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Photochemical Stability Drugs
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Book Synopsis Photostability Of Drugs And Drug Formulations by : Hanne Hjorth Tonnesen
Download or read book Photostability Of Drugs And Drug Formulations written by Hanne Hjorth Tonnesen and published by CRC Press. This book was released on 1996-09-03 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text discusses various aspects of the combination of drugs and light. Degradation processes, stabilization of photolabile drug substances within formulations, benefits from the combination of drugs and light, and testing of drug photoreactivity, are some of the topics discussed.
Download or read book Drugs written by Angelo Albini and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Pasteur in 1846, scientists have been aware that many drugs are photoreactive, but until recently research in this area had been somewhat limited. However, since the introduction of acutely sensitive analytical methods, the realisation of the need to identify the photochemical properties of a potential drug as early in its development as possible and the increased attention to the phototoxic effect of drugs, more details are becoming available. Drugs: Photochemistry and Photostability presents the basic elements of the science, and serves as an excellent introduction to this emerging field of photochemistry. Detailed experimental conditions for photostability studies are given, along with a discussion of the recently implemented ICH Guidelines for drug photostability. With contributions from international experts in the field and including a comprehensive literature review, this book provides all the up-to-date information needed by researchers in many fields, especially medicinal and pharmaceutical chemistry.
Book Synopsis Photostability of Drugs and Drug Formulations, Second Edition by : Hanne Hjorth Tonnesen
Download or read book Photostability of Drugs and Drug Formulations, Second Edition written by Hanne Hjorth Tonnesen and published by CRC Press. This book was released on 2004-06-29 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource. The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features Assists non-experts in this field design a test protocol and interpret the results Covers in vitro and in vivo aspects of interactions between drugs and light Explores the kinetic and chemical aspects of drug photodecomposition Discusses the problems frequently encountered in photochemical stability testing Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint Offers specific guidance in photostability testing and screening of drug photoreactivity
Book Synopsis Pharmaceutical Photostability and Stabilization Technology by : Joseph T. Piechocki
Download or read book Pharmaceutical Photostability and Stabilization Technology written by Joseph T. Piechocki and published by CRC Press. This book was released on 2006-09-18 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a training course developed by Dr. Joseph T. Piechocki and other experts in this field whose contributions appear in this book for two International Meetings on the Photostability of Drugs and Drug Products, this text clarifies the guidelines set by the International Conference on Harmonization (ICH) and provides a comprehensive background
Book Synopsis Pharmaceutical Crystals by : Tonglei Li
Download or read book Pharmaceutical Crystals written by Tonglei Li and published by John Wiley & Sons. This book was released on 2018-09-03 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.
Book Synopsis Drug Stability for Pharmaceutical Scientists by : Thorsteinn Loftsson
Download or read book Drug Stability for Pharmaceutical Scientists written by Thorsteinn Loftsson and published by Academic Press. This book was released on 2014-01-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries. Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material Provides answers and explanations to test your knowledge Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability
Book Synopsis Organic Chemistry of Drug Degradation by : Min Li
Download or read book Organic Chemistry of Drug Degradation written by Min Li and published by Royal Society of Chemistry. This book was released on 2012 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines drug degradation pathways with an emphasis on the underlying chemical mechanisms.
Book Synopsis ICH Quality Guidelines by : Andrew Teasdale
Download or read book ICH Quality Guidelines written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2017-10-09 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. • Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies • Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines • Uses case studies to help readers understand and apply ICH guidelines • Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines • Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)
Book Synopsis The Syringe Driver by : Andrew Dickman
Download or read book The Syringe Driver written by Andrew Dickman and published by Oxford University Press. This book was released on 2016 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text serves as a valuable reference source, providing a comprehensive review of syringe driver use and administration of drugs via CSCI, a safe and effective way of drug administration when other routes are inappropriate.
Book Synopsis Handbook of Stability Testing in Pharmaceutical Development by : Kim Huynh-Ba
Download or read book Handbook of Stability Testing in Pharmaceutical Development written by Kim Huynh-Ba and published by Springer Science & Business Media. This book was released on 2008-11-16 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the first to cover all aspects of stability testing in pharmaceutical development. Written by a group of international experts, the book presents a scientific understanding of regulations and balances methodologies and best practices.
Book Synopsis Drug Stability and Chemical Kinetics by : Muhammad Sajid Hamid Akash
Download or read book Drug Stability and Chemical Kinetics written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2020-11-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics.
Book Synopsis Photostabilization of Polymers by : J.F. Rabek
Download or read book Photostabilization of Polymers written by J.F. Rabek and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, the production of polymers and plastics has been increasing rapidly. In spite of developing new polymers and polymeric materials, only 40-60 are used commercially on a large scale. It has been estimated that half of the annual production of polymers is employed outdoors. Increasing the stability of polymers and plastics towards heat, light, atmospheric oxygen and other environmental agents and weathering conditions has always been a very important problem. The photochemical instability of most of polymers limits them to outdoor application, where they are photo degraded fast over periods ranging from months to a few years. To the despair of technologists and consumers alike, photodegrada tion and environmental ageing of polymers occur much faster than can be expected from knowledge collected in laboratories. In many cases, improved methods of preparation and purification of both monomers and polymers yield products of better quality and higher resistance to heat and light. However, without stabilization of polymers by applica tion of antioxidants (to decrease thermal oxidative degradation) and photostabilizers (to decrease photo-oxidative degradation) it would be impossible to employ polymers and plastics in everyday use.
Book Synopsis Stability of Drugs and Dosage Forms by : Sumie Yoshioka
Download or read book Stability of Drugs and Dosage Forms written by Sumie Yoshioka and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug products are complex mixtures of drugs and excipients and, as such, their chemical and physical stability kinetics are complex. This book discusses the stability of these dosage forms with preformulation studies through to the studies on the final products. The book is intended for graduate students, researchers and professionals in the field of Pharmaceutics and Pharmaceutical Chemistry.
Book Synopsis The Science of Photobiology by : Kendric C. Smith
Download or read book The Science of Photobiology written by Kendric C. Smith and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of The Science of Photobiology was published in 1977, and was the first textbook to cover all of the major areas of photobiology. The science of photobiology is currently divided into 14 subspecialty areas by the American Society for Photobiology. In this edition, however, the topics of phototechnology and spectroscopy have been com bined in a new chapter entitled "Photophysics." The other subspecialty areas remain the same, i.e., Photochemistry, Photosensitization, UV Radiation Effects, Environmental Photobiology, Photomedicine, Circadian Rhythms, Extraretinal Photoreception, Vision, Photomorphogenesis, Photomovement, Photosynthesis, and Bioluminescence. This book has been written as a textbook to introduce the science of photobiology to advanced undergraduate and graduate students. The chapters are written to provide a broad overview of each topic. They are designed to contain the amount of information that might be presented in a one-to two-hour general lecture. The references are not meant to be exhaustive, but key references are included to give students an entry into the literature. Frequently a more recent reference that reviews the literature will be cited rather than the first paper by the author making the original discovery. The chapters are not meant to be a repository of facts for research workers in the field, but rather are concerned with demon strating the importance of each specialty area of photobiology, and documenting its relevance to current and/or future problems of man.
Download or read book Flavins written by Eduardo Silva and published by Royal Society of Chemistry. This book was released on 2006 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flavins and flavoproteins are a widely investigated and highly versatile group of compounds. Participation of these compounds in photochemistry and photobiology processes are of particular importance in the fields of biology, chemistry and medicine. Written by leading experts in the field each section of the book includes a historical overview of the subject, state of the art developments and future perspectives. Flavins: Photochemistry and Photobiology begins with the properties and applications of flavins, including their photochemistry in aqueous and organic solutions. Subsequent sections discuss riboflavin as a visible light sensitizer in the photo degradation of drugs, antiviral and antibacterial effects, the role of flavins in light induced toxicity and blue light initiated DNA repair by photolyase. Finally there are sections on the flavin based photoreceptors in plants, bacteria and eukaryotic photosynthetic flagelettes. This book brings together leading experts with a unique interdisciplinary emphasis, to provide an authoritative resource on flavins and their role in photochemistry and photobiology.
Book Synopsis Photochemical Conversion and Storage of Solar Energy by : John Connolly
Download or read book Photochemical Conversion and Storage of Solar Energy written by John Connolly and published by Elsevier. This book was released on 2012-12-02 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photochemical Conversion and Storage of Solar Energy contains the proceedings of the Third International Conference on Photochemical Conversion and Storage of Solar Energy held in Boulder, Colorado, on August 3-8, 1980. The papers review the state of the art in the areas of photochemistry and photoelectrochemistry in the context of solar energy conversion and storage. Topics covered include photosynthetic quantum conversion; biomimetic systems for solar energy conversion; and photochemical electron transfer reactions in homogeneous solutions. This volume is comprised of 11 chapters and begins by describing an artificial photosynthetic system that can capture solar quanta and convert them into a stable chemical form. The discussion then turns to biomimetic approaches to solar energy conversion; fluorescent concentrators for photovoltaic cells; requirements for homogeneous photoredox chemistry in inorganic systems; and the use of inorganic components coupled with catalysts in heterogeneous assemblies for photochemical water splitting. The following chapters focus on photogalvanic cells, electrochemical photovoltaic cells, and photoelectrosynthetic reactions at the semiconductor-electrolyte interface. The final chapter examines the thermodynamic limits on photoconversion and storage of solar energy. This monograph will be of interest to chemists and other scientists concerned with the photochemical aspects of solar energy conversion and storage.
Book Synopsis Modern Pharmaceutics by : Gilbert S. Banker
Download or read book Modern Pharmaceutics written by Gilbert S. Banker and published by CRC Press. This book was released on 2002-05-24 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Completely revised and expanded throughout. Presents a comprehensive integrated, sequenced approach to drug dosage formulation, design, and evaluation. Indentifies the pharmacodynamic and physicochemical factors influencing drug action through various routes of administration."
