Biomolecular NMR Spectroscopy

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Author :
Publisher : IOS Press
ISBN 13 : 1607506947
Total Pages : 488 pages
Book Rating : 4.6/5 (75 download)

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Book Synopsis Biomolecular NMR Spectroscopy by : Andrew J. Dingley

Download or read book Biomolecular NMR Spectroscopy written by Andrew J. Dingley and published by IOS Press. This book was released on 2011 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful technique for characterization of biomolecular structures at atomic resolution in the solution state. This timely book, entitled "Biomolecular NMR Spectroscopy," focuses on the latest state-of-the-art NMR techniques for characterization of biological macromolecules in the solid and solution state. The editors, Dr. Andrew Dingley (University of Auckland, New Zealand) and Dr. Steven Pascal (Massey University, New Zealand) have organized the book into four sections, covering the following topics: sample preparation, structure and dynamics of proteins, structure and dynamics of nucleic acids and protein-nucleic acid complexes, and rapid and hybrid techniques--

Excipient Applications in Formulation Design and Drug Delivery

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Author :
Publisher : Springer
ISBN 13 : 3319202065
Total Pages : 700 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Excipient Applications in Formulation Design and Drug Delivery by : Ajit S Narang

Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Recognition Receptors in Biosensors

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1441909192
Total Pages : 864 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Recognition Receptors in Biosensors by : Mohammed Zourob

Download or read book Recognition Receptors in Biosensors written by Mohammed Zourob and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.

Technetium-99m Radiopharmaceuticals

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Author :
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Technetium-99m Radiopharmaceuticals by : IAEA.

Download or read book Technetium-99m Radiopharmaceuticals written by IAEA. and published by . This book was released on 2010 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technetium-99m radiopharmaceuticals will continue to have a significant impact in several areas of nuclear medicine. This publication is intended to provide a broad overview of the current status of technetium-99m radiopharmaceuticals. It includes chapters on the most advanced chemical techniques for labelling biomolecules and synthesizing suitable multifunctional ligands that will help in the development of specific radiotracers. Of special interest for the reader are details of recent research to develop technetium-99m tracers for monitoring different biological processes enabling the develo.

Nitroxides

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Author :
Publisher : Springer Nature
ISBN 13 : 3030348229
Total Pages : 323 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Nitroxides by : Gertz I. Likhtenshtein

Download or read book Nitroxides written by Gertz I. Likhtenshtein and published by Springer Nature. This book was released on 2020-01-03 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a pioneer in the development of spin labeling in biophysics, this expert book covers the fundamentals of nitroxide spin labeling through cutting-edge applications in chemistry, physics, materials science, molecular biology, and biomedicine. Nitroxides have earned their place as one of the most popular organic paramagnets due to their suitability as inhibitors of oxidative processes, as a means to polarize magnetic nuclei, and, in molecular biology, as probes and labels to understand molecular structures and dynamics AS DRAGS FOR CANCER AND OTHER DISEASES. Beginning with an overview of the basic methodology and nitroxides’ 145-year history, this book equips students with necessary background and techniques to undertake original research and industry work in this growing field.

Telomerase Inhibition

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1588296830
Total Pages : 197 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Telomerase Inhibition by : Lucy Andrews

Download or read book Telomerase Inhibition written by Lucy Andrews and published by Springer Science & Business Media. This book was released on 2007-11-29 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition. The techniques described provide the researcher with a diverse and comprehensive set of tools for the study of telomerase inhibition. The volume is aimed at biochemists, molecular biologists, cancer researchers, and geneticists.

Metal Complexes in Aqueous Solutions

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1489914862
Total Pages : 259 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Metal Complexes in Aqueous Solutions by : Arthur E. Martell

Download or read book Metal Complexes in Aqueous Solutions written by Arthur E. Martell and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stability constants are fundamental to understanding the behavior of metal ions in aqueous solution. Such understanding is important in a wide variety of areas, such as metal ions in biology, biomedical applications, metal ions in the environment, extraction metallurgy, food chemistry, and metal ions in many industrial processes. In spite of this importance, it appears that many inorganic chemists have lost an appreciation for the importance of stability constants, and the thermodynamic aspects of complex formation, with attention focused over the last thirty years on newer areas, such as organometallic chemistry. This book is an attempt to show the richness of chemistry that can be revealed by stability constants, when measured as part of an overall strategy aimed at understanding the complexing properties of a particular ligand or metal ion. Thus, for example, there are numerous crystal structures of the Li+ ion with crown ethers. What do these indicate to us about the chemistry of Li+ with crown ethers? In fact, most of these crystal structures are in a sense misleading, in that the Li+ ion forms no complexes, or at best very weak complexes, with familiar crown ethers such as l2-crown-4, in any known solvent. Thus, without the stability constants, our understanding of the chemistry of a metal ion with any particular ligand must be regarded as incomplete. In this book we attempt to show how stability constants can reveal factors in ligand design which could not readily be deduced from any other physical technique.

G Protein-Coupled Receptors

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733449
Total Pages : 549 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis G Protein-Coupled Receptors by : Jesus Giraldo

Download or read book G Protein-Coupled Receptors written by Jesus Giraldo and published by Royal Society of Chemistry. This book was released on 2011-08-16 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.

Epitope Mapping Protocols

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Author :
Publisher : Humana Press
ISBN 13 : 9781934115176
Total Pages : 450 pages
Book Rating : 4.1/5 (151 download)

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Book Synopsis Epitope Mapping Protocols by : Ulrich Reineke

Download or read book Epitope Mapping Protocols written by Ulrich Reineke and published by Humana Press. This book was released on 2009-05-20 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the versatile utility of the determinination of epitopes, beneficial to a wide variety of scientists from immunologists to structural biologists to biotechnologists, the need for a thorough, state-of-the-art collection of experimental protocols is clear. In Epitope Mapping Protocols, Second Edition, expert contributors from a broad spectrum of scientific backgrounds update and expand the successful first edition with cutting-edge techniques and applications, including approaches to both antibody or B-cell epitope mapping and T-cell epitope mapping as well as a new section on the profiling of antibody signatures in biological fluids. Written in the popular Methods in Molecular BiologyTM series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Epitope Mapping Protocols, Second Edition is a reliable and valuable reference for all those who wish to understand and further investigate the diversifying field of epitope mapping.

Iron and Copper Proteins

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Author :
Publisher : Springer
ISBN 13 : 9781468432725
Total Pages : 0 pages
Book Rating : 4.4/5 (327 download)

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Book Synopsis Iron and Copper Proteins by : Kerry Yasunobu

Download or read book Iron and Copper Proteins written by Kerry Yasunobu and published by Springer. This book was released on 2012-12-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Fe- and Cu-Protein Symposium was held on December 15-18, 1975 at the East West Center-University of Hawaii and was sponsored by the United States-Japan Cooperative Science Program under the auspices of the National Science Foundation and the Japan Society for the Promotion of Science. It was recognized by the organizers of the symposium that metalloproteins are very important in the field of health science and a subject worthy of discussion by experts from the United States, Japan and Europe. The meeting was restricted to Fe- and Cu-proteins but this is still a very broad subject matter and therefore, selected topics of current interest in this field were chosen. This book contains the collected papers from most of the symposium participants. The subject matter covered in this book is divided into four parts. These are: 1) the iron-sulfur proteins (which are not a part of the mitochondrial electron transport system); 2) the iron-sulfur proteins and heme proteins of the mitochondrial electron transport system; 3) other heme and nonheme iron proteins; and 5) selected copper proteins. The organizers of the symposium wish to express their gratitude to the participants, the session chairmen, and Drs. I.C. Gunsalus and E. Frieden who assisted in the organization of the symposium.

Photochemistry and Photophysics of Coordination Compounds II

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Author :
Publisher : Springer
ISBN 13 : 3540733493
Total Pages : 336 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Photochemistry and Photophysics of Coordination Compounds II by : Vincenzo Balzani

Download or read book Photochemistry and Photophysics of Coordination Compounds II written by Vincenzo Balzani and published by Springer. This book was released on 2007-08-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photochemistry (a term that broadly speaking includes photophysics) is abranchofmodernsciencethatdealswiththeinteractionoflightwithmatter and lies at the crossroadsof chemistry, physics, and biology. However, before being a branch of modern science, photochemistry was (and still is today), an extremely important natural phenomenon. When God said: “Let there be light”, photochemistry began to operate, helping God to create the world as wenowknowit.Itislikelythatphotochemistrywasthesparkfortheoriginof life on Earth and played a fundamental role in the evolution of life. Through the photosynthetic process that takes place in green plants, photochemistry is responsible for the maintenance of all living organisms. In the geological past photochemistry caused the accumulation of the deposits of coal, oil, and naturalgasthat wenowuseasfuels.Photochemistryisinvolved inthecontrol ofozoneinthestratosphereandinagreatnumber ofenvironmentalprocesses thatoccurintheatmosphere,inthesea,andonthesoil.Photochemistryisthe essenceoftheprocessofvisionandcausesavarietyofbehavioralresponsesin living organisms. Photochemistry as a science is quite young; we only need to go back less than one century to ?nd its early pioneer [1]. The concept of coordination compound is also relatively young; it was established in 1892, when Alfred Werner conceived his theory of metal complexes [2]. Since then, the terms coordination compound and metal complex have been used as synonyms, even if in the last 30 years, coordination chemistry has extended its scope to the binding ofall kinds of substrates [3, 4].

Topology of Polymers

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Author :
Publisher : Springer Nature
ISBN 13 : 4431568883
Total Pages : 85 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Topology of Polymers by : Koya Shimokawa

Download or read book Topology of Polymers written by Koya Shimokawa and published by Springer Nature. This book was released on 2019-12-06 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plastics, films, and synthetic fibers are among typical examples of polymer materials fabricated industrially in massive quantities as the basis of modern social life. By comparison, polymers from biological resources, including proteins, DNAs, and cotton fibers, are essential in various processes in living systems. Such polymers are molecular substances, constituted by the linking of hundreds to tens of thousands of small chemical unit (monomer) components. Thus, the form of polymer molecules is frequently expressed by line geometries, and their linear and non-linear forms are believed to constitute the fundamental basis for their properties and functions. In the field of polymer chemistry and polymer materials science, the choice of macromolecules has continuously been extended from linear or randomly branched forms toward a variety of precisely controlled topologies by the introduction of intriguing synthetic techniques. Moreover, during the first decade of this century, a number of impressive breakthroughs have been achieved to produce an important class of polymers having a variety of cyclic and multicyclic topologies. These developments now offer unique opportunities in polymer materials design to create unique properties and functions based on the form, i.e., topology, of polymer molecules. The introduction and application of topological geometry (soft geometry) to polymer molecules is a crucial requirement to account for the basic geometrical properties of polymer chains uniquely flexible in nature, in contrast to small chemical compounds conceived upon Euclidian geometry (hard geometry) principles. Topological geometry and graph theory are introduced for the systematic classification and notation of the non-linear constructions of polymer molecules, including not only branched but also single cyclic and multicyclic polymer topologies. On that basis, the geometrical–topological relationship between different polymers having distinctive constructions is discussed. A unique conception of topological isomerism is thus formed, which contrasts with that of conventional constitutional and stereoisomerism occurring in small chemical compounds. Through the close collaboration of topology experts Shimokawa and Ishihara and the polymer chemist Tezuka, this monograph covers the fundamentals and selected current topics of topology applied in polymers and topological polymer chemistry. In particular, the aim is to provide novel insights jointly revealed through a unique interaction between mathematics (topology) and polymer materials science.

Calorimetry and Thermal Analysis of Polymers

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Author :
Publisher : Hanser Gardner Publications
ISBN 13 : 9781569901267
Total Pages : 369 pages
Book Rating : 4.9/5 (12 download)

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Book Synopsis Calorimetry and Thermal Analysis of Polymers by : Vincent B. F. Mathot

Download or read book Calorimetry and Thermal Analysis of Polymers written by Vincent B. F. Mathot and published by Hanser Gardner Publications. This book was released on 1994-01 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radiopharmaceutical Chemistry

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Publisher : Springer
ISBN 13 : 3319989472
Total Pages : 648 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Radiopharmaceutical Chemistry by : Jason S. Lewis

Download or read book Radiopharmaceutical Chemistry written by Jason S. Lewis and published by Springer. This book was released on 2019-04-02 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Peptide and Protein Engineering

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Author :
Publisher : Humana
ISBN 13 : 9781071607220
Total Pages : 289 pages
Book Rating : 4.6/5 (72 download)

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Book Synopsis Peptide and Protein Engineering by : Olga Iranzo

Download or read book Peptide and Protein Engineering written by Olga Iranzo and published by Humana. This book was released on 2021-07-23 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thorough book aims to present the methods that have enabled the success of peptides and proteins in a wide variety of applications. It opens with a section on chemical tools applied to the production or engineering of peptides and proteins, and concludes with a collection of chapters on biological approaches used to engineer structure and function in peptides and proteins. As a book in the Springer Protocols Handbooks series, chapters include the kind of detailed descriptions and tips necessary for successful results in practice. Authoritative and practical, Peptide and Protein Engineering: From Concepts to Biotechnological Applications will be of great use to scientists in academia and industry seeking a better understanding of the emerging principles and methodologies in peptide and protein engineering.

Masters Theses in the Pure and Applied Sciences

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Publisher : Springer
ISBN 13 : 9780306341205
Total Pages : 320 pages
Book Rating : 4.3/5 (412 download)

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Book Synopsis Masters Theses in the Pure and Applied Sciences by : Wade H. Shafer

Download or read book Masters Theses in the Pure and Applied Sciences written by Wade H. Shafer and published by Springer. This book was released on 1976 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Masters Theses in the Pure and Applied Sciences was first conceived, published, and dis· seminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS) *at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemination phases of the ac· tivity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all concerned if the printing and distribution of the volume were handled by an international publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Corporation of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 20 (thesis year 1975) a total of 10,374 theses titles from 28 Canadian and 239 United States universities. We are sure that this broader base for theses titles reported will greatly enhance the value of this important annual reference work. The organization of Volume 20 is identical to that of past years. It consists of theses titles arranged by discipline and by university within each discipline.

Topics in Heterocyclic Chemistry

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Author :
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (41 download)

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Book Synopsis Topics in Heterocyclic Chemistry by : Raymond Nielson Castle

Download or read book Topics in Heterocyclic Chemistry written by Raymond Nielson Castle and published by John Wiley & Sons. This book was released on 1969 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: