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Positioning Inventory In Clinical Trial Supply Chains
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Book Synopsis Positioning Inventory in Clinical Trial Supply Chains by : Adam Fleischhacker
Download or read book Positioning Inventory in Clinical Trial Supply Chains written by Adam Fleischhacker and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of slow patient recruitment and high patient costs in the United States, clinical trials are increasingly going global. While recruitment efforts benefit from a larger global footprint, the supply chain has to work harder at getting the right drug supply, to the right place, at the right time. Certain clinical trial supply chains, especially those supplying biologics, have a combination of unique attributes that have yet to be addressed by existing supply chain models. These attributes include a fixed patient horizon, an inflexible supply process, a unique set of service-level requirements, and an inability to transfer drug supplies among testing sites. In this paper, we provide a new class of multi-echelon inventory models to address these unique aspects. The resulting mathematical program is a nonlinear integer programming problem with chance constraints. Despite this complexity, we develop a solution method that transforms the original formulation into a linear integer equivalent. By analyzing special cases and through numerical study of both real-life and simulated examples, we develop novel insights into inventory positioning and the cost drivers in clinical trial supply chains.
Book Synopsis An Investigation of Clinical Trial Supply Chains by : Adam Fleischhacker
Download or read book An Investigation of Clinical Trial Supply Chains written by Adam Fleischhacker and published by . This book was released on 2009 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation investigates production and inventory decisions made within clinical trial supply chains in order to reduce drug supply costs. By investigating the SEC filings of public companies, we find that drug supply costs frequently account for a significant portion of pharmaceutical companies' R & D spending. To unlock value tied up in clinical trial supply chains, three unique aspects of clinical trial supply chains are explored and associated supply chain decisions are optimized. The first unique factor that differentiates the supply chains for clinical trials is the risk of failure, meaning that the investigational drug is proven unsafe or ineffective during human testing. Upon failure, any unused inventory is essentially wasted and needs to be destroyed. We explore the effect of this failure on production planning decisions and find the planner's decision to be a balancing act between waste and destruction costs versus production inefficiency. To optimally achieve this balance, we generalize the Wagner-Whitin model to incorporate the risk of failure. A second unique aspect of clinical trials is that demand can go from being quite unpredictable to fully predictable during the course of a trial. To take advantage of this demand learning, intra-trial batches can be produced, but at the expense of scale economies. Using various learning curves, we study this balance between learning and economies of scale in a finite horizon inventory model with fixed production costs and two production options: the pre-trial batch and the intra-trial batch. We characterize the optimal policy for both production batches in regards to optimally scheduling and sizing production. Lastly, we analyze the distribution networks of global clinical trial supply chains. Unique to these networks is their temporary existence; trials are ceased after patient enrollment goals are met. To manage these networks, we present a new class of multi-echelon inventory models to make stock positioning decisions, develop algorithms to identify lower and upper bounds on the optimal objective function for this new class, and leverage those algorithms to provide insights into optimal supply chain configurations.
Book Synopsis Supply Chain Planning for Clinical Trials by : Ryan Mills
Download or read book Supply Chain Planning for Clinical Trials written by Ryan Mills and published by John Wiley & Sons. This book was released on 2024-08-13 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ensure your clinical trial supply chain is running smoothly with this practical guide Clinical trials are a critical part of the pharmaceutical development process. These trials cannot proceed without timely and regular receipt of the drugs being tested, which can prove a challenge for drug manufacturers who have not yet established the structures required to produce quality-controlled specimens of the drug at scale. Managing supply chains of pre-production drugs for clinical trials is therefore an essential component of drug development. Supply Chain Planning for Clinical Trials offers a practical introduction to this process for researchers and industry professionals. Beginning with the basics of clinical trial supply chain management, it proceeds step by step through all aspects of demand and supply planning for clinical trials. The result is a thorough overview that also offers practical examples of how to plan supply for clinical trials. Supply Chain Planning for Clinical Trials readers will also find: Tools for minimizing risk and expense by optimizing the relationship between supply and demand Detailed discussion of topics including quality and regulatory considerations and the business processes that support clinical trial supply chain management Spreadsheet-based models to illustrate key concepts, adaptable to the readers’ specific scenarios Supply Chain Planning for Clinical Trails is ideal for pharmaceutical industry professionals involved in clinical trial supply planning, as well as academics and researchers interested in the pharmaceutical industry and its logistics.
Book Synopsis Inventory and Production Management in Supply Chains by : Edward A. Silver
Download or read book Inventory and Production Management in Supply Chains written by Edward A. Silver and published by CRC Press. This book was released on 2016-12-19 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by a team of experts, the new edition of this bestseller presents practical techniques for managing inventory and production throughout supply chains. It covers the current context of inventory and production management, replenishment systems for managing individual inventories within a firm, managing inventory in multiple locations and firms, and production management. The book presents sophisticated concepts and solutions with an eye towards today’s economy of global demand, cost-saving, and rapid cycles. It explains how to decrease working capital and how to deal with coordinating chains across boundaries.
Book Synopsis Strategic Inventory Placement in Multi-echelon Supply Chains by : Tor Ivar Schoenmeyr
Download or read book Strategic Inventory Placement in Multi-echelon Supply Chains written by Tor Ivar Schoenmeyr and published by . This book was released on 2008 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: (cont.) In a case study, we obtained data from the supply chain of an electronic test system, as well as characterized the forecasting process. We found that incorporating the forecast process led to 25% reduction of safety stocks.
Book Synopsis Industrial Engineering and Operations Management by : João Carlos Gonçalves dos Reis
Download or read book Industrial Engineering and Operations Management written by João Carlos Gonçalves dos Reis and published by Springer Nature. This book was released on 2024-01-21 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings volume gathers selected, blinded peer-reviewed contributions presented at the XXIX International Joint Conference on Industrial Engineering and Operations Management (IJCIEOM), held in Lisbon, Portugal, from June 28th to 30th, 2023. This volume focuses especially on the applications of Industrial Engineering and Operations Management for research and practice. It includes relevant information for academics since most of the chapters focus on real-world case studies and systematic reviews. It also provides valuable insights for professionals in the industrial sector by presenting solutions to complex industrial challenges. The 2023 iteration of the IJCIEOM conference had the theme "Developing resilience in Industrial Engineering and Operations Management" and aimed to analyze the resilience of supply chains in the post-COVID-19 era. The works published in this volume focus on how Digital Transformation (DX) and Artificial Intelligence (AI) have made the manufacturing and service industry more resistant to VUCA elements (i.e., volatile, uncertain, complex, and ambiguous). Regarding DX and AI, the research specifically focused on supply chain management, project management, and Industry 4.0. Other studies explore how industrial engineering incorporated innovative and technological concepts into service and product operations. Overall, this volume provides a valuable resource for researchers and practitioners alike as it presents numerous relevant contributions in identifying new challenges and opportunities for industrial engineering and operations management. This conference was sponsored by renowned international industry engineering associations, particularly the American Society for Engineering Management (ASEM), the Institute of Industrial & Systems Engineers (IISE), and the Asociación para el Desarrollo de la Ingeniería de Organización (ADINGOR).
Book Synopsis Supply Chain Management in the Drug Industry by : Hedley Rees
Download or read book Supply Chain Management in the Drug Industry written by Hedley Rees and published by John Wiley & Sons. This book was released on 2011-04-06 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between practitioners of supply-chain management and pharmaceutical industry experts. It aims to help both these groups understand the different worlds they live in and how to jointly contribute to meaningful improvements in supply-chains within the globally important pharmaceutical sector. Scientific and technical staff must work closely with supply-chain practitioners and other relevant parties to help secure responsive, cost effective and risk mitigated supply chains to compete on a world stage. This should not wait until a drug has been registered, but should start as early as possible in the development process and before registration or clinical trials. The author suggests that CMC (chemistry manufacturing controls) drug development must reset the line of sight – from supply of drug to the clinic and gaining a registration, to the building of a patient value stream. Capable processes and suppliers, streamlined logistics, flexible plant and equipment, shorter cycle times, effective flow of information and reduced waste. All these factors can and should be addressed at the CMC development stage.
Book Synopsis Strategic Positioning of Inventory in Supply Chain Models by : Shreyas R. Bhat
Download or read book Strategic Positioning of Inventory in Supply Chain Models written by Shreyas R. Bhat and published by . This book was released on 2002 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Positioning of Inventory in Supply Chain Using Simulation Modeling by : Satyendra Kumar Sharma
Download or read book Positioning of Inventory in Supply Chain Using Simulation Modeling written by Satyendra Kumar Sharma and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Inventory costs are the major costs in production costs, so in order to gain global competitive advantage and to obtain a stable position in the market for one's product, one needs to reduce the inventory in the entire supply chain rather than optimizing at a single location. This study focuses on reducing the inventory in a three-stage model with two echelon supply chain considering two identical retailers with one distribution center and one manufacturer. The study considered continuous review time in the inventory replenishment policies and also took single product into consideration. Arena is one of the most sophisticated simulation software available. In this model, simulation is performed using arena simulation for optimizing the inventory. Moreover it identifies the reorder point and reorder quantity in order to optimize the inventory at both the echelons in the supply chain.
Book Synopsis The Definitive Guide to Inventory Management by : CSCMP
Download or read book The Definitive Guide to Inventory Management written by CSCMP and published by Pearson Education. This book was released on 2014-03-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master and apply both the technical and behavioral skills you need to succeed in any inventory management role or function! Now, there’s an authoritative and comprehensive guide to best-practice inventory management in any organization. Authored by world-class experts in collaboration with the Council of Supply Chain Management Professionals (CSCMP), this text illuminates planning, organizing, controlling, directing, motivating and coordinating all the activities used to efficiently control product flow. The Definitive Guide to Inventory Management covers long-term strategic decisions; mid-term tactical decisions; and even short-term operational decisions. Topics discussed include: Basic inventory management goals, roles, concepts, purposes, and terminology Key inventory management elements, processes, and interactions Principles/strategies for establishing efficient and effective inventory flows Using technology in inventory planning and management New approaches to inventory reduction: postponement, vendor-managed inventories, cross-docking, and quick response systems Trade-offs between inventory and transportation costs, including carrying costs Requirements and challenges of global inventory management Best practices, metrics, and frameworks for assessing inventory management performance
Book Synopsis Supply Chain Engineering and Logistics Handbook by : Erick C. Jones
Download or read book Supply Chain Engineering and Logistics Handbook written by Erick C. Jones and published by CRC Press. This book was released on 2019-11-12 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook begins with the history of Supply Chain (SC) Engineering, it goes on to explain how the SC is connected today, and rounds out with future trends. The overall merit of the book is that it introduces a framework similar to sundial that allows an organization to determine where their company may fall on the SC Technology Scale. The book will describe those who are using more historic technologies, companies that are using current collaboration tools for connecting their SC to other global SCs, and the SCs that are moving more towards cutting edge technologies. This book will be a handbook for practitioners, a teaching resource for academics, and a guide for military contractors. Some figures in the eBook will be in color. Presents a decision model for choosing the best Supply Chain Engineering (SCE) strategies for Service and Manufacturing Operations with respect to Industrial Engineering and Operations Research techniques Offers an economic comparison model for evaluating SCE strategies for manufacturing outsourcing as opposed to keeping operations in-house Demonstrates how to integrate automation techniques such as RFID into planning and distribution operations Provides case studies of SC inventory reductions using automation from AIT and RFID research Covers planning and scheduling, as well as transportation and SC theory and problems
Book Synopsis Handbook of Healthcare Analytics by : Tinglong Dai
Download or read book Handbook of Healthcare Analytics written by Tinglong Dai and published by John Wiley & Sons. This book was released on 2018-10-16 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can analytics scholars and healthcare professionals access the most exciting and important healthcare topics and tools for the 21st century? Editors Tinglong Dai and Sridhar Tayur, aided by a team of internationally acclaimed experts, have curated this timely volume to help newcomers and seasoned researchers alike to rapidly comprehend a diverse set of thrusts and tools in this rapidly growing cross-disciplinary field. The Handbook covers a wide range of macro-, meso- and micro-level thrusts—such as market design, competing interests, global health, personalized medicine, residential care and concierge medicine, among others—and structures what has been a highly fragmented research area into a coherent scientific discipline. The handbook also provides an easy-to-comprehend introduction to five essential research tools—Markov decision process, game theory and information economics, queueing games, econometric methods, and data science—by illustrating their uses and applicability on examples from diverse healthcare settings, thus connecting tools with thrusts. The primary audience of the Handbook includes analytics scholars interested in healthcare and healthcare practitioners interested in analytics. This Handbook: Instills analytics scholars with a way of thinking that incorporates behavioral, incentive, and policy considerations in various healthcare settings. This change in perspective—a shift in gaze away from narrow, local and one-off operational improvement efforts that do not replicate, scale or remain sustainable—can lead to new knowledge and innovative solutions that healthcare has been seeking so desperately. Facilitates collaboration between healthcare experts and analytics scholar to frame and tackle their pressing concerns through appropriate modern mathematical tools designed for this very purpose. The handbook is designed to be accessible to the independent reader, and it may be used in a variety of settings, from a short lecture series on specific topics to a semester-long course.
Book Synopsis Optimizing Safety Stock Placement in General Network Supply Chains by : Ekaterina Lesnaia
Download or read book Optimizing Safety Stock Placement in General Network Supply Chains written by Ekaterina Lesnaia and published by . This book was released on 2004 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amount of safety stock to hold at each stage in a supply chain is an important problem for a manufacturing company that faces uncertain demand and needs to provide a high level of service to its customers. The amount of stock held should be small to minimize holding and storage costs while retaining the ability to serve customers on time and satisfy most, if not all, of the demand. This thesis analyzes this problem by utilizing the framework of deterministic service time models and provides an algorithm for safety stock placement in general-network supply chains. We first show that the general problem is NP-hard. Next, we develop several conditions that characterize an optimal solution of the general-network problem. We find that we can identify all possible candidates for the optimal service times for a stage by constructing paths from the stage to each other stage in the supply chain. We use this construct, namely these paths, as the basis for a branch and bound algorithm for the general-network problem. To generate the lower bounds, we create and solve a spanning-tree relaxation of the general-network problem. We provide a polynomial algorithm to solve these spanning tree problems. We perform a set of computational experiments to assess the performance of the general-network algorithm and to determine how to set various parameters for the algorithm. In addition to the general network case, we consider two-layer network problems. We develop a specialized branch and bound algorithm for these problems and show computationally that it is more efficient than the general-network algorithm applied to the two-layer networks.
Book Synopsis Demand-Driven Inventory Optimization and Replenishment by : Robert A. Davis
Download or read book Demand-Driven Inventory Optimization and Replenishment written by Robert A. Davis and published by John Wiley & Sons. This book was released on 2016-01-19 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remove built-in supply chain weak points to more effectively balance supply and demand Demand-Driven Inventory Optimization and Replenishment shows how companies can support supply chain metrics and business initiatives by removing the weak points built into their inventory systems. Beginning with a thorough examination of Just in Time, Efficient Consumer Response, and Collaborative Forecasting, Planning, and Replenishment, this book walks you through the mathematical shortcuts set up in your management system that prevent you from attaining supply chain excellence. This expanded second edition includes new coverage of inventory performance, business verticals, business initiatives, and metrics, alongside case studies that illustrate how optimized inventory and replenishment delivers results across retail, high-tech, men's clothing, and food sectors. Inventory optimization allows you to avoid out-of-stock situations without impacting the bottom line with excessive inventory maintenance. By keeping just the right amount of inventory on hand, your company is better able to meet demand without sacrificing the cost-effectiveness of other supply chain strategies. The trick, however, is determining "just the right amount"—and this book provides the background and practical guidance you need to do just that. Examine the major supply chain strategies of the last 30 years Remove the shortcuts that prohibit supply chain excellence Optimize your supply/demand balance in any vertical Overcome systemic weaknesses to strengthen the bottom line Inventory optimization is benefitting companies around the world, as exemplified here by case studies involving Matas, PWT, Wistron, and Amway. When inefficiencies are built into the system, it's only smart business to identify and remove them—and implement a new streamlined process that runs like a well-oiled machine. Demand-Driven Inventory Optimization and Replenishment is an essential resource for exceptional supply chain management.
Book Synopsis A Supply Chain Logistics Program for Warehouse Management by : David E. Mulcahy
Download or read book A Supply Chain Logistics Program for Warehouse Management written by David E. Mulcahy and published by CRC Press. This book was released on 2008-05-28 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: A well-planned, well-structured warehouse management system (WMS) offers significant advantages to an organization, particularly in its ability to make warehouse operations more efficient, more cost effective, and more responsive. A Supply Chain Logistics Program for Warehouse Management details the concepts, applications, and practices n
Book Synopsis Supply Chain Planning by : Hans-Otto Günther
Download or read book Supply Chain Planning written by Hans-Otto Günther and published by Springer Science & Business Media. This book was released on 2009-03-05 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, supply chain planning has emerged as one of the most challenging problems in the industry. As a consequence, the planning focus is shifting from the management of plant-speci?c operations to a holistic view of the various logistics and productionstages, that is an approach in which suppliers, productionplants and customers are considered as constituents of an integrated network. A major dr- ing force behind this development lies in the globalization of the world economy, which has facilitated the co-operation between different partners working together in world-wide logistics networks. Hence, considerable cost savings can be gained from optimizing the structure and the operations of complex supply networks li- ing plants, suppliers, distribution centres and customers. Consequently, to improve the performance of the entire logistic chain, more sophisticated planning systems and more effective decision support are needed. Clearly, successful applications of supply chain management have driven the development of advanced planning systems (APS), which are concerned with s- porting decision-making activities at the strategic, tactical and operational decision level. These software packages basically rely on the application of quantitative methods, which are used to model the underlying complex decision problems c- sidering the limited availability of resources and the need to react on time to customer orders. The core module at the mid-term level of APS comprises op- ational supply chain planning. In many industries, productionstages are assigned to differentplantsand distribution centreshave been established at geographicallyd- persed locations.
Book Synopsis An Exploration of the Global Clinical Trial Ancillary Supply Chain and the Drivers of Success During the Pre, In, and Post Phases by : Joanne DeFusco Santomauro
Download or read book An Exploration of the Global Clinical Trial Ancillary Supply Chain and the Drivers of Success During the Pre, In, and Post Phases written by Joanne DeFusco Santomauro and published by . This book was released on 2019 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, academic and practitioner research on clinical trial supply chains focused on identifying innovative models and solutions in providing comparator and study drugs to global clinical sites. Due to the expansion of outsourcing efforts by pharmaceutical organizations, newly enacted global laws and regulations, and the continued push to increase the speed at which new drugs gain market approval, a new and extremely complex global "ancillary" supply chain has emerged. This manuscript focuses on the clinical trial ancillary supply chain: a supply chain that develops the end-to-end process resulting in the distribution and quality management of medical products and devices, consumable supplies, and patient giveaways to global clinical trial sites. Based on a series of quantitative analyses, this research assesses the influence of the customer, country, and product on the overall success of the supply chain. Three factors emerged from these analyses as having a direct influence on the clinical trial ancillary supply chain; product characteristics, magnitude (components of size), and stability (components of changes in scope). Part II of this research sought to understand the success of the supply chain by evaluating the moderating effects of knowledge management, organizational culture, therapeutic area, and type of shipment. Assessments of 444 customer and server surveys yielded components of a sense of shared culture, shared communication and transparency, and feeling educated and supported. Quantitative data analysis supported that these components had a moderating influence on success during the pre-trial phase of the supply chain. These research findings provide insight into the internal and external drivers of success within the complex and emergent clinical trial supply chain - a supply chain that helps pharmaceutical organizations bring innovative therapies to market and most important, those patients in need of such therapies to improve or even save their lives.
