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Author : Lawrence Kass
Publisher : Charles C. Thomas Publisher
ISBN 13 :
Total Pages : 210 pages
Book Rating : 4.3/5 (91 download)
Download or read book Preleukemic Disorders written by Lawrence Kass and published by Charles C. Thomas Publisher. This book was released on 1979 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M. Bessis
Publisher : Springer Science & Business Media
ISBN 13 : 3642663125
Total Pages : 550 pages
Book Rating : 4.6/5 (426 download)
Download or read book Hemopoietic Dysplasias (Preleukemic States) written by M. Bessis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F. Schmalzl
Publisher : Springer Science & Business Media
ISBN 13 : 3642674704
Total Pages : 305 pages
Book Rating : 4.6/5 (426 download)
Download or read book Preleukemia written by F. Schmalzl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical hematologists are frequently faced with the intriguing problem of agnogenic myelo dysplastic syndromes; these syndromes are peculiar in their failing or poor response to therapy and in that they frequently terminate in acute leukemia. An international symposium held in Innsbruck in 1978 was dedicated to clinical and pathophysiologic aspects of the preleukemic syndromes. This monograph consists of articles that correspond to the papers presented at the symposium and of the edited discussions. It was the aim of the symposium and of this monograph to outline comprehensively the pathophysiologic background of the preleukemic syndromes and to summarize the present information about their clinical management. The first part of the monograph covers that pathology of these disorders: Disturbed maturation and proliferation of the hemopoietic cells are the causes of cyto penias, of structural and ultrastructural anomalies, and of enzymatic and functional defects. Further articles are concerned with the evaluation of these features and of chromosome anomalies as possible tools for the diagnostic and prognostic classification of myelodysplasias. Pathogenetic data and immunologic considerations form the rationale for therapeutic ap proaches. F. Schmalzl K.-P. Hellriegel v Contents K.-P. Hellriegel and F. Schmalzl Preleukemia: Definition and Classification ... H. Heirnpel Conventional Morphological Examination of Blood and Bone Marrow Cells in the Diagnosis of Preleukemic Syndromes ... 4 C. Peschle Pure Red Cell Aplasia Type III: Progression to Acute Myeloid Leukemia and Absence of the IgG Inhibitor to Erythropoiesis ... 12 Discussion ... '. ... 14 ... I. Fohlmeister, H.E. Schaefer, K.-P. Hellriegel, and R.
Author : Grover C. Bagby
Publisher : Springer
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.3/5 (91 download)
Download or read book PRELEUKEMIC SYNDROME HEMOPOIETIC DYSPLASIA written by Grover C. Bagby and published by Springer. This book was released on 1985-08-27 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ronald Hoffman
Publisher :
ISBN 13 : 9780443066283
Total Pages : 2821 pages
Book Rating : 4.0/5 (662 download)
Download or read book Hematology written by Ronald Hoffman and published by . This book was released on 2005 with total page 2821 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajay Vora
Publisher : Springer
ISBN 13 : 3319397087
Total Pages : 345 pages
Book Rating : 4.3/5 (193 download)
Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Author : Nasrollah T. Shahidi
Publisher : Springer Science & Business Media
ISBN 13 : 1461232546
Total Pages : 233 pages
Book Rating : 4.4/5 (612 download)
Download or read book Aplastic Anemia and Other Bone Marrow Failure Syndromes written by Nasrollah T. Shahidi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup pressive agents for bone marrow transplantation; failure to achieve en graftment in some identical twins without prior immunosuppressive ther apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat ing the role of activated cytotoxic T lymphocytes and abnormal produc tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.
Author : National Cancer Institute (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1092 pages
Book Rating : 4.3/5 (91 download)
Download or read book Journal written by National Cancer Institute (U.S.) and published by . This book was released on 1977-07 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 810 pages
Book Rating : 4.:/5 (319 download)
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1977 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ronald Hoffman
Publisher : Elsevier Health Sciences
ISBN 13 : 0323733891
Total Pages : 2886 pages
Book Rating : 4.3/5 (237 download)
Download or read book Hematology E-Book written by Ronald Hoffman and published by Elsevier Health Sciences. This book was released on 2022-10-27 with total page 2886 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource. - Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume. - Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice. - Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies - Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system. - Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs. - Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches. - Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders. - Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders. - Presents relevant basic science as background for clinical application in later sections. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Author : P. Alexander
Publisher : Springer Science & Business Media
ISBN 13 : 3642658954
Total Pages : 875 pages
Book Rating : 4.6/5 (426 download)
Download or read book Geschwülste / Tumors I written by P. Alexander and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bald nach Erscheinen des Bandes "Geschwülste" "Geschwiilste" 1956 1956 wurde wurde deutlich, deutlich, daß daB dies dies nur ein Anfang gewesen sein konnte. Die grundlegenden Beitrage Beiträge dieses Bandes spiegelten den Wissensstand am Beginn des 6. Jahrzehnts wider. Sie waren wahrscheinlich zugleich die letzten echten Handbuchbeitrage Handbuchbeiträge zu diesem Thema: umfassend und enzyklopadisch enzyklopädisch vollständig vollstandig und trotzdem als Ganzes lesbar, verfaßt verfaBt von den damals besten Sachkennern in Deutschland. Inzwischen hat sich das Handbuch der Allgemeinen Pathologie gewandelt. Entsprechend der Weitung des Faches vergrößerten vergroBerten sich die Themen. Neben den Bänden Banden tiber über die die Organe Organe zum zum Hilfsmechanismus Hilfsmechanismus des des Stoffwechsels, Stoffwechsels, tiber über die die Zelle, Zelle, das das Altern Altern usw. usw. nahm sich der Geschwulstband vergleichsweise bescheiden aus. Das steht im Gegensatz zur Stellung des Geschwulstproblems in der Allgemeinen Pathologie. Die Krebsforschung erfuhr gerade in den letzten beiden Jahrzehnten einen vorher nicht geahnten Aufschwung, so daß daB eine eine enzyklopädische enzyklopadische Zusammenfassung Zusammenfassung heute heute den den Umfang Umfang des des gesamten gesamten Handbuches Handbuches einnehmen einnehmen würde wtirde -- wenn wenn sich sich jemand fände, rande, das das zu zu versuchen. versuchen. Und wenn der letzte Band gedruckt wäre, ware, ware wäre der erste hoffnungslos veraltet.
Author : D. Metcalf
Publisher : Springer Science & Business Media
ISBN 13 : 364281140X
Total Pages : 397 pages
Book Rating : 4.6/5 (428 download)
Download or read book Hemopoietic Colonies written by D. Metcalf and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been successfully cultured in vitro. The time seemed appropriate to write a short general account of this exciting new area of hematology, emphasizing particularly the potential value of these new techniques for direct studies on patients with leukemia and allied diseases. I had hoped to refer to, or at least record, every paper published in this field, but the literature proved to be larger than I had realized, and furthermore, some areas were so active that chapters had to be rewritten over a period of less than a year. I regret that ·what follows is an incomplete account and no doubt, by the time this book becomes available, the material will be even more out of date. However, I have described the basic techniques in some detail and have tried, where possible, to explain how and why the techniques can fail. It is already possible to see patterns, perhaps even principles, emerging from this work which may well be applicable to other cell populations. These have been emphasized in the text in an attempt to make this review as creative as possible.
Author :
Publisher : Academic Press
ISBN 13 : 008056206X
Total Pages : 365 pages
Book Rating : 4.0/5 (85 download)
Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 1977-03-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research
Author : James F. Holland
Publisher : PMPH-USA
ISBN 13 : 9781607950141
Total Pages : 2052 pages
Book Rating : 4.9/5 (51 download)
Download or read book Holland-Frei Cancer Medicine 8 written by James F. Holland and published by PMPH-USA. This book was released on 2010 with total page 2052 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland Frei Cancer Medicine serves as a quick reference to current information on an extensive list of cancers, including breast, lung, thyroid, colorectal, ovarian, prostate, and gastric cancer, to name but a few. Presented as an accessible pocket-sized handbook, the chapters are organized in an outline format, offering only the most essential information on the etiology, staging (including TNM staging) and treatment for each cancer type. Individual chapters are devoted to the molecular biology of cancer, cancer prevention, cancer screening, the mechanisms of chemotherapy, and diagnostic imaging in cancer. Additionally, each chapter lists all the major phase III clinical trials, and therefore, serves as an excellent reference of the major randomized controlled trials for each cancer reported to date. Specific chapters are also dedicated to the discussion of oncologic emergencies, pain and palliation, and prescription complications. At the conclusion of the book, a glossary of oncologic terms and chemotherapeutic drug programs, a table of common cancer incidences, and an overview of the mechanisms, common uses, and related toxicities of various anti-cancer agents are featured. In addition, performance status tables, mathematical formulas and a listing of common biomedical / cancer web sites are highlighted.
Author :
Publisher :
ISBN 13 :
Total Pages : 960 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1981 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : E. Thiel
Publisher : Springer Science & Business Media
ISBN 13 : 3642822495
Total Pages : 359 pages
Book Rating : 4.6/5 (428 download)
Download or read book Leukemia written by E. Thiel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of the attention presently paid to leukemia is the result of recent progress in understanding and treatment. Chemotherapy of leukemia started in the late 1940s, and combination therapy evolved in the late 1950s. It was at that time that the clonality of leukemia was realized, after the discovery of chromosomal and then biochemical and immunological markers. And now we have the new data on retroviral and cellular oncogenes and the reports on human T -cell lymphoma/ leukemia viruses. Many more steps forward could be enumerated in a field which is so rapidly making the hematological textbooks outdated. In this volume, thirteen in-depth reviews from large multicenter trials in the Federal Republic of Germany summarize the current state of diagnosis and management of leukemias. Childhood ALL and AML adult ALL and AUL were investigated. While cure appears to be achievable for more and more patients with acute leukemia, we still pursue the aim of optimal palliation in chronic leukemias. The management of patients with leukemia therefore varies to a large extent in aggressiveness of therapy. In some situations, rescue from an otherwise lethal disease is provided by bone marrow transplanta tion, which is discussed in two chapters.
Author : Steven Gray
Publisher : Academic Press
ISBN 13 : 0128002247
Total Pages : 748 pages
Book Rating : 4.1/5 (28 download)
Download or read book Epigenetic Cancer Therapy written by Steven Gray and published by Academic Press. This book was released on 2015-07-01 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas - Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs
