Preconception And Preimplantation Diagnosis Of Human Genetic Disease

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Preconception and Preimplantation Diagnosis of Human Genetic Disease

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Author : Robert G. Edwards
Publisher : CUP Archive
ISBN 13 : 9780521404259
Total Pages : 362 pages
Book Rating : 4.4/5 (42 download)

Book Synopsis Preconception and Preimplantation Diagnosis of Human Genetic Disease by : Robert G. Edwards

Download or read book Preconception and Preimplantation Diagnosis of Human Genetic Disease written by Robert G. Edwards and published by CUP Archive. This book was released on 1993-04-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of human in vitro fertilization and developments in molecular science have made it possible to diagnose genetic disease in fetuses at a very early stage of development. This book presents the most recent advances and developments in this new area of applied research. Experts in the field describe and discuss the latest technology, from micromanipulation of single cells to sophisticated methods of DNA analysis. The book considers the implications of this new technology for fetal screening and the prevention of genetic disease, as well as for the control and manipulation of the normal sex ratio. It draws together current knowledge and discusses the new clinical opportunities for disease prevention. The book begins with an overview of the genetics of some common inherited diseases and the historical development of prenatal screening. It then draws together the most recent advances in preimplantation diagnostic techniques, including tissue assays for specific genetic disorders, and methods for typing and separating spermatozoa. The practical aspects of the new methodologies are considered, along with the potential for developing safer, more reliable and less invasive methods of diagnosis. The ethical and legal implications of this diagnostic approach are also discussed.

Preimplantation Genetics

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Author : A. Kuliev
Publisher : Springer Science & Business Media
ISBN 13 : 1468413511
Total Pages : 314 pages
Book Rating : 4.4/5 (684 download)

Book Synopsis Preimplantation Genetics by : A. Kuliev

Download or read book Preimplantation Genetics written by A. Kuliev and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yury Verlinskyand Anver Kuliev Reproductive Genetics Institute, Illinois Masonic Medical Center, 836 W. Wellington chicago, IL 60657 Although introduction of a first trimester prenatal diagnosis by chorionic viIIus sampling (CVS) has considerably improved the possibility for prevention of genetic diseases, it requires a selective abortion in case of an affected fetus. Following the direction of an earlier prenatal diagnosis and to avoid the need for abortion, preimplantation genetic diagnosis has been initiated based on polar body removal and pre-embryo biopsy. The First International symposium on Preimplantation Genetics, Chicago, September 17-19, 1990, was organized to explore these important developments, to review the state of knowledge in the field, and to address existing problems to be solved for developing and improving current approaches for preimplantation diagnosis of genetic disorders. A growing interest in the subject was obvious from the wide attendance of the meeting: over 250 scientists from 19 countries participated. This was the first attempt to put together the advances in different areas of basic and applied research relevant to Preimplantation Genetic Diagnosis, with the multidisciplinary scientific program including the sessions on embryology, micromanipulation and biopsy, genetic analysis of gametes and pre-embryos, IVF, gene expression and gene therapy, and ethical and legal issues. The deliberations of the Symposium presented in the above mentioned sessions, which comprise the contents of correspond ing sections of the Proceedings, open a newarea in medical research based on the interaction of IVF and New Genetics.

Prenatal Testing for Late-onset Neurogenetic Diseases

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Author : G Evers-Kiebooms
Publisher : CRC Press
ISBN 13 : 0203450299
Total Pages : 242 pages
Book Rating : 4.2/5 (34 download)

Book Synopsis Prenatal Testing for Late-onset Neurogenetic Diseases by : G Evers-Kiebooms

Download or read book Prenatal Testing for Late-onset Neurogenetic Diseases written by G Evers-Kiebooms and published by CRC Press. This book was released on 2003-12-16 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the biological, moral and legal issues which arising prenatal testing of late onset neurogenetic disease. The contributors focus specifically on Huntington's Disease, which is used as a model for other late onset neurogenetic diseases. The ethical and legal aspects of prenatal testing and preimplantation genetic diagnosis are discussed with reference to case histories. This volume will provide valuable insights for all those involved in dealing with these challenging issues.

Prenatal and Preimplantation Diagnosis

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Author : Joann Paley Galst
Publisher : Springer
ISBN 13 : 3319189115
Total Pages : 356 pages
Book Rating : 4.3/5 (191 download)

Book Synopsis Prenatal and Preimplantation Diagnosis by : Joann Paley Galst

Download or read book Prenatal and Preimplantation Diagnosis written by Joann Paley Galst and published by Springer. This book was released on 2015-08-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to expand the awareness and understanding of the emotional sequelae of prenatal/preimplantation diagnosis, prenatal decision-making, pregnancy interruption for fetal anomaly, multifetal reduction for high-order multifetal pregnancies and preimplantation choices involving the selection of embryos. Featuring a multi-disciplinary approach, it examines prenatal and preimplantation diagnosis from medical, legal, ethical and psychosocial perspectives. Prenatal and Preimplantation Diagnosis is an excellent resource for obstetricians, reproductive endocrinologists, clinical geneticists, genetic counselors and mental health professionals seeking to better support patients faced with difficult choices.

Before Birth

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Author : Elena O. Nightingale
Publisher : Harvard University Press
ISBN 13 : 9780674063907
Total Pages : 144 pages
Book Rating : 4.0/5 (639 download)

Book Synopsis Before Birth by : Elena O. Nightingale

Download or read book Before Birth written by Elena O. Nightingale and published by Harvard University Press. This book was released on 1990 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'An extremely informative, well-written and amply diagrammed book, which should be of great value to laypersons and their physicians who require further genetic review and background for present and future gene therapies.' - Theodore Kushnick, M.D., Journal of the American Medical Association.

Preimplantation Diagnosis of Genetic Disease

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Author : Yury Verlinsky
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Preimplantation Diagnosis of Genetic Disease by : Yury Verlinsky

Download or read book Preimplantation Diagnosis of Genetic Disease written by Yury Verlinsky and published by Wiley-Liss. This book was released on 1993 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation Diagnosis of Genetic Diseases A New Technique in Assisted Reproduction Editors: Yury Verlinsky and Anver M. Kuliev For individuals with hereditary genetic disorders such as cystic fibrosis, muscular dystrophy, or hemophilia, the decision to reproduce can be a profoundly difficult and emotional problem. For specialists in reproductive medicine, this situation can raise a myriad of complex—often conflicting—ethical questions. Recently, a revolutionary approach to screening for genetic disorders has emerged, offering unique possibilities for resolving this dilemma. Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction details the latest procedures for detecting congenital disease in gametes prior to fertilization or in embryos fertilized in vitro prior to uteral implantation. This book covers current methods used in oocyte and preembryo sampling as well as the latest techniques in DNA and cytogenetic analysis in preimplantation development. This text presents detailed, practical information on such crucial topics as: blastomere and blastocyst biopsy for preimplanation genetic analysis oocyte retrieval and embryo transfer for in vitro fertilization preparation of necessary media and micromanipulation tools polymerase chain reaction techniques for DNA analysis of polar bodies and preembryos preimplantation cytogenetic and enzymatic analyses ethical issues involved in preimplantation genetic screening. Serving as both a practical manual for current methods and a reference for future research and clinical applications, Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction provides a complete overview of this dramatic development in reproductive medicine. This book will be of interest to specialists in fertility medicine, obstetrics and gynecology, embryology, genetics, molecular biology, and cytogenetics whose work defines this new frontier in biomedical science.

Preimplantation Genetic Diagnosis

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Author : Joyce C. Harper
Publisher : John Wiley & Sons
ISBN 13 : 0470851732
Total Pages : 278 pages
Book Rating : 4.4/5 (78 download)

Book Synopsis Preimplantation Genetic Diagnosis by : Joyce C. Harper

Download or read book Preimplantation Genetic Diagnosis written by Joyce C. Harper and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation Genetic Diagnosis (PGD) is the detection and screening of genetic abnormality in gametes prior to fertilisation and embryos fertilised in vitro prior to implantation. This exciting new text provides an introduction and overview of the principles of PGD. An exciting fusion of prenatal diagnosis (PD) with in vitro fertilisation (IVF), this book is will appeal to both the prenatal diagnosis community, of clinical geneticists and foetal medicine specialists within obstetrics and gynaecology, and the IVF community within reproductive medicine. It is also an essential introduction to PD, clinical genetics and IVF for non-specialists. A concise introduction to the field of PGD Detailed explanations of the techniques and procedures used The law and ethical implications of PGD Future uses of PGD

Women and Prenatal Testing

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Author : Karen H. Rothenberg
Publisher : Ohio State University Press
ISBN 13 : 0814206409
Total Pages : 332 pages
Book Rating : 4.8/5 (142 download)

Book Synopsis Women and Prenatal Testing by : Karen H. Rothenberg

Download or read book Women and Prenatal Testing written by Karen H. Rothenberg and published by Ohio State University Press. This book was released on 1994 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: "For pregnant women in the 1990s, technological developments have ushered in new and expanding reproductive genetic testing options. Some herald these procedures as advances providing women with previously unavailable information about their pregnancies. Others contend that with this surge of information come increasing and perhaps unwarranted obligations: while some women have greater knowledge about their pregnancies, they also face far more complex decisions and a greater pressure to do as much as is technologically possible to ensure the birth of a healthy child." "This book focuses on the major women's issues surrounding the development and application of reproductive genetic testing. Although much has been written about the biological safety and efficacy of these technologies, few publications have addressed their psychological, sociocultural, ethical, legal, and political impact on women and their experience of pregnancy." "The first of three sections provides the contextual framework in which the debate should be analyzed. The second section sets forth the philosophical foundations and complex ethical and legal questions that need to be addressed, and the final section delineates a variety of perspectives on the psychological and sociocultural issues raised by reproductive genetic testing. These fourteen essays on the cutting edge of the debate are essential reading for anyone interested in women's studies, human genetics, health law; and bioethics and prenatal care providers."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Genetic Disorders and the Fetus

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Author : Aubrey Milunsky
Publisher : John Wiley & Sons
ISBN 13 : 1119676975
Total Pages : 1392 pages
Book Rating : 4.1/5 (196 download)

Book Synopsis Genetic Disorders and the Fetus by : Aubrey Milunsky

Download or read book Genetic Disorders and the Fetus written by Aubrey Milunsky and published by John Wiley & Sons. This book was released on 2021-03-30 with total page 1392 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The time is fast approaching when virtually all the culprit genes and their mutations for 7,000 rare monogenic disorders1 will be known. Thus far causal single genes and their mutations have been determined for 5,6732 genetic disorders, enabling pre-implantation genetic testing or prenatal genetic diagnosis. These advances using chromosomal microarrays, whole exome sequencing and even whole genome sequencing together with fetal imaging, and non-invasive prenatal testing, expand the era in which all couples have the option of avoiding or preventing having children with irreversible, irremediable, crippling, or lethal monogenic disorders. Primary care physicians, and those in all medical specialties, will need to inform their patients of this key option. This imperative is already partly in current practice. Missing is the requirement of physicians to request and obtain the precise name of the genetic disorder in question or an existing DNA report on a family member, for prospective parents to benefit from available options"--

Genetic Disorders and the Fetus

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Author : Aubrey Milunsky
Publisher : John Wiley & Sons
ISBN 13 : 1118981545
Total Pages : 1216 pages
Book Rating : 4.1/5 (189 download)

Book Synopsis Genetic Disorders and the Fetus by : Aubrey Milunsky

Download or read book Genetic Disorders and the Fetus written by Aubrey Milunsky and published by John Wiley & Sons. This book was released on 2015-09-21 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment, Seventh Edition is the eagerly awaited new edition of the discipline-leading text that has been at the forefront of diagnosis, prevention, and treatment of fetal genetic disorders for over 36 years. The seventh edition continues the long-established tradition of excellence that has become synonymous with this text. The book builds on the foundations of preconception and prenatal genetic counseling and the original pillars of prenatal diagnosis while also providing authoritative coverage of exciting developments in non-invasive genetic testing and rapidly developing molecular techniques, including microarray analysis and next generation sequencing, that are revolutionizing the field. Chapters are once again authored by internationally recognized authorities in the field of prenatal diagnosis. The editors have added three entirely new chapters to this edition to complement the complete revision of existing content. The three new chapters focus on non-invasive prenatal screening, placental genetics, and the psychology of prenatal and perinatal grief. The broad-ranging coverage and international scope will ensure that the new edition maintains its role as the major repository for information on all aspects of prenatal diagnosis. The editors have brought together an invaluable collection of evidence-based facts bolstered by knowledge and decades of experience in the field. Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment, 7th Edition is a timely update to this world-leading text.

Genetic Disorders and the Fetus

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Author : Aubrey Milunsky
Publisher : Springer Science & Business Media
ISBN 13 : 1468434381
Total Pages : 718 pages
Book Rating : 4.4/5 (684 download)

Book Synopsis Genetic Disorders and the Fetus by : Aubrey Milunsky

Download or read book Genetic Disorders and the Fetus written by Aubrey Milunsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances continue to expand the number of genetic disorders that can be diagnosed in utero. Utilization of this new technology has de manded special expertise available in relatively few academic centers. As these new applications have become more widespread so have the realities of the medicolegal implications. Notwithstanding the laboratory challenges, most legal action, at least in the United States, has arisen from the physician's failure to inform a patient about the risks of a genetic disorder or the oppor tunities presented by prenatal diagnosis. Hence an extensive thorough reex amination of the subject seems appropriate and timely. The steady escalation in the number of prenatal genetic studies now being done in the western world makes it imperative for the physician to have a thorough comprehension of the subject in its entirety. I am, therefore, fortu nate in having colleagues who as acknowledged experts have shared their knowledge and experience in order to make this volume a major critical repository of facts and guidance about prenatal genetic diagnosis. The subject matter ranges from a consideration of required genetic counseling through the intricacies of establishing prenatal diagnoses. Special attention is focused on new advances using ultrasound, a-fetoprotein, fetoscopy, and first trimester diagnosis. Both ethical and legal implications are discussed in detail, as is the development of public policy.

Preimplantation Genetic Diagnosis in Clinical Practice

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Author : Tarek El-Toukhy
Publisher : Springer Science & Business Media
ISBN 13 : 1447129482
Total Pages : 233 pages
Book Rating : 4.4/5 (471 download)

Book Synopsis Preimplantation Genetic Diagnosis in Clinical Practice by : Tarek El-Toukhy

Download or read book Preimplantation Genetic Diagnosis in Clinical Practice written by Tarek El-Toukhy and published by Springer Science & Business Media. This book was released on 2013-11-08 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation genetic diagnosis (PGD) is a rapidly advancing field of reproductive genetics. With the significant improvements achieved over the last few years in the understanding of many genetic diseases and in the techniques of molecular genetic testing, new genetic diseases are being added to the list of conditions amenable to PGD almost on a weekly basis. Therefore, the subject of PGD is becoming relevant to a much wider variety of medical disciplines and an increasing number of patients who may wish to know more about this treatment option. This unique book offers a comprehensive yet practical “user-friendly” guide to preimplantation genetic diagnosis (PGD). It provides understanding of and insight into the complete procedure, its recent clinical and laboratory developments and its future prospects, whilst offering an easy point of reference for patient enquiries. Concluding with perspectives on the ethical and social issues often encountered by healthcare professionals counselling patients with regards to PGD. Each chapter within Preimplantation Genetic Diagnosis in Clinical Practice is written by established authorities in their fields. An essential resource for PGD specialists and non-specialists, and for all practitioners working within the disciplines of fertility, reproductive medicine and medical genetics.

Born and Made

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Author : Sarah Franklin
Publisher : Princeton University Press
ISBN 13 : 0691121931
Total Pages : 282 pages
Book Rating : 4.6/5 (911 download)

Book Synopsis Born and Made by : Sarah Franklin

Download or read book Born and Made written by Sarah Franklin and published by Princeton University Press. This book was released on 2006-11-19 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Born and Made' examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called 'designer baby' method. It shows that far from being a runaway technology, the regulation of PGD provides an example of precaution and restraint.

Assessing Genetic Risks

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Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309047986
Total Pages : 353 pages
Book Rating : 4.3/5 (9 download)

Book Synopsis Assessing Genetic Risks by : Institute of Medicine

Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Regulating Pre-implantation Genetic Diagnosis

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Author : Sheila McLean
Publisher : Routledge
ISBN 13 : 041568644X
Total Pages : 266 pages
Book Rating : 4.4/5 (156 download)

Book Synopsis Regulating Pre-implantation Genetic Diagnosis by : Sheila McLean

Download or read book Regulating Pre-implantation Genetic Diagnosis written by Sheila McLean and published by Routledge. This book was released on 2013 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful achievement of pregnancies following pre-implantation genetic diagnosis (PGD) was first reported in April 1990. The technology is often used for patients who are at substantial risk of conceiving a pregnancy affected by a known genetic disorder, however from this technology other more controversial uses have arisen such as HLA typing to save the life of a sibling, gender selection for social reasons, the prevention of late onset diseases, or the prevention of diseases which may be genetically predisposed to developing such as breast cancer. The technology surrounding PGD is constantly developing, giving rise to new and unexpected consequences that create fresh ethical and legal dilemmas. Featuring internationally recognized experts in the field, this book critically explores the regulation of PGD and the broader legal and ethical issues associated with it. It looks at the regulatory situation in a number of jurisdictions including New Zealand, Australia and the United Kingdom, but it also explores a number of themes of wide significance including a historical consideration of PGD and its part in the creation of the "genetic embryo" as a political tool, the over regulation of PGD and the ethical difficulties in handling additional unexpected medical information yielded by new technologies. This book will be of particular interest to academics and students of law, medicine and ethics.

Genes, Women, Equality

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Author : Mary Briody Mahowald
Publisher : Oxford University Press
ISBN 13 : 9780199771189
Total Pages : 344 pages
Book Rating : 4.7/5 (711 download)

Book Synopsis Genes, Women, Equality by : Mary Briody Mahowald

Download or read book Genes, Women, Equality written by Mary Briody Mahowald and published by Oxford University Press. This book was released on 1999-10-14 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics is not gender neutral in its impact. Mahowald cites a wide range of biological and psychosocial examples that reveal its different impact on men and women, especially with regard to reproduction and caregiving. She examines the extent to which these differences are associated with gender injustice, arguing for positions that reduce inequality between the sexes. The critical perspective Mahowald brings to this analysis is an egalitarian interpretation of feminism that demands attention to inequalities arising from racism, ethnocentricism, albleism, and classism as well as sexism. Eschewing a notion of equality as sameness, Mahowald defines equality as attribution of the same value to different objects. Gender justice, she claims, imputes the same value to men and women, despite their differences. It can only be maximized by practical efforts to equalize the burdens and benefits associated with genetics. The topics considered include participation in research, allocation of genetic services, cultural difference, sex selection, misattributed paternity, prenatal and preimplantation diagnosis, carrier testing, genetic interventions, genetic disabilities, preferences for genetic ties to offspring, genetic susceptibility to late onset disorders, behavioral genetics, genetic discrimination in employment and insurance, and human cloning. Cases, both real and concocted, are used to illustrate the questions addressed.

Reproductive Genetics

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Author : Sean Kehoe
Publisher : RCOG
ISBN 13 : 1906985162
Total Pages : 245 pages
Book Rating : 4.9/5 (69 download)

Book Synopsis Reproductive Genetics by : Sean Kehoe

Download or read book Reproductive Genetics written by Sean Kehoe and published by RCOG. This book was released on 2009-11 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the findings of the RCOG Study Group findings on genetics underlying reproductive function.