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Pharmacodynamic Models Of Selected Toxic Chemicals In Man
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Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man by : A.D. Smith
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man written by A.D. Smith and published by Springer. This book was released on 2014-01-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Dynamics of Selected Toxic Materials in Man". vii 2 Summary This report presents results from the second phase of a study on the metabolism of selected actual and potential human carcin ogens. In the first phase of this work a comprehensive review of literature relating to the metabolism of these materials was under taken and pharmacokinetic models were proposed to represent that meta bolism. It was suggested that these models, and the reviews on which they were based, would provide information relevant to the development of monitoring programmes and in the interpretation of dose-response data. In the second phase of the study, attention has been concen trated on the implementation of the models proposed for the various substances reviewed, i.e. arsenic, beryllium, cadmium, lead, nickel, chromium, asbestos, benzene, vinyl chloride monomer, benzidine and its congeners, carbon tetrachloride and methyl iodide. However, this programme has been supplemented by an on-going review of the relevant literature on these substances and a detailed analysis of the applica bili ty of the pharmacokinetic models used for the organs of intake, i.e. the lung and gastrointestinal tract.
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man by : M.C. Thorne
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man written by M.C. Thorne and published by Springer. This book was released on 1986-10-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes present the results of two studies undertaken for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities. The aim was to review available data concerning the metabolism of a selection of toxic chemi cals in man and to develop mathematical models representing this meta bolism. Volume 1 is the report from the first study and presents re views of the data for each of the substances and proposes models for their metabolic behaviour. Volume 2 is the report of the second study and contains a review of new data relevant to the development of meta bolic models for each substance. The modelling of uptake and retention by the two major routes of uptake (the respiratory system and the gas trointestinal tract) is also reviewed. The implementation of the models in a computer code is described and results are presented illus trating organ concentrations and rates of excretion for typical regimes of exposure. vi 1 Foreword This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Models for the Metabolism of Chemical Carcinogens in Man". vii 2 Summary This report includes results of a review of the metabolism of selected actual and potential human carcinogens and proposals for pharmacokinetic models to represent that metabolism.
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man by : A.D. Smith
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man written by A.D. Smith and published by Springer. This book was released on 2011-10-13 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Dynamics of Selected Toxic Materials in Man". vii 2 Summary This report presents results from the second phase of a study on the metabolism of selected actual and potential human carcin ogens. In the first phase of this work a comprehensive review of literature relating to the metabolism of these materials was under taken and pharmacokinetic models were proposed to represent that meta bolism. It was suggested that these models, and the reviews on which they were based, would provide information relevant to the development of monitoring programmes and in the interpretation of dose-response data. In the second phase of the study, attention has been concen trated on the implementation of the models proposed for the various substances reviewed, i.e. arsenic, beryllium, cadmium, lead, nickel, chromium, asbestos, benzene, vinyl chloride monomer, benzidine and its congeners, carbon tetrachloride and methyl iodide. However, this programme has been supplemented by an on-going review of the relevant literature on these substances and a detailed analysis of the applica bili ty of the pharmacokinetic models used for the organs of intake, i.e. the lung and gastrointestinal tract.
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man: Review of metabolic data by : M. C. Thorne
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man: Review of metabolic data written by M. C. Thorne and published by . This book was released on 1986 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man: Routes of intake and implementation of pharmacodynamic models by : M. C. Thorne
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man: Routes of intake and implementation of pharmacodynamic models written by M. C. Thorne and published by . This book was released on 1986 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacodynamic models of selected toxic chemicals in man by :
Download or read book Pharmacodynamic models of selected toxic chemicals in man written by and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man; Review of Metabolic Data by : MC. THORNE
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man; Review of Metabolic Data written by MC. THORNE and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis PHARMACODYNAMIC MODELS OF SELECTED TOXIC CHEMICALS IN MAN; ROUTES OF INTAKE AND IMPLEMENTATION OF PHARMACODYNAMIC MODELS by : AD. SMITH
Download or read book PHARMACODYNAMIC MODELS OF SELECTED TOXIC CHEMICALS IN MAN; ROUTES OF INTAKE AND IMPLEMENTATION OF PHARMACODYNAMIC MODELS written by AD. SMITH and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man by : M.C. Thorne
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man written by M.C. Thorne and published by Springer. This book was released on 2014-01-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes present the results of two studies undertaken for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities. The aim was to review available data concerning the metabolism of a selection of toxic chemi cals in man and to develop mathematical models representing this meta bolism. Volume 1 is the report from the first study and presents re views of the data for each of the substances and proposes models for their metabolic behaviour. Volume 2 is the report of the second study and contains a review of new data relevant to the development of meta bolic models for each substance. The modelling of uptake and retention by the two major routes of uptake (the respiratory system and the gas trointestinal tract) is also reviewed. The implementation of the models in a computer code is described and results are presented illus trating organ concentrations and rates of excretion for typical regimes of exposure. vi 1 Foreword This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Models for the Metabolism of Chemical Carcinogens in Man". vii 2 Summary This report includes results of a review of the metabolism of selected actual and potential human carcinogens and proposals for pharmacokinetic models to represent that metabolism.
Book Synopsis Pharmacodynamic Models of Selected Toxic Chemicals in Man by :
Download or read book Pharmacodynamic Models of Selected Toxic Chemicals in Man written by and published by . This book was released on 1986 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacodynamic models of selected toxic chemicals in man by : M. C. Thorne
Download or read book Pharmacodynamic models of selected toxic chemicals in man written by M. C. Thorne and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Routes of Intake and Implementation of Pharmacodynamic Models by :
Download or read book Routes of Intake and Implementation of Pharmacodynamic Models written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council
Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2003 with total page 1532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biopersistence of Respirable Synthetic Fibers and Minerals by :
Download or read book Biopersistence of Respirable Synthetic Fibers and Minerals written by and published by . This book was released on 1994 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
