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Positive Selection In The Human Lineage Across Time Scales
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Book Synopsis In the Light of Evolution by : National Academy of Sciences
Download or read book In the Light of Evolution written by National Academy of Sciences and published by . This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.
Book Synopsis Evolution after Gene Duplication by : Katharina Dittmar
Download or read book Evolution after Gene Duplication written by Katharina Dittmar and published by John Wiley & Sons. This book was released on 2011-06-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox, globins, olfactory receptors and MHC (immune system) A complete post-genome treatment of the topic originally covered by Ohno's 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways Taps the significant increase in multi-gene family data that has resulted from comparative genomics Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.
Book Synopsis Multiplicity of Time Scales in Complex Systems by : Bernhelm Booss-Bavnbek
Download or read book Multiplicity of Time Scales in Complex Systems written by Bernhelm Booss-Bavnbek and published by Springer Nature. This book was released on 2024 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zusammenfassung: This highly interdisciplinary volume brings together a carefully curated set of case studies examining complex systems with multiple time scales (MTS) across a variety of fields: materials science, epidemiology, cell physiology, mathematics, climatology, energy transition planning, ecology, economics, sociology, history, and cultural studies. The book addresses the vast diversity of interacting processes underlying the behaviour of different complex systems, highlighting the multiplicity of characteristic time scales that are a common feature of many and showcases a rich variety of methodologies across disciplinary boundaries. Self-organizing, out-of-equilibrium, ever-evolving systems are ubiquitous in the natural and social world. Examples include the climate, ecosystems, living cells, epidemics, the human brain, and many socio-economic systems across history. Their dynamical behaviour poses great challenges in the pressing context of the climate crisis, since they may involve nonlinearities, feedback loops, and the emergence of spatial-temporal patterns, portrayed by resilience or instability, plasticity or rigidity; bifurcations, thresholds and tipping points; burst-in excitation or slow relaxation, and worlds of other asymptotic behaviour, hysteresis, and resistance to change. Chapters can be read individually by the reader with special interest in such behaviours of particular complex systems or in specific disciplinary perspectives. Read together, however, the case studies, opinion pieces, and meta-studies on MTS systems presented and analysed here combine to give the reader insights that are more than the sum of the book's individual chapters, as surprising similarities become apparent in seemingly disparate and unconnected systems. MTS systems call into question naïve perceptions of time and complexity, moving beyond conventional ways of description, analysis, understanding, modelling, numerical prediction, and prescription of the world around us. This edited collection presents new ways of forecasting, introduces new means of control, and - perhaps as the most demanding task - it singles out a sustainable description of an MTS system under observation, offering a more nuanced interpretation of the floods of quantitative data and images made available by high- and low-frequency measurement tools in our unprecedented era of information flows
Book Synopsis Evolution and Selection of Quantitative Traits by : Bruce Walsh
Download or read book Evolution and Selection of Quantitative Traits written by Bruce Walsh and published by Oxford University Press. This book was released on 2018-06-21 with total page 1504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.
Book Synopsis Admixture Dynamics, Natural Selection and Diseases in Admixed Populations by : Wenfei Jin
Download or read book Admixture Dynamics, Natural Selection and Diseases in Admixed Populations written by Wenfei Jin and published by Springer. This book was released on 2015-10-20 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
Book Synopsis The Mammals of Luzon Island by : Lawrence R. Heaney
Download or read book The Mammals of Luzon Island written by Lawrence R. Heaney and published by JHU Press. This book was released on 2016-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A beautifully illustrated guide to the complete mammalian biodiversity of the Philippines’ largest island. Revealing the astounding mammalian diversity found on the largest Philippine island, The Mammals of Luzon Island is a unique book that functions both as a field guide and study of tropical fauna. The book features 120 fully illustrated species profiles and shows how the mammals fit into larger questions related to evolution, ecology, and biogeography. Luzon’s stunning variety of mammals includes giant fruit-eating bats; other bats so small that they can roost inside bamboo stems; giant plant-eating rodents that look like, but are not, squirrels; shrews that weigh less than half an ounce; the rapidly disappearing Philippine warty pig; and the long-tailed macaque, Luzon’s only nonhuman primate. While celebrating Luzon’s remarkably rich mammal fauna, the authors also suggest conservation strategies for the many species that are under threat from a variety of pressures. Based on a century of accumulated data and fifteen years of intensive study, The Mammals of Luzon Island delivers a message that will appeal equally to scientists, conservationists, and ecologically minded travelers.
Book Synopsis Evolution, pathogenesis, host interactions and therapeutic strategies against monkeypox virus by : Saadullah Khattak
Download or read book Evolution, pathogenesis, host interactions and therapeutic strategies against monkeypox virus written by Saadullah Khattak and published by Frontiers Media SA. This book was released on 2023-11-01 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Statistical Population Genomics by : Julien Y Dutheil
Download or read book Statistical Population Genomics written by Julien Y Dutheil and published by . This book was released on 2020-10-08 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Book Synopsis Encyclopedia of AIDS by : Thomas J. Hope
Download or read book Encyclopedia of AIDS written by Thomas J. Hope and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Human Evolutionary Biology by : Michael P. Muehlenbein
Download or read book Human Evolutionary Biology written by Michael P. Muehlenbein and published by Cambridge University Press. This book was released on 2010-07-29 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide-ranging and inclusive text focusing on topics in human evolution and the understanding of modern human variation and adaptability.
Book Synopsis Adaptive Diversification by : Michael Doebeli
Download or read book Adaptive Diversification written by Michael Doebeli and published by Princeton University Press. This book was released on 2011-08-01 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the mechanisms driving biological diversity remains a central problem in ecology and evolutionary biology. Traditional explanations assume that differences in selection pressures lead to different adaptations in geographically separated locations. This book takes a different approach and explores adaptive diversification--diversification rooted in ecological interactions and frequency-dependent selection. In any ecosystem, birth and death rates of individuals are affected by interactions with other individuals. What is an advantageous phenotype therefore depends on the phenotype of other individuals, and it may often be best to be ecologically different from the majority phenotype. Such rare-type advantage is a hallmark of frequency-dependent selection and opens the scope for processes of diversification that require ecological contact rather than geographical isolation. Michael Doebeli investigates adaptive diversification using the mathematical framework of adaptive dynamics. Evolutionary branching is a paradigmatic feature of adaptive dynamics that serves as a basic metaphor for adaptive diversification, and Doebeli explores the scope of evolutionary branching in many different ecological scenarios, including models of coevolution, cooperation, and cultural evolution. He also uses alternative modeling approaches. Stochastic, individual-based models are particularly useful for studying adaptive speciation in sexual populations, and partial differential equation models confirm the pervasiveness of adaptive diversification. Showing that frequency-dependent interactions are an important driver of biological diversity, Adaptive Diversification provides a comprehensive theoretical treatment of adaptive diversification.
Book Synopsis Host and Microbe Adaptations in the Evolution of Immunity by : Larry J. Dishaw
Download or read book Host and Microbe Adaptations in the Evolution of Immunity written by Larry J. Dishaw and published by Frontiers Media SA. This book was released on 2019-12-31 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of metazoans has been accompanied by new interfaces with the microbial environment that include biological barriers and surveillance by specialized cell types. Increasingly complex organisms require increased capacities to confront pathogens, achieved by co-evolution of recognition mechanisms and regulatory pathways. Two distinct but interactive forms of immunity have evolved. Innate immunity, shared by all metazoans, is traditionally viewed as simple and non-specific. Adaptive immunity possesses the capacity to anticipate new infectious challenges and recall previous exposures; the most well-understood example of such a system, exhibited by lymphocytes of vertebrates, is based on somatic gene alterations that generate extraordinary specificity in discrimination of molecular structures. Our understanding of immune phylogeny over the past decades has tried to reconcile immunity from a vertebrate standpoint. While informative, such approaches cannot completely address the complex nature of selective pressures brought to bear by the complex microbiota (including pathogens) that co-exist with all metazoans. In recent years, comparative studies (and new technologies) have broadened our concepts of immunity from a systems-wide perspective. Unexpected findings, e.g., genetic expansions of innate receptors, high levels of polymorphism, RNA-based forms of generating diversity, adaptive evolution and functional divergence of gene families and the recognition of novel mediators of adaptive immunity, prompt us to reconsider the very nature of immunity. Even fundamental paradigms as to how the jawed vertebrate adaptive immune system should be structured for “optimal” recognition potential have been disrupted more than once (e.g., the discovery of the multicluster organization and germline joining of immunoglobulin genes in sharks, gene conversion as a mechanism of somatic diversification, absence of IgM or MHC II in certain teleost fishes). Mechanistically, concepts of innate immune memory, often referred to as “trained memory,” have been realized further, with the development of new discoveries in studies of epigenetic regulation of somatic lineages. Immune systems innovate and adapt in a taxon-specific manner, driven by the complexity of interactions with microbial symbionts (commensals, mutualists and pathogens). Immune systems are shaped by selective forces that reflect consequences of dynamic interactions with microbial environments as well as a capacity for rapid change that can be facilitated by genomic instabilities. We have learned that characterizing receptors and receptor interactions is not necessarily the most significant component in understanding the evolution of immunity. Rather, such a subject needs to be understood from a more global perspective and will necessitate re-consideration of the physical barriers that afford protection and the developmental processes that create them. By far, the most significant paradigm shifts in our understanding of immunity and the infection process has been that microbes no longer are considered to be an automatic cause or consequence of illness, but rather integral components of normal physiology and homeostasis. Immune phylogeny has been shaped not only by an arms race with pathogens but also perhaps by mutualistic interactions with resident microbes. This Research Topic updates and extends the previous eBook on Changing Views of the Evolution of Immunity and contains peer-reviewed submissions of original research, reviews and opinions.
Book Synopsis G Protein-Coupled Receptors by : Sandra Siehler
Download or read book G Protein-Coupled Receptors written by Sandra Siehler and published by Cambridge University Press. This book was released on 2010-09-30 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Introduction to Paleobiology and the Fossil Record by : Michael J. Benton
Download or read book Introduction to Paleobiology and the Fossil Record written by Michael J. Benton and published by John Wiley & Sons. This book was released on 2020-04-14 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview of the science of the history of life. Paleobiologists bring many analytical tools to bear in interpreting the fossil record and the book introduces the latest techniques, from multivariate investigations of biogeography and biostratigraphy to engineering analysis of dinosaur skulls, and from homeobox genes to cladistics. All the well-known fossil groups are included, including microfossils and invertebrates, but an important feature is the thorough coverage of plants, vertebrates and trace fossils together with discussion of the origins of both life and the metazoans. All key related subjects are introduced, such as systematics, ecology, evolution and development, stratigraphy and their roles in understanding where life came from and how it evolved and diversified. Unique features of the book are the numerous case studies from current research that lead students to the primary literature, analytical and mathematical explanations and tools, together with associated problem sets and practical schedules for instructors and students. New to this edition The text and figures have been updated throughout to reflect current opinion on all aspects New case studies illustrate the chapters, drawn from a broad distribution internationally Chapters on Macroevolution, Form and Function, Mass extinctions, Origin of Life, and Origin of Metazoans have been entirely rewritten to reflect substantial advances in these topics There is a new focus on careers in paleobiology
Book Synopsis The Network of Life by : David P. Mindell
Download or read book The Network of Life written by David P. Mindell and published by Princeton University Press. This book was released on 2024-06-04 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why evolution is like a network, not a family tree—and why it matters for understanding the health of all living things In The Network of Life, David Mindell explains why the conventional narrative of evolution needs to evolve. Ever since Darwin, evolution has largely been thought to work like a family tree in which species are related through a series of branching events. But, today, a growing knowledge of the ways species share genetic materials in a process known as horizontal evolution has revealed that evolution is actually a network of shared genealogy in which species are more interconnected than previously thought. In this book, Mindell presents this new narrative of life’s evolution and its profound implications for all life on Earth. The Network of Life describes the drivers of horizontal evolution—interbreeding and genetic recombination, the merger of species, horizontal gene transfer, and coevolution. The network view of evolution that emerges supports a new symbiotic theory of health, which holds that the future health of humans, other species, and our shared environments depends on evolution and adaptation across life’s network. Difficult times lie ahead for many of Earth’s species as climates and habitats transform. At the same time, new and altered life-forms are arising and spreading in association with human activities. We are also learning to reshape and create life by mimicking the mechanisms of horizontal evolution, and we are coevolving with technology as we enhance our bodies, brains, and life spans. The Network of Life shows why and how increasing our knowledge of horizontal evolution can provide critical lessons as we navigate our looming challenges.
Book Synopsis Genomes, Evolution, and Culture by : Rene J. Herrera
Download or read book Genomes, Evolution, and Culture written by Rene J. Herrera and published by John Wiley & Sons. This book was released on 2016-03-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines recent information and discoveries in the field of human molecular biology and human molecular evolution. It provides an interdisciplinary approach drawing together data from various diverse disciplines to address both the more classical anthropological content and the current more contemporary molecular focus of courses. Chapters include a history of human evolutionary genetics; the human genome structure and function; population structure and variability; gene and genomic dynamics; culture; health and disease; bioethics; future.
