Protein Homeostasis Diseases

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Protein Homeostasis Diseases

Author : Angel L. Pey
Publisher : Academic Press
ISBN 13 : 0128191333
Total Pages : 450 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Protein Homeostasis Diseases by : Angel L. Pey

Download or read book Protein Homeostasis Diseases written by Angel L. Pey and published by Academic Press. This book was released on 2020-02-13 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Proteostasis and Disease

Author : Rosa Barrio
Publisher : Springer
ISBN 13 : 9783030382681
Total Pages : 348 pages
Book Rating : 4.3/5 (826 download)

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Book Synopsis Proteostasis and Disease by : Rosa Barrio

Download or read book Proteostasis and Disease written by Rosa Barrio and published by Springer. This book was released on 2021-04-24 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Protein Homeostasis in Growth, Development and Disease

Author : Francesco Fazi
Publisher : Frontiers Media SA
ISBN 13 : 2832517064
Total Pages : 136 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Protein Homeostasis in Growth, Development and Disease by : Francesco Fazi

Download or read book Protein Homeostasis in Growth, Development and Disease written by Francesco Fazi and published by Frontiers Media SA. This book was released on 2023-03-08 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Homeostasis, Second Edition

Author : Richard I. Morimoto
Publisher : Perspectives Cshl
ISBN 13 : 9781621822967
Total Pages : 562 pages
Book Rating : 4.8/5 (229 download)

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Book Synopsis Protein Homeostasis, Second Edition by : Richard I. Morimoto

Download or read book Protein Homeostasis, Second Edition written by Richard I. Morimoto and published by Perspectives Cshl. This book was released on 2019 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). Discussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.

Protein Homeostasis

Author : Richard I. Morimoto
Publisher :
ISBN 13 : 9781936113064
Total Pages : 0 pages
Book Rating : 4.1/5 (13 download)

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Book Synopsis Protein Homeostasis by : Richard I. Morimoto

Download or read book Protein Homeostasis written by Richard I. Morimoto and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proper folding of proteins is crucial for cell function. Chaperones and enzymes that post-translationally modify newly synthesized proteins help ensure that proteins fold correctly, and the unfolded protein response functions as a homeostatic mechanism that removes misfolded proteins when cells are stressed. This book covers the entire spectrum of proteostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry.

Proteostasis and Chaperone Surveillance

Author : Laishram Rajendrakumar Singh
Publisher : Springer
ISBN 13 : 8132224671
Total Pages : 184 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Proteostasis and Chaperone Surveillance by : Laishram Rajendrakumar Singh

Download or read book Proteostasis and Chaperone Surveillance written by Laishram Rajendrakumar Singh and published by Springer. This book was released on 2015-11-26 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances and the essential role of molecular and chemical chaperones.

The Networking of Chaperones by Co-chaperones

Author : Gregory Lloyd Blatch
Publisher : Springer
ISBN 13 : 3319117319
Total Pages : 286 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Networking of Chaperones by Co-chaperones by : Gregory Lloyd Blatch

Download or read book The Networking of Chaperones by Co-chaperones written by Gregory Lloyd Blatch and published by Springer. This book was released on 2014-12-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses

Author : Axel Mogk
Publisher : Frontiers Media SA
ISBN 13 : 2889741931
Total Pages : 334 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses by : Axel Mogk

Download or read book Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses written by Axel Mogk and published by Frontiers Media SA. This book was released on 2022-02-01 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cover Image for This Research Topic is Used With Permission of the Authors and Publishers of the Following Article: Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21

HSF1 and Molecular Chaperones in Biology and Cancer

Author : Marc Laurence Mendillo
Publisher : Springer Nature
ISBN 13 : 3030402045
Total Pages : 185 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo

Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Protein Quality Control in Neurodegenerative Diseases

Author : Richard I. Morimoto
Publisher : Springer Science & Business Media
ISBN 13 : 3642279287
Total Pages : 145 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Protein Quality Control in Neurodegenerative Diseases by : Richard I. Morimoto

Download or read book Protein Quality Control in Neurodegenerative Diseases written by Richard I. Morimoto and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Protein Homeostasis in Drug Discovery

Author : Milka Kostic
Publisher : John Wiley & Sons
ISBN 13 : 1119774128
Total Pages : 564 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Protein Homeostasis in Drug Discovery by : Milka Kostic

Download or read book Protein Homeostasis in Drug Discovery written by Milka Kostic and published by John Wiley & Sons. This book was released on 2022-12-01 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Homeostasis in Drug Discovery Comprehensive resource on all aspects of protein homeostasis, covering both historical perspectives and emerging technologies that are revolutionizing the field Protein Homeostasis in Drug Discovery highlights drug discovery and development efforts targeting protein homeostasis and considers the emerging appreciation that a protein’s activity may not be the only factor to consider when developing therapeutic agents. The chapters cover various aspects of protein homeostasis such as cellular localization, abundance, interactions, and more. Moreover, the text contains up-to-date information regarding targeted protein degradation, an emerging drug discovery modality. Readers interested in targeting different regulatory events that control protein homeostasis or modulating protein abundance will find this book an excellent resource. Furthermore, those interested in the link between biological function and regulating protein levels in living organisms, especially in the context of drug discovery, will learn from numerous examples discussed in this book. In Protein Homeostasis in Drug Discovery, readers can expect to find information on: Protein folding, quality control, pharmacology, and drug targeting processes Recent advances in our understanding of protein homeostasis, covering emerging technologies and opportunities for therapeutic intervention Targeted protein degradation (TPD) and strategies such as PROTACs and molecular glues, including a chapter on TPD as an antiviral drug discovery strategy Drug discovery and development efforts aimed at correcting, stabilizing, and rescuing proteins, with examples included Advantages and key shortcomings of both phenotypic and target-based traditional drug discovery methods Collectively, Protein Homeostasis in Drug Discovery offers the reader an opportunity to learn more about the importance of considering and targeting protein homeostasis. The text is a must-read resource for academics, professionals in the pharmaceutical industry, and advanced students in various science-related fields.

Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health & Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.:/5 (98 download)

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Book Synopsis Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health & Disease by :

Download or read book Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health & Disease written by and published by . This book was released on 2016 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Impairment of Protein Homeostasis in Parkinson's Disease

Author : Maike Lichtenberg
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Impairment of Protein Homeostasis in Parkinson's Disease by : Maike Lichtenberg

Download or read book Impairment of Protein Homeostasis in Parkinson's Disease written by Maike Lichtenberg and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chaperones, Protein Homeostasis and Protein Aggregation Diseases

Author : Harm Harmannus Kampinga
Publisher :
ISBN 13 : 9789036771900
Total Pages : pages
Book Rating : 4.7/5 (719 download)

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Book Synopsis Chaperones, Protein Homeostasis and Protein Aggregation Diseases by : Harm Harmannus Kampinga

Download or read book Chaperones, Protein Homeostasis and Protein Aggregation Diseases written by Harm Harmannus Kampinga and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Role for Processing-bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells

Author : Qian Shi
Publisher :
ISBN 13 :
Total Pages : 125 pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis A Role for Processing-bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells by : Qian Shi

Download or read book A Role for Processing-bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells written by Qian Shi and published by . This book was released on 2020 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proper maintenance of protein homeostasis is critical for the normal physiology and survival of all cells. These functions are carried out by a large group of proteins that is collectively referred to as the protein quality control (PQC) system of cell. Under normal conditions, misfolded proteins are refolded, degraded, or sequestered within distinct quality control compartments. A failure to maintain proper protein homeostasis is linked to many human diseases, including cancers, autoimmune conditions and neurodegenerative disorders. For example, mutant forms of huntingtin protein are prone to misfolding, accumulation and aggregation. This misfolded aggregation is thought to be responsible for the pathology of Huntington’s disease. A better understanding of the overall PQC system is therefore likely to lead to potential routes of therapy for individuals afflicted with these disorders.

Finding Balance in Huntington's Disease

Author : Joseph Ochaba
Publisher :
ISBN 13 : 9781369174205
Total Pages : 254 pages
Book Rating : 4.1/5 (742 download)

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Book Synopsis Finding Balance in Huntington's Disease by : Joseph Ochaba

Download or read book Finding Balance in Huntington's Disease written by Joseph Ochaba and published by . This book was released on 2016 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The disruption of protein quality control networks that ensure proper folding and degradation of cellular proteins is likely central to pathology in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other "protein misfolding" diseases (La Spada and Taylor, 2010; Wilkinson et al., 2010). A detailed understanding of the proteostasis network components and their contributions to pathology are therefore crucial to developing improved therapeutic interventions. HD is caused by the abnormal expansion of a CAG repeat within the HD gene resulting in an expanded stretch of polyglutamines in the Huntingtin (HTT) protein (Group, 1993a). A key pathological feature is the accumulation of mutant HTT protein (mHTT) (Cisbani and Cicchetti, 2012; Zhao et al., 2016). Post-translational modifications of HTT, including SUMOylation and phosphorylation (Ehrnhoefer et al., 2011; Pennuto et al., 2009), appear to contribute to mechanisms underlying mHTT function, clearance, and accumulation (O'Rourke et al., 2013; Ochaba et al., 2016; Zhao et al., 2016).The work presented here represents an innovative conceptual shift to address questions fundamental to HD and other diseases where protein homeostasis is affected. This approach may therefore provide insight into a broad spectrum of protein misfolding disorders. My dissertation utilized gain-of and loss-of-function approaches to query the importance of HTT function, modulation of PIAS1-regulatory networks, and SUMO-interaction motifs in the context of cell culture and in vivo mouse model systems to assess the impact on critical disease regulatory networks and HD pathogenesis. The precise mechanisms involved in the aforementioned have not yet been elucidated, nor has the PIAS and SUMO pathways been tested in vivo for its relevance to the following: the accumulation of neurodegenerative disease-causing proteins, neuroinflammation, protein clearance networks, or overall impact on disease phenotypes. My dissertation suggests that PIAS1 may link protein homeostasis and neuroinflammation in HD through a combination of modulating accumulation of toxic HMW species of HTT and compensating for dysfunctional inflammatory signaling cascades between neurons and microglia, potentially allowing improved flux through protein clearance pathways, of which HTT itself is likely involved in regulating.

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Author : Diana Fernandes Lázaro
Publisher : Frontiers Media SA
ISBN 13 : 2889635074
Total Pages : 158 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases by : Diana Fernandes Lázaro

Download or read book Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases written by Diana Fernandes Lázaro and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.