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Book Synopsis Prolactin Inhibits Epidermal Growth Factor Induced Cellular Signaling in Mouse Mammary Epithelial Cells by : Julie Lynn Johnson
Download or read book Prolactin Inhibits Epidermal Growth Factor Induced Cellular Signaling in Mouse Mammary Epithelial Cells written by Julie Lynn Johnson and published by . This book was released on 1996 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of Epidermal Growth Factor-induced Cell Signaling in Mammary Epithelium by Prolactin by : Suzanne E. Fenton
Download or read book Modulation of Epidermal Growth Factor-induced Cell Signaling in Mammary Epithelium by Prolactin written by Suzanne E. Fenton and published by . This book was released on 1993 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterizing the Role of Prolactin-induced Tyrosine Phosphorylation of Grb2 in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells by : Eric Haines
Download or read book Characterizing the Role of Prolactin-induced Tyrosine Phosphorylation of Grb2 in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells written by Eric Haines and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prolactin Regulation of Epidermal Growth Factor Receptor Kinase in Mammary Epithelial Cells by : Victor J. Quijano
Download or read book Prolactin Regulation of Epidermal Growth Factor Receptor Kinase in Mammary Epithelial Cells written by Victor J. Quijano and published by . This book was released on 1998 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transgenic Mouse Models of Prolactin, Transforming Growth Factor Alpha, and Estrogen Interactions in Breast Cancer by : Lisa Marie Arendt
Download or read book Transgenic Mouse Models of Prolactin, Transforming Growth Factor Alpha, and Estrogen Interactions in Breast Cancer written by Lisa Marie Arendt and published by . This book was released on 2007 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biology of the Mammary Gland by : John A. Mol
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Book Synopsis Characterizing the Role of Prolactin-induced Grb2 Tyrosine Phosphorylation in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells by : Eric Haines
Download or read book Characterizing the Role of Prolactin-induced Grb2 Tyrosine Phosphorylation in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells written by Eric Haines and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Prolactin Receptor Signaling in the Development of Mammary Adenocarcinoma by : Charles Gerard Rickert
Download or read book The Role of Prolactin Receptor Signaling in the Development of Mammary Adenocarcinoma written by Charles Gerard Rickert and published by . This book was released on 2014 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signaling through the prolactin receptor (PrlR) has been associated with human ER[alpha]+ breast cancer through several correlative studies. Work in murine models of breast cancer have corroborated these findings by showing that increased PrlR signaling in the mammary gland is to be capable of inducing the development of mammary adenocarcinomas. These results have prompted extensive work on the development of PrlR antagonists that may eventually provide an additional therapeutic modality in the treatment of ER[alpha]+ breast cancer. However, a complete understanding of the natural regulation of PrlR-signaling that prevents it from developing into an oncogenic signaling cascade has been lacking. Furthermore, no mouse models of breast cancer have demonstrated, as yet, that a lack of normal PrlR regulation contributes to the outgrowth of mammary adenocarcinomas. Careful studies of such regulation may provide an additional therapeutic target for blocking a potentially oncogenic signaling cascade. Previous work in our laboratory identified that mice lacking STAT1 develop mammary adenocarcinomas while none of the other immunocompromised mouse strains do. These tumors recapitulate several key features of human luminal breast cancer, including ERa expression and growth-dependence on ovarian hormones. These studies prompted a careful investigation of STAT1 expression in human luminal breast cancer. Immunohistological analyses of human breast cancer revealed that, in fact, a substantial portion (~40%) of human luminal breast cancer exhibits a reduced level of STAT1. We now show that mammary adenocarcinoma cells of STAT1-/- mice display persistent PrlR signaling, resulting in activation of Janus Kinase-2 (JAK2), STAT3, and STATs 5A/5B, and that these ER[alpha]+ mammary tumor cells are addicted to PrlR-JAK2-STAT3/STAT5A/5B signaling. Furthermore, these tumors exhibit increased expression of JAK2 is the result of increased JAK2 transcription. The pro-oncogenic PrlR signaling in STAT1-/- mammary epithelial cells results from failed upregulation of SOCS1, a STAT1-induced inhibitor of JAK2. Enforced expression of SOCS1 in the STAT1-/- mammary tumors results in decreased PrlR-signaling and cell death. Importantly, blocking the upregulation of SOCS1 using SOCS1-specific shRNA inhibits this cell death. Thus, STAT1 functions as a tumor suppressor in mammary glands by preventing the natural developmental function of a growth factor receptor from becoming pro-oncogenic.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Extracellular Matrix: Pathobiology and Signaling by : Nikos Karamanos
Download or read book Extracellular Matrix: Pathobiology and Signaling written by Nikos Karamanos and published by Walter de Gruyter. This book was released on 2012-08-31 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden
Download or read book The Pituitary written by Shlomo Melmed and published by Academic Press. This book was released on 2010-12-09 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
Book Synopsis Intercellular Signalling in the Mammary Gland by : C.H. Knight
Download or read book Intercellular Signalling in the Mammary Gland written by C.H. Knight and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.
Book Synopsis Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors by : Sameer Mohammad
Download or read book Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors written by Sameer Mohammad and published by Frontiers Media SA. This book was released on 2022-01-28 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Towards targeting prolactin signaling in human diseases: Stimulate or inhibit? by : Vincent Goffin
Download or read book Towards targeting prolactin signaling in human diseases: Stimulate or inhibit? written by Vincent Goffin and published by Frontiers Media SA. This book was released on 2023-07-24 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Yen & Jaffe's Reproductive Endocrinology E-Book by : Jerome F. Strauss
Download or read book Yen & Jaffe's Reproductive Endocrinology E-Book written by Jerome F. Strauss and published by Elsevier Health Sciences. This book was released on 2017-12-23 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now celebrating its 40th anniversary, Yen & Jaffe’s Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field. Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy. Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section.
Download or read book Apoptosis written by Douglas R. Green and published by Cambridge University Press. This book was released on 2011-08-22 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
Book Synopsis Breast Cancer: Cellular and Molecular Biology by : Marc E. Lippman
Download or read book Breast Cancer: Cellular and Molecular Biology written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre quently publish good in-depth reviews of cancer topics, and published sym posium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
