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Author : Thomas Winder
Publisher :
ISBN 13 :
Total Pages : 65 pages
Book Rating : 4.:/5 (892 download)
Download or read book Predictive and Prognostic Biomarkers and Novel Therapeutic Targets in Colorectal Cancer written by Thomas Winder and published by . This book was released on 2010 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sunil Badve
Publisher : Springer
ISBN 13 : 3319952285
Total Pages : 635 pages
Book Rating : 4.3/5 (199 download)
Download or read book Predictive Biomarkers in Oncology written by Sunil Badve and published by Springer. This book was released on 2018-12-06 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.
Author : Muzafar Ahmad Macha
Publisher : Frontiers Media SA
ISBN 13 : 2832526195
Total Pages : 359 pages
Book Rating : 4.8/5 (325 download)
Download or read book Emerging therapeutic targets, potential diagnostic or prognostic markers for colorectal cancer written by Muzafar Ahmad Macha and published by Frontiers Media SA. This book was released on 2023-06-09 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zequn Li
Publisher : Frontiers Media SA
ISBN 13 : 2832538983
Total Pages : 467 pages
Book Rating : 4.8/5 (325 download)
Download or read book Biomarkers, Functional Mechanisms, and Therapeutic Potentials in Gastrointestinal Cancers written by Zequn Li and published by Frontiers Media SA. This book was released on 2023-11-17 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development. This Research Topic aims at presenting recent advances on gastrointestinal cancer biomarkers and their underlying functional mechanisms, providing a better understanding of carcinogenesis, tumor progression, tumor relapse, as well as drug resistance. This will subsequently contribute to the development of novel therapeutic interventions targeting gastrointestinal cancers, thus improving patients' outcomes.
Author : Cesar Lopez-Camarillo
Publisher : BoD – Books on Demand
ISBN 13 : 9535110411
Total Pages : 242 pages
Book Rating : 4.5/5 (351 download)
Download or read book Oncogenomics and Cancer Proteomics written by Cesar Lopez-Camarillo and published by BoD – Books on Demand. This book was released on 2013-03-13 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.
Author : Dhananjay Shukla
Publisher : Springer Nature
ISBN 13 : 3030727025
Total Pages : 459 pages
Book Rating : 4.0/5 (37 download)
Download or read book Colon Cancer Diagnosis and Therapy Vol. 3 written by Dhananjay Shukla and published by Springer Nature. This book was released on 2022-02-14 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Author : Manal Elmasry
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (116 download)
Download or read book Identification of Novel Prognostic and Predictive Biomarkers in Colorectal Cancer written by Manal Elmasry and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sherry X. Yang
Publisher : CRC Press
ISBN 13 : 9814364665
Total Pages : 511 pages
Book Rating : 4.8/5 (143 download)
Download or read book Handbook of Therapeutic Biomarkers in Cancer written by Sherry X. Yang and published by CRC Press. This book was released on 2013-06-21 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests
Author :
Publisher :
ISBN 13 : 9789083230191
Total Pages : 0 pages
Book Rating : 4.2/5 (31 download)
Download or read book Predictive and Prognostic Biomarkers for Colorectal Cancer Patients written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is the second most frequent cause of cancer-related death worldwide. Detecting CRC in a premalignant or early stage can improve survival of patients. When the CRC is metastasized (mCRC) to other organs patients are offered systemic treatment to prolong survival. However, not all patients respond to the available treatment while they do suffer from treatment related toxicities. In this thesis we studied the effects of CRC screening programmes on incidence and mortality. In addition, we studied tumor genomics and clinicopathological factors for the prediction of response to systemic therapy in patients with mCRC. The first chapter of this thesis described the effects of CRC screening on incidence and survival of patients with CRC. It was expected that screening for CRC would result in the detection of 1600 additional stage I and II CRCs per year in the first few years after its introduction in The Netherlands. This increase in detected stage I and II resulted in a decrease in the proportion of CRCs diagnosed at stages III or IV from 47% to 20%. Studies described in the next chapters aimed to improve treatment of patients with mCRC and to reduce unnecessary treatment related toxicity by patient selection for systemic therapy. Patient selection can be done with predictive biomarkers based on tumor genomics. A large number of genomic tumor characteristics can be analysed. This high dimensional data makes statistics challenging, as corrections for multiple testing are crucial to avoid overoptimistic results. Moreover, stable estimation of parameters is crucial for determining reproducible biomarkers. In chapter 2 we described a method with multi-parameter shrinkage options to overcome these statistical challenges. In chapter 3 we demonstrated that the miRNA expression profiles of metastases closely resemble that of their corresponding primary CRCs (pCRC).
Author : Valeria Barresi
Publisher : Mdpi AG
ISBN 13 : 9783036529226
Total Pages : 284 pages
Book Rating : 4.5/5 (292 download)
Download or read book Colorectal Cancer written by Valeria Barresi and published by Mdpi AG. This book was released on 2022-01-17 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions.
Author : Heinz-Josef Lenz
Publisher : Springer Science & Business Media
ISBN 13 : 1441997547
Total Pages : 456 pages
Book Rating : 4.4/5 (419 download)
Download or read book Biomarkers in Oncology written by Heinz-Josef Lenz and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST. International experts provide insight into toxicity markers and surrogate markers. Attention is also given to biomarker assay development, validation, and strategies. A powerful tool for determining decisions on therapy, selecting drug regimens, monitoring the efficacy of treatment, and performing individualized surveillance, biomarkers represent the forefront of cancer research and treatment. As these technologies become increasingly available for clinical use, this book will be an essential resource for oncologists and translational researchers.
Author : Ganji Purnachandra Nagaraju
Publisher : Springer Nature
ISBN 13 : 3030633691
Total Pages : 374 pages
Book Rating : 4.0/5 (36 download)
Download or read book Colon Cancer Diagnosis and Therapy written by Ganji Purnachandra Nagaraju and published by Springer Nature. This book was released on 2021-06-10 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Author : Naveen Kumar Vishvakarma
Publisher : Springer Nature
ISBN 13 : 3030646688
Total Pages : 453 pages
Book Rating : 4.0/5 (36 download)
Download or read book Colon Cancer Diagnosis and Therapy written by Naveen Kumar Vishvakarma and published by Springer Nature. This book was released on 2021-06-04 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
ISBN 13 : 981154431X
Total Pages : 238 pages
Book Rating : 4.8/5 (115 download)
Download or read book Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2020-07-21 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
Author : Mauro Bologna
Publisher : Springer Science & Business Media
ISBN 13 : 161779614X
Total Pages : 572 pages
Book Rating : 4.6/5 (177 download)
Download or read book Biotargets of Cancer in Current Clinical Practice written by Mauro Bologna and published by Springer Science & Business Media. This book was released on 2012-04-05 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.
Author : Alejandro Pazos Sierra
Publisher : Academic Press
ISBN 13 : 0323885713
Total Pages : 672 pages
Book Rating : 4.3/5 (238 download)
Download or read book Foundations of Colorectal Cancer written by Alejandro Pazos Sierra and published by Academic Press. This book was released on 2021-10-28 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foundations of Colorectal Cancer provides a holistic and comprehensive dive into colorectal cancer, discussing the contributions of each discipline that studies it, allowing its understanding from the most demographic and ethical facts, to the treatment process, its varieties and genetic background. Written by experts in diverse areas such as cancer research, oncology, genetics, biochemistry, psychology, social sciences, bioinformatics and palliative care, the book brings real-world experiences to help readers with any challenge they may face when dealing with patients or during their research workflow.The content is split into nine sections: Clinical manifestations and disease detection, covering primary and secondary prevention, and the role of primary care; Diagnosis and staging, discussing endoscopy, colonoscopy, molecular pathology, and anatomopathological diagnosis; Treatment, including endoscopic, surgical, radiological, and postoperative approaches; Molecular and biological mechanisms, with the role of intestinal microbiota, stem cells and signaling pathways; New diagnostic methods, encompassing biomarkers and bioinformatics tools for research; Biobanks, with an overview of their regulations and importance in the research; Epidemiological studies, focusing on incidence and mortality globally and by regions; Hereditary colorectal cancer, differentiating nonpolyposis and polyposis types; and Addressing the consequences of colorectal cancer, covering psychological effects, nutrition and ethical issues. - Provides a multidisciplinary approach with a holistic view of colorectal cancer, ranging from basic science to population studies, with its social and environmental influences and impacts, interpreting the disease as a medical, chemical, physical, microbial, psychological, and social condition - Written by a diverse group of specialists with complementary expertise, including oncologists, radiologists, biochemists, surgeons, psychologists, social workers and clinicians, all members of the Galician Research Network of Colorectal Cancer (REGICC) with vast collaboration experience to bring comprehensive knowledge on the subject - Encompasses reliable information suitable for different workers within the healthcare sector and research community dedicated to colorectal cancer, from clinicians and healthcare providers, researchers on several aspects of cancer, to bioinformaticians who deal with health data - Includes many case studies throughout the chapters discussed by specialists with high scientific accuracy and didactic value, in order to clearly and precisely share their professional experience on the subject with readers
Author : Ondrej Slaby
Publisher : Springer
ISBN 13 : 3319420593
Total Pages : 251 pages
Book Rating : 4.3/5 (194 download)
Download or read book Non-coding RNAs in Colorectal Cancer written by Ondrej Slaby and published by Springer. This book was released on 2016-08-29 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.
