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Author : Zhi Qi
Publisher : Frontiers Media SA
ISBN 13 : 2889769194
Total Pages : 357 pages
Book Rating : 4.8/5 (897 download)
Download or read book Programmed Cell Death and Cardiovascular Disease written by Zhi Qi and published by Frontiers Media SA. This book was released on 2022-09-12 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Heribert Schunkert
Publisher : Springer Science & Business Media
ISBN 13 : 0585381437
Total Pages : 347 pages
Book Rating : 4.5/5 (853 download)
Download or read book Apoptosis in Cardiac Biology written by Heribert Schunkert and published by Springer Science & Business Media. This book was released on 2007-06-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease. In patients with heart failure the activation of apoptosis may result in the loss of irreplaceable cardiac myocytes promoting the clinical course of the syndrome. Moreover, in the coronary arteries inflammation and apoptosis may weaken critical structures of the vessel wall leading to plaque rupture and, subsequently, to myocardial infarction. Given these deleterious consequences, it seems almost paradoxical that programmed cell death is an active process that, if initiated under physiological circumstances, is essential for both coordinated tissue growth or destruction of malignant cells. Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart. The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in vascular smooth muscle and endothelial cells. Furthermore, novel therapeutic options arising from the outstanding pathophysiological significance of cardiac apoptosis are presented. This comprehensive review of Apoptosis in Cardiac Biology will be of interest to both clinicians and basic researchers who are active in the fields of cardiology and atherosclerosis.
Author : Jr., Robert R. Ruffolo
Publisher : CRC Press
ISBN 13 : 0203304624
Total Pages : 267 pages
Book Rating : 4.2/5 (33 download)
Download or read book Apoptosis in Health and Disease written by Jr., Robert R. Ruffolo and published by CRC Press. This book was released on 2000-09-15 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation
Author : Yuli Huang
Publisher : Frontiers Media SA
ISBN 13 : 2832534414
Total Pages : 98 pages
Book Rating : 4.8/5 (325 download)
Download or read book Cytokines, Novel Cell Death Models and Pathways in Cardiovascular Diseases written by Yuli Huang and published by Frontiers Media SA. This book was released on 2023-09-26 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are soluble proteins secreted by a wide variety of cells in the body, playing crucial roles in many physiological responses and are involved in the pathophysiology of cardiovascular diseases (CVDs). Recently, there is great progress in discoveries that some novel cytokines, including secreted frizzled-related proteins (SFRPs), adiponectin, and C1q/TNF-Related Proteins (CTRPs), can perform a protective effect in cardiometabolic diseases, heart failure and coronary heart disease. However, the mechanisms underlying the molecular and pathophysiological actions of these cytokines in CVDs are still vague. Novel mechanisms of cell death including pyroptosis, autophagy, ferroptosis, cuproptosis, and PANoptosis have been considered novel therapeutic targets for CVDs. Some cytokines have been shown to regulate the cell death pathway in the incidence and development of CVDs. Further investigations are needed to understand the link between these novel cytokines and novel cell death models and pathways in CVDs.
Author : S. Estus
Publisher : Elsevier Science
ISBN 13 : 9780444507303
Total Pages : 0 pages
Book Rating : 4.5/5 (73 download)
Download or read book Programmed Cell Death, Volume II written by S. Estus and published by Elsevier Science. This book was released on 2001-04-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most recent insight into how abnormalities in the regulation of cell death lead to a variety of diseases. Each chapter in this book is written by an internationally recognized expert on the role of aberrant cell death in the pathogenesis of a particular disease. In addition to various types of cancer and neurodegenerative disorders, this book covers diseases ranging from arthritis to cardiovascular disease to diabetes. The chapters each integrate information obtained from patients with data obtained in experimental models of the disease to arrive at an emerging view of the pathogenic mechanisms of the disease. Applications of this fundamental knowledge to prevention and treatment of the diseases are considered. When taken together with http://www.elsevier.nl/locate/isbn/0444504931Programmed Cell Death, Volume 1, this title will provide graduate students, postdocs and senior investigators in an array of biomedical disciplines invaluable resource for their pursuit of the causes and cures of many different human diseases.
Author : Bernard Swynghedauw
Publisher :
ISBN 13 :
Total Pages : 718 pages
Book Rating : 4.3/5 (555 download)
Download or read book Cardiac Hypertrophy and Failure written by Bernard Swynghedauw and published by . This book was released on 1990 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac insufficiency, a major cause of premature mortality, is a key focus of medical and pharmaceutical research. This book aims to bring clinicians and researchers up-to-date on recent biophysical, cellular physiological and molecular biological developments and their clinical applications.
Author : Mark Paul Mattson
Publisher :
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.3/5 (91 download)
Download or read book Programmed Cell Death written by Mark Paul Mattson and published by . This book was released on 2001 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most recent insight into how abnormalities in the regulation of cell death lead to a variety of diseases. Each chapter in this book is written by an internationally recognized expert on the role of aberrant cell death in the pathogenesis of a particular disease. In addition to various types of cancer and neurodegenerative disorders, this book covers diseases ranging from arthritis to cardiovascular disease to diabetes. The chapters each integrate information obtained from patients with data obtained in experimental models of the disease to arrive at an emerging view of the pathogenic mechanisms of the disease. Applications of this fundamental knowledge to prevention and treatment of the diseases are considered. When taken together with http://www.elsevier.nl/locate/isbn/0444504931Programmed Cell Death, Volume 1, this title will provide graduate students, postdocs and senior investigators in an array of biomedical disciplines invaluable resource for their pursuit of the causes and cures of many different human diseases.
Author : Pundrique Radheyshyam Sharma
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (592 download)
Download or read book Programmed Cell Death During Heart Development written by Pundrique Radheyshyam Sharma and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 146144599X
Total Pages : 495 pages
Book Rating : 4.4/5 (614 download)
Download or read book Mitochondria and Their Role in Cardiovascular Disease written by José Marín-García and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
Author : Klaus-Dieter Schlüter
Publisher : Springer
ISBN 13 : 3319312510
Total Pages : 286 pages
Book Rating : 4.3/5 (193 download)
Download or read book Cardiomyocytes – Active Players in Cardiac Disease written by Klaus-Dieter Schlüter and published by Springer. This book was released on 2016-06-28 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.
Author : Zahra Zakeri
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.F/5 ( download)
Download or read book Mechanisms of Cell Death written by Zahra Zakeri and published by . This book was released on 1999 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics
Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author : Ewald A. W. J. Dumont
Publisher :
ISBN 13 : 9789090175515
Total Pages : 124 pages
Book Rating : 4.1/5 (755 download)
Download or read book Molecular Imaging of Programmed Cell Death in the Heart written by Ewald A. W. J. Dumont and published by . This book was released on 2003 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Naranjan S. Dhalla
Publisher : Springer Science & Business Media
ISBN 13 : 1441971300
Total Pages : 381 pages
Book Rating : 4.4/5 (419 download)
Download or read book Molecular Defects in Cardiovascular Disease written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2011-08-09 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Bashir Matata
Publisher : Bentham Science Publishers
ISBN 13 : 981516502X
Total Pages : 185 pages
Book Rating : 4.8/5 (151 download)
Download or read book Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease written by Bashir Matata and published by Bentham Science Publishers. This book was released on 2023-07-18 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease is an update on the recent advances in the development of antioxidant-based therapies. It starts with an overview of the mechanisms underlying the genesis of oxidative stress, summarizing the link between oxidative stress and a number of cardiovascular conditions. This is followed by an explanation of how oxidative stress interacts with lipid metabolism and the placental environment. Three chapters on the role of antioxidant-based therapy for cardiovascular diseases round up the book. Key Features - Outlines several cell-signaling pathways that are modulated by the interplay between reducing and oxidizing agents (redox status) and gene expression in the cardiovascular disease process - Brings information about maternal programming environment in the placenta - Covers development of novel nanotechnology-based antioxidant delivery systems for effective drug delivery - Includes references for further reading The book is aimed at a broad readership of scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences. It also serves as a reference for scholars who want to understand the complex biochemical mechanisms of antioxidant agents.
Author : Chandrasekharan C. Kartha
Publisher : Springer Nature
ISBN 13 : 3030855368
Total Pages : 356 pages
Book Rating : 4.0/5 (38 download)
Download or read book Cardiomyocytes in Health and Disease written by Chandrasekharan C. Kartha and published by Springer Nature. This book was released on 2021-09-13 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
