Biology of Inositols and Phosphoinositides

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Publisher : Springer Science & Business Media
ISBN 13 : 0387276009
Total Pages : 340 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Biology of Inositols and Phosphoinositides by : A. Lahiri Majumder

Download or read book Biology of Inositols and Phosphoinositides written by A. Lahiri Majumder and published by Springer Science & Business Media. This book was released on 2006-10-03 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward. With the current genomic and proteomic tools in place the new role of inositols, inositol phosphates and phosphoinositides in cell signaling or stress response has been explored. These advances are described in this volume and are expected to give new insights into the functional implications of inositol compounds across evolutionary diverse species.

Biology of Phosphoinositides

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Author :
Publisher : Oxford University Press, USA
ISBN 13 : 9780199637645
Total Pages : 372 pages
Book Rating : 4.6/5 (376 download)

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Book Synopsis Biology of Phosphoinositides by : Shamshad Cockcroft

Download or read book Biology of Phosphoinositides written by Shamshad Cockcroft and published by Oxford University Press, USA. This book was released on 2000 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the current opinions on lipid signalling research with an emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate, but in the light of recent research it has become apparent that any work in this area must include the two, as this book does. In the text, control of synthesis, translocation, and degradation of phosphoinositides is given extensive coverage; there is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation-state of membrane proteins; the regulation of phospholipase C, phospholipase D, the phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth.

Phosphoinositides in Subcellular Targeting and Enzyme Activation

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Publisher : Springer Science & Business Media
ISBN 13 : 3642188052
Total Pages : 215 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Phosphoinositides in Subcellular Targeting and Enzyme Activation by : Harald Stenmark

Download or read book Phosphoinositides in Subcellular Targeting and Enzyme Activation written by Harald Stenmark and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.

Phosphoinositides II: The Diverse Biological Functions

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Publisher : Springer Science & Business Media
ISBN 13 : 9400730152
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides II: The Diverse Biological Functions by : Tamas Balla

Download or read book Phosphoinositides II: The Diverse Biological Functions written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-02-28 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Phosphoinositides and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9400750242
Total Pages : 322 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides and Disease by : Marco Falasca

Download or read book Phosphoinositides and Disease written by Marco Falasca and published by Springer Science & Business Media. This book was released on 2012-10-21 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

Inositol and Phosphoinositides

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Publisher : Springer Science & Business Media
ISBN 13 : 1461251842
Total Pages : 690 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Inositol and Phosphoinositides by : John E. Bleasdale

Download or read book Inositol and Phosphoinositides written by John E. Bleasdale and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides. The first took place in 1968 in New York [Ann. New York Acad. Sci. (1969), 765,508-819] and the second was held in 1977 in East Lansing, Michigan [eyclitols and Phosphoinositides, Wells, W. W. and Eisenberg, F. , eds. , (1978) Academic press, New York, pp. 1-607. ] In the interim since the previous conference, not only has the pace of research in the field accelerated markedly, but the physiological importance of phosphoinositide metabolism has become apparent to an increasing number of investigators from diverse fields in the life sciences. Thus it seemed to us timely for both recent and established workers in this area, as well as others whose interests impinged on it, to meet in order to disseminate new information, to review, and perhaps arrive at, a consensus of our current understanding of the role of inositol and phosphoinositides, and to establish new directions for research for the next few years. The expansion of the field since the last meeting made it mandatory to restrict the scope of the topics covered at the conference, primarily to aspects dealing with mammalian systems. We sincerely regretted the exclusion of recent research on cyclitols and phosphoinositides in microbes and plants and hope that these areas will be included in future conferences.

Phosphoinositides I: Enzymes of Synthesis and Degradation

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Publisher : Springer Science & Business Media
ISBN 13 : 940073011X
Total Pages : 361 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction

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Publisher : Springer Science & Business Media
ISBN 13 : 1461303435
Total Pages : 433 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction by : B.B. Biswas

Download or read book myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction written by B.B. Biswas and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: `The heterogeneity of topics ... is very ambitious, and the result is, overall, successful because of the high quality of the individual contributions ... highly recommended.' -American Scientist, from a review of a previous volume Volume 26 examines the emerging areas of signal transduction based on myoinositol phosphates and Ca2+ while focusing on plant and animal responses. Chapters explore synthesis, separation, and identification of different inositol phosphates.

Ionic Channels of Excitable Membranes

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Publisher : Sinauer Associates, Incorporated
ISBN 13 :
Total Pages : 632 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Ionic Channels of Excitable Membranes by : Bertil Hille

Download or read book Ionic Channels of Excitable Membranes written by Bertil Hille and published by Sinauer Associates, Incorporated. This book was released on 1992 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.

Diabetes Mellitus

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Publisher : Springer Science & Business Media
ISBN 13 : 1592593771
Total Pages : 190 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Diabetes Mellitus by : Sabire Özcan

Download or read book Diabetes Mellitus written by Sabire Özcan and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is the collective name for a group of diseases associated with hyperglycemia (high levels of blood glucose) caused by defects in insulin p- duction, insulin action, or both. About 6. 2% of the US population (17 million people) have diabetes mellitus. It is the leading cause of kidney failure, bli- ness, and amputations. It is also a major risk factor for heart diseases, stroke, and birth defects. Diabetes Mellitus: Methods and Protocols provides a state-of-the-art account of the experimental methodology for studying the molecular defects leading to diabetes mellitus, both at the molecular and biochemical levels. The chapters cover a wide range of topics written by experts in their respective fields and are organized in two sections: Insulin Production and Insulin Action. The detailed experimental protocols presented, including the notes of interest, provide a very useful tool for basic researchers and clinicians for investigating and treating this disease. Each chapter starts with an introduction to a specific technique and explains its application in the field of diabetes research. Following the list of materials, a detailed description of the technique is presented in the methods section in a way that enables the successful execution of the protocol. The “Notes” section at the end discusses the pitfalls of the technique and alternative approaches. I am grateful to the numerous scientists who have contributed to this volume by writing both highly detailed and understandable chapters.

Signal Transduction in Plants

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Publisher : Springer Science & Business Media
ISBN 13 : 1461513650
Total Pages : 328 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Signal Transduction in Plants by : S.K. Sopory

Download or read book Signal Transduction in Plants written by S.K. Sopory and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the mechanisms by which plants perceive environmental cues, both physical and chemical, and transduce the signals that influence specific expression of genes, is an area of intensive scientific research. With the completion of the genome sequence of Arabidopsis it is understood now that a larger number of genes encode for proteins involved in signalling cascades and transcription factors. In this volume, different chapters deal with plant receptors, second messengers like calcium ions, phosphoinositides, salicylic acid and nitrous oxide, calcium binding proteins and kinases. In addition to dealing with the response of plants to light, hormones, pathogens, heat, etc. on cellular activity, work currently going on in apoptosis, cell division, and plastid gene expression is also covered in this book.

Phosphoinositides

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Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Phosphoinositides by : K. S. Bruzik

Download or read book Phosphoinositides written by K. S. Bruzik and published by . This book was released on 1999 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes current research on cellular signal transduction involving inositol phosphates and phospholipids and features contributions from some of the leading laboratories. The chapters span three key topics: the metabolism of inositol phosphates and identification of proteins that interact with polyphosphorylated phosphatidylinositols; the mechanisms and structure of phosphatidylinositol-specific phospholipase C; and the synthesis and biological properties of analogs for phosphoinositides.

Actin-Binding Proteins and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 0387717498
Total Pages : 362 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Actin-Binding Proteins and Disease by : Cris dos Remedios

Download or read book Actin-Binding Proteins and Disease written by Cris dos Remedios and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.

Cell Membrane Nanodomains

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Publisher : CRC Press
ISBN 13 : 1482209918
Total Pages : 496 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Cell Membrane Nanodomains by : Alessandra Cambi

Download or read book Cell Membrane Nanodomains written by Alessandra Cambi and published by CRC Press. This book was released on 2014-10-27 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Membrane Nanodomains: From Biochemistry to Nanoscopy describes recent advances in our understanding of membrane organization, with a particular focus on the cutting-edge imaging techniques that are making these new discoveries possible. With contributions from pioneers in the field, the book explores areas where the application of these novel

Basic Neurochemistry

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Publisher : Elsevier
ISBN 13 : 0080472079
Total Pages : 1020 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Basic Neurochemistry by : R. Wayne Albers

Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Elsevier. This book was released on 2005-11-11 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical education. Completely updated with 60% new authors and material, and entirely new chapters Over 400 fully revised figures in splendid color

Cyclitols and Phosphoinositides: Chemistry, Metabolism, and Function

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Publisher :
ISBN 13 :
Total Pages : 324 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Cyclitols and Phosphoinositides: Chemistry, Metabolism, and Function by :

Download or read book Cyclitols and Phosphoinositides: Chemistry, Metabolism, and Function written by and published by . This book was released on 1969 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclitols and Phosphoinositides

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Publisher :
ISBN 13 :
Total Pages : 640 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cyclitols and Phosphoinositides by : William W. Wells

Download or read book Cyclitols and Phosphoinositides written by William W. Wells and published by . This book was released on 1978 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: