Task Performance written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-07 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
Book Synopsis Providing Pharmacological Access to the Brain by : Thomas R. J. Flanagan
Download or read book Providing Pharmacological Access to the Brain written by Thomas R. J. Flanagan and published by . This book was released on 1994 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice. Highlights * Polymeric, cellular, and molecular drug delivery * Neuropharmacology * Blood-brain barrier * Central nervous system
Download or read book Drugs, Brains, and Behavior written by and published by . This book was released on 2007 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurotransmitters, Drugs and Brain Function by : Roy Webster
Download or read book Neurotransmitters, Drugs and Brain Function written by Roy Webster and published by John Wiley & Sons. This book was released on 2001-11-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitter sind ein wesentlicher Bestandteil des zentralen Nervensystems, das Nervenimpulse zwischen Rezeptoren und Effektoren koordiniert. "Neurotransmitters, Drugs and Brain Function" stellt eine Verbindung her zwischen grundlegenden Aspekten der Aktivität von Neurotransmittern auf Rezeptor- und Synapsenebene und ihrer jeweiligen Funktion bei normaler Hirnfunktion, bei Erkrankungen und bei Drogeneinwirkung. Dieser Band untersucht, wie die zentrale synaptische Wirkung bestimmter Drogen auf die mögliche Beteiligung von Neurotransmittern bei der Entstehung von Krankheiten schließen lässt und wie die Wirkungsweise von Medikamenten bei solchen Erkrankungen erklärt werden kann. "Neurotransmitters, Drugs and Brain Function" ist für Studenten und Forscher in den Bereichen Pharmakologie, Neurowissenschaft, Medizin und Psychologie von unschätzbarem Wert.
Book Synopsis Neural Mechanisms of Addiction by : Mary Torregrossa
Download or read book Neural Mechanisms of Addiction written by Mary Torregrossa and published by Academic Press. This book was released on 2018-08-24 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. - Transcends multiple neural, neurochemical and behavioral domains - Summarizes advances in the field of addiction research since the advent of optogenetics - Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms
Book Synopsis Drugs, the Brain, and Behavior by : John Brick
Download or read book Drugs, the Brain, and Behavior written by John Brick and published by Routledge. This book was released on 2013-06-26 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the brain and discover the clinical and pharmacological issues surrounding drug abuse and dependence. The authors, research scientists with years of experience in alcohol and drug studies, provide definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. You will learn about: • how psychoactive drugs affect cognition, behavior, and emotion • the brain/behavior relationship • the specific effects of major addictive and psychoactive drug groups • new definitions and thinking about abuse and dependence • the medical and forensic consequences of drugs use Drugs, the Brain, and Behavior uses a balance of instruction, illustrations, and tables and formulas that will give you a broad, lasting introduction to this intriguing subject. Whether you're a nurse, chemical dependency counselor, psychologist, or clinician, this book will be a quick reference guide long after the first reading.
Book Synopsis Imaging of the Human Brain in Health and Disease by : Philip Seeman
Download or read book Imaging of the Human Brain in Health and Disease written by Philip Seeman and published by Elsevier. This book was released on 2013-11-15 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
Book Synopsis Brain Targeted Drug Delivery Systems by : Huile Gao
Download or read book Brain Targeted Drug Delivery Systems written by Huile Gao and published by Academic Press. This book was released on 2018-09-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. - Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers - Discusses key points in developing brain targeting drug delivery systems - Summarizes and presents currently available strategies for brain targeting drug delivery - Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research
Book Synopsis Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance by : Giuseppe Di Giovanni
Download or read book Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance written by Giuseppe Di Giovanni and published by Elsevier. This book was released on 2008-09-26 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions. - Provides an understanding of the interaction between Serotonin and Dopamine - Appeals equally to specialists, general practitioners, students and researchers - Contributes to the debate on new pharmacological approaches to several psychopathological states - Gives a comprehensive anatomical description plus the physiology and pharmacology of dopaminergic and serotonergic systems - Singles out neuropsychiatric and suggests new therapeutic approaches
Book Synopsis Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics by : Carl Faingold
Download or read book Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: - How the brain carries out important tasks via networks - How these networks interact in normal brain function - Major mechanisms that control network function - The interaction of the normal networks to produce more complex behaviors - How brain disorders can result from abnormal interactions - How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. - Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant - Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders - Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Author :Margareta Hammarlund-Udenaes Publisher :Springer Science & Business Media ISBN 13 :1461491053 Total Pages :737 pages Book Rating :4.4/5 (614 download)
Book Synopsis Drug Delivery to the Brain by : Margareta Hammarlund-Udenaes
Download or read book Drug Delivery to the Brain written by Margareta Hammarlund-Udenaes and published by Springer Science & Business Media. This book was released on 2013-12-03 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.
Author :Office of the Surgeon General Publisher :Createspace Independent Publishing Platform ISBN 13 :9781974580620 Total Pages :420 pages Book Rating :4.5/5 (86 download)
Book Synopsis Facing Addiction in America by : Office of the Surgeon General
Download or read book Facing Addiction in America written by Office of the Surgeon General and published by Createspace Independent Publishing Platform. This book was released on 2017-08-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.
Book Synopsis Nutraceuticals in Brain Health and Beyond by : Dilip Ghosh
Download or read book Nutraceuticals in Brain Health and Beyond written by Dilip Ghosh and published by Academic Press. This book was released on 2020-11-12 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer's, Parkinson's, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health.Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. - Addresses nutritional psychiatry and cognitive health at all stages of the lifespan - Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients - Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders - Explores the role of genomics and epigenetics, including discussion of the gut–brain axis
Book Synopsis Nanotechnology Methods for Neurological Diseases and Brain Tumors by : Yasemin Gürsoy Özdemir
Download or read book Nanotechnology Methods for Neurological Diseases and Brain Tumors written by Yasemin Gürsoy Özdemir and published by Academic Press. This book was released on 2017-07-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer's, Parkinson's and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.
