Photocarcinogenesis & Photoprotection

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Author :
Publisher : Springer
ISBN 13 : 9811054932
Total Pages : 177 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Photocarcinogenesis & Photoprotection by : Ratan Singh Ray

Download or read book Photocarcinogenesis & Photoprotection written by Ratan Singh Ray and published by Springer. This book was released on 2018-11-30 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the problem of UV-R-induced photocarcinogenesis and its molecular mechanism. It covers different photosensitive xenobiotics (drugs, cosmetics, and environmental pollutants) and their photosensitization mechanisms under ambient UV-R exposure. It also summarizes the role of nanotechnology in skin cancer remedies. It provides a brief overview of the various novel nanocarriers for cosmeceuticals like nanoemulsions, liposomes, solid lipid nanoparticles (SLNs), dendrimers, inorganic nanoparticles, nanocrystals, etc., nanotechnology-based cosmeceutical products which are available in the market. It highlights the possible health hazards caused by nanoparticles on exposure of nano-based cosmetics and describes the recent regulatory rules applied to avoid the nanotoxicity.

Environment and Skin

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Author :
Publisher : Springer
ISBN 13 : 3319431021
Total Pages : 130 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Environment and Skin by : Jean Krutmann

Download or read book Environment and Skin written by Jean Krutmann and published by Springer. This book was released on 2017-11-20 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​This book is a rich source of information on skin disorders due to toxicants in the environment. State of the art knowledge is summarized concerning the molecular basis of skin damage caused by well-appreciated environmental noxae. The book also provides a uniquely comprehensive overview of the detrimental dermatological effects of exposure to air pollution and global climate change. A special focus is contact allergy, which, beyond representing a major problem in dermatotoxicology, serves as a prime example for the development of toxicological approaches to risk assessment. A further chapter is devoted to contact urticaria, a condition that can progress to life-threatening anaphylactic reactions. The novel information offered in this book will enable the reader to go beyond the traditional thinking of dermatotoxicology and achieve a modern appreciation of the highly complex interplay between skin and environment.

Principles and Practice of Photoprotection

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Publisher : Springer
ISBN 13 : 3319293826
Total Pages : 487 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Principles and Practice of Photoprotection by : Steven Q. Wang

Download or read book Principles and Practice of Photoprotection written by Steven Q. Wang and published by Springer. This book was released on 2016-04-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders, and covering all facets of photoprotection, this book summarizes the beneficial roles of photoprotection in skin cancers, photoaging, photodermatoses, autoimmune diseases, and other skin conditions. It provides an update on the current state of UV filters, boosters, photostabilizers and formulation of sunscreen, and showcases the current techniques and regulation in the evaluating of UV filters and sunscreen products. Furthermore, it discusses the role of nanotechnology, antioxidants, DNA repair technology, and oral and systemic agents in photoprotection. Each chapter encapsulates decades of clinical, research or practical experience on topics that will surely be an interest for clinicians, researchers, industry scientists, regulators, and consumers.

Prevention of Skin Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 9401705119
Total Pages : 328 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Prevention of Skin Cancer by : David Hill

Download or read book Prevention of Skin Cancer written by David Hill and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our series Cancer Prevention - Cancer Control continues to address the causes and prevention of cancer. In this volume, Hill, Elwood, and English bring together a rich resource summarizing the state of science underpinning the primary prevention of skin cancer. While skin cancer causes an increasing burden, particularly in populations of European origin, our understanding of the role of sun exposure together with the genetic components of skin cancer continues to grow. Given the emphasis on evidence-based medicine and public health prevention efforts, it is noteworthy that, although we can all access the same evidence base, countries around the world have had remarkably different responses to the application of this knowledge to prevent skin cancer. The outstanding contribution of the Australian public health community to the scientific understanding of skin cancer etiology and the translation of this knowledge into national prevention efforts uniquely positions the editors to compile this volume focused on the primary prevention of skin cancer. In so doing they draw on an international team of authors to present a “state of the science” summary of skin cancer prevention and to identify those areas where uncertainty remains. To achieve successful prevention of cancer we must translate our scientific knowledge base into effective prevention programs. This book offers the reader keen insights into the depth of our understanding of etiologic pathways for skin cancer. This etiologic science base is complemented by rigorous prevention science placing emphasis on the social context for effective and sustained prevention efforts.

Sunlight, Vitamin D and Skin Cancer

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Author :
Publisher : Springer Nature
ISBN 13 : 3030462277
Total Pages : 428 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Sunlight, Vitamin D and Skin Cancer by : Jörg Reichrath

Download or read book Sunlight, Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Quick Guide to Contact Dermatitis

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Author :
Publisher : Springer
ISBN 13 : 3662477149
Total Pages : 325 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Quick Guide to Contact Dermatitis by : Jeanne Duus Johansen

Download or read book Quick Guide to Contact Dermatitis written by Jeanne Duus Johansen and published by Springer. This book was released on 2015-09-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a quick guide for clinicians, specialists, and residents. It provides a concise overview of the practical aspects of contact dermatitis, supplying the tools to allow a fast and reliable diagnosis. The book describes the clinical features of contact dermatitis, explains how to make an exposure assessment and covers other essentials in the diagnostic work. Information is presented on testing with patients’ own products and overviews are provided on the allergens contained in various products. In addition, a helpful list of the most frequent allergens is included. The authors are leading practitioners in the field, and their expertise has enabled the compilation of an approachable text supplemented by a large number of full color illustrations, tables and check lists. This book will help the reader to gain a better understanding of the subject and to achieve greater competence in everyday practice.

Oxidative Stress, Disease and Cancer

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Author :
Publisher : World Scientific
ISBN 13 : 1783260114
Total Pages : 1104 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Oxidative Stress, Disease and Cancer by : Keshav K Singh

Download or read book Oxidative Stress, Disease and Cancer written by Keshav K Singh and published by World Scientific. This book was released on 2006-04-04 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a comprehensive review of the most up-to-date knowledge of the sources and molecular mechanisms of oxidative stress, and its role in disease and cancer. It also focuses on the novel agents and methods that can be employed to prevent oxidative stress and associated diseases. The authors first review the most recent data on the basic mechanisms of oxidative stress. The second section discusses oxidative stress leading to several diseases and cancers, and in the third section, the strategies employed in the prevention and treatment of oxidative stress-related diseases are discussed. Contents:Yin and Yang of Mitochondrial ROS (A Starkov & K B Wallace)Intracellular Oxidative Stress Caused by Ionizing Radiation (H J Majima et al.)Oxidative Damage to Mitochondria (J C Tilak & T P A Devasagayam)Oxidative Stress and Antioxidant Defenses in Plants (O Blokhina & K Fagerstedt)Lipid- and Protein-Mediated Oxidative Damage to DNA (M D Evans & M S Cooke)Oxidative Damage to Nucleotide: Consequences and Preventive Mechanisms (Y Nakatsu & M Sekiguchi)Oxidative Damage to DNA and Its Repair (L J Rasmussen)Cellular Responses to Reactive Oxygen Species (I W Dawes)Oxidative Stress, Cell Proliferation, and Apoptosis (J S Carew et al.)Oxidative Damage to Carbohydrates and Amino Acids (M d'Ischia et al.)Superoxide Dismutase 2 Deficient Mice: The Role of Increased Reactive Oxygen Species in Genomic Instability (E Samper et al.)Oxidative Stress, Genetic Variation, and Disease (L Lyrenäs et al.)Oxidative Stress and Autoimmune Diseases (J Saegusa et al.)Does Oxidative Stress Determine Lifespan? (F L Muller & H Van Remmen)Oxidative Stress and Ataxia–Telangiectasia (E M Dunner & D J Watters)Oxidative Stress and Cardiovascular Disease (S Johar et al.)Oxidative Stress, Insulin Resistance, and Cardiovascular Disease (A Ceriello)Pathogenesis and Etiology of Down's Syndrome in Relation to Oxidative Stress (S Arbuzova & H Cuckle)Oxidative Stress and Ulcerative Colitis: Experimental Evidence and Implications for Treatment (D N Seril et al.)Oxidative Stress and Neurodegenerative Disease (K Schüssel et al.)Oxidative Stress and Mitochondrial Disease (C-Y Lu et al.)Oxidative Stress and Respiratory Disease (R Maselli & G Pelaia)Oxidative Stress and Human Reproduction (A Agarwal & S Allamaneni)Oxidative Stress and Multistage Carcinogenesis (P C Goswami & K K Singh)Oxidative Stress and Cancer Cachexia (G Mantovani & C Madeddu)Oxidative Stress in Cancer-Prone Diseases (G Pagano)Iron-Induced Carcinogenesis (S Toyokuni)Copper and Carcinogenesis (T Theophanides & J Anastassopoulou)Arsenic, Oxidative Stress, and Carcinogenesis (M F Hughes & K T Kitchin)Estrogen-Induced Carcinogenesis: Importance of Oxidative Stress (H K Bhat)Oxidative Stress in HIV Infection (W Dröge)Oxidative Stress and Breast Cancer (J Ahn & C B Ambrosone)Oxidative Stress and Photocarcinogenesis: Strategies for Prevention (S K Katiyar)Oxidative Stress and Coenzyme Q10 Therapy (F L Rosenfeldt et al.)Plant-Derived Antioxidants (F H Sarker & Y Li)Oxidative Stress and Cancer Therapy (K Pong)Nanoscale Antioxidant Therapeutics (T Dziubla et al.)Use of Biomarkers of Oxidative Stress in Human Studies (C-Y Chen & J B Blumberg) Readership: Academics, researchers, scientists, clinicians, physicians, members of the society for free radical biology and medicine and members of SFRR. Key Features:The first book that describes the roles of oxidative stress in diseasesOver 35 of the leading experts in the oxidative stress field have contributed to this book. Their expertise ranges from basic to translational to therapeutic aspects of oxidative stress-associated diseasesKeywords:Oxidative Stress;Disease;Cancer;Free Radical;Superoxide;Mitochondria;Aging;Antioxidant;Antioxidant Therapy

Polyphenols in Human Health and Disease

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Publisher : Academic Press
ISBN 13 : 012398467X
Total Pages : 1504 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Polyphenols in Human Health and Disease by : Ronald Ross Watson

Download or read book Polyphenols in Human Health and Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2013-10-26 with total page 1504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. Explores neuronal protection by polyphenol metabolites and their application to medical care Defines modulation of enzyme actions to help researchers see and study polyphenols’ mechanisms of action, leading to clinical applications Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases

Clinical Guide to Sunscreens and Photoprotection

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Author :
Publisher : CRC Press
ISBN 13 : 9780367386153
Total Pages : 300 pages
Book Rating : 4.3/5 (861 download)

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Book Synopsis Clinical Guide to Sunscreens and Photoprotection by : Henry W Lim

Download or read book Clinical Guide to Sunscreens and Photoprotection written by Henry W Lim and published by CRC Press. This book was released on 2019-08-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed with practicing dermatologists, dermatology trainees, physicians, and scientists interested in photoprotection in mind, this concise and highly illustrated guide provides the latest knowledge of photoprotection in dermatology and cosmetic science. Clinical Guide to Sunscreens and Photoprotection also addresses recent important international and domestic regulatory activity and requirements on the use of novel sun protective chemicals and proper labeling of products to ensure increased consumer awareness. This concisely written, problem-oriented text explores:

Carotenoids

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Publisher : MDPI
ISBN 13 : 3039218646
Total Pages : 168 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Carotenoids by : Volker Böhm

Download or read book Carotenoids written by Volker Böhm and published by MDPI. This book was released on 2019-12-05 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carotenoids are a group of natural pigments, consisting of more than 750 compounds. They are mostly yellow, orange, or red in color, due to the system of conjugated double bonds. This structural element is also responsible for the good antioxidant properties of many carotenoids. Carotenoids have shown numerous biological activities (not only as provitamin A), e.g., preventive properties of fruits and vegetables. As lipophilic compounds, their uptake and storage in the body are dependent on various conditions. In vitro and in vivo data showed stimulating and inhibitory effects of matrix compounds on bioaccessibility and bioavailability of carotenoids. ​​​​​​​This Special Issue presents the most recent advances in carotenoids research, in addition to the search for antioxidant properties. Chapters present the photoprotective properties of carotenoids as well as the activities of carotenoids related to liver health. Research data on the effect of degree of ripeness on carotenoids pattern in rosehip and possibilities to use shrimp waste as source of carotenoids are presented. Other investigations characterized apocarotenoids in microalgae and the properties of inclusion complexes of lycopene and beta-cyclodextrin. Biological activities of synthesized retinoyl-flavonolignan hybrids were also reported. In addition, the effects of in vitro digestion of human milk on the micellization of carotenoids were investigated.

Therapeutic Hotline: New Developments in Dermatology, An Issue of Dermatologic Clinics

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323682839
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Therapeutic Hotline: New Developments in Dermatology, An Issue of Dermatologic Clinics by : Seemal R Desai

Download or read book Therapeutic Hotline: New Developments in Dermatology, An Issue of Dermatologic Clinics written by Seemal R Desai and published by Elsevier Health Sciences. This book was released on 2019-03-13 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Dermatologic Clinics, guest edited by Dr. Seemal R. Desai of The University of Texas Southwestern Medical Center, is devoted to Therapeutic Hotline: New Developments in Dermatology. Articles in this timely issue address updates in psoriasis, hair loss, nail diseases, photoprotection, melanoma, pediatric dermatology, pigmentary disorders, women’s skin health, acne, atopic dermatitis, bullous diseases; rosacea, and genetic skin diseases.

Photomedicine

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Publisher : Frontiers Media SA
ISBN 13 : 2889631125
Total Pages : 104 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Photomedicine by : Peter Wolf

Download or read book Photomedicine written by Peter Wolf and published by Frontiers Media SA. This book was released on 2019-11-25 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic in Frontiers in Medicine offers a concise overview of the latest knowledge in the field of Photomedicine on therapeutic and preventive modalities, and UV pathogenesis of skin cancer. Photomedicine has revolutionized the treatment of inflammatory and neoplastic skin diseases over the last century since Niels Ryberg Finsen was awarded in 1903 the Nobel Prize “in recognition of his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science”. From then on, the field has moved on in leaps and bounds to expand phototreatment to many inflammatory as well as neoplastic skin diseases. With this Research Topic we aim to promote the field by giving the latest insights into Photomedicine’s therapeutic modalities and molecular mechanisms in treatment of diseases of the skin and beyond, as well as prevention from photodermatoses and carcinogenesis, as the dark sites of light. By engaging clinicians and scientists we intend to advance basic, clinical and translational research in the field of Photomedicine with its numerous facets.

Sunscreen Photobiology: Molecular, Cellular and Physiological Aspects

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Publisher : Springer Science & Business Media
ISBN 13 : 3662101351
Total Pages : 205 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Sunscreen Photobiology: Molecular, Cellular and Physiological Aspects by : Francis P. Gasparro

Download or read book Sunscreen Photobiology: Molecular, Cellular and Physiological Aspects written by Francis P. Gasparro and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sunscreens are universally recommended by dermatologists not only to prevent the immediate effects of overexposure to sunlight but also to prevent skin cancer. While the former goal is immediately evident, the latter remains an unproven hypothesis and is a topic of some controversy. Recent epidemiological studies suggesting a correlation between increased use of sunscreens over the past two decades and the rise in skin cancer have led to the question whether sunscreens applied to skin may be undergoing photoreactions, the effects of which are elaborated many years later. By addressing the key questions, this book advances the field of sunscreen photobiology and provides the reader with an unbiased perspective on this important field.

Anti-Ageing Nutrients

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Publisher : John Wiley & Sons
ISBN 13 : 1118823214
Total Pages : 424 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Anti-Ageing Nutrients by : Deliminda Neves

Download or read book Anti-Ageing Nutrients written by Deliminda Neves and published by John Wiley & Sons. This book was released on 2015-04-22 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ageing is a complex, time-related biological phenomenon that is genetically determined and environmentally modulated. According to even the most pessimistic projections, average lifespan is expected to increase around the world during the next 20 years, significantly raising the number of aged individuals. But increasing life expectancy presents new problems, and industrialized countries are facing a pronounced increase in lifestyle diseases which constitute barriers to healthy ageing. Anti-Ageing Nutrients: Evidence-based Prevention of Age-Associated Diseases is written by a multi-disciplinary group of researchers, all interested in the nutritional modulation of ageing mechanisms. Structured in three parts, Part 1 looks at the cellular modifications that underlie senescence of cells and ageing of the organisms; the effects of energy restriction on cellular and molecular mechanisms and in the whole organism; and the epigenetic modifications associated with ageing. Part 2 includes chapters which discuss the nutritional modulation of age-associated pathologies and the functional decline of organs, with a focus on those primarily affected by chronological ageing. Part 3 summarises the knowledge presented in the previous chapters and considers the best diet pattern for the aged individuals. The book reflects the most recent advances in anti-ageing nutrition and will be a valuable resource for professionals, educators and students in the health, nutritional and food sciences.

Nutritional Cosmetics

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Author :
Publisher : William Andrew
ISBN 13 : 0815520301
Total Pages : 582 pages
Book Rating : 4.8/5 (155 download)

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Book Synopsis Nutritional Cosmetics by : Aaron Tabor

Download or read book Nutritional Cosmetics written by Aaron Tabor and published by William Andrew. This book was released on 2009-07-30 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutritional cosmetics is an emerging area of intense research and marketing and encompasses the concept that orally consumed dietary products can support healthier and more beautiful skin. There are numerous dietary ingredients now being marketed for their potential skin health and beauty benefits and many of these are supported by growing scientific evidence. The purpose of this book is to compile the scientific evidence showing the potential benefits of some of the more extensively researched ingredients. As far as possible, information about the benefits of ingredients consumed orally for skin health is presented. The information contained in this book will help provide insights into an emerging research area and provide scientific background for the potential clinical effectiveness for some of the better researched nutricosmetic ingredients. ABOUT THE EDITORS Aaron Tabor, M.D. is the CEO of Physicians Pharmaceuticals and author of The Revival Slim & Beautiful Diet. A graduate of the Johns Hopkins School of Medicine, Dr. Tabor oversees all clinical research on the Revival Slim & Beautiful Diet plan, conducting randomized, double-blinded, placebo-controlled studies at leading hospitals in the U.S. Areas of note include weight loss, skin/hair/nail appearance, energy, menopause, PMS, cholesterol, memory, and diabetic health. He is also responsible for directing new Revival product development based on clinical research results. Robert M. Blair, Ph.D. is the Research Manager for Physicians Pharmaceuticals, Inc. and manages the daily activities of the Research and Nutrition departments. Dr. Blair received his Ph.D. from Oklahoma State University in the field of Reproductive Physiology. Before joining Physicians Pharmaceuticals, Inc., he worked as an Assistant Professor of Comparative Medicine at the Wake Forest University School of Medicine where he examined the effects of dietary soy on cardiovascular health and cognitive function. Reviews the most-popular and most-researched nutricosmetic ingredients Presents information specifically about the benefits of ingredients consumed orally for skin health Considers the benefits of whey protein, rosemary, soy – and green tea and milk thistle, specifically, for protection against sun damage and photocarcinogenesis Provides information on antioxidants, incl: potential benefits of botanical antioxidants; carotenoids; coenzyme Q10; healthy fruits; olive fruit; and natural enzymes

Skin Stress Response Pathways

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Author :
Publisher : Springer
ISBN 13 : 3319431579
Total Pages : 457 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Skin Stress Response Pathways by : Georg T. Wondrak

Download or read book Skin Stress Response Pathways written by Georg T. Wondrak and published by Springer. This book was released on 2016-08-22 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.

Evidence Based Dermatology

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Author :
Publisher : PMPH-USA
ISBN 13 : 9781607950394
Total Pages : 1142 pages
Book Rating : 4.9/5 (53 download)

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Book Synopsis Evidence Based Dermatology by : Howard I. Maibach

Download or read book Evidence Based Dermatology written by Howard I. Maibach and published by PMPH-USA. This book was released on 2011 with total page 1142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-based thinking in clinical medicine has impacted greatly on the physician's approach to clinical care. Evidence-Based Dermatology introduces and encourages the concept of evidence-based patient care in dermatology. Incorporating a text that is much more than merely the summary of trial data, the authors worked to explore disease mechanisms and treatments in greater depth and detail in order to provide more insight for the reader. In addition to promoting the understanding of the evidence-based philosophy, the authors have focused on some of the fundamentals in dermatology that need to be approached differently. Issues such as the interpretation of clinical research, disease-oriented evidence versus patient-care evidence, and the use of placebo are examined.