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Proteinase And Peptidase Inhibition
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Book Synopsis Proteinase and Peptidase Inhibition by : H. John Smith
Download or read book Proteinase and Peptidase Inhibition written by H. John Smith and published by CRC Press. This book was released on 2002-03-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the
Book Synopsis Plant Protease Inhibitors by : Yehudith Birk
Download or read book Plant Protease Inhibitors written by Yehudith Birk and published by Springer Science & Business Media. This book was released on 2003-04-08 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant protease inhibitors are diverse in number & specificity towards various proteolytic enzymes.
Download or read book Proteinase Inhibitors written by H. Fritz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 751 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings contain the papers presented at the Bayer-Symposium V which was held in Grosse Ledder on October 16-21, 1973 and which was simultaneously the Second International Research Conference on Proteinase Inhibitors. The cordial atmosphere, the frank discussions and the profitable exchange of ideas during the First International Research Conference on Proteinase Inhibitors which was held on November 4--6, 1970 in Munich were a stimulant for us to consider holding a Second Conference especially as the steadily increasing research activities in this and related fields called for a new assessment of recent efforts in proteinase inhibitor research. In the three years since the First Conference was held, this field has developed particularly in the areas of molecular aspects of protein-protein interactions and in the extension to inhibitors of nonserine proteinases and peptidases. In planning this meeting the Organizing Committee was faced with the problem of selecting a limited number of participants and we decided that it was appropriate and necessary to focus in detail on the chemistry of proteinase inhibitors, their interac tions with a variety of enzymes and also to invite more general papers to survey the physiological and clinical aspects of the subject which we felt would be of importance in the future.
Book Synopsis Proteinase Inhibitors by : Alan J. Barrett
Download or read book Proteinase Inhibitors written by Alan J. Barrett and published by Elsevier Publishing Company. This book was released on 1986 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: The twelfth volume in this well established series presents the latest research on proteinases, which are known or suspected to be implicated in many aspects of normal physiology and disease processes. In order to understand the nature of this involvement the researcher must repeatedly resort to our current understanding of proteinase inhibitors. The chapters in this book cover various approaches to the investigation and treatment of a wide variety of medical problems, including malignancy, arthritis, hypertension and coagulation disorders, viral, bacterial and parasitic infections, muscular dystrophy, pulmonary emphysema and neurological disease. Due to the level of sophistication of naturally occurring protein inhibitors, techniques such as X-ray crystallography are being used intensively, and the results are being fed back into the design of artificial inhibitors made chemically or by genetic engineering. Rapid technical progress in these synthetic methods encourages the full use of new information available, and the outcome is that a range of new drugs are in the stage of pre-clinical trials.
Book Synopsis Proteases as Targets for Therapy by : Klaus, von der Helm
Download or read book Proteases as Targets for Therapy written by Klaus, von der Helm and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Book Synopsis Natural Proteinase Inhibitors by : Rosmarie Vogel
Download or read book Natural Proteinase Inhibitors written by Rosmarie Vogel and published by Elsevier. This book was released on 2012-12-02 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Proteinase Inhibitors focuses on natural inhibitors for proteolytic enzymes, which occur in plants and animals. It presents the theoretical and practical importance of the natural proteinase inhibitors of man and animal organisms. Organized into four chapters, this book starts with an overview of inhibitors for peptide and peptdohydrolases. This text then explores the important enzyme called kallikreins, which are found in the pancreas, the intestinal wall, the plasma, the submandibular gland, and the urine. Other chapters examine the various plant inhibitors, which are present in soybean, lima beans, potatoes, grains, and beetroots. This book discusses as well the inhibition of proteolytic enzymes by substances from body tissues. The final chapter deals with the prevention of uncontrolled liberation of kinins by proteinases, which is of great significance because the kinins are involved in the occurrence of pathological processes such as inflammation. Biologists and graduate students will find this book extremely useful.
Book Synopsis Medical Aspects of Proteases and Protease Inhibitors by : Nobuhiko Katunuma
Download or read book Medical Aspects of Proteases and Protease Inhibitors written by Nobuhiko Katunuma and published by IOS Press. This book was released on 1997 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presents articles on proteases and their inhibitors as mediators of biological functions. Topics addressed: cathepsin B and L; MHC and peptide interaction; procathepsin L; cysteine proteinases; selective neuronal cell death; HIV and influenza virus; tumor invasion; gingivitis; bacterial infection. Readers: professionals in the area of molecular medicine, biochemists, molecular biologists, clinical pharmacologists, pharmaceutical companies.
Book Synopsis Proteinases and Their Inhibitors in Cells and Tissues by : György Rappay
Download or read book Proteinases and Their Inhibitors in Cells and Tissues written by György Rappay and published by . This book was released on 1989 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Protease Action by : Laszlo Polgar
Download or read book Mechanisms of Protease Action written by Laszlo Polgar and published by CRC Press. This book was released on 1989-01-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.
Book Synopsis Proteinases and Their Inhibitors by : V. Turk
Download or read book Proteinases and Their Inhibitors written by V. Turk and published by Elsevier. This book was released on 2014-05-23 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteinases and their Inhibitors: Structure, Function, and Applied Aspects documents the proceedings of an international symposium organized by the Department of Biochemistry, Jozef Stefan Institute, E. Kardelj University, Ljubljana, and the Department of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Zagreb, held in Portoroz, Yugoslavia, September 29-October 3, 1980. The volume contains 34 papers that are organized into four parts. Part I on biological functions includes studies such as muscle protein breakdown in human catabolic state and age-dependent changes in intracellular protein turnover. The papers in Part II, which deals with properties and structure of enzymes, cover topics such as structures and biological functions of cathepsin B and L; and human erythrocytes peptidases. Part III is devoted to industrial applications, such as exogenous proteinases in dairy technology and the application of immobilized proteinases. Part IV on proteinase inhibitors includes papers on thiol inhibitors of proteases and and intracellular neutral proteinases and inhibitors. The papers in this volume provide new data, concepts, and visions which will not only prove useful, but will also stimulate further investigations of proteinases and their inhibitors.
Book Synopsis Proteases New Perspectives by : Vito Turk
Download or read book Proteases New Perspectives written by Vito Turk and published by Birkhäuser. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.
Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel
Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Book Synopsis Proteases, Protease Inhibitors, and Protease-derived Peptides by : John Chris Dion Cheronis
Download or read book Proteases, Protease Inhibitors, and Protease-derived Peptides written by John Chris Dion Cheronis and published by Birkhauser. This book was released on 1993 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proceedings of the International Research Conference on Proteinase Inhibitors, Munich, November 4–6, 1970 by : Hans Fritz
Download or read book Proceedings of the International Research Conference on Proteinase Inhibitors, Munich, November 4–6, 1970 written by Hans Fritz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-03 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Proceedings of the International Research Conference on Proteinase Inhibitors, Munich, November 4-6, 1970".
Book Synopsis Recombinant Protease Inhibitors in Plants by : Dominique Michaud
Download or read book Recombinant Protease Inhibitors in Plants written by Dominique Michaud and published by CRC Press. This book was released on 2001-07-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pocket-sized text provides the procedures for taking accurate vital signs. Provides an historical overview and covers such vital signs as temperature, heart rate, respiration, blood pressure, and level of consciousness. For nurses, residents and physicians. Wire-spiral binding.
Book Synopsis Protease Inhibitors: Advances in Research and Application: 2011 Edition by :
Download or read book Protease Inhibitors: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protease Inhibitors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protease Inhibitors in a concise format. The editors have built Protease Inhibitors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protease Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protease Inhibitors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Regulatory Proteolytic Enzymes and Their Inhibitors by : Staffan Magnusson
Download or read book Regulatory Proteolytic Enzymes and Their Inhibitors written by Staffan Magnusson and published by Elsevier. This book was released on 2014-05-18 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper continues with the work of Reich and co-workers who found that transformation of cultured fibroblasts from different species by oncogenic viruses is related to the production and release of proteases that are responsible in activating the proenzyme plasminogen into plasmin. Another paper discusses plasminogen activation as having some relationship with pathological processes. The book also reviews the plasminogen activator secretion by normal and neoplastic human tissues. The text discusses the results when primary cultures established from biopsies of normal kidneys secreted plasminogen activators in amounts over those secreted by actual malignant tissues. The book then notes the role of neutral and acid proteinases in male reproduction and the role of plasminogen activators in female ovulation. This collection can be useful for micro-biologists, research biologists, molecular scientists, and students of molecular biology.
