Intentional Human Dosing Studies for EPA Regulatory Purposes

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Publisher : National Academies Press
ISBN 13 : 0309166411
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council

Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Pesticides in the Diets of Infants and Children

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Publisher : National Academies Press
ISBN 13 : 0309048753
Total Pages : 402 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Pesticides in the Diets of Infants and Children by : National Research Council

Download or read book Pesticides in the Diets of Infants and Children written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.

Kinetics of Soil Chemical Processes

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Publisher : Academic Press
ISBN 13 : 1483289192
Total Pages : 227 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Kinetics of Soil Chemical Processes by : Donald L. Sparks

Download or read book Kinetics of Soil Chemical Processes written by Donald L. Sparks and published by Academic Press. This book was released on 2013-10-22 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The kinetics of reactions in soil and aquatic environments is a topic of extreme importance and interest. To properly understand the fate of applied fertilizers, pesticides, and organic pollutants with time, and to thus improve nutrient availability and the quality of our groundwater, one must study kinetics. This is the first compre Demonstrates different kinetic methodologies Shows how reactions on soil and soil constituents can be measured by utilizing different techniques Describes rates and mechanisms of interactions with pesticides and organic pollutants with soil Covers the kinetics of chemical weathering Discusses how to use mathematical modeling and computer simulation to model kinetic reactions

Pesticide Kinetics

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Publisher :
ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.:/5 (277 download)

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Book Synopsis Pesticide Kinetics by : United States. National Technical Information Service

Download or read book Pesticide Kinetics written by United States. National Technical Information Service and published by . This book was released on 1982 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pesticide Biotransformation and Disposition

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Publisher : Academic Press
ISBN 13 : 0123854822
Total Pages : 236 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Pesticide Biotransformation and Disposition by : Ernest Hodgson

Download or read book Pesticide Biotransformation and Disposition written by Ernest Hodgson and published by Academic Press. This book was released on 2012-01-01 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations

Kinetics of Pesticide Volatilization from the Surface of Water

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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (293 download)

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Book Synopsis Kinetics of Pesticide Volatilization from the Surface of Water by : R. James Maguire

Download or read book Kinetics of Pesticide Volatilization from the Surface of Water written by R. James Maguire and published by . This book was released on 1990 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work demonstrates for the first time the importance of the volatilization of pesticides from the surface microlayer after they are sprayed on water. It provides direct laboratory evidence of fast volatilization of fenitrothion and deltamethrin from the surface of sprayed water. This phenomenon must be taken into account in attempts to calculate mass balances for sprayed pesticides in aquatic ecosystems.

Water Resources Research Catalog

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Publisher :
ISBN 13 :
Total Pages : 1464 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Water Resources Research Catalog by :

Download or read book Water Resources Research Catalog written by and published by . This book was released on 1966 with total page 1464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Kinetics of Pesticide Volatilization from the Surface of Water

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Author :
Publisher : Burlington, Ont. : National Water Research Institute
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (293 download)

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Book Synopsis Kinetics of Pesticide Volatilization from the Surface of Water by : Maguire, R. J. (R. James)

Download or read book Kinetics of Pesticide Volatilization from the Surface of Water written by Maguire, R. J. (R. James) and published by Burlington, Ont. : National Water Research Institute. This book was released on 1990 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pesticides Remediation Technologies from Water and Wastewater

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Publisher : Elsevier
ISBN 13 : 0323908942
Total Pages : 464 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Pesticides Remediation Technologies from Water and Wastewater by : Mohammad Hadi Dehghani

Download or read book Pesticides Remediation Technologies from Water and Wastewater written by Mohammad Hadi Dehghani and published by Elsevier. This book was released on 2022-04-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pesticides Remediation Technologies from Water and Wastewater focuses on environmental aspects and health effects of pesticides, the use of conventional and AOPs technologies, and adsorption processes and nanomaterials for the removal of pesticides from water and wastewater. The deterioration of water quality is of great concern due to its effects on aquatic organisms, humans and the ecosystem. Among the pollutants, pesticides are a major concern in villages and farm land. This edited book bridges the gap between old and new knowledge about the categorization of pesticides, the presence of them in water, wastewater, soil and foods, and new methods to detect them from water matrices. This edited book provides the necessary basic knowledge to new researchers who want to learn about pesticides and the ways to eliminate them in aqueous matrices. Moreover, it is also a helpful resource for mature researchers in this field, providing them with new trends in water and wastewater treatment processes, preparation and application of novel adsorbent materials. Includes methods for effectively removing pesticides from potable water and water bodies Provides techniques that are eco-friendly and that do not use toxic chemicals and are lower in cost Presents information needed to identify severe health effects on human beings and aquatic animals

Organophosphate Pesticide Degradation Under Drinking Water Treatment Conditions

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Publisher :
ISBN 13 :
Total Pages : 68 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Organophosphate Pesticide Degradation Under Drinking Water Treatment Conditions by : Stephen E. Duirk

Download or read book Organophosphate Pesticide Degradation Under Drinking Water Treatment Conditions written by Stephen E. Duirk and published by . This book was released on 2005 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Little work to date has solely investigated the kinetics and pathways of pesticide transformations under drinking water treatment conditions. Free chlorine has been found to react with s-triazine, carbamate, and organophosphate pesticides. However, these experimental conditions did not account for naturally occurring aquatic constituents such as natural organic matter (NOM) or inorganic ions (i.e., bromide). The kinetics and degradation pathways for chlorpyrifos (CP), an OP pesticide, have been established in buffered deionized water. However, the effect of NOM and bromide on the rate of CP has yet to be thoroughly investigated. This research was designed to examine the influence of NOM and bromide on the loss of CP in the presence of free chlorine.

Cholinesterases and Anticholinesterase Agents

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Publisher : Springer Science & Business Media
ISBN 13 : 3642998755
Total Pages : 1228 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Cholinesterases and Anticholinesterase Agents by : George B. Koelle

Download or read book Cholinesterases and Anticholinesterase Agents written by George B. Koelle and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 1228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.

Kinetics of Pesticide Volatilization from the Surface of Water

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Author :
Publisher :
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (293 download)

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Book Synopsis Kinetics of Pesticide Volatilization from the Surface of Water by : R. James Maguire

Download or read book Kinetics of Pesticide Volatilization from the Surface of Water written by R. James Maguire and published by . This book was released on 1990 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work demonstrates for the first time the importance of the volatilization of pesticides from the surface microlayer after they are sprayed on water. It provides direct laboratory evidence of fast volatilization of fenitrothion and deltamethrin from the surface of sprayed water. This phenomenon must be taken into account in attempts to calculate mass balances for sprayed pesticides in aquatic ecosystems.

Pesticides in the Soil Environment

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Author :
Publisher :
ISBN 13 : 9780891187912
Total Pages : 0 pages
Book Rating : 4.1/5 (879 download)

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Book Synopsis Pesticides in the Soil Environment by : Hwei-Hsien Cheng

Download or read book Pesticides in the Soil Environment written by Hwei-Hsien Cheng and published by . This book was released on 1990 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pesticides in the soil environment - an overview. Pesticide sources to the soil and principles of spray physics. The retention processes: mechanisms. Sorption estimates for modeling. Abiotic transformations in water, sediments, and soil. Biological transformation processes of pesticides. Volatilization and vapor transport processes. Organic chemical transport to Groundwater. Movement of pesticides into surface waters. Modeling pesticide fate in soils. Efficacy of soil-applied pesticides. Impact of pesticides on the environment. Risk/benefit and regulations. Chemical index.

Activated Carbon Surfaces in Environmental Remediation

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Publisher : Elsevier
ISBN 13 : 0080455956
Total Pages : 587 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Activated Carbon Surfaces in Environmental Remediation by : Teresa J. Bandosz

Download or read book Activated Carbon Surfaces in Environmental Remediation written by Teresa J. Bandosz and published by Elsevier. This book was released on 2006-02-27 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Activated Carbon Surfaces in Environmental Remediation provides a comprehensive summary of the environmental applications of activated carbons. In order to understand the removal of contaminants and pollutants on activated carbons, the theoretical bases of adsorption phenomena are discussed. The effects of pore structure and surface chemistry are also addressed from both science and engineering perspectives. Each chapter provides examples of real applications with an emphasis on the role of the carbon surface in adsorption or reactive adsorption. The practical aspects addressed in this book cover the broad spectrum of applications from air and water cleaning and energy storage to warfare gas removal and biomedical applications. This book can serve as a handbook or reference book for graduate students, researchers and practitioners with an interest in filtration, water treatment, adsorbents and air cleaning, in addition to environmental policies and regulations. Addresses fundamental carbon science and how it relates to applications of carbon surfaces Describes the broad spectrum of activated carbon applications in environmental remediation Serves as a handbook or reference book for graduate students, researchers and practitioners in the field

Decontamination of Pesticide Residues in the Environment

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Publisher : Springer Science & Business Media
ISBN 13 : 1461584558
Total Pages : 216 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Decontamination of Pesticide Residues in the Environment by : Francis A. Gunther

Download or read book Decontamination of Pesticide Residues in the Environment written by Francis A. Gunther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: That residues of pesticide and other "foreign" chemicals in food stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of "Residue Reviews" and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals per sisting into our foodstuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and toxicological disciplines.

PCB in Water

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Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis PCB in Water by : Water Resources Scientific Information Center

Download or read book PCB in Water written by Water Resources Scientific Information Center and published by . This book was released on 1973 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Steady State Degradation Kinetics of the Chloroaromatic Pesticide Dicamba

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Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (288 download)

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Book Synopsis Steady State Degradation Kinetics of the Chloroaromatic Pesticide Dicamba by : Sally Anne Thomas

Download or read book Steady State Degradation Kinetics of the Chloroaromatic Pesticide Dicamba written by Sally Anne Thomas and published by . This book was released on 1993 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: