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Protein Prenylation In Saccharomyces Cerevesiae
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Book Synopsis Prenylation-dependent Processing of Proteins in Saccharomyces Cerevisiae by : Victor Leontievich Boyartchuk
Download or read book Prenylation-dependent Processing of Proteins in Saccharomyces Cerevisiae written by Victor Leontievich Boyartchuk and published by . This book was released on 1998 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Prenylation by : Christine A. Hrycyna
Download or read book Protein Prenylation written by Christine A. Hrycyna and published by Academic Press. This book was released on 2011 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Prenylation in Saccharomyces Cerevesiae by : William Ronald Schafer
Download or read book Protein Prenylation in Saccharomyces Cerevesiae written by William Ronald Schafer and published by . This book was released on 1991 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Saccharomyces Cerevisiae Rheb Small G-protein, ScRheb, Regulates the Uptake of Arginine and Lysine in a Farnesylation Dependent Manner by : Jun Urano
Download or read book The Saccharomyces Cerevisiae Rheb Small G-protein, ScRheb, Regulates the Uptake of Arginine and Lysine in a Farnesylation Dependent Manner written by Jun Urano and published by . This book was released on 1999 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Extraction and Isolation of Protein from Saccharomyces Cerevisiae by : Gail Barnes
Download or read book The Extraction and Isolation of Protein from Saccharomyces Cerevisiae written by Gail Barnes and published by . This book was released on 1984 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Prenylation, Part B written by and published by Academic Press. This book was released on 2011-11-08 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book Protein Prenylation, Part A written by and published by Academic Press. This book was released on 2011-07-10 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Book Synopsis Investigating the Role of the Saccharomyces Cerevisiae Poly(A) Binding Protein in 5-cap Complex Formation in Vitro by : Jennifer Marie Blanchette
Download or read book Investigating the Role of the Saccharomyces Cerevisiae Poly(A) Binding Protein in 5-cap Complex Formation in Vitro written by Jennifer Marie Blanchette and published by . This book was released on 2000 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Messenger RNA and Protein Metabolism During Sporulation of Saccharomyces Cerevisiae by : Ellen B. Kraig
Download or read book Messenger RNA and Protein Metabolism During Sporulation of Saccharomyces Cerevisiae written by Ellen B. Kraig and published by . This book was released on 1981 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Secretion in Saccharomyces Cerevisiae by : Thomas Payne
Download or read book Protein Secretion in Saccharomyces Cerevisiae written by Thomas Payne and published by . This book was released on 2007 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Saccharomyces Cerevisiae Fin1 Protein: a Binding Partner of the 14-3-3 Proteins by : Martijn Jeroen Hemert
Download or read book Characterization of the Saccharomyces Cerevisiae Fin1 Protein: a Binding Partner of the 14-3-3 Proteins written by Martijn Jeroen Hemert and published by . This book was released on 2001 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Membrane Dynamics and Domains by : Peter J. Quinn
Download or read book Membrane Dynamics and Domains written by Peter J. Quinn and published by Springer Science & Business Media. This book was released on 2004-07-02 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.
Book Synopsis Dissecting Fundamental Mechanisms of Protein Translation in Saccharomyces Cerevisiae by : Dustin Howard Hite
Download or read book Dissecting Fundamental Mechanisms of Protein Translation in Saccharomyces Cerevisiae written by Dustin Howard Hite and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The central dogma of biology states that DNA, the genetic information, is transcribed into RNA, an information containing intermediate, which is then translated into proteins, actionable molecules which perform the majority of tasks required for life. To synthesize proteins, the cell employs a massive, macromolecular machine, the ribosome, and a myriad of protein factors to successfully translate an mRNA. My graduate studies have focused both on the ribosome and the protein translation factors that interact with the ribosome to facilitate translation initiation, elongation, and termination. First, utilizing recent advances in high throughput sequencing, we discovered that sequencing of ribosome protected fragments could illuminate in vivo dynamics of ribosome structural changes in Saccharomyces cerevisiae. We demonstrated that the ribosome protects two distinct sizes of fragments and assigned each fragment population to approximate stages of the translation elongation cycle where large structural rearrangements of the ribosome are known to occur. Once these assignments were made, we were able to model elongation speed and demonstrated that, contrary to previous reports, tRNA abundance and codon optimality were not the major determinants of elongation speed; surprisingly our data indicated that the polarity of the amino acid being decoded dictated elongation rates under these conditions, with polar amino acids acting to slow elongation rates. This study also implicated Dom34, a known NO GO decay factor, as a novel component of canonical translation termination and ribosome recycling. Second, we used another genome-wide assay of translation, "gradient encoding" microarray analysis, to interrogate the genome-wide effects of depleting five individual translation factors. Based on the current understanding of the molecular mechanisms of each translation factor, we hypothesized that the depletion of each factor would result in differential translation of mRNAs based on the physical properties of each mRNA species. However, we were startled to observe that the translational program of S. cerevisiae was relatively unperturbed by the depletion of three initiation factors, one elongation factor, and one termination factor. Further investigation revealed that yeast were actively compensating for the deficiency of each factor by either increasing or decreasing translation initiation rates such that the depleted factor was no longer limiting. This tuning was mediated by changes in eIF2[alpha] phosphorylation levels, a known modulator of translation initiation. Overall, we have leveraged high throughput technologies to provide novel understanding of in vivo structural dynamics of the ribosome and reveal a novel, unexpected robustness of the translational program in S. cerevisiae.
Book Synopsis Characterization of Saccharomyces Cerevisiae Proteins Involved in Vacuolar Protein Transport by : Lorena M. Eguez
Download or read book Characterization of Saccharomyces Cerevisiae Proteins Involved in Vacuolar Protein Transport written by Lorena M. Eguez and published by . This book was released on 2003 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein-protein Interactions in Nucleic Acids Metabolism in Saccharomyces Cerevisiae by : Heidrun Interthal
Download or read book Protein-protein Interactions in Nucleic Acids Metabolism in Saccharomyces Cerevisiae written by Heidrun Interthal and published by . This book was released on 1996 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Analysis of Protein Trafficking in the Yeast Saccharomyces Cerevisiae by : Tamara Krsmanović
Download or read book Analysis of Protein Trafficking in the Yeast Saccharomyces Cerevisiae written by Tamara Krsmanović and published by . This book was released on 2004 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Farnesyltransferase Inhibitors in Cancer Therapy by : Saïd M. Sebti
Download or read book Farnesyltransferase Inhibitors in Cancer Therapy written by Saïd M. Sebti and published by Springer Science & Business Media. This book was released on 2000-10-22 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of research on genes capable of causing cancer, it has become clear that mutations in the GTPase, Ras, a major regulator of cell division, are found in about 30% of all human cancers, and that farnesylation, a lipid posttranslational modification of Ras, is required for its cancer-causing activity. In Farnesyltransferase Inhibitors in Cancer Therapy, cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farnesyltransferase inhibitors (FTIs) and geranylgeranyltransferase inhibitors (GGTIs) that can be used as anticancer drugs and in cardiovascular and parasitic therapy. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other cytotoxic agents, such as gemcitabine, cisplatin, and taxanes. The book also discusses the results from several phase I and II human clinical trials using a variety of FTIs, and demonstrates the design of hypothesis-driven clinical trials with proof-of-concept using biochemical endpoints. Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy constitutes today's standard reference for the pathbreaking use of FTIs and GGTIs in anticancer therapy and offers basic and clinical investigators a comprehensive treatment of the scientific and medical aspects of farnesyltransferase inhibitors.