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Plasma Homovanillic Acid In Schizophrenia
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Book Synopsis Plasma Homovanillic Acid in Schizophrenia by : Arnold J. Friedhoff
Download or read book Plasma Homovanillic Acid in Schizophrenia written by Arnold J. Friedhoff and published by American Psychiatric Pub. This book was released on 1997 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of dopamine in schizophrenia has been a significant area of research. The measurement of the major dopamine metabolite, homovanillic acid (HVA), in various body fluids, especially in blood plasma, is one of the primary methods to assess brain dopamine neuronal activity in schizophrenic patients. Written by leading researchers in the field, Plasma Homovanillic Acid in Schizophrenia provides the most comprehensive and current collection of information on plasma HVA levels to be found anywhere. It provides a concise synthesis and critique of current data as well as interesting proposals for future research. This book will be of great value to any serious student of the biology of schizophrenia and other psychiatric disorders involving abnormal levels of plasma HVA.
Book Synopsis Therapy-Resistant Schizophrenia by : H. Elkis
Download or read book Therapy-Resistant Schizophrenia written by H. Elkis and published by Karger Medical and Scientific Publishers. This book was released on 2010-07-29 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The psychotic symptoms of up to 30% of schizophrenic patients do not respond adequately to treatment with antipsychotic drugs, other than clozapine. These refractory patients are generally among the most disabled of all people with schizophrenia and require special assessment and treatment. This volume presents the latest research and recommendations on the definition, causes and therapy of treatment-resistant schizophrenia (TRS). Methods for identification and optimal management of TRS are reviewed. Clozapine and other atypical antipsychotic drugs which are the primary treatment for TRS, as well as non-pharmacologic treatments such as transcranial magnetic stimulation, cognitive behavior therapy and ECT are discussed in depth. Potential causative factors and identifying features such as genetic factors, poor premorbid functioning, longer duration of untreated psychosis, and biological measures such as structural and functional brain abnormalities are also reviewed in depth in the present volume.
Download or read book Schizophrenia Bulletin written by and published by . This book was released on 1997 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Schizophrenia, 1993 by : David Shore
Download or read book Schizophrenia, 1993 written by David Shore and published by DIANE Publishing. This book was released on 1996-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia remains the most puzzling, chronic, and disabling of the severe mental disorders. Presents recent developments in research: diagnosis and classification, relation of symptoms to cognitive deficits, information processing and attention dysfunctions, genetics, psychopharmacologic treatment, tardive dyskinesia, psychosocial treatment, neuroimaging, infection and autoimmunity, neurochemistry and neuroendocrinology, and neuropathology. A nontechnical summary of each major area proceeds the articles.
Book Synopsis Etiopathogenetic Hypotheses of Schizophrenia by : C.L. Cazzullo
Download or read book Etiopathogenetic Hypotheses of Schizophrenia written by C.L. Cazzullo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Association for Research in Nervous and Mental Disease. Meeting Publisher :American Psychiatric Pub ISBN 13 :9780880487467 Total Pages :572 pages Book Rating :4.4/5 (874 download)
Book Synopsis Biology of Schizophrenia and Affective Disease by : Association for Research in Nervous and Mental Disease. Meeting
Download or read book Biology of Schizophrenia and Affective Disease written by Association for Research in Nervous and Mental Disease. Meeting and published by American Psychiatric Pub. This book was released on 1996 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Decade of the Brain has brought with it many advances in our understanding of the biology of major mental disorders. Biology of Schizophrenia and Affective Disease provides a state-of-the-art look at the biological bases of severe mental illness from the perspective of the researchers making these exceptional discoveries. In 17 chapters, some of the best investigators in the field furnish overviews of their ground-breaking findings and set course for future research efforts. From the biology of stress to excitotoxicity in the development of corticolimbic alterations in the schizophrenic brain, this outstanding reference tool explores the explosive progress in the fields of biochemistry, molecular genetics, neuroscience, and brain circuit anatomy and the resultant advances in nearly every aspect of the biology of the brain and mental illness. Dissolution of cerebral cortical mechanisms in patients with schizophrenia, linkage and molecular genetics in infantile autism, and postmortem studies of suicide victims and schizophrenic patients are among the topics covered. The book also discusses treatment issues, including the mechanisms of action of antidepressants and atypical antipsychotic drugs. Practitioners and students will find this volume an invaluable reference tool for understanding the mechanisms of normal and pathological brain function and potential areas for further insight into the biological bases of mental illness.
Download or read book Special Report written by and published by . This book was released on 1993 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Critical Pathways to Success in CNS Drug Development by : Neal R. Cutler
Download or read book Critical Pathways to Success in CNS Drug Development written by Neal R. Cutler and published by John Wiley & Sons. This book was released on 2010-01-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations
Download or read book MHPG written by James W. Maas and published by . This book was released on 1983 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: MHPG: Basic Mechanisms and Psychopathology discusses the interactions between clinical biological psychiatry and basic neuropsychopharmacology. Composed of 10 chapters, this book focuses on the role of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) in psychiatric disorders, particularly, in depression and mania. The book first examines the enzyme systems that produce MHPG in the brain and the features of these enzymes that could be used to reconcile several contradictions with regard to the origin of urinary MHPG. It then discusses the correlation between changes in impulse flow in central norad ...
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1992 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prediction of Neuroleptic Treatment Outcome in Schizophrenia by : W. Gaebel
Download or read book Prediction of Neuroleptic Treatment Outcome in Schizophrenia written by W. Gaebel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prognosis is a core concept in psychiatry. This book is concerned with prediction of neuroleptic treatment outcome in schizophrenia from a conceptual and methodological point of view. Various aspects of the topic, such as definition and measurement of response, dimensions of treatment outcome, neuropsychological, neuropsychopharmacological and neurobiochemical predictors as well as the clinical application of neuroimaging methods and neurogenetics are treated by experts in the field. One aim of the book is to summarize the present state of the art in prediction research and thereby to provide a useful compendium. Moreover guidelines for future research strategies are formulated.
Book Synopsis Antipsychotics by : John G. Csernansky
Download or read book Antipsychotics written by John G. Csernansky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antipsychotic drugs were first discovered in 1953, and not since the late 1970s has the Handbook of Experimental Pharmacology taken up this topic. A new treatment of this topic would be due under any circumstances; however, this is now particularly true, since remarkable progress has been made on several fronts in furthering our understanding of the mechanisms of antipsychotic drug action. First, we have learned that schizophrenia is an illness with particu lar neuroanatomical abnormalities, many of which suggest that the illness is caused by errors in neurodevelopment. These findings have helped to form a context for understanding neurochemical aberrations in the illness and suggest new approaches for pharmacological treatment. Propelled forward by rapid advances in neurochemical anatomy, current pathophysiological hypotheses of schizophrenia and antipsychotic drug action have taken on the appearance of complex electrical circuit diagrams. Second, molecular biology studies have now revealed that there is a multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong, D , D , and D ), some of which may become entirely new targets for 3 4 s antipsychotic drug action. Ironically, the development of drugs that are selec tive for these receptors and that can be used to investigate their function lags behind; yet the discovery of these new receptors offers unparalleled opportu nities for developing drugs with improved efficacy and fewer side effects.
Download or read book Schizophrenia written by Steven R. Hirsch and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is one of the most complex and puzzling diseases toaffect mankind. It is the most common of the severe mentalillnesses (psychoses) with an estimated prevalence of 0.5 - 1% inthe general population and accounts for a very large portion of theday to day workload of the average psychiatrist. 50% of long-termpsychiatric patients in mental hospitals are schizophrenic. There is a great deal of controversy about the causes, diagnosisand treatment of schizophrenia with the consequence that a hugeamount of research is carried out in the field by psychiatrists,psychologists, neuroscientists and pharmacologists. For the averagepractising psychiatrist seeing schizophrenics on a regular basis,making sense of the vast body of information on the subject andfiltering out what is of clinical relevance can be very difficult.There is a constant stream of new drugs emerging and the newergeneration of drugs (the so-called atypicals) is very effective,but often expensive. The Editors (one American and one British) are both highlyrespected clinical psychiatrists who are probably the leadingexperts on schizophrenia from their respective countries andjointly have published almost 150 papers on the subject. They have brought together a strong group of contributors from theUSA, UK and Europe to produce what will be an essential referencefor the trainee and practising psychiatrist. The book consists of four sections; descriptive aspects,causative aspects, physical treatments andpsychological/behavioural/social treatments. There will bediscussion of the theoretical controversies over symptomatology,classification and aetiology, the relationship of schizophrenia tothe other psychoses, the significance of positive and negativesymptoms and pre-morbid personality. There will be chapters onorganic models of schiziophrenia, neurodevelopmental, genetic andstructural studies and the role of high-expressed emotion. Thefinal section will cover social and environmental treatment, therole of the families of schizophrenics and the psychoanalyticaltherapies. There is a new chapter on the patient's perspectivewritten by a former patient.
Book Synopsis Handbook of Pharmacology on Aging by : Jay Roberts
Download or read book Handbook of Pharmacology on Aging written by Jay Roberts and published by CRC Press. This book was released on 1996-08-14 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: As adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions.
Book Synopsis Plasticity and Morphology of the Central Nervous System by : C.L. Cazzullo
Download or read book Plasticity and Morphology of the Central Nervous System written by C.L. Cazzullo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years ways of thinking in psychiatry have undergone considerable change thanks to advances in the fields of morphology and plasticity of the CNS, particularly with regard to schizophrenic and mood disorders. In addition, the rapid and considerable development of neuroimaging techniques (CT, MRI, PET and computerized EEG) and of molecular genetics (through DNA recombinant meth odologies) have widened the approach to these disorders in a way unimagined a few years ago. These advances and the new etiopathogenetic hypotheses that have sprung from them were the central theme of the Second International Meeting on Schizophre nia "Morphology and Plasticity of the Central Nervous System - A Challenge for Psychiatry of the Nineties" which was organized by the Association for Research on Schizophrenia (ARS), the Schizophrenia Research Center of the Institute of Psychiatry of the University of Milan and the T. and F. Legrenzi Foundation, held in Milan on October 22-24, 1987. This book contains the contributions from participants of the meeting, which took place in a warm and friendly atmosphere and marked by lively and exhaustive discussions on the various papers. The contributions were recently revised for the present publication. We would like to express our appreciation to the book's contributors for the high quality of their reports.
Book Synopsis Substance Abuse Comorbidity in Schizophrenia by :
Download or read book Substance Abuse Comorbidity in Schizophrenia written by and published by . This book was released on 1990 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Treatment–Refractory Schizophrenia by : Peter F. Buckley
Download or read book Treatment–Refractory Schizophrenia written by Peter F. Buckley and published by Springer Science & Business Media. This book was released on 2014-03-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.