Proteomics In Nephrology

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Proteomics in Nephrology

Author : Visith Thongboonkerd
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805576366
Total Pages : 344 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Proteomics in Nephrology by : Visith Thongboonkerd

Download or read book Proteomics in Nephrology written by Visith Thongboonkerd and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The novel discipline of proteomics has experienced a rapid growth in the recent past and has a great potential for the future. Involving several fields, it offers various advantages: The study of proteins on a genomic scale allows to examine a large number of them simultaneously. Moreover, proteomic analysis provides information about post-translational modifications and functions of gene products or proteins that cannot be obtained by genomic analysis. The knowledge thus gained is also important for a better understanding of renal physiology and pathophysiology, to identify disease biomarkers, and to develop new target therapies.This book is the first one that applies the science of proteomics to nephrology: It sets out to give an overview of the discipline, providing detailed background information and outlining scope, advantages, and limitations of proteomics.The second section reviews principles of commonly used proteomic techniques, including sample preparation, two-dimensional gel electrophoresis, various types of mass spectrometry, expression proteomics, quantitative proteomics, practical bioinformatics, and clinical proteomics. In the last section, examples and perspectives are provided of how proteomics can be applied to various fields in nephrology, including nephrotoxicity, sodium transport, diabetic nephropathy, renal Fanconi syndrome, IgA nephropathy, physiology of podocytes and mesangial cells, hypertension, urological malignancies, and dialysis. The publication ends with a discussion of biomarker discovery in glomerular diseases and drug discovery.Written by acclaimed experts in both proteomics and nephrology, this truly remarkable book is essential reading for students, residents, fellows, scientists, and nephrologists who are interested in or devoted to research, as well as for general health professionals and clinicians.

Proteomics in Nephrology

Author : Visith Thongboonkerd
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805585446
Total Pages : 213 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Proteomics in Nephrology by : Visith Thongboonkerd

Download or read book Proteomics in Nephrology written by Visith Thongboonkerd and published by Karger Medical and Scientific Publishers. This book was released on 2008 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first volume on proteomics in nephrology, methodologies and protocols for renal and urinary proteome analyses have been continuously improved, resulting in considerable progress towards clinical application. Proteomics not only contributes to a better understanding of the renal physiology and pathogenic mechanisms of kidney diseases, but also assists in the search for novel biomarkers for diagnostics and prognostics and supports the definition and development of new therapeutic targets and drugs for better therapeutic outcome. While the first volume focused mainly on an overview, technologies and methodologies, this volume highlights successful applications of proteomics to several kidney diseases, including acute kidney injury, nephrotic syndrome, diabetic nephropathy, renal allograft rejection, renal cell carcinoma, obstructive nephropathy, kidney stone disease, uremia, and others. Written by acclaimed experts in proteomics and nephrology, this book is an excellent resource of references for nephrologists, clinicians, pharmacists, other healthcare professionals, proteomists, physiologists, scientists, and trainees.

Renal and Urinary Proteomics

Author : Visith Thongboonkerd
Publisher : John Wiley & Sons
ISBN 13 : 3527319743
Total Pages : 423 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Renal and Urinary Proteomics by : Visith Thongboonkerd

Download or read book Renal and Urinary Proteomics written by Visith Thongboonkerd and published by John Wiley & Sons. This book was released on 2009-12-21 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on research and results from the international Human Kidney and Urine Proteome Project, this handbook and reference presents current methods and protocols for the analysis of human kidney and urine. The world's leading experts cover everything from basic techniques for routine analysis to advanced methods for difficult samples or analytes. Written with the practitioner in mind, all the methods and techniques are described with step-by-step protocols backed by much valuable practical advice taken from real life experiments.

Proteomics in Nephrology

Author : V. Thongboonkerd
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (751 download)

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Book Synopsis Proteomics in Nephrology by : V. Thongboonkerd

Download or read book Proteomics in Nephrology written by V. Thongboonkerd and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first volume on proteomics in nephrology, methodologies and protocols for renal and urinary proteome analyses have been continuously improved, resulting in considerable progress towards clinical application. Proteomics not only contributes to a better understanding of the renal physiology and pathogenic mechanisms of kidney diseases, but also assists in the search for novel biomarkers for diagnostics and prognostics and supports the definition and development of new therapeutic targets and drugs for better therapeutic outcome. While the first volume focused mainly on an overview, technologies and methodologies, this volume highlights successful applications of proteomics to several kidney diseases, including acute kidney injury, nephrotic syndrome, diabetic nephropathy, renal allograft rejection, renal cell carcinoma, obstructive nephropathy, kidney stone disease, uremia, and others. Written by acclaimed experts in proteomics and nephrology, this book is an excellent resource of references for nephrologists, clinicians, pharmacists, other healthcare professionals, proteomists, physiologists, scientists, and trainees.

Urine Proteomics in Kidney Disease Biomarker Discovery

Author : Youhe Gao
Publisher : Springer
ISBN 13 : 9401795231
Total Pages : 202 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Urine Proteomics in Kidney Disease Biomarker Discovery by : Youhe Gao

Download or read book Urine Proteomics in Kidney Disease Biomarker Discovery written by Youhe Gao and published by Springer. This book was released on 2014-10-29 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".

Biomarkers of Kidney Disease

Author : Charles L. Edelstein
Publisher : Academic Press
ISBN 13 : 0123756731
Total Pages : 455 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Biomarkers of Kidney Disease by : Charles L. Edelstein

Download or read book Biomarkers of Kidney Disease written by Charles L. Edelstein and published by Academic Press. This book was released on 2010-10-27 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier or more effective treatments for kidney diseases. Biomarkers of Kidney Disease reviews the basic and clinical research on biomarkers of the common kidney diseases including acute kidney injury, chronic kidney disease, renal cancer, diabetic nephropathy, glomerular disease and preeclampsia. The characteristics of an ideal biomarker of kidney diseases and statistical analysis of biomarker studies is detailed. The latest techniques for biomarker detection like metabolomics and proteomics is covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation and preeclampsia. Presents a comprehensive, translational source for all aspects of renal biomarkers in one reference work Experts in renal disease biomarkers (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism) to new therapeutic approaches

Biomarkers of Kidney Disease

Author : Charles L. Edelstein
Publisher : Academic Press
ISBN 13 : 0128030356
Total Pages : 634 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biomarkers of Kidney Disease by : Charles L. Edelstein

Download or read book Biomarkers of Kidney Disease written by Charles L. Edelstein and published by Academic Press. This book was released on 2016-11-08 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine. Explores both the practical and conceptual steps performed in the discovery of biomarkers in kidney disease Presents a comprehensive account of newer biomarker discover strategies, such as metabolomics and proteomics, all illustrated by clear examples Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including AKI, transplantation, cancer, CKD, PKD, diabetic nephropathy, preeclampsia, and glomerular disease

Translational Urinomics

Author : Hugo Miguel Baptista Carreira dos Santos
Publisher : Springer Nature
ISBN 13 : 3030639088
Total Pages : 147 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Translational Urinomics by : Hugo Miguel Baptista Carreira dos Santos

Download or read book Translational Urinomics written by Hugo Miguel Baptista Carreira dos Santos and published by Springer Nature. This book was released on 2021-05-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.

Extracellular Matrix in the Kidney

Author : Hikaru Koide
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Extracellular Matrix in the Kidney by : Hikaru Koide

Download or read book Extracellular Matrix in the Kidney written by Hikaru Koide and published by . This book was released on 1994 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Application of Mass Spectrometry and Proteomics to Study Kidney Function

Author :
Publisher :
ISBN 13 :
Total Pages : 476 pages
Book Rating : 4.:/5 (926 download)

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Book Synopsis Application of Mass Spectrometry and Proteomics to Study Kidney Function by :

Download or read book Application of Mass Spectrometry and Proteomics to Study Kidney Function written by and published by . This book was released on 2004 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomarkers in Renal Disease

Author : Mitchell H. Rosner
Publisher : Nova Publishers
ISBN 13 : 9781604561135
Total Pages : 164 pages
Book Rating : 4.5/5 (611 download)

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Book Synopsis Biomarkers in Renal Disease by : Mitchell H. Rosner

Download or read book Biomarkers in Renal Disease written by Mitchell H. Rosner and published by Nova Publishers. This book was released on 2008 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in long-term improvement and outcomes of patients with kidney disease will require the use of novel biomarkers to identify patients at high risk for kidney disease and to diagnose kidney disease early for effective treatment. A biomarker is a substance found in the blood, body fluids or tissues that provides a measure of normal biological or pathological processes or response to pharmacological compounds or drugs. There are a wide variety of biomarkers including but not limited to mRNA, proteins and peptides, and lipid molecules. In AKI, important pathophysiological processes such as inflammation, apoptotic and necrotic cell death and, tubule regeneration may be reflected in blood or urine. An array of candidate markers along with clinical information in long-term clinical studies with appropriate analytical methodologies will likely provide prognostic information. Despite well-known limitations, currently the most widely used biomarkers for the early diagnosis of CKD and AKI are proteinuria, serum creatinine and blood urea nitrogen. Most clinicians are aware that serum creatinine and blood urea nitrogen are poor biomarkers due to inherent characteristics of these molecules and handling by the kidney. Creatinine is secreted and urea nitrogen is reabsorbed by the renal tubules. Many endogenous substances interfere in the assay for creatinine. Serum creatinine and urea appear late after acute kidney injury and the serum levels in part depend on the generation (large or small body mass). Acute kidney injury is a non steady state condition thus serum creatinine and urea nitrogen will lag behind kidney injury. For these reasons new biomarkers are imperative. With knowledge of these limitations in use of current biomarkers and the lack of progress in reducing the mortality and morbidity from kidney disease, there has been a great surge of interest in identifying novel biomarkers with a particular emphasis on the early diagnosis of kidney disease. A variety of methods have been employed including transcriptomics, proteomics, gene arrays and lipidomics. Currently, candidate biomarkers have been found in different disorders and have been tested in humans and many candidate biomarkers have yet to be identified. Most studies to date are preliminary and require validation in large multicentre studies followed by commercial assay development validation and testing. This new book outlines the rapid advances made in the field of biomarker development for kidney disease in which a variety of novel molecules have been identified and studied in humans.

Proteomic Insights Into the Molecular Mechanism of Renal Injury and Stone Formation

Author : Shifa Narula
Publisher : Independent Author
ISBN 13 : 9784186147186
Total Pages : 0 pages
Book Rating : 4.1/5 (471 download)

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Book Synopsis Proteomic Insights Into the Molecular Mechanism of Renal Injury and Stone Formation by : Shifa Narula

Download or read book Proteomic Insights Into the Molecular Mechanism of Renal Injury and Stone Formation written by Shifa Narula and published by Independent Author. This book was released on 2023-01-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. Kidney stones can be caused by diet, excess body weight, some medical conditions, and certain supplements and medications.

Proteomics Sample Preparation

Author : Jörg von Hagen
Publisher : John Wiley & Sons
ISBN 13 : 3527644695
Total Pages : 498 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Proteomics Sample Preparation by : Jörg von Hagen

Download or read book Proteomics Sample Preparation written by Jörg von Hagen and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.

Proteomics and the Kidney

Author : Jon B. Klein
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (5 download)

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Book Synopsis Proteomics and the Kidney by : Jon B. Klein

Download or read book Proteomics and the Kidney written by Jon B. Klein and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Podocytopathy

Author : Z.-H. Liui
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026514
Total Pages : 274 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Podocytopathy by : Z.-H. Liui

Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Silva's Diagnostic Renal Pathology

Author : Xin J. Zhou
Publisher : Cambridge University Press
ISBN 13 : 1316613984
Total Pages : 691 pages
Book Rating : 4.3/5 (166 download)

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Book Synopsis Silva's Diagnostic Renal Pathology by : Xin J. Zhou

Download or read book Silva's Diagnostic Renal Pathology written by Xin J. Zhou and published by Cambridge University Press. This book was released on 2017-03-02 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes

Author : J.A. Kellum
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318024074
Total Pages : 218 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes by : J.A. Kellum

Download or read book ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes written by J.A. Kellum and published by Karger Medical and Scientific Publishers. This book was released on 2013-05-14 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk.Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.