Powder Technology And Pharmaceutical Processes

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Granulation

Author : Agba D. Salman
Publisher : Elsevier
ISBN 13 : 0080467881
Total Pages : 1403 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Granulation by : Agba D. Salman

Download or read book Granulation written by Agba D. Salman and published by Elsevier. This book was released on 2006-11-24 with total page 1403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Granulation provides a complete and comprehensive introduction on the state-of-the-art of granulation and how it can be applied both in an academic context and from an industrial perspective. Coupling science and engineering practices it covers differing length scales from the sub-granule level through behaviour through single granules, to bulk granule behaviour and equipment design. With special focus on a wide range of industrially relevant areas from fertilizer production, through to pharmaceuticals. Experimental data is complemented by mathematical modelling in this emerging field, allowing for a greater understanding of the basis of particle products and this important industry sector.Four themes run through the book: 1. The Macro Scale processing for Granulation – including up to date descriptions of the methods used for granulation and how they come about and how to monitor – on-line these changes.2. The Applications of granulation from an industrial perspective, with current descriptive roles and how they are undertaken with relevance to industry, and effective properties.3. Mechanistic descriptions of granulation and the different rate processes occurring within the granulator. This includes methods of modelling the process using Population – Balance Equations, and Multi-level Computational Fluid Dynamics Models.4. The Micro Scale: Granules and Smaller, looking at single granules and there interactions and modelling, while also considering the structure of granules and their constituent liquid bridges.* Covers a wide range of subjects and industrial applications* Provides an understanding of current issues for industrial and academic environments* Allows the reader an understanding of the science behind engineered granulation processes

Pharmaceutical Powder Compaction Technology

Author : Metin Çelik
Publisher : CRC Press
ISBN 13 : 1420089188
Total Pages : 360 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Pharmaceutical Powder Compaction Technology by : Metin Çelik

Download or read book Pharmaceutical Powder Compaction Technology written by Metin Çelik and published by CRC Press. This book was released on 2016-04-19 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists,

Particle Breakage

Author : Agba D. Salman
Publisher : Elsevier
ISBN 13 : 008055346X
Total Pages : 1241 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Particle Breakage by : Agba D. Salman

Download or read book Particle Breakage written by Agba D. Salman and published by Elsevier. This book was released on 2007-11-01 with total page 1241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Particle breakage is an important process within a wide range of solids processing industries, including pharmaceuticals, food, agricultural and mining. Breakage of particles can be defined as intentional and unintentional, depending on whether it is desired or not. Through understanding of the science and underlying mechanisms behind this phenomenon, particle breakage can be either minimised or encouraged within an efficient and effective process. Particle Breakage examines particle breakage at three different length scales, ranging from single particle studies through groups of particles and looking at solid processing steps as a whole. This book is the widest ranging book in the field and includes the most up-to-date techniques such as Distinct Element Method (DEM), Monte Carlo simulations and Population Balance Equations (PBE). This handbook provides an overview of the current state-of-the- art and particle breakage. From the small scale of a single particle, to the study of whole processes for breakage; both by experimental study and mathematical modelling.* Covering a wide range of subjects and industrial applications* Allows the reader an understanding of the science behind engineered breakage processes* Giving an unrestrictive and interdisciplinary approach

Pharmaceutical Blending and Mixing

Author : P. J. Cullen
Publisher : John Wiley & Sons
ISBN 13 : 0470710551
Total Pages : 508 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Pharmaceutical Blending and Mixing by : P. J. Cullen

Download or read book Pharmaceutical Blending and Mixing written by P. J. Cullen and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering.

Pharmaceutical Powder and Particles

Author : Anthony J. Hickey
Publisher : Springer
ISBN 13 : 9783030082017
Total Pages : 116 pages
Book Rating : 4.0/5 (82 download)

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Book Synopsis Pharmaceutical Powder and Particles by : Anthony J. Hickey

Download or read book Pharmaceutical Powder and Particles written by Anthony J. Hickey and published by Springer. This book was released on 2019-09-06 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.

Powder Technology and Pharmaceutical Processes

Author : Dominique Chulia
Publisher : Elsevier Science & Technology
ISBN 13 : 9780444815330
Total Pages : 557 pages
Book Rating : 4.8/5 (153 download)

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Book Synopsis Powder Technology and Pharmaceutical Processes by : Dominique Chulia

Download or read book Powder Technology and Pharmaceutical Processes written by Dominique Chulia and published by Elsevier Science & Technology. This book was released on 1994 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume offers a multidisciplinary approach to the operations most commonly used in processing solids in the field of pharmacy and also in the fields of fine chemicals, cosmetics, foods, etc. The authors combine the triple standpoint of formulation, physical characterization of materials and process engineering and have selected the basic facts needed to understand the phenomena by which molecules become particles, particles become granules and granules become tablets, extrudates, microcapsules, etc. These operations are then described in very practical terms, including assessment of their effectiveness and limitations, and critical steps are highlighted.About twenty operations carried out on divided solids are described, ranging from crystallization to formulation, in a manner intended to be within the grasp of all involved: it is not a book solely for specialists, but offers a multidisciplinary background and a methodological help to p

Principles of Powder Technology

Author : M. J. Rhodes
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 464 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Principles of Powder Technology by : M. J. Rhodes

Download or read book Principles of Powder Technology written by M. J. Rhodes and published by John Wiley & Sons. This book was released on 1990 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Powder processing. Characterizing the single particle. Characterization of powder. mixing and segregation in powders. the storage and flow of powders. Gas fluidization. Pneumatic conveying. Solid-gas separation. Size enlargement. Size reduction. Explosion and fire hazards of powders. health risks of fine powders. Flow of liquid-solid suspensions. Solid-liquid separation.

Pharmaceutical Process Scale-Up

Author : Michael Levin
Publisher : CRC Press
ISBN 13 : 082474196X
Total Pages : 588 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Pharmaceutical Process Scale-Up by : Michael Levin

Download or read book Pharmaceutical Process Scale-Up written by Michael Levin and published by CRC Press. This book was released on 2001-12-12 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling,

Chemical Engineering in the Pharmaceutical Industry

Author : Mary T. am Ende
Publisher : John Wiley & Sons
ISBN 13 : 111928550X
Total Pages : 1435 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Chemical Engineering in the Pharmaceutical Industry by : Mary T. am Ende

Download or read book Chemical Engineering in the Pharmaceutical Industry written by Mary T. am Ende and published by John Wiley & Sons. This book was released on 2019-04-08 with total page 1435 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Powder Flow

Author : Ali Hassanpour
Publisher : Royal Society of Chemistry
ISBN 13 : 1788018478
Total Pages : 238 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Powder Flow by : Ali Hassanpour

Download or read book Powder Flow written by Ali Hassanpour and published by Royal Society of Chemistry. This book was released on 2019-07-12 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Powder flow has attracted increased attention in recent years as novel formulated and functional products are being developed in powder forms, particularly in pharmaceutical and high value additive manufacturing industries. This book meets a need for a truly integrated modern treatment of dry powder flow, covering theory, robust characterisation techniques, modelling tools and applications. Written by leaders in the field, the book opens by introducing the wide range of powder processing problems faced by industry, the complexities of powders and the myriad of ways their flow behaviour can be characterised. The authors then move on, with contributions from experts, to describe fundamental properties that can be measured, defining the states of stress and shear rate and the considerations that need to be taken account. By providing a comprehensive treatment of all available characterisation techniques, as well as various modelling tools, the reader obtains a clear, practical overview. Case studies and applications connect theory to practical examples across a broad range of industries. This book stands out by not only providing the reader with guidance on what to measure but also how to interpret results, ensuring this is an invaluable text for anyone working on powder flow in the chemical, pharmaceutical and manufacturing industries, as well as students and researchers across chemical and process engineering disciplines.

Particle Adhesion

Author : David J. Quesnel
Publisher : CRC Press
ISBN 13 : 9789056997250
Total Pages : 546 pages
Book Rating : 4.9/5 (972 download)

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Book Synopsis Particle Adhesion by : David J. Quesnel

Download or read book Particle Adhesion written by David J. Quesnel and published by CRC Press. This book was released on 2002-02-07 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whenever a curved surface interacts with another surface, the principles of adhesion are at work. From the cells in your body to the dust on your glasses, intermolecular forces cause materials to attract one another. Elastic deformations resulting from these adhesive interactions store strain that can be liberated during particle detachment. Time dependent changes in adhesion can result from plastic deformation that both increases the real effective contact area and reduces the stored energy available to assist in particle removal. Processes such as these, based on the fundamentals tenets of particle adhesion, are now finding applications across many disciplines leading to a rich and rapid development of knowledge. This book documents the use of particle adhesion concepts in a variety of disciplines. Fields as varied as the cleaning of semiconductors, to the controlling of cancer metastasis, to the abatement of environmental pollution all benefit from applications of particle adhesion concepts.

Food Powders

Author : Enrique Ortega-Rivas
Publisher : Springer Science & Business Media
ISBN 13 : 0387276130
Total Pages : 382 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Food Powders by : Enrique Ortega-Rivas

Download or read book Food Powders written by Enrique Ortega-Rivas and published by Springer Science & Business Media. This book was released on 2006-04-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful reference is the first book to address key aspects of food powder technology. It assembles organized and updated information on the physical properties, production, and functionality of food powder, previously unavailable in book form.

Handbook of Pharmaceutical Granulation Technology

Author : Dilip M. Parikh
Publisher : CRC Press
ISBN 13 : 1000366383
Total Pages : 905 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Handbook of Pharmaceutical Granulation Technology by : Dilip M. Parikh

Download or read book Handbook of Pharmaceutical Granulation Technology written by Dilip M. Parikh and published by CRC Press. This book was released on 2021-05-11 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies

The Science and Engineering of Granulation Processes

Author : Jim Litster
Publisher : Springer Science & Business Media
ISBN 13 : 9781402018770
Total Pages : 268 pages
Book Rating : 4.0/5 (187 download)

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Book Synopsis The Science and Engineering of Granulation Processes by : Jim Litster

Download or read book The Science and Engineering of Granulation Processes written by Jim Litster and published by Springer Science & Business Media. This book was released on 2004-03-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book had its origins in a meeting between two (relatively) young particle technology researchers on Rehobeth Beach in Delaware in 1992 near the holiday house of Reg Davies (then Director of the Particle Science and Technology Research Center in Dupont). As we played in the sand, we shared an excitement for developments in particle technology, especially particle characterization, that would lead operations such as granulation to be placed on a sound scientific and engineering footing. The immediate outcome from this interaction was the development of new industry short courses in granulation and related topics which we taught together both in Australia and North America. This book follows closely the structure and approaches developed in these courses, particularly the emphasis on particle design in granulation, where the impact of both formulation properties and process variables on product attributes needs to be understood and quantified. The book has been a long time in the making. We have been actively preparing the book for at least five years. Although the chapters have relatively good bibliographies, this book is not a review of the field. Rather it is an attempt by the authors to present a comprehensive engineering approach to granulator design, scale up and operation. It is exciting for us to see the explosion of research interest around the world in this area in the last five to seven years. Some of the most recent work will have to find its way into the second edition.

Pharmaceutical Process Development

Author : John Blacker
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733074
Total Pages : 375 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Pharmaceutical Process Development by : John Blacker

Download or read book Pharmaceutical Process Development written by John Blacker and published by Royal Society of Chemistry. This book was released on 2011-08-17 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of: both early and late stage chemical development, how safe and scaleable synthetic routes are designed, selected and developed, the importance of the chemical engineering, analytical and manufacturing interfaces, the key enabling technologies, including catalysis and biocatalysis, the importance of the green chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery.

Pharmaceutical Manufacturing Handbook

Author : Shayne Cox Gad
Publisher : John Wiley & Sons
ISBN 13 : 0470259809
Total Pages : 1386 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Pharmaceutical Manufacturing Handbook by : Shayne Cox Gad

Download or read book Pharmaceutical Manufacturing Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2008-03-11 with total page 1386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook features contributions from a team of expert authors representing the many disciplines within science, engineering, and technology that are involved in pharmaceutical manufacturing. They provide the information and tools you need to design, implement, operate, and troubleshoot a pharmaceutical manufacturing system. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.

Continuous Pharmaceutical Processing and Process Analytical Technology

Author : Ajit S. Narang
Publisher : CRC Press
ISBN 13 : 100080447X
Total Pages : 495 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Continuous Pharmaceutical Processing and Process Analytical Technology by : Ajit S. Narang

Download or read book Continuous Pharmaceutical Processing and Process Analytical Technology written by Ajit S. Narang and published by CRC Press. This book was released on 2023-03-01 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous manufacturing of pharmaceuticals, including aspects of modern process development is highlighted in this book with both the ‘why’ and the ‘how’, emphasizing process modeling and process analytical technologies. Presenting specific case studies and drawing upon extensive experience from industry and academic opinion leaders, this book focuses on the practical aspects of continuous manufacturing. It gives the readers the strategic perspective and technical depth needed to adopt and implement these technologies, where appropriate, in order to gain the competitive edge in speed, agility, and reliability. Features: Discusses scientific solutions and process analytical technology to enable continuous manufacturing in the development of new drugs Includes short stories about how some companies have adopted CM and what their drivers were and what benefits were realized Addresses economic and practical considerations, unlike many other technical books Emphasizes the practical aspects to give the reader the strategic imperative and technological depth to adopt and implement these technologies Highlights the "why" and the "how", focusing on the need analysis and process modeling and process analytical technologies