Plasticity Of The Developing Visual Cortex In Normal And Mutant Mice

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Tau oligomers

Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Tau oligomers by : Jesus Avila

Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.

Plasticity of the Developing Visual Cortex in Normal and Mutant Mice

Author : Joshua A. Gordon
Publisher :
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.:/5 (66 download)

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Book Synopsis Plasticity of the Developing Visual Cortex in Normal and Mutant Mice by : Joshua A. Gordon

Download or read book Plasticity of the Developing Visual Cortex in Normal and Mutant Mice written by Joshua A. Gordon and published by . This book was released on 1995 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neural Plasticity and Memory

Author : Federico Bermudez-Rattoni
Publisher : CRC Press
ISBN 13 : 1420008412
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neural Plasticity and Memory by : Federico Bermudez-Rattoni

Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Developmental Psychopathology, Volume 2

Author : Dante Cicchetti
Publisher : John Wiley & Sons
ISBN 13 : 0470048190
Total Pages : 896 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Developmental Psychopathology, Volume 2 by : Dante Cicchetti

Download or read book Developmental Psychopathology, Volume 2 written by Dante Cicchetti and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Psychopathology, Second Edition, contains in three volumes the most complete and current research on every aspect of developmental psychopathology. This seminal reference work features contributions from national and international expert researchers and clinicians who bring together an array of interdisciplinary work to ascertain how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns and the pathways by which the same developmental outcomes may be achieved. This volume addresses theoretical perspectives and methodological.

Development of the Visual System

Author : Retina Research Foundation (U.S.). Symposium
Publisher : MIT Press
ISBN 13 : 9780262121545
Total Pages : 330 pages
Book Rating : 4.1/5 (215 download)

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Book Synopsis Development of the Visual System by : Retina Research Foundation (U.S.). Symposium

Download or read book Development of the Visual System written by Retina Research Foundation (U.S.). Symposium and published by MIT Press. This book was released on 1991 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of the Visual System presents a selection of current studies that clearly illustrate principles of visual system development. These range from retinal development in fish and frogs to the effects of abnormal visual experience on the primary visual cortex of the cat. The book is unique in addressing four specific and fundamental aspects of development: cell lineage and cell fate, specificity and targeting of axons, specification of visual cortex, and correlates of the critical period. Encompassing technical advances in cellular and molecular biology and in video imaging and microscopy, contributions in each of these areas provide new information at the cellular and molecular levels to complement the now classic descriptions of visual development previously available at the level of neural systems.ContributorsKaren L. Allendoerfer, David M. Altshuler, Antonella Antonini, Seymour Benzer, Edward M. Callaway, Constance L. Cepko, Hollis T. Cline, Max S. Cynader, N. W. Daw, Scott E. Fraser, K. Fox, Eckhard Friauf, Anirvan Ghosh, R. W. Guillery, William A. Harris, Christine E. Holt, Lawrence C. Katz, Susan McConnell, Pamela A. Raymond, Thomas A. Reh, Carla J. Shatz, Michael P. Stryker, Claudia A. 0. Stuermer, Mriganka Sur, David L. Turner, T. N. Wiesel

Molecular Substrates of Plasticity in the Developing Visual Cortex

Author : Sharif Taha
Publisher :
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (82 download)

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Book Synopsis Molecular Substrates of Plasticity in the Developing Visual Cortex by : Sharif Taha

Download or read book Molecular Substrates of Plasticity in the Developing Visual Cortex written by Sharif Taha and published by . This book was released on 2001 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cognitive Plasticity in Neurologic Disorders

Author : Joseph I. Tracy
Publisher : Oxford University Press, USA
ISBN 13 : 0199965242
Total Pages : 433 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy

Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Excitatory-Inhibitory Balance

Author : Takao K. Hensch
Publisher : Springer Science & Business Media
ISBN 13 : 1461500397
Total Pages : 286 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Excitatory-Inhibitory Balance by : Takao K. Hensch

Download or read book Excitatory-Inhibitory Balance written by Takao K. Hensch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. It is a timely contribution emphasizing how this balance is established, maintained, and modified from the molecular to system levels. The broad spectrum of topics from molecular to cellular and system/computational neuroscience will appeal to a wide audience of advanced graduate students, post-docs, and faculty. Moreover, this book this book features active young researchers from around the world, who are currently educating the brain scientists of tomorrow.

Perceiving in Depth, Volume 1: Basic Mechanisms

Author : Ian P. Howard
Publisher : Oxford University Press
ISBN 13 : 0199877343
Total Pages : 671 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis Perceiving in Depth, Volume 1: Basic Mechanisms by : Ian P. Howard

Download or read book Perceiving in Depth, Volume 1: Basic Mechanisms written by Ian P. Howard and published by Oxford University Press. This book was released on 2012-01-27 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-volume work Perceiving in Depth is a sequel to Binocular Vision and Stereopsis and to Seeing in Depth, both by Ian P. Howard and Brian J. Rogers. This work is much broader in scope than the previous books and includes mechanisms of depth perception by all senses, including aural, electrosensory organs, and the somatosensory system. Volume 1 reviews sensory coding, psychophysical and analytic procedures, and basic visual mechanisms. Volume 2 reviews stereoscopic vision. Volume 3 reviews all mechanisms of depth perception other than stereoscopic vision. The three volumes are extensively illustrated and referenced and provide the most detailed review of all aspects of perceiving the three-dimensional world. Volume 1 starts with a review of the history of visual science from the ancient Greeks to the early 20th century with special attention devoted to the discovery of the principles of perspective and stereoscopic vision. The first chapter also contains an account of early visual display systems, such as panoramas and peepshows, and the development of stereoscopes and stereophotography. A chapter on the psychophysical and analytic procedures used in investigations of depth perception is followed by a chapter on sensory coding and the geometry of visual space. An account of the structure and physiology of the primate visual system proceeds from the eye through the LGN to the visual cortex and higher visual centers. This is followed by a review of the evolution of visual systems and of the development of the mammalian visual system in the embryonic and post-natal periods, with an emphasis on experience-dependent neural plasticity. An account of the development of perceptual functions, especially depth perception, is followed by a review of the effects of early visual deprivation during the critical period of neural plasticity on amblyopia and other defects in depth perception. Volume 1 ends with accounts of the accommodation mechanism of the human eye and vergence eye movements.

Synaptic Plasticity in the Hippocampus

Author : Helmut L. Haas
Publisher : Springer Science & Business Media
ISBN 13 : 364273202X
Total Pages : 219 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Synaptic Plasticity in the Hippocampus by : Helmut L. Haas

Download or read book Synaptic Plasticity in the Hippocampus written by Helmut L. Haas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.

The Oxford Handbook of Developmental Psychology, Vol. 1

Author : Philip David Zelazo
Publisher : Oxford University Press
ISBN 13 : 0199958459
Total Pages : 1049 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis The Oxford Handbook of Developmental Psychology, Vol. 1 by : Philip David Zelazo

Download or read book The Oxford Handbook of Developmental Psychology, Vol. 1 written by Philip David Zelazo and published by Oxford University Press. This book was released on 2013-03-21 with total page 1049 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.

The Blackwell Handbook of Early Childhood Development

Author : Kathleen McCartney
Publisher : John Wiley & Sons
ISBN 13 : 1444357131
Total Pages : 953 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis The Blackwell Handbook of Early Childhood Development by : Kathleen McCartney

Download or read book The Blackwell Handbook of Early Childhood Development written by Kathleen McCartney and published by John Wiley & Sons. This book was released on 2011-09-07 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Blackwell Handbook of Early Childhood Development presents a comprehensive summary of research into child development from age two to seven. Comprises 30 contributions from both established scholars and emerging leaders in the field The editors have a distinguished reputation in early childhood development Covers biological development, cognitive development, language development, and social, emotional and regulatory development Considers the applications of psychology to the care and education of young children, treating issues such as poverty, media, and the transition to school A valuable resource for students, scholars and practitioners dealing with young children

The Neocortex

Author : Wolf Singer
Publisher : MIT Press
ISBN 13 : 0262043246
Total Pages : 449 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis The Neocortex by : Wolf Singer

Download or read book The Neocortex written by Wolf Singer and published by MIT Press. This book was released on 2019-10-29 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts review the latest research on the neocortex and consider potential directions for future research. Over the past decade, technological advances have dramatically increased information on the structural and functional organization of the brain, especially the cerebral cortex. This explosion of data has radically expanded our ability to characterize neural circuits and intervene at increasingly higher resolutions, but it is unclear how this has informed our understanding of underlying mechanisms and processes. In search of a conceptual framework to guide future research, leading researchers address in this volume the evolution and ontogenetic development of cortical structures, the cortical connectome, and functional properties of neuronal circuits and populations. They explore what constitutes “uniquely human” mental capacities and whether neural solutions and computations can be shared across species or repurposed for potentially uniquely human capacities. Contributors Danielle S. Bassett, Randy M. Bruno, Elizabeth A. Buffalo, Michael E. Coulter, Hermann Cuntz, Stanislas Dehaene, James J. DiCarlo, Pascal Fries, Karl J. Friston, Asif A. Ghazanfar, Anne-Lise Giraud, Joshua I. Gold, Scott T. Grafton, Jennifer M. Groh, Elizabeth A. Grove, Saskia Haegens, Kenneth D. Harris, Kristen M. Harris, Nicholas G. Hatsopoulos, Tarik F. Haydar, Takao K. Hensch, Wieland B. Huttner, Matthias Kaschube, Gilles Laurent, David A. Leopold, Johannes Leugering, Belen Lorente-Galdos, Jason N. MacLean, David A. McCormick, Lucia Melloni, Anish Mitra, Zoltán Molnár, Sydney K. Muchnik, Pascal Nieters, Marcel Oberlaender, Bijan Pesaran, Christopher I. Petkov, Gordon Pipa, David Poeppel, Marcus E. Raichle, Pasko Rakic, John H. Reynolds, Ryan V. Raut, John L. Rubenstein, Andrew B. Schwartz, Terrence J. Sejnowski, Nenad Sestan, Debra L. Silver, Wolf Singer, Peter L. Strick, Michael P. Stryker, Mriganka Sur, Mary Elizabeth Sutherland, Maria Antonietta Tosches, William A. Tyler, Martin Vinck, Christopher A. Walsh, Perry Zurn

Critical Periods in Brain Development

Author : Takao Hensch
Publisher :
ISBN 13 : 9784431543817
Total Pages : 350 pages
Book Rating : 4.5/5 (438 download)

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Book Synopsis Critical Periods in Brain Development by : Takao Hensch

Download or read book Critical Periods in Brain Development written by Takao Hensch and published by . This book was released on 2016-01-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal circuits are shaped by experience during ‘critical periods’ of early postnatal life. The ability to control the timing, duration, and closure of these heightened levels of brain plasticity has recently become experimentally accessible, especially in the developing visual system. This book summarizes for the first time our current neurobiological understanding of how critical periods work across several systems and species, including humans. It delineates a number of emerging fundamental principles: functional competition between inputs, role for neural activity, structural consolidation, regulation by experience (not simply age), special role for inhibition in the CNS, potent influence of attention and motivation, unique timing and duration as well as use of distinct molecular mechanisms across brain regions, and the potential for reactivation in adulthood. It is a timely piece, as the experimental data have mostly become available within the past five years while social demand to apply this information to human learning has risen dramatically. A deeper understanding of critical periods opens new avenues to nurture the brain – from nascent international efforts to link brain science and education to improving recovery from injury in adults, devising new strategies for therapy and for life-long learning.

Neurogenesis and Neural Plasticity

Author : Catherine Belzung
Publisher : Springer Science & Business Media
ISBN 13 : 364236232X
Total Pages : 447 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Neurogenesis and Neural Plasticity by : Catherine Belzung

Download or read book Neurogenesis and Neural Plasticity written by Catherine Belzung and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 826 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Visual Development

Author : Nigel W. Daw
Publisher : Springer Science & Business Media
ISBN 13 : 1475769407
Total Pages : 362 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Visual Development by : Nigel W. Daw

Download or read book Visual Development written by Nigel W. Daw and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the first introductory-level text in its field, Visual Development offers a comprehensive understanding of the development of the visual system and the effects of visual deprivation. The material is treated from the behavioral, anatomical, and physiological points of view. Complete with ample illustrations and a helpful glossary, this text is invaluable for graduate students, optometry students, and ophthalmology residents as well as for experts in related fields.