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Protein Stability And Stabilization Through Protein Engineering
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Book Synopsis Protein Stability and Stabilization Through Protein Engineering by : Yoshiaki Nosoh
Download or read book Protein Stability and Stabilization Through Protein Engineering written by Yoshiaki Nosoh and published by Ellis Horwood. This book was released on 1991 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Old and New Views of Protein Folding by : Kunihiro Kuwajima
Download or read book Old and New Views of Protein Folding written by Kunihiro Kuwajima and published by Elsevier Science & Technology. This book was released on 1999 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folding of B-lactoglobolin, a case of the inconsistency of local and non-local interactions. (Y. Goto, M. Hoshino, K. Kuwata and C. A. Batt). Dynamic stability of bovine B-lactoglobulin studied by hydrogen/deuterium exchange. (V. Forge, M. Hoshino, K. Kuwata, C. A. Batt, and Y. Goto). Folding intermediates of equine B-lactoglobulin. (M. Ikeguchi). Structural analysis of protein folding intermediates by solution X-ray scattering. (M. Arau, K. Ito, K. Maki, T. Ikura, T. Inobe, H. Kihara, Y. Amemiya and K. Kuwajima). Nonnative structure of proteins and its implications for protein folding. (K. Soda and Y. Seki). Dynamics of a-helices, B-hairpins and loops. (J. Hofrichter, P. A. Thompson, V. Muñoz, G. S. Jas, E. Henry, S. J. Hagen, L. Lapidus and W. A. Eaton). Kinetic and structural characterization of early events in protein folding. (H. Roder, M. C. R. Shastry, J. M. Sauder and S.-H. Park). CD measurements on the early folding intermediate of cytochrome c using the fast flow mixer. (S. Takahashi, S. Akiyama, K. Ishimori and I. Morishima). Fast protein dynamics probed by vibrational spectroscopy. (Y. Mizutani, K. Yamamoto and T. Kitagawa). The consistency principle revisited. (N. Go). Complete structure reconstruction for model proteins using mutation calorimetry. (M. P. Morrissey and E. I. Shakhnovich). Site resolved landscape theory of fast folding proteins. (S. Takada). Hierarchy and connectivity in the folding funnel. (H. K. Nakamura and M. Sasai). The folding mechanisms of a-lactalbumin and Ca - binding Iysozyme. (K. Kuwajima, M. Arai, M. Mizuguchi, T. Koshiba and K. Nitta). Determinants of the native-like tertiary topology in the a-lactakbumin molten globule. (Z.-y. Peng). Kinetic folding reactions and molecular dynamics simulations of a-lactalbumin. (T. Yoda, M. Saito, M. Arai, K. Horii, K. Tsumoto, M. Matsushima, I. Kumagai, T. K. Chaudhuri and K. Kuwajima). Folding-unfolding processes of four species of 3SS-variant of lysozyme - the role of an individual disulfide bridge. (A. Yakota, Y. Noda, H. Tachibana and S.-I. Segawa). Evaluation of some factors that contribute to conformational stability of a protein using database of stability/structure. (K. Yutani, K. Takano and J. Funahashi). Computational analysis of protein thermal stability and dennatured state. (Y. Sugita). Hydrophobic effects: roles of water and denaturants. /M. Ikeguchi, S. Nakamura and K. Shimizu). Effects of deletion or insertions on the structure, stability and function of staphylococcal nuclease. (M. Kataoka, J. Tunoki and H. Takahara). Statistical analysis of unfolding process of protein G BI domain with 50 runs of molecular dynamics simulations. (T. Takahashi, A. Tanaka and K. Nagayama). Protein folding simulations by generalized-ensemble algorithms. (Y. Okamoto). Protein folding and genome evolution. (M. Go and K. Yura). Symmetry in protein folds: implication in evolution and folding. (K. Kinoshita, A. Kidera and N. Go). Multistate kinetics of folding and unfolding of barstar. (A. K. Bhuyan and J. B. Udgaonkar). Equilibrium and kinetics of folding of staphylococcal nuclease and its proline mutants. (K. Maki, T. Ikura, A. Mohs and K. Kuwajima). Cold denaturation and folding/unfolding of a protein at low temperature. (A. Tamura). Folding elements in dihydrofolate reductase suggested by circular permutation analysis. (M. Iwakura). Thermodynamic analysis of protein induced folding upon DNA binding. (M. Oda, K. Furukawa, K. Ogata, A. Sarai and H. Nakamura). High pressure NMR study on protein dynamics and folding. (K. Akasaka).
Book Synopsis Protein Stability by : David S. Eisenberg
Download or read book Protein Stability written by David S. Eisenberg and published by . This book was released on 1995 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topics covered by this volume include: protein destabilization at low temperatures; engineering the stability and function of Gene V Protein; free energy balance in protein folding; modelling protein stability as a heteropolymer collapse; stability of alpha helices; protein stability with T4 Lysozyme.
Book Synopsis Biocatalysis: Biochemical Fundamentals And Applications (Second Edition) by : Peter Grunwald
Download or read book Biocatalysis: Biochemical Fundamentals And Applications (Second Edition) written by Peter Grunwald and published by World Scientific Publishing Company. This book was released on 2017-08-04 with total page 1314 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.
Book Synopsis Protein Engineering by : Huimin Zhao
Download or read book Protein Engineering written by Huimin Zhao and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rational design, and semi-rational design of proteins and offers a review of the most recent applications in industrial and medical biotechnology. This important book: Covers technologies and methodologies used in protein engineering Includes the strategies behind the approaches, designed to help with the adaptation and implementation of these strategies for new applications Offers a comprehensive and thorough treatment of protein engineering from primary strategies to applications in industrial and medical biotechnology Presents cutting edge advances in the continuously evolving field of protein engineering Written for students and professionals of bioengineering, biotechnology, biochemistry, Protein Engineering: Tools and Applications offers an essential resource to the design strategies in protein engineering and reviews recent applications.
Book Synopsis Stability and Stabilization of Biocatalysts by : A. Ballesteros
Download or read book Stability and Stabilization of Biocatalysts written by A. Ballesteros and published by Elsevier Science Limited. This book was released on 1998 with total page 757 pages. Available in PDF, EPUB and Kindle. Book excerpt: Six years after the symposium on Stability and Stabilization of Enzymes, a second symposium, Stability and Stabilization of Biocatalysts, on which this book is based, was organized. At the symposium, 210 participants representing all continents came together to learn from 150 oral and poster communications. The volume brings up-to-date the work already going on, and identifies possible breakthroughs in the research. This timely book therefore presents cutting edge developments in topics such as non-covalent processes in solution, protein engineering and thermophile enzymes, immobilized enzymes, non-conventional media, and whole cells. An excellent addition to the available literature, it will make a useful contribution to this key area of applied biocatalysis.
Book Synopsis Industrial Biocatalysis by : Peter Grunwald
Download or read book Industrial Biocatalysis written by Peter Grunwald and published by CRC Press. This book was released on 2014-12-11 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts-with
Book Synopsis Directed Enzyme Evolution by : Frances H. Arnold
Download or read book Directed Enzyme Evolution written by Frances H. Arnold and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Directed evolution comprises two distinct steps that are typically applied in an iterative fashion: (1) generating molecular diversity and (2) finding among the ensemble of mutant sequences those proteins that perform the desired fu- tion according to the specified criteria. In many ways, the second step is the most challenging. No matter how cleverly designed or diverse the starting library, without an effective screening strategy the ability to isolate useful clones is severely diminished. The best screens are (1) high throughput, to increase the likelihood that useful clones will be found; (2) sufficiently sen- tive (i. e. , good signal to noise) to allow the isolation of lower activity clones early in evolution; (3) sufficiently reproducible to allow one to find small improvements; (4) robust, which means that the signal afforded by active clones is not dependent on difficult-to-control environmental variables; and, most importantly, (5) sensitive to the desired function. Regarding this last point, almost anyone who has attempted a directed evolution experiment has learned firsthand the truth of the dictum “you get what you screen for. ” The protocols in Directed Enzyme Evolution describe a series of detailed p- cedures of proven utility for directed evolution purposes. The volume begins with several selection strategies for enzyme evolution and continues with assay methods that can be used to screen enzyme libraries. Genetic selections offer the advantage that functional proteins can be isolated from very large libraries s- ply by growing a population of cells under selective conditions.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hydrogen Bonding in Biological Structures by : George A. Jeffrey
Download or read book Hydrogen Bonding in Biological Structures written by George A. Jeffrey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogen bonds are weak attractions, with a binding strength less than one-tenth that of a normal covalent bond. However, hydrogen bonds are of extraordinary importance; without them all wooden structures would collapse, cement would crumble, oceans would vaporize, and all living things would disintegrate into random dispersions of inert matter. Hydrogen Bonding in Biological Structures is informative and eminently usable. It is, in a sense, a Rosetta stone that unlocks a wealth of information from the language of crystallography and makes it accessible to all scientists. (From a book review of Kenneth M. Harmon, Science 1992)
Book Synopsis Protein Engineering Handbook, Volume 3 by : Stefan Lutz
Download or read book Protein Engineering Handbook, Volume 3 written by Stefan Lutz and published by John Wiley & Sons. This book was released on 2012-09-14 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction collects 17 innovative approaches to engineer novel and improved proteins for diverse applications in biotechnology, chemistry, bioanalytics and medicine. As such, key developments covered in this reference and handbook include de novo enzyme design, cofactor design and metalloenzymes, extremophile proteins, and chemically resistant proteins for industrial processes. The editors integrate academic innovations and industrial applications so as to arrive at a balanced view of this multi-faceted topic. Throughout, the content is chosen to complement and extend the previously published two-volume handbook by the same editors, resulting in a superb overview of this burgeoning field.
Book Synopsis Protein Engineering For Industrial Biotechnology by : Lilia Alberghina
Download or read book Protein Engineering For Industrial Biotechnology written by Lilia Alberghina and published by CRC Press. This book was released on 2003-09-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein engineering has proved to be one of the more fruitful technological approaches in biotechnology, being both very powerful and able to generate valuable intellectual property. This book aims to present examples in which the application of protein engineering has successfully solved problems arising in industrial biotechnology. There is a section on its use to enhance purification of recombinant proteins. The use of protein engineering to modify the activity or the stability of industrial enzymes from lipases to proteases, from carboxypeptidases to glucanases and glucosidases, and from pectin modifying enzymes to enzymes able to degrade recalcitrant compounds is extensively covered. It is shown how areas as diverse as agrofood technology, fine chemistry, detergents, bioremediation and biosensors receive significant contributions from protein and solvent engineering. The application of protein engineering to health care is also covered, from the development of new vaccines to new potential therapeutic proteins. A specific notation is given to protein engineering in the development of target molecules for drug discovery. International in scope, the many contributions are drawn from academia and industry. The text should be of interest to students and researchers in industrial biotechnology as well as to everybody interested in basic research in protein structure, molecular genetics, bio-organic chemistry, biochemistry, agrobiotechnology, pharmaceutical sciences and medicine.
Book Synopsis Computational Protein Design by : Ilan Samish
Download or read book Computational Protein Design written by Ilan Samish and published by Humana. This book was released on 2016-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.
Book Synopsis Stability and Stabilization of Biocatalysts by : F.J. Plou
Download or read book Stability and Stabilization of Biocatalysts written by F.J. Plou and published by Elsevier. This book was released on 1998-11-10 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Six years after the symposium on Stability and Stabilization of Enzymes, a second symposium, Stability and Stabilization of Biocatalysts, on which this book is based, was organized. At the symposium, 210 participants representing all continents came together to learn from 150 oral and poster communications.The volume brings up-to-date the work already going on, and identifies possible breakthroughs in the research. This timely book therefore presents cutting edge developments in topics such as non-covalent processes in solution, protein engineering and thermophile enzymes, immobilized enzymes, non-conventional media, and whole cells.An excellent addition to the available literature, it will make a useful contribution to this key area of applied biocatalysis.
Download or read book Non-Natural Amino Acids written by and published by Academic Press. This book was released on 2009-07-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Book Synopsis Protein Structure by : Eshel Faraggi
Download or read book Protein Structure written by Eshel Faraggi and published by BoD – Books on Demand. This book was released on 2012-04-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of recorded history, and probably even before, men and women have been grasping at the mechanisms by which they themselves exist. Only relatively recently, did this grasp yield anything of substance, and only within the last several decades did the proteins play a pivotal role in this existence. In this expose on the topic of protein structure some of the current issues in this scientific field are discussed. The aim is that a non-expert can gain some appreciation for the intricacies involved, and in the current state of affairs. The expert meanwhile, we hope, can gain a deeper understanding of the topic.
Book Synopsis Engineering and Manufacturing for Biotechnology by : M. Hofman
Download or read book Engineering and Manufacturing for Biotechnology written by M. Hofman and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early integration is the key to success in industrial biotechnology. This is as true when a selected wild-type organism is put to work as when an organism is engineered for a purpose. The present volume Engineering and Manufacturing for Biotechnology took advantage of the 9th European Congress on Biotechnology (Brussels, Belgium, July 11-15, 1999): in the topics handled and in the expertise of the contributors, the engineering science symposia of this congress offered just what was needed to cover the important topic of integration of process engineering and biological research. The editors have solicited a number of outstanding contributions to illustrate the intimate interaction between productive organisms and the numerous processing steps running from the initial inoculation to the packaged product. Upstream processing of the feed streams, selection of medium components, product harvesting, downstream processing, and product conditioning are just a few major steps. Each step imposes a number of important choices. Every choice is to be balanced against time to market, profitability, safety, and ecology.