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Placental Pharmacology
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Book Synopsis Placental Pharmacology by : B. V. Rama Sastry
Download or read book Placental Pharmacology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1996-05-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placenta plays a very significant role in the development of secretory and regulatory functions for the maintenance of pregnancy and in the nutrition of the embryo. It shares many functions of the heart, lung, liver, endocrines, and other organs. In Placental Pharmacology, fourteen expert authors discuss how placenta and its component parts can be used effectively in drug development research and in the study of transfer mechanisms across membranes. This reference begins by describing the use of modern biophysical methods to study placental function and prospects for their application in pharmacological research. The next three chapters deal with placental hemodynamics, use of placental tissues and cells in pharmacological assays, and placental transfer of drugs used in pregnancy. Three more chapters contain up-to-date information on molecular biological aspects of placenta currently receiving lots of attention - phospholipase A2 isozymes, imprinted genes and embryogenesis, and placental growth factors. The final chapter describes the clinically relevant topics of placental metabolism and toxicity of homocysteine in placenta. Easy to understand, thorough, and complete, Placental Pharmacology is the perfect resource for scientists interested in placenta and its uses in drug development and testing.
Book Synopsis Placental Toxicology by : B. V. Rama Sastry
Download or read book Placental Toxicology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1995-02-24 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in
Book Synopsis Placental Pharmacology -- Implications for Therapy in Pregnancy by : Priya Bapat
Download or read book Placental Pharmacology -- Implications for Therapy in Pregnancy written by Priya Bapat and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Medication use during pregnancy requires a balance between treating a condition in the mother, and minimizing potential risks in the fetus. In recent years, it has been estimated that between 50 and 70% of pregnant women in North America will take at least one prescription medication during their pregnancy. The decision to begin or continue treatment during pregnancy relies heavily on evaluating the risk-benefit ratio, and an important determinant in this risk assessment is estimating fetal drug exposure. The use of medications in pregnant women can be especially challenging, as there is very limited safety data in pregnancy. Recently, novel oral anticoagulants have been developed and approved for clinical use. However, the information regarding their fetal safety and placental transfer in humans is unknown. We used the ex vivo placenta perfusion model to investigate anticoagulant (dabigatran, rivaroxaban, apixaban) transfer across the human placenta. Rivaroxaban and apixaban rapidly crossed the term human placenta, while dabigatran crossed the placenta to a lesser extent. The placenta perfusion results were adjusted to account for protein binding and pH differences between the mother and fetus. We also developed a pharmacokinetic model that adequately described the transplacental transfer of anticoagulants by using data from our experiments. While the placenta perfusion model can be technically challenging, its results strongly correlate with in vivo placental transfer data. By evaluating the success rate of the perfusion model in our laboratory, we determined that establishing the fetal circulation is an important stage of the protocol. This information can be used to create a focused training program to help increase the overall success rate of this model and productivity of the lab. Drug use in pregnancy is multifactorial, and placental transfer data is important in assessing which drugs can be used to treat the mother while protecting the unborn.
Book Synopsis Placental Toxicology by : B. V. Rama Sastry
Download or read book Placental Toxicology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1995-02-24 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in vitro perfusion of human placenta Abuse of alcohol, nicotine, morphine, and cocaine during pregnancy, their placental transfer and fetal growth retardation Placental transfer and fetal toxicities of environmental insecticides Placental hormones and fetal well-being Placental transfer of HIV and treatment of pregnant women with anti-HIV drugs
Book Synopsis Oxford Textbook of Obstetric Anaesthesia by : Vicki Clark
Download or read book Oxford Textbook of Obstetric Anaesthesia written by Vicki Clark and published by Oxford University Press. This book was released on 2016 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an up-to-date summary of the scientific basis, assessment for and provision of anaesthesia throughout pregnancy and labour. It is divided into nine sections including physiology, assessment, complications and systemic disease.
Book Synopsis Fundamentals of Anaesthesia by : Colin Pinnock
Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-01-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate.
Book Synopsis Cellular Biology and Pharmacology of the Placenta by : Richard Kermit Miller
Download or read book Cellular Biology and Pharmacology of the Placenta written by Richard Kermit Miller and published by Plenum Publishing Corporation. This book was released on 1987-01-01 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Therapy During Pregnancy by : Tom K. A. B. Eskes
Download or read book Drug Therapy During Pregnancy written by Tom K. A. B. Eskes and published by Elsevier. This book was released on 2013-10-22 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.
Book Synopsis Exploring Maternal-Fetal Pharmacology Through PBPK Modeling Approaches by : André Dallmann
Download or read book Exploring Maternal-Fetal Pharmacology Through PBPK Modeling Approaches written by André Dallmann and published by Frontiers Media SA. This book was released on 2022-06-06 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Pharmacology During Pregnancy by : Donald Mattison
Download or read book Clinical Pharmacology During Pregnancy written by Donald Mattison and published by Academic Press. This book was released on 2021-09-24 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations. Uses an evidence-based approach for therapeutics during pregnancy Presents a summary of specific medications by indication, including up-to-date information on dosing and efficacy in pregnancy for the given indication Includes significant new sections on physiologic changes and the ethics of pharmacological research in pregnancy
Download or read book PHARMACOLOGY-1 written by Mr.Arman Dalal and published by JEC PUBLICATION. This book was released on with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: As pharmaceuticals are the mainstay of treatment for human ailments, pharmacology is a medical discipline that serves as the foundation of the medical industry. In order to optimize the advantages and reduce the hazards of medications for recipients, it is crucial to describe the pharmacological basis of therapies. This pharmacology lecture note is primarily intended for undergraduate health science students, including those pursuing careers as health officers, nurses, midwives, and laboratory technicians. But other health professionals whose line of work involves drug therapy or associated topics ought to find much of the information relevant as well. The objective is to equip the practitioner with knowledge of the core scientific ideas underlying pharmacology. To facilitate understanding, the effects of archetypal medicines on physiological and pathological systems are thoroughly described. There is a brief mention of other related medications. The medications were chosen based on the national pharmaceuticals list for Ethiopia and the cumulative knowledge from teaching pharmacology to numerous students of health professions. The chapters begin with a set of goals to direct the reader, and the majority of them end with questions that test the reader's comprehension of the ideas discussed in the chapter. Most sections begin with an introduction that gives a general description of the material that will be discussed. We believe that this information will be a helpful companion in our search of a fundamental understanding of the most intriguing field of clinical knowledge, pharmacology, and invite readers to consult the references listed for more information.
Book Synopsis Biopharmaceutics and Pharmacokinetics Considerations by :
Download or read book Biopharmaceutics and Pharmacokinetics Considerations written by and published by Academic Press. This book was released on 2021-07-07 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology
Book Synopsis Fundamentals of Pharmacology by : Shane Bullock
Download or read book Fundamentals of Pharmacology written by Shane Bullock and published by Pearson Higher Education AU. This book was released on 2013-10-15 with total page 1249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Pharmacology 7e presents key scientific and clinical principles to facilitate a greater understanding of pharmacology. This wholly Australasian text provides comprehensive and current coverage of topics, written in a clear style with a reader-friendly full colour design.
Book Synopsis Drug Toxicity and Metabolism in Pediatrics by : Sam Kacew
Download or read book Drug Toxicity and Metabolism in Pediatrics written by Sam Kacew and published by CRC Press. This book was released on 2018-01-18 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.
Download or read book Pharmacology written by Gary C. Rosenfeld and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise review of medical pharmacology is designed for medical students, dental students, and others in the health care professions. It is intended primarily to help students prepare for licensing examinations such as the USMLE Step 1 or similar examinations. Each chapter presents specific drugs and discusses their general properties, mechanism of action, pharmacologic effects, therapeutic uses, and adverse effects. Drug lists and two-color tables and figures summarize essential drug information in all chapters. Clinically oriented USMLE-style review questions and answers with explanations follow each chapter. A comprehensive examination consisting of USMLE-style questions appears at the end of the book.
Book Synopsis Cellular Biology and Pharmacology of the Placenta by : Richard Miller
Download or read book Cellular Biology and Pharmacology of the Placenta written by Richard Miller and published by Springer. This book was released on 1987-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Basic and Therapeutic Aspects of Perinatal Pharmacology by : Paolo Lucio Morselli
Download or read book Basic and Therapeutic Aspects of Perinatal Pharmacology written by Paolo Lucio Morselli and published by . This book was released on 1975 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
