Porcupine Dependent Wnt Signaling In Endometriosis Development And Maintenance

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Porcupine-dependent Wnt Signaling in Endometriosis Development and Maintenance

Author : Roxane Assaf
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis Porcupine-dependent Wnt Signaling in Endometriosis Development and Maintenance by : Roxane Assaf

Download or read book Porcupine-dependent Wnt Signaling in Endometriosis Development and Maintenance written by Roxane Assaf and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Endometriosis is a debilitating condition that affects over 10% of women and is characterized by the presence of endometrial tissue outside the uterus, most often in the pelvic cavity. It is thought to arise through retrograde menstruation where endometrial tissue is displaced into the peritoneal cavity where it implants and develops into lesions that can cause inflammation, tissue scarring, and it can subsequently result in pelvic pain in response to estrogen cycling. Although this disease affects a large number of women and impacts their quality of life, its underlying molecular mechanisms are not understood. Wnt signaling plays a role in uterine development and function. Specifically, Porcupine-dependent Wnt signaling is needed for the maintenance of endometrial glands and stromal proliferation. Some evidence suggests that Wnt signaling is aberrantly activated in patients' endometriosis lesions, but the pattern of its activation has not been established. We hypothesized that Porcupine-dependent Wnt signaling plays a role in the development and maintenance of endometriosis, and that it could be a potential therapeutic target. Using the auto-transplantation mouse model and a Tcf/Lef-LacZ construct, we characterized canonical Wnt signaling activation in endometriosis in vivo. We found that canonical Wnt signaling was activated in the endometrial epithelium of these endometriotic lesions. To assess the role of canonical Wnt signaling, reproductive tract-specific conditional Porcupine mutant female mice which do not secrete Wnt ligands in the uterus were used. No Wnt signaling activation was found in the lesions of Porcupine mutant, suggesting that in control mice, Wnt signaling is auto-activated by ligands that are secreted by the lesions themselves, and not by surrounding tissue. Additionally, in these mutants, endometriotic lesions developed with increased growth, which was not due to differences in cell proliferation rates but was rather associated with somewhat increased fibrosis. A similar result was observed when we treated wild-type mice with IWP-2, a Porcupine inhibitor, although this compound also resulted in lower levels of endometriosis-associated pain. Our findings therefore suggest that Porcupine-dependent Wnt signaling is activated in endometriosis and affects lesion size and endometriosis-associated pain." --

Porcupine-dependant Wnt Signaling is Required for Proper Uterine Development and Function

Author : Omar Farah
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Porcupine-dependant Wnt Signaling is Required for Proper Uterine Development and Function by : Omar Farah

Download or read book Porcupine-dependant Wnt Signaling is Required for Proper Uterine Development and Function written by Omar Farah and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The work presented in this thesis provides new insights into Porcupine function and how it affects reproductive outcomes. Since Porcupine function is a precursor to Wnt secretion and subsequent signaling, we have also shed light on the mechanism by which Porcupine-dependent Wnt signaling is controlling various reproductive processes. The work within the three manuscripts has revealed a role for porcupine in adenogenesis, stromal maintenance, luminal closure and decidualization. Briefly, we first generated and assessed the phenotype of a Porcupine conditional mutant in the entire female reproductive tract using a LoxP system, where the Cre recombinase is driven under the progesterone receptor (Chapter 2: Manuscript I). We have observed that deletion of Porcupine within the entire female reproductive tract allows for the development of endometrial glands postnatally, but then these same glands are lost during adulthood. Furthermore, a decrease in stromal proliferation leads to a very small stromal compartment. These females were infertile, despite being able to produce viable embryos after fertilization. Since porcupine mutant females are still responsive to exogenously supplemented Wnts, we were able to establish a system by which we could assess single Wnt contribution. By injecting recombinant Wnts into the lumen, we were able to establish that WNT7a is sufficient to drive adenogenesis in adult females, while WNT5a increases stromal proliferation in order to maintain stromal size. In Chapter 3: Manuscript II, we assessed the phenotype of aberrant Wnt signaling by utilizing the fact that porcupine is located on the X-chromosome. Due to random X inactivation, Porcupine heterozygous females would become natural mosaics upon excision of the Porcupine locus by the Cre-recombinase. We observed a wide range of phenotypes that spanned across a spectrum from wildtype looking uteri, to ones that presented with enlarged endometrial glands. By using a GFP reporter on the wildtype X-chromosome, we were able to correlate the enlarged gland phenotype to a mostly Porcupine mutant stroma within the uterus; suggesting that stromal Wnt function is required to regulate endometrial gland size. In the final part of this thesis (Chapter 4: Manuscript III), we studied the affects of Porcupine ablation only in the uterine epithelium; only preventing the secretion of epithelial-derived WNTs. Interestingly, these females were infertile despite the fact that adenogenesis was not disrupted. These females exhibited defects in luminal closure, decidualization and canonical Wnt signaling at implantation. Microarray analysis of the uterine transcriptome during the window of implantation has revealed deregulation of both Wnt and Notch signaling pathways after epithelial ablation of Porcupine. The work presented in this thesis has revealed exciting new aspects of porcupine-dependent Wnt signaling in adenogenesis, stroma maintenance, luminal closure and decidualization." --

Endometrial Gene Expression

Author : Joanne Kwak-Kim
Publisher : Springer Nature
ISBN 13 : 3030285847
Total Pages : 220 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Endometrial Gene Expression by : Joanne Kwak-Kim

Download or read book Endometrial Gene Expression written by Joanne Kwak-Kim and published by Springer Nature. This book was released on 2019-11-08 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.

Regulatory Networks in Stem Cells

Author : Vinagolu K. Rajasekhar
Publisher : Springer Science & Business Media
ISBN 13 : 1603272275
Total Pages : 590 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Regulatory Networks in Stem Cells by : Vinagolu K. Rajasekhar

Download or read book Regulatory Networks in Stem Cells written by Vinagolu K. Rajasekhar and published by Springer Science & Business Media. This book was released on 2009-03-04 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals of developmental biology.

The Human Endometrium

Author : Carlo Bulletti
Publisher :
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Human Endometrium by : Carlo Bulletti

Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.

Stem Cells in Human Reproduction

Author : Carlos Simón
Publisher : CRC Press
ISBN 13 : 1841847291
Total Pages : 274 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Stem Cells in Human Reproduction by : Carlos Simón

Download or read book Stem Cells in Human Reproduction written by Carlos Simón and published by CRC Press. This book was released on 2009-09-18 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following a successful first edition, this new book updates the revolutionary advances in stem cell science that may potentially impact human reproductive medicine. The contents cover the production and regeneration of female and male germ cells, trophoblasts and endometrium from human embryonic and adult stem cells. New developments in hESC d

Molecular Research of Endometrial Pathophysiology

Author : Paola Viganò
Publisher : MDPI
ISBN 13 : 3039214950
Total Pages : 378 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Molecular Research of Endometrial Pathophysiology by : Paola Viganò

Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by MDPI. This book was released on 2019-10-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]

Hype or Hope: New Frontiers in Endometrial Research

Author : Madhuri S. Salker
Publisher : Frontiers Media SA
ISBN 13 : 2889745228
Total Pages : 265 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Hype or Hope: New Frontiers in Endometrial Research by : Madhuri S. Salker

Download or read book Hype or Hope: New Frontiers in Endometrial Research written by Madhuri S. Salker and published by Frontiers Media SA. This book was released on 2022-02-25 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ovarian Cancers

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309380499
Total Pages : 397 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Ovarian Cancers by : National Academies of Sciences, Engineering, and Medicine

Download or read book Ovarian Cancers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Molecular Genetics of Endometrial Carcinoma

Author : Lora Hedrick Ellenson
Publisher : Springer
ISBN 13 : 3319431390
Total Pages : 284 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Molecular Genetics of Endometrial Carcinoma by : Lora Hedrick Ellenson

Download or read book Molecular Genetics of Endometrial Carcinoma written by Lora Hedrick Ellenson and published by Springer. This book was released on 2016-12-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

Endometrial Gene Expression

Author : Joanne Kwak-Kim
Publisher : Springer
ISBN 13 : 9783030285869
Total Pages : 0 pages
Book Rating : 4.2/5 (858 download)

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Book Synopsis Endometrial Gene Expression by : Joanne Kwak-Kim

Download or read book Endometrial Gene Expression written by Joanne Kwak-Kim and published by Springer. This book was released on 2020-11-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.

Human Embryonic Stem Cells

Author : Arlene Chiu
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Embryonic Stem Cells by : Arlene Chiu

Download or read book Human Embryonic Stem Cells written by Arlene Chiu and published by Springer Science & Business Media. This book was released on 2003-08 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

Handbook of Gynecology

Author : Donna Shoupe
Publisher : Springer Nature
ISBN 13 : 3031148819
Total Pages : 1295 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Handbook of Gynecology by : Donna Shoupe

Download or read book Handbook of Gynecology written by Donna Shoupe and published by Springer Nature. This book was released on 2024-01-07 with total page 1295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive, up-to-date reference on general and subspecialty gynecology. Covering all aspects of gynecology commonly encountered in day-to-day practice, this exhaustive and fully updated new edition provides a practical, one-stop reference work for clinicians working in the field. This carefully-designed volume includes ten sections, beginning with comprehensive coverage of office-based gynecology, and continuing on to present disease processes and management information by patient age group. Each chapter includes background information, current recommendations for screening, diagnostic criteria, common and uncommon associated problems, approach to diagnosis, summary of treatment options, and an overview of ICD-10 codes for specific diagnoses. Importantly, many areas that are covered in the handbook as subspecialty problems are pertinent and important information to many of the general practitioners who handle and develop some expertise in these areas. These include ovulation induction, medical management of incontinence, management of abnormal Pap smears, and work-up of abnormal bleeding. The handbook concludes with an easy-to-navigate presentation of minimally-invasive operations, surgical procedures, neoplasms, and pathology. Advantages and risks associated with management of particular diseases are covered, along with multiple tips for avoiding complications. This second edition is fully updated. With extensive updates on cervical cancer screening, pelvic organ prolapse, and more, many chapters will be completely rewritten to reflect the latest guidelines, procedures, and methods of care in women’s health. The text additionally includes two new chapters, covering the impact of COVID on gynecology care, and the work-up and surgical management of chronic pelvic pain. This is an ideal guide for practicing gynecologists, family and internal medicine physicians, physician assistants, nurse practitioners, fellows, residents, medical students, and all women’s health care providers.

Mesenchymal Stem Cell Derived Exosomes

Author : Yaoliang Tang
Publisher : Academic Press
ISBN 13 : 0128004975
Total Pages : 287 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mesenchymal Stem Cell Derived Exosomes by : Yaoliang Tang

Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Temporomandibular Disorders

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309670489
Total Pages : 427 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Temporomandibular Disorders by : National Academies of Sciences, Engineering, and Medicine

Download or read book Temporomandibular Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-01 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.

Physiologic and Pathologic Angiogenesis

Author : Dan Simionescu
Publisher : BoD – Books on Demand
ISBN 13 : 9535130234
Total Pages : 466 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Physiologic and Pathologic Angiogenesis by : Dan Simionescu

Download or read book Physiologic and Pathologic Angiogenesis written by Dan Simionescu and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Textbook of Clinical Embryology

Author : Kevin Coward
Publisher : Cambridge University Press
ISBN 13 : 110727625X
Total Pages : 408 pages
Book Rating : 4.1/5 (72 download)

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Book Synopsis Textbook of Clinical Embryology by : Kevin Coward

Download or read book Textbook of Clinical Embryology written by Kevin Coward and published by Cambridge University Press. This book was released on 2013-10-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.