Prostaglandins And Leukotrienes

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Prostaglandins, Leukotrienes, and the Immune Response

Author : John L. Ninnemann
Publisher : Cambridge University Press
ISBN 13 : 0521334837
Total Pages : 236 pages
Book Rating : 4.5/5 (213 download)

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Book Synopsis Prostaglandins, Leukotrienes, and the Immune Response by : John L. Ninnemann

Download or read book Prostaglandins, Leukotrienes, and the Immune Response written by John L. Ninnemann and published by Cambridge University Press. This book was released on 1988-09-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.

Advances in Prostaglandin and Leukotriene Research

Author : Bengt Samuelsson
Publisher : Springer Science & Business Media
ISBN 13 : 9401597219
Total Pages : 209 pages
Book Rating : 4.4/5 (15 download)

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Book Synopsis Advances in Prostaglandin and Leukotriene Research by : Bengt Samuelsson

Download or read book Advances in Prostaglandin and Leukotriene Research written by Bengt Samuelsson and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the proceedings of the 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, held in Florence, Italy, on June 4-8, 2000, which continues the tradition of covering both basic and clinical aspects of prostaglandin and leukotriene research. At this meeting particular emphasis was given to the potential application of the novel COX-2 inhibitors, the genetics of asthma relating to the production of leukotrienes, and novel cellular networks for the production of leukotrienes and lipoxins. Traditionally, as has been done in past meetings of this series, a considerable amount of new material was presented and discussed this year, with particular attention given to the newest clinical data.

Introduction to Basics of Pharmacology and Toxicology

Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Chemistry of the Prostaglandins and Leukotrienes

Author : John E. Pike
Publisher :
ISBN 13 : 9780881670875
Total Pages : 444 pages
Book Rating : 4.6/5 (78 download)

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Book Synopsis Chemistry of the Prostaglandins and Leukotrienes by : John E. Pike

Download or read book Chemistry of the Prostaglandins and Leukotrienes written by John E. Pike and published by . This book was released on 1985 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Prostaglandins, Leukotrienes, Lipoxins, and PAF

Author : J. Martyn Bailey
Publisher : Springer Science & Business Media
ISBN 13 : 1489907270
Total Pages : 453 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Prostaglandins, Leukotrienes, Lipoxins, and PAF by : J. Martyn Bailey

Download or read book Prostaglandins, Leukotrienes, Lipoxins, and PAF written by J. Martyn Bailey and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the XIth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 13-17, 1991

Prostaglandins and Leukotrienes in Gastrointestinal Diseases

Author : W. Domschke
Publisher : Springer Science & Business Media
ISBN 13 : 3642733166
Total Pages : 523 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Prostaglandins and Leukotrienes in Gastrointestinal Diseases by : W. Domschke

Download or read book Prostaglandins and Leukotrienes in Gastrointestinal Diseases written by W. Domschke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: In OCtober 1986, recognized authorities from a variety of disciplines met in Lisbon, Portugal, to review recent knowledge on eicosanoids - i. e., prostaglandins, throm boxane A , and leukotrienes - and their role in gastrointestinal diseases. 2 Briefly, in the stomach endogenous as well as exogenous prostaglandins may mediate cytoprotective actions in that they stimulate gastric mucus production, bicar bonate secretion and cellular regeneration while providing adequate mucosal blood flow. In contrast, thromboxane A2 by vasoconstriction may act as an ulcerogenic substance. Diarrheal states may be associated with prostaglandins of types E and F as they are capable to enhance intestinal water and electrolyte secretions. In chronic in flammatory bowel disease, mucosal synthesis of leukotrienes was found to be increased more markedly than that of prostaglandins suggesting that leukotrienes may have a major part in the pathogenesis of that disease. In this volume, which is an elaborated collection of the papers given on occasion of the above-mentioned symposium, the facts and problems associated with prostanoid substances are dealt with in four sections on 1. biochemistry, biology and pharmacology of eicosanoids, 2. physiologic and pathophysiologic aspects, 3. established therapeutic implications, and 4. treatment perspectives. We believe that the publication of these contributions by leading workers in the given fields provides a comprehensive and up-to-date appraisal of the role of eicosanoids in gastrointestinal diseases, and it is hoped that this volume will be of value to both basic scientists and practicing clinicians.

Prostaglandins and Leukotrienes

Author : Jonathan M. Gerrard
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prostaglandins and Leukotrienes by : Jonathan M. Gerrard

Download or read book Prostaglandins and Leukotrienes written by Jonathan M. Gerrard and published by Marcel Dekker. This book was released on 1985 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prostaglandins, Leukotrienes and Other Eicosanoids

Author : Friedrich Marks
Publisher : John Wiley & Sons
ISBN 13 : 3527613633
Total Pages : 408 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Prostaglandins, Leukotrienes and Other Eicosanoids by : Friedrich Marks

Download or read book Prostaglandins, Leukotrienes and Other Eicosanoids written by Friedrich Marks and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intracellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new light on today's most common diseases including atherosclerosis, cancer, Alzheimer's, allergies, and rheumatic diseases. The recent advances already have far-reaching implications in medicine. This detailed account, written by leading experts, covers the ground-breaking developments in recent eicosanoid research. The topics span eicosanoid biogenesis, new aspects of their pathophysiology, for example their influence on the cardiovascular system, as well as the clinical application of synthetic eicosanoids and their antagonists. Researchers and students working in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry will value this informative introduction to one of the most rapidly developing fields in cell biology.

Prostaglandins, Leukotrienes, and Lipoxins

Author : J. Bailey
Publisher : Springer Science & Business Media
ISBN 13 : 146844946X
Total Pages : 681 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Prostaglandins, Leukotrienes, and Lipoxins by : J. Bailey

Download or read book Prostaglandins, Leukotrienes, and Lipoxins written by J. Bailey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Leukotrienes and Prostacyclin

Author : F. Berti
Publisher : Springer Science & Business Media
ISBN 13 : 1468443917
Total Pages : 296 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Leukotrienes and Prostacyclin by : F. Berti

Download or read book Leukotrienes and Prostacyclin written by F. Berti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research

Author : Zeliha Yazici
Publisher : Springer Science & Business Media
ISBN 13 : 1441991948
Total Pages : 240 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research by : Zeliha Yazici

Download or read book Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research written by Zeliha Yazici and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the Proceedings of the 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research: Basic Science and Clinical Applications, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid research with special attention to cancer, cardiovascular diseases, gastrointestinal diseases and respiratory diseases. Specific topics covered include the role of leukotrienes and lipoxins in inflammation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.

Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Author : Helmut Sinzinger
Publisher : Springer Science & Business Media
ISBN 13 : 1489918108
Total Pages : 447 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research by : Helmut Sinzinger

Download or read book Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research written by Helmut Sinzinger and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Symposium on Prostaglandins and Related Compounds, first held in Vienna 1972, revisited the city after 24 years for the 10TH Symposium. For the many re searchers working in this multi-disciplinary field it was an opportunity to exchange their ex periences and share new data with colleagues from all around the world. This scientific exchange was largely encouraged by the unseasonably cold and rainy weather. For the first time, there was quite a large attendance from the former Communist countries. Eugene Garfield prepared a key note address delivered during the meeting (The Sci entist 1996, 12) reviewing the contribution of the Nobel Laureates U.S. von Euler, l.R. Vane, S.K. Bergstrom, and B.I. Samuelsson, discussing the relevance of the more than 40,000 pa pers in this area published since 1991. Overall, there is still a rapidly growing interest, and in particular a great variety of clinical applications of this family of compounds which were dis cussed in detail during the meeting. Beside the lectures there were 19 workshops covering nearly all the topics of key in terest. All the speakers were invited to prepare a manuscript which has resulted in the volume now in your hands. Special thanks to Dr. Patrick Wong and the new publisher of this series who helped to publish the proceedings in the usual quality and reasonable period of time. Looking forward to seeing all of you again in Florence in 1999, hopefully with much more sun.

Prostaglandins and Related Compounds

Author :
Publisher :
ISBN 13 : 9780881677423
Total Pages : 1012 pages
Book Rating : 4.6/5 (774 download)

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Book Synopsis Prostaglandins and Related Compounds by :

Download or read book Prostaglandins and Related Compounds written by and published by . This book was released on 1991 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Eicosanoids

Author : Peter Curtis-Prior
Publisher : John Wiley & Sons
ISBN 13 : 047002061X
Total Pages : 654 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis The Eicosanoids by : Peter Curtis-Prior

Download or read book The Eicosanoids written by Peter Curtis-Prior and published by John Wiley & Sons. This book was released on 2004-07-16 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Biochemistry of Arachidonic Acid Metabolism

Author : William E.M. Lands
Publisher : Springer Science & Business Media
ISBN 13 : 9780898387179
Total Pages : 468 pages
Book Rating : 4.3/5 (871 download)

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Book Synopsis Biochemistry of Arachidonic Acid Metabolism by : William E.M. Lands

Download or read book Biochemistry of Arachidonic Acid Metabolism written by William E.M. Lands and published by Springer Science & Business Media. This book was released on 1985-04-30 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Prostaglandins and Immunity

Author : James S. Goodwin
Publisher : Springer Science & Business Media
ISBN 13 : 1461326036
Total Pages : 230 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Prostaglandins and Immunity by : James S. Goodwin

Download or read book Prostaglandins and Immunity written by James S. Goodwin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.