Protein Crystallography

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Protein Crystallography

Author : Eaton E. Lattman
Publisher : JHU Press
ISBN 13 : 0801896843
Total Pages : 149 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Protein Crystallography by : Eaton E. Lattman

Download or read book Protein Crystallography written by Eaton E. Lattman and published by JHU Press. This book was released on 2008-04-28 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.

Principles of Protein X-ray Crystallography

Author : Jan Drenth
Publisher : Springer Science & Business Media
ISBN 13 : 1475730926
Total Pages : 355 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Principles of Protein X-ray Crystallography by : Jan Drenth

Download or read book Principles of Protein X-ray Crystallography written by Jan Drenth and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.

Protein Crystallography

Author : Alexander Wlodawer
Publisher : Humana Press
ISBN 13 : 9781493969982
Total Pages : 672 pages
Book Rating : 4.9/5 (699 download)

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Book Synopsis Protein Crystallography by : Alexander Wlodawer

Download or read book Protein Crystallography written by Alexander Wlodawer and published by Humana Press. This book was released on 2017-06-02 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.

Practical Protein Crystallography

Author : Duncan E. McRee
Publisher : Elsevier
ISBN 13 : 0080539408
Total Pages : 514 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Practical Protein Crystallography by : Duncan E. McRee

Download or read book Practical Protein Crystallography written by Duncan E. McRee and published by Elsevier. This book was released on 1999-09-27 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for easy use by both beginning and experienced protein crystallographers, the second edition of Practical Protein Crystallography is an essential handbook for any scientist interested in solving a protein structure. The book includes examples of actual experiments and data, electron density maps, and computer methods. This second edition has new material covering CCP4, SHELX, cryocrystallography, MAD and automated fitting. In-depth coverage of every aspect of crystallography Coverage of the small details that can make or break projects Strongly application-oriented Exceptionally well illustrated Simple and easy-to-follow robust methods Tutorials with actual data available on the Web Useful for a broad spectrum of scientists

Protein Crystallization

Author : Terese M. Bergfors
Publisher : Internat'l University Line
ISBN 13 : 0972077448
Total Pages : 505 pages
Book Rating : 4.9/5 (72 download)

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Book Synopsis Protein Crystallization by : Terese M. Bergfors

Download or read book Protein Crystallization written by Terese M. Bergfors and published by Internat'l University Line. This book was released on 2009 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Crystallography

Author : Gwyndaf Evans
Publisher : Royal Society of Chemistry
ISBN 13 : 1782627286
Total Pages : 244 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Protein Crystallography by : Gwyndaf Evans

Download or read book Protein Crystallography written by Gwyndaf Evans and published by Royal Society of Chemistry. This book was released on 2018-06-21 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.

Protein Crystallography

Author : Konstantinos Beis
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014774
Total Pages : 244 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Protein Crystallography by : Konstantinos Beis

Download or read book Protein Crystallography written by Konstantinos Beis and published by Royal Society of Chemistry. This book was released on 2018-06-19 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.

Principles of Protein X-ray Crystallography

Author : Jan Drenth
Publisher : Springer Science & Business Media
ISBN 13 : 1475730926
Total Pages : 355 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Principles of Protein X-ray Crystallography by : Jan Drenth

Protein Crystallography in Drug Discovery

Author : Robert E. Babine
Publisher : John Wiley & Sons
ISBN 13 : 3527606351
Total Pages : 278 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Protein Crystallography in Drug Discovery by : Robert E. Babine

Download or read book Protein Crystallography in Drug Discovery written by Robert E. Babine and published by John Wiley & Sons. This book was released on 2008-07-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Practical Protein Crystallography

Author : Duncan E. McRee
Publisher : Academic Press
ISBN 13 : 0323138888
Total Pages : 403 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Practical Protein Crystallography by : Duncan E. McRee

Download or read book Practical Protein Crystallography written by Duncan E. McRee and published by Academic Press. This book was released on 2012-12-02 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for easy use by both new and experienced protein crystallographers, this much-needed book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples ofactual experiments and data, including electron density maps. Computer methods and computer code samples are presented. Practical Protein Crystallography is loaded with new information on area detectors, synchrotron radiation techniques, and the latest computer methods, and features the XtalView software system. Graduate students and teachers in physical biochemistry and pharmaceutical researchers will find this text a timely and convenient aid.

Protein Crystallography

Author : T. L. Blundell
Publisher : Academic Press
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Protein Crystallography by : T. L. Blundell

Download or read book Protein Crystallography written by T. L. Blundell and published by Academic Press. This book was released on 1976-01-28 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Crystallization of Membrane Proteins

Author : Hartmut Michel
Publisher : CRC Press
ISBN 13 : 1351088173
Total Pages : 343 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Crystallization of Membrane Proteins by : Hartmut Michel

Download or read book Crystallization of Membrane Proteins written by Hartmut Michel and published by CRC Press. This book was released on 2018-01-18 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer‘s.

Biomolecular Crystallography

Author : Bernhard Rupp
Publisher : Garland Science
ISBN 13 : 1134064195
Total Pages : 832 pages
Book Rating : 4.1/5 (34 download)

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Book Synopsis Biomolecular Crystallography by : Bernhard Rupp

Download or read book Biomolecular Crystallography written by Bernhard Rupp and published by Garland Science. This book was released on 2009-10-20 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.

Advanced Topics on Crystal Growth

Author : Sukarno Ferreira
Publisher : BoD – Books on Demand
ISBN 13 : 9535110101
Total Pages : 436 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advanced Topics on Crystal Growth by : Sukarno Ferreira

Download or read book Advanced Topics on Crystal Growth written by Sukarno Ferreira and published by BoD – Books on Demand. This book was released on 2013-02-20 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystal growth is the key step of a great number of very important applications. The development of new devices and products, from the traditional microelectronic industry to pharmaceutical industry and many others, depends on crystallization processes. The objective of this book is not to cover all areas of crystal growth but just present, as specified in the title, important selected topics, as applied to organic and inorganic systems. All authors have been selected for being key researchers in their field of specialization, working in important universities and research labs around the world. The first section is mainly devoted to biological systems and covers topics like proteins, bone and ice crystallization. The second section brings some applications to inorganic systems and describes more general growth techniques like chemical vapor crystallization and electrodeposition. This book is mostly recommended for students working in the field of crystal growth and for scientists and engineers in the fields of crystalline materials, crystal engineering and the industrial applications of crystallization processes.

Crystallography Made Crystal Clear

Author : Gale Rhodes
Publisher : Academic Press
ISBN 13 : 0323137784
Total Pages : 217 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Crystallography Made Crystal Clear by : Gale Rhodes

Download or read book Crystallography Made Crystal Clear written by Gale Rhodes and published by Academic Press. This book was released on 2012-12-02 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallography Made Crystal Clear is designed to meet the need for an X-ray analysis that is between brief textbook sections and complete treatments. The book provides non-crystallographers with an intellectually satisfying explanation of the principles of how protein models are gleaned from X-ray analysis. The understanding of these concepts will foster wise use of the models, including the recognition of the strengths and weaknesses of pictures or computer graphics. Since proteins comprise the majority of the mass of macromolecules in cells and carry out biologically important tasks, the book will be of interest to biologists. Provides accessible descriptions of principles of x-ray crystallography, built on simple foundations for anyone with a basic science backgroundLeads the reader through clear, thorough, unintimidating explanations of the mathematics behind crystallographyExplains how to read crystallography papers in research journalsIf you use computer-generated models of proteins or nucleic acids for:Studying molecular interactionsDesigning ligands, inhibitors, or drugsEngineering new protein functionsInterpreting chemical, kinetic, thermodynamic, or spectroscopic dataStudying protein foldingTeaching macromolecule structure,and if you want to read new structure papers intelligently; become a wiser user of macromolecular models; and want to introduce undergraduates to the important subject of x-ray crystallography, then this book is for you.

X-Ray Crystallography

Author : Gregory S. Girolami
Publisher : University Science Books
ISBN 13 : 9781891389771
Total Pages : 0 pages
Book Rating : 4.3/5 (897 download)

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Book Synopsis X-Ray Crystallography by : Gregory S. Girolami

Download or read book X-Ray Crystallography written by Gregory S. Girolami and published by University Science Books. This book was released on 2015-07-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-Ray Crystallography is a well-balanced, thorough, and clearly written introduction to the most important and widely practiced technique to determine the arrangement of atoms in molecules and solids. Featuring excellent illustrations and homework problems throughout, the book is intended both for advanced undergraduate and graduate students who are learning the subject for the first time, as well as for those who have practical experience but seek a text summarizing the theory of diffraction and X-ray crystallography. It is organized into three parts: Part 1 deals with symmetry and space groups, Part 2 explains the physics of X rays and diffraction, and Part 3 examines the methods for solving and refining crystal structures. The discussion proceeds in a logical and clear fashion from the fundamentals through to advanced topics such as disorder, twinning, microfocus sources, low energy electron diffraction, charge flipping, protein crystallography, the maximum likelihood method of refinement, and powder, neutron, and electron diffraction. The author's clear writing style and distinctive approach is well suited for chemists, biologists, materials scientists, physicists, and scientists from related disciplines.