Binaural Hearing

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Author :
Publisher : Springer Nature
ISBN 13 : 3030571009
Total Pages : 425 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Binaural Hearing by : Ruth Y. Litovsky

Download or read book Binaural Hearing written by Ruth Y. Litovsky and published by Springer Nature. This book was released on 2021-03-01 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of Binaural Hearing involves studies of auditory perception, physiology, and modeling, including normal and abnormal aspects of the system. Binaural processes involved in both sound localization and speech unmasking have gained a broader interest and have received growing attention in the published literature. The field has undergone some significant changes. There is now a much richer understanding of the many aspects that comprising binaural processing, its role in development, and in success and limitations of hearing-aid and cochlear-implant users. The goal of this volume is to provide an up-to-date reference on the developments and novel ideas in the field of binaural hearing. The primary readership for the volume is expected to be academic specialists in the diverse fields that connect with psychoacoustics, neuroscience, engineering, psychology, audiology, and cochlear implants. This volume will serve as an important resource by way of introduction to the field, in particular for graduate students, postdoctoral scholars, the faculty who train them and clinicians.

Neurolaryngology

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Author :
Publisher : Springer
ISBN 13 : 3319617249
Total Pages : 248 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Neurolaryngology by : Christian Sittel

Download or read book Neurolaryngology written by Christian Sittel and published by Springer. This book was released on 2017-10-30 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, endorsed by the European Laryngological Society, is a comprehensive guide to key topics in neurolaryngology, which enables readers to quickly identify and implement solutions in concrete situations likely to arise in everyday clinical practice. It includes detailed information on conditions such as vocal cord paresis/paralysis, laryngeal dystonia, and upper motor neuron disorders and offers clear advice on imaging and assessment, highlighting the role and performance of electromyography. Treatment options are extensively described, and there are individual chapters on functional therapy, botulinum toxin injection, the full range of phonosurgery options (including transoral endoscopic techniques, office-based phonosurgery, framework surgery, and laryngeal reinnervation), and laryngeal transplantation. With numerous accompanying videos, the book is a valuable resource for otorhinolaryngologists, speech pathologists and neurologists.

Auditory Prostheses

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Publisher : Springer Science & Business Media
ISBN 13 : 1441994343
Total Pages : 397 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Auditory Prostheses by : Fan-Gang Zeng

Download or read book Auditory Prostheses written by Fan-Gang Zeng and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cochlear implants are currently the standard treatment for profound sensorineural hearing loss. In the last decade, advances in auditory science and technology have not only greatly expanded the utility of electric stimulation to other parts of the auditory nervous system in addition to the cochlea, but have also demonstrated drastic changes in the brain in responses to electric stimulation, including changes in language development and music perception. Volume 20 of SHAR focused on basic science and technology underlying the cochlear implant. However, due to the newness of the ideas and technology, the volume did not cover any emerging applications such as bilateral cochlear implants, combined acoustic-electric stimulation, and other types of auditory prostheses, nor did it review brain plasticity in responses to electric stimulation and its perceptual and language consequences. This proposed volume takes off from Volume 20, and expands the examination of implants into new and highly exciting areas. This edited book starts with an overview and introduction by Dr. Fan-Gang Zeng. Chapters 2-9 cover technological development and the advances in treating the full spectrum of ear disorders in the last ten years. Chapters 10-15 discuss brain responses to electric stimulation and their perceptual impact. This volume is particularly exciting because there have been quantum leap from the traditional technology discussed in Volume 20. Thus, this volume is timely and will be of real importance to the SHAR audience.

Presidents, Populism, and the Crisis of Democracy

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Author :
Publisher : University of Chicago Press
ISBN 13 : 022672882X
Total Pages : 276 pages
Book Rating : 4.2/5 (267 download)

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Book Synopsis Presidents, Populism, and the Crisis of Democracy by : William G. Howell

Download or read book Presidents, Populism, and the Crisis of Democracy written by William G. Howell and published by University of Chicago Press. This book was released on 2020-07-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: To counter the threat America faces, two political scientists offer “clear constitutional solutions that break sharply with the conventional wisdom” (Steven Levitsky, New York Times–bestselling coauthor of How Democracies Die). Has American democracy’s long, ambitious run come to an end? Possibly yes. As William G. Howell and Terry M. Moe argue in this trenchant new analysis of modern politics, the United States faces a historic crisis that threatens our system of self-government—and if democracy is to be saved, the causes of the crisis must be understood and defused. The most visible cause is Donald Trump, who has used his presidency to attack the nation’s institutions and violate its democratic norms. Yet Trump is but a symptom of causes that run much deeper: social forces like globalization, automation, and immigration that for decades have generated economic harms and cultural anxieties that our government has been wholly ineffective at addressing. Millions of Americans have grown angry and disaffected, and populist appeals have found a receptive audience. These were the drivers of Trump’s dangerous presidency, and they’re still there for other populists to weaponize. What can be done? The disruptive forces of modernity cannot be stopped. The solution lies, instead, in having a government that can deal with them—which calls for aggressive new policies, but also for institutional reforms that enhance its capacity for effective action. The path to progress is filled with political obstacles, including an increasingly populist, anti-government Republican Party. It is hard to be optimistic. But if the challenge is to be met, we need reforms of the presidency itself—reforms that harness the promise of presidential power for effective government, but firmly protect against that power being put to anti-democratic ends.

Regenerative Medicine for the Inner Ear

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Author :
Publisher : Springer
ISBN 13 : 4431548629
Total Pages : 311 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Regenerative Medicine for the Inner Ear by : Juichi Ito

Download or read book Regenerative Medicine for the Inner Ear written by Juichi Ito and published by Springer. This book was released on 2014-08-05 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.

Novel Drug Delivery Technologies

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Author :
Publisher : Springer Nature
ISBN 13 : 9811336423
Total Pages : 448 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Novel Drug Delivery Technologies by : Ambikanandan Misra

Download or read book Novel Drug Delivery Technologies written by Ambikanandan Misra and published by Springer Nature. This book was released on 2020-02-12 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.

Melt Extrusion

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461484324
Total Pages : 472 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Melt Extrusion by : Michael A. Repka

Download or read book Melt Extrusion written by Michael A. Repka and published by Springer Science & Business Media. This book was released on 2013-10-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.

Rescuing the Planet

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Author :
Publisher : Knopf
ISBN 13 : 0525654828
Total Pages : 322 pages
Book Rating : 4.5/5 (256 download)

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Book Synopsis Rescuing the Planet by : Tony Hiss

Download or read book Rescuing the Planet written by Tony Hiss and published by Knopf. This book was released on 2021-03-30 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: An urgent, resounding call to protect 50 percent of the earth's land by 2050—thereby saving millions of its species—and a candid assessment of the health of our planet and our role in conserving it, from the award-winning author of The Experience of Place and veteran New Yorker staff writer. "An upbeat and engaging account of the remarkable progress being made to preserve vast wild spaces for animals to roam." —The Wall Street Journal Beginning in the vast North American Boreal Forest that stretches through Canada, and roving across the continent, from the Northern Sierra to Alabama's Paint Rock Forest, from the Appalachian Trail to a ranch in Mexico, Tony Hiss sets out on a journey to take stock of the "superorganism" that is the earth: its land, its elements, its plants and animals, its greatest threats--and what we can do to keep it, and ourselves, alive. Hiss not only invites us to understand the scope and gravity of the problems we face, but also makes the case for why protecting half the land is the way to fix those problems. He highlights the important work of the many groups already involved in this fight, such as the Indigenous Leadership Initiative, the Yellowstone to Yukon Conservation Initiative, and the global animal tracking project ICARUS. And he introduces us to the engineers, geologists, biologists, botanists, oceanographers, ecologists, and other "Half Earthers" like Hiss himself who are allied in their dedication to the unifying, essential cause of saving our own planet from ourselves. Tender, impassioned, curious, and above all else inspiring, Rescuing the Planet is a work that promises to make all of us better citizens of the earth.

Filtration and Purification in the Biopharmaceutical Industry

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Author :
Publisher : CRC Press
ISBN 13 : 0849379547
Total Pages : 816 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Filtration and Purification in the Biopharmaceutical Industry by : Maik J. Jornitz

Download or read book Filtration and Purification in the Biopharmaceutical Industry written by Maik J. Jornitz and published by CRC Press. This book was released on 2007-11-28 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filtration and Purification in the Biopharmaceutical Industry, First Edition greatly expands its focus with extensive new material on the critical role of purification and the significant advances in filtration science and technology. This new edition provides state-of-the-science information on all aspects of filtration and purification, in

Brazil That Never Was

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Author :
Publisher : New York Review of Books
ISBN 13 : 1912559218
Total Pages : 153 pages
Book Rating : 4.9/5 (125 download)

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Book Synopsis Brazil That Never Was by : A.J. Lees

Download or read book Brazil That Never Was written by A.J. Lees and published by New York Review of Books. This book was released on 2020-10-06 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: A famed British neurologist embarks on an expedition in Brazil to follow the trail of Percy Fawcett, an occult-obsessed explorer who went missing in the Amazon rainforest and was the subject of the 2016 film The Lost City of Z. As a boy growing up near Liverpool in the 1950s, Andrew Lees would visit the docks with his father to watch the ships from Brazil unload their exotic cargo of coffee, cotton bales, molasses, and cocoa. One day, his father gave him a dog-eared book called Exploration Fawcett. The book told the true story of Lieutenant Colonel Percy Fawcett, a British explorer who in 1925 had gone in search of a lost city in the Amazon and never returned. The riveting story of Fawcett's encounters with deadly animals and hostile tribes, his mission to discover an Atlantean civilization, and the many who lost their own lives when they went in search of him inspired the young Lees to believe that there were still earthly places where one could "fall off the edge." Years later, after becoming a successful neurologist, Lees set off in search of the mysterious figure of Fawcett. What he found exceeded his wildest imaginings. With access to the cache of "Secret Papers," Lees discovered that Fawcett's quest was far stranger than searching for a lost city. There was a "greater mission," one that involved the occult and a belief in a community of evolved beings living in a hidden parallel plane in the Mato Grosso. Lees traveled to Manaus in Fawcett's footsteps. After a time-bending psychedelic experience in the forest, he understood that his yearning for the imaginary Brazil of his boyhood, like Fawcett's search for an earthly paradise, was a nostalgia for what never was. Part travelogue, part memoir, Lees paints a portrait of an elusive Brazil, and of a flawed explorer whose doomed mission ruined lives.

Atlas at War

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Author :
Publisher : Naval Institute Press
ISBN 13 : 1682475298
Total Pages : 273 pages
Book Rating : 4.6/5 (824 download)

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Book Synopsis Atlas at War by : Michael Vassallo

Download or read book Atlas at War written by Michael Vassallo and published by Naval Institute Press. This book was released on 2020-06-17 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas at War! collects fifty hard-hitting stories from Atlas Comics, the company that became Marvel Comics and published more war titles than anyone in the industry between the years 1951 and 1960. Comics historian Dr. Michael J. Vassallo has chosen the best of the best, many of which are coming back into print for the first time, from sixteen different Atlas war titles and featuring the artwork of twenty different artists--giants of the genre, including Russ Heath, John Severin, Bernie Krigstein, Joe Maneely, Jerry Robinson, Steve Ditko, and Jack Kirby. Each page has been meticulously restored from its first printing by comic art restorer Allan Harvey. Atlas at War! covers the brutal pre-code period where graphic depictions of war action were rendered by artists who were World War II veterans themselves, as well as the post-code period, where code restrictions forced creators to tell stories without graphic violence but produced some of the most beautiful comic art of the genre. In addition to the artists, stories cover all aspects of war--from famous campaigns, weaponry, and personal soldier stories to political topics, Nazi atrocities, and even one story tinged with pre-code horror! Often overlooked in favor of its competitors, Atlas at War! will finally show that Atlas' war titles were second to no one.

Foretelling the End of Capitalism

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Author :
Publisher : Harvard University Press
ISBN 13 : 0674919327
Total Pages : 337 pages
Book Rating : 4.6/5 (749 download)

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Book Synopsis Foretelling the End of Capitalism by : Francesco Boldizzoni

Download or read book Foretelling the End of Capitalism written by Francesco Boldizzoni and published by Harvard University Press. This book was released on 2020-05-12 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intellectuals since the Industrial Revolution have been obsessed with whether, when, and why capitalism will collapse. This riveting account of two centuries of failed forecasts of doom reveals the key to capitalism’s durability. Prophecies about the end of capitalism are as old as capitalism itself. None have come true. Yet, whether out of hope or fear, we keep looking for harbingers of doom. In Foretelling the End of Capitalism, Francesco Boldizzoni gets to the root of the human need to imagine a different and better world and offers a compelling solution to the puzzle of why capitalism has been able to survive so many shocks and setbacks. Capitalism entered the twenty-first century triumphant, its communist rival consigned to the past. But the Great Recession and worsening inequality have undermined faith in its stability and revived questions about its long-term prospects. Is capitalism on its way out? If so, what might replace it? And if it does endure, how will it cope with future social and environmental crises and the inevitable costs of creative destruction? Boldizzoni shows that these and other questions have stood at the heart of much analysis and speculation from the early socialists and Karl Marx to the Occupy Movement. Capitalism has survived predictions of its demise not, as many think, because of its economic efficiency or any intrinsic virtues of markets but because it is ingrained in the hierarchical and individualistic structure of modern Western societies. Foretelling the End of Capitalism takes us on a fascinating journey through two centuries of unfulfilled prophecies. An intellectual tour de force and a plea for political action, it will change our understanding of the economic system that determines the fabric of our lives.

The Amateur Hour

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Author :
Publisher : JHU Press
ISBN 13 : 1421439107
Total Pages : 309 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Amateur Hour by : Jonathan Zimmerman

Download or read book The Amateur Hour written by Jonathan Zimmerman and published by JHU Press. This book was released on 2020-10-27 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first full-length history of college teaching in the United States from the nineteenth century to the present, this book sheds new light on the ongoing tension between the modern scholarly ideal—scientific, objective, and dispassionate—and the inevitably subjective nature of day-to-day instruction. American college teaching is in crisis, or so we are told. But we've heard that complaint for the past 150 years, as critics have denounced the poor quality of instruction in undergraduate classrooms. Students daydream in gigantic lecture halls while a professor drones on, or they meet with a teaching assistant for an hour of aimless discussion. The modern university does not reward teaching, so faculty members at every level neglect it in favor of research and publication. In the first book-length history of American college teaching, Jonathan Zimmerman confirms but also contradicts these perennial complaints. Drawing upon a wide range of previously unexamined sources, The Amateur Hour shows how generations of undergraduates indicted the weak instruction they received. But Zimmerman also chronicles institutional efforts to improve it, especially by making teaching more "personal." As higher education grew into a gigantic industry, he writes, American colleges and universities introduced small-group activities and other reforms designed to counter the anonymity of mass instruction. They also experimented with new technologies like television and computers, which promised to "personalize" teaching by tailoring it to the individual interests and abilities of each student. But, Zimmerman reveals, the emphasis on the personal inhibited the professionalization of college teaching, which remains, ultimately, an amateur enterprise. The more that Americans treated teaching as a highly personal endeavor, dependent on the idiosyncrasies of the instructor, the less they could develop shared standards for it. Nor have they rigorously documented college instruction, a highly public activity which has taken place mostly in private. Pushing open the classroom door, The Amateur Hour illuminates American college teaching and frames a fresh case for restoring intimate learning communities, especially for America's least privileged students. Anyone who wants to change college teaching will have to start here.

Winning Independence

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Author :
Publisher : Bloomsbury Publishing USA
ISBN 13 : 1635572770
Total Pages : 753 pages
Book Rating : 4.6/5 (355 download)

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Book Synopsis Winning Independence by : John Ferling

Download or read book Winning Independence written by John Ferling and published by Bloomsbury Publishing USA. This book was released on 2021-05-11 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: Co-Winner of the 2022 Harry M. Ward Book Prize From celebrated historian John Ferling, the underexplored history of the second half of the Revolutionary War, when, after years of fighting, American independence often seemed beyond reach. It was 1778, and the recent American victory at Saratoga had netted the U.S a powerful ally in France. Many, including General George Washington, presumed France's entrance into the war meant independence was just around the corner. Meanwhile, having lost an entire army at Saratoga, Great Britain pivoted to a “southern strategy.” The army would henceforth seek to regain its southern colonies, Virginia, North Carolina, South Carolina, and Georgia, a highly profitable segment of its pre-war American empire. Deep into 1780 Britain's new approach seemed headed for success as the U.S. economy collapsed and morale on the home front waned. By early 1781, Washington, and others, feared that France would drop out of the war if the Allies failed to score a decisive victory that year. Sir Henry Clinton, commander of Britain's army, thought “the rebellion is near its end.” Washington, who had been so optimistic in 1778, despaired: “I have almost ceased to hope.” Winning Independence is the dramatic story of how and why Great Britain-so close to regaining several southern colonies and rendering the postwar United States a fatally weak nation ultimately failed to win the war. The book explores the choices and decisions made by Clinton and Washington, and others, that ultimately led the French and American allies to clinch the pivotal victory at Yorktown that at long last secured American independence.

Young Guns

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Author :
Publisher : Simon and Schuster
ISBN 13 : 1451607350
Total Pages : 186 pages
Book Rating : 4.4/5 (516 download)

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Book Synopsis Young Guns by : Eric Cantor

Download or read book Young Guns written by Eric Cantor and published by Simon and Schuster. This book was released on 2010-09-14 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: America urgently needs a new direction. But who will provide it? The time has come to move the country forward with a clear agenda based on common sense for the common good. THERE IS A BETTER WAY. Make no mistake: Congressmen Eric Cantor, Paul Ryan, and Kevin McCarthy are proud Republicans. But they believe the party had lost sight of the ideals it believes in, like economic freedom, limited government, the sanctity of life, and putting families first. This isn’t your grandfather’s Republican party. These Young Guns of the House GOP—Cantor (the leader), Ryan (the thinker), and McCarthy (the strategist)—are ready to take their belief in the principles that have made America great and translate it into solutions that will make the future even better, solutions that will create private sector jobs, maximize individual freedom, and establish a better world for our children. This groundbreaking book is a call to action that sets forth a plan for growth, opportunity, and commitment that will propel this country to prosperity once again. Together, the Young Guns are changing the face of the Republican party and giving us a new road map back to the American dream.

Oversight of the Department of Justice

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Author :
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781976150753
Total Pages : 100 pages
Book Rating : 4.1/5 (57 download)

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Book Synopsis Oversight of the Department of Justice by : United States. Congress

Download or read book Oversight of the Department of Justice written by United States. Congress and published by Createspace Independent Publishing Platform. This book was released on 2017-09-06 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oversight of the Department of Justice : hearing before the Committee on the Judiciary, House of Representatives, One Hundred Fourteenth Congress, second session, July 12, 2016.

Vocal Fold Scar

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Author :
Publisher :
ISBN 13 : 9781909082250
Total Pages : 186 pages
Book Rating : 4.0/5 (822 download)

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Book Synopsis Vocal Fold Scar by : Jaime Eaglin Moore

Download or read book Vocal Fold Scar written by Jaime Eaglin Moore and published by . This book was released on 2016-05-13 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vocal fold scar remains one of the most demanding and, in some ways, frustrating challenges of laryngology and voice therapy. Treatments for this complex condition are inconsistent and often produce suboptimal results. Yet, while hopes for full recovery remain slim, surgical methods and improving technologies, along with improved therapy techniques, have combined to yield better and better outcomes; and further advances are on the horizon. In this new book, Moore, Sataloff, and Hawshaw have collaborated with world leaders in laryngology and speech-language pathology to compile the latest information on the pathophysiology of vocal fold scar, treatments, procedures and, importantly, look at the promising directions in research. The authors introduce the various causes and sequelae of scar, examine anatomy and pathophysiology, and take the reader through diagnostic procedures. Thereafter, they review preoperative therapy options and providing practical guidance on surgical methods including medialization, techniques for freeing the epithelium, management of sulcus, grafting, and the use of lasers. The book discusses tissue engineering and newer treatment options, including epidermal growth factor (EGF) and transforming growth factor-beta 1 (TGF- 1). The book summarizes the state of the art in diagnosis and treatment of vocal fold scar and should be valuable for any clinician who cares for the patient with this vexing problem."