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Peptide Coordinated Iron Oxide Nanoparticles For Enhance Magnetic Resonance Imaging
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Book Synopsis Peptide Coordinated Iron Oxide Nanoparticles for Enhance Magnetic Resonance Imaging by : Samuel Ajamu
Download or read book Peptide Coordinated Iron Oxide Nanoparticles for Enhance Magnetic Resonance Imaging written by Samuel Ajamu and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The current technologies at our disposal for diagnostic imaging consist of CT, X-Rays, Ultrasound, PET, and MRI. Among all of these imaging modalities, MRI is one of the most versatile and detailed instruments for imaging internal organs. It is exceptional because it provides clear differences in abnormal and normal tissues and it does not subject patients to x-rays that could be harmful with repetitive use. This thesis will explore a peptide-based material to enhance the capacity of MRI imaging but specifically to cancer tissue. The material is a peptide- based colloidal material that enables the magnetic resonance imaging of cancer cell. The colloidal material will consist of iron oxide particles and metal- chelating peptide that holds the structure together. This peptide and iron oxide colloid will serve as a contrast agent that are controlled to a specific size to ensure that they utilize a phenomenon in cancer tissue called enhanced permeability and retention effect. Overall, the purpose of this thesis is to obtain a better understanding of how peptide can be used for imaging materials. The anticipated outcome of this process will be to obtain qualitative and quantitative information on the effectiveness of the uptake of the peptide chelated iron oxide particles. This aimed to verify the production of the iron- oxide contrast agent and the ability to control their size with a high affinity peptide. The data for effective uptake will be taken using Dynamic Light Scattering. This will be done using controls as a way of quantifying the effects of the peptide on the size of the iron oxide particles. Additionally the effectiveness of the nanoparticles will be measured using MRI to view the magnetic effects of the contrast agents. This will be done on just the particles to see if they retain their magnetic properties. The collective data as a whole will show the way a novel contrast agent passively targeting cancer cells can be produced.
Book Synopsis Applications of Theranostic Nanoparticles as Contrast Agents in Magnetic Resonance Imaging by : Richard Aaron Revia
Download or read book Applications of Theranostic Nanoparticles as Contrast Agents in Magnetic Resonance Imaging written by Richard Aaron Revia and published by . This book was released on 2020 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in materials science that have allowed for the engineering of nanoscale structures represent a revolutionary paradigm shift for the detection and remediation of diseases such as cancer. Worldwide research efforts are currently leveraging the tools of nanotechnology to aid the fight against cancer by developing novel material architectures that are designed to provide quicker diagnoses of disease at earlier time points than are currently available and improved therapeutic responses by efficiently killing cancer tissue while minimizing off-target side effects. One nanotechnology in particular, iron oxide nanoparticles (NPs), has received intense interest due to its many beneficial attributes: biodegradability, chemical surface properties, and superparamagnetism. Unlike other metal-core NPs, iron oxide NPs are nontoxic when decomposed and prepared for excretion by the body as the iron in their cores may be used by the body in iron-containing proteins (e.g., hemoglobin and ferritin). Additionally, the chemical composition of iron oxide lends itself for use in chemical passivation techniques that seek to coat the iron oxide cores in polymers that confer advantageous qualities of biocompatibility and ligation of functional moieties. Finally, the magnetic properties of iron oxide particles of nanoscale proportions allow the NPs to serve as contrast enhancing agents in magnetic resonance imaging (MRI), a tool that is widely used to image the soft tissue of the body for cancer detection. This dissertation details the use of iron oxide NPs as contrast agents for MRI and as therapeutic agents targeting an insidiously aggressive brain cancer: glioblastoma. First, noninvasive MRI is used to determine the biodistribution of iron oxide NPs in both mice and nonhuman primates in a first-of-its-kind, cross-species comparison of iron oxide NP pharmacokinetics. It was found that the pharmacokinetics of iron oxide NPs between the two species were similar in some organs (i.e., blood, liver, spleen, and muscle) but distinct in others (i.e., kidneys, brain, and bone marrow). Next, iron oxide NPs are directly delivered to brain tumors in mice via convection-enhanced delivery (CED), and their distribution throughout the tumor volume is tracked in real-time using MRI. The distribution of iron oxide NPs ligated with a glioblastoma-targeting peptide, chlorotoxin, is compared to the distribution of bare NPs; results show that NPs attached to chlorotoxin are better able to suffuse throughout the tumor volume than NPs lacking the tumor-targeting moiety. Following these research efforts that display the ability of iron oxide NPs to serve as contrast agents in MRI, a therapeutic example of iron oxide NPs in oncology is provided as these NPs are used to enhance the radiation dose delivered to mice-bearing orthotopic glioblastoma tumors. Mice treated with NPs prior to receiving radiotherapy exhibited a 2-fold increase in median survival compared to mice receiving only radiotherapy. Finally, a novel nanotechnology platform, boron-doped graphene quantum dots, is explored for use as a nontoxic MRI contrast agents.
Book Synopsis Magnetic Nanoparticles in Human Health and Medicine by : Costica Caizer
Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
Book Synopsis Metal, Metal Oxides and Metal Sulphides for Biomedical Applications by : Saravanan Rajendran
Download or read book Metal, Metal Oxides and Metal Sulphides for Biomedical Applications written by Saravanan Rajendran and published by Springer Nature. This book was released on 2021-01-25 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advances in inorganic nanomaterials for healthcare, with focus on the synthesis, medical applications and toxicity of metals, metal oxides and metal sulfides. Major applications include diagnosis, bioimaging, biosensing, healing and therapy in cancer, diabetes, cardiovascular diseases, obesity, metabolic syndrome, dentistry and antimicrobials.
Book Synopsis Iron Oxide Nanoparticles for Biomedical Applications by : Sophie Laurent
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Book Synopsis Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis by : Juanye Zhang
Download or read book Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis written by Juanye Zhang and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contrast agents are commonly used in magnetic resonance imaging (MRI) for their ability to selectively highlight or darken image brightness from different tissue components depending on their chemical nature. This work explores and discusses potential of colloidal iron oxide nanoparticles as non-toxic MRI contrast agents for diagnosis. Novel single-nanometer iron oxide (SNIO) nanoparticles exhibited contrast enhancement in T1-weighted MRI superior than commercially used gadolinium-based contrast agents, with unprecedentedly fast and clean renal clearance in inorganic colloidal nanoparticles. An approach for size determination based on small-angle X-ray scattering (SAXS) was developed, and understanding of particle size distribution led to successful development of alkyne-functionalized nanoparticles allowing for conjugation with biological cargos, creating a novel vehicle for drug delivery. SNIO-CBP, product from conjugating functionalized SNIO nanoparticles with a nature-inspired cyclic collagen-binding peptide (CBP) through newly developed preparatory copper-catalyzed alkyne-azide coupling CuAAC, exhibited binding affinity towards type I collagen, a natural indicator of fibrosis abundant in the extracellular matrix. SNIO-CBP was able to quickly detect hepatotoxin-induced and diet-induced non-alcoholic steatohepatitis (NASH) in mice through T1-weighted MRI upon intravenous administration. New formulations of hydrophilic iron oxide nanoparticles were explored. Tailored for quantitative ultra-short time-to-echo contrast-enhanced (QUTE-CE) MRI, catechol-coated iron oxide with 10 nm mean diameter was optimized; carboxymethyl dextran as a new ligand system was developed on SNIO and formation of nanoparticle clusters was observed, implying its potential for the emergent preclinical technique of magnetic particle imaging (MPI).
Book Synopsis Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging by : Carlos F. G. C. Geraldes
Download or read book Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging written by Carlos F. G. C. Geraldes and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Since the development of the first clinical MRI contrast agent, GdDTPA or Magnevista in the early 1980s, another three linear and three macrocyclic eg. Gd DOTA Dotarema have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems"--
Book Synopsis Magnetic Iron Oxide Nanoparticles as Potential Contrast Agents for Magnetic Resonance Imaging by :
Download or read book Magnetic Iron Oxide Nanoparticles as Potential Contrast Agents for Magnetic Resonance Imaging written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents the development of novel formulations on the basis of magnetic iron oxide nanoparticles. Optimization of the synthesis route resulted in the development of particles meeting general requirements for eventual applications. Furthermore, the selection of appropriate stabilizing agents imparted the nanoparticles with beneficial features, making an in vivo application possible. In doing so, the formulations seem to be especially promising for the application as contrast agents in magnetic resonance imaging. Chapter 1 gives a brief insight into current research in the field of magnetic nanoparticles. While the originally promoted idea of dragging nanoparticles to the site of action by a massive external field is becoming less important, the use of magnetic carriers as single and multifunctional imaging agents is gaining in importance. Chapter 2 describes the synthesis of magnetic iron oxide nanoparticles with optimal properties for MRI contrast enhancement and the comparative assessment of polymeric macromolecules as stabilizers for such nanoparticles. It was revealed that particles covered by poly(ethylene imine)-g-poly(ethylene glycol) performed better than their poly(ethylene imine) counterparts, in terms of stability and cytotoxicity. The systems containing the former polymer showed pronounced colloidal stability even in protein-rich cell media. In addition, cytotoxicity was reduced by more than an order of magnitude. In this respect, the assumptions made in the run-up to the studies have found confirmation. Indeed, the introduction of hydrophilic poly(ethylene glycol) moieties to the polymer backbone positively manipulated the above properties. In addition, the physicochemical properties of the generated iron oxide nanoparticles were found to be excellent, despite the simplicity of the synthesis procedure. The iron oxide cores displayed high crystallinity, high saturation magnetization and superparamagnetic features. The polymer-coated nanopartic.
Book Synopsis Magnetic Iron Oxide Nanoparticles as Potential Contrast Agents for Magnetic Resonance Imaging by : Christoph Schweiger
Download or read book Magnetic Iron Oxide Nanoparticles as Potential Contrast Agents for Magnetic Resonance Imaging written by Christoph Schweiger and published by . This book was released on 2010 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biocompatible Fluorescent Magnetic Nanoparticles for Imaging of Cancer Cells by : Debarati de
Download or read book Biocompatible Fluorescent Magnetic Nanoparticles for Imaging of Cancer Cells written by Debarati de and published by . This book was released on 2023-03-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocompatible fluorescent magnetic nanoparticles are an emerging class of materials that are being extensively studied for imaging of cancer cells. These nanoparticles are composed of magnetic core materials, such as iron oxide, coated with a biocompatible polymer or ligand that provides a stable surface for functionalization with fluorescent dyes. The combination of magnetic and fluorescent properties in a single nanoparticle allows for both imaging and magnetic manipulation of cells, making them a promising tool for cancer diagnosis and treatment. The use of biocompatible fluorescent magnetic nanoparticles for imaging of cancer cells has several advantages over traditional imaging techniques. First, these nanoparticles can be targeted to specific cells or tissues, allowing for more precise imaging of cancer cells. Second, the magnetic properties of these nanoparticles allow for magnetic resonance imaging (MRI), which can provide higher resolution images than traditional imaging techniques. Third, the fluorescent properties of these nanoparticles allow for visualization of cells in real time, providing valuable information about the behavior of cancer cells. The synthesis of biocompatible fluorescent magnetic nanoparticles involves several steps. The first step is the preparation of the magnetic core material, which is typically iron oxide. The iron oxide nanoparticles are then coated with a biocompatible polymer or ligand, such as polyethylene glycol (PEG) or dextran, to provide a stable surface for functionalization with fluorescent dyes. The surface of the nanoparticles is then modified with a targeting ligand, such as an antibody or peptide, to allow for specific binding to cancer cells. The fluorescent dyes used to functionalize these nanoparticles are typically organic dyes, such as fluorescein or rhodamine, or inorganic quantum dots. Organic dyes are preferred for their biocompatibility and ease of synthesis, while quantum dots are preferred for their bright fluorescence and narrow emission spectra. The choice of dye depends on the specific application of the nanoparticles. Biocompatible fluorescent magnetic nanoparticles have been extensively studied for their use in cancer diagnosis and treatment. One application is in the detection of circulating tumor cells (CTCs), which are cancer cells that have detached from the primary tumor and entered the bloodstream. The detection of CTCs is important for the early detection of cancer metastasis, which can improve patient outcomes. Biocompatible fluorescent magnetic nanoparticles can be targeted to CTCs using specific antibodies or peptides, and then imaged using fluorescence microscopy or MRI.
Download or read book TiO2 Nanoparticles written by Aiguo Wu and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique book that summarizes the properties, toxicology, and biomedical applications of TiO2-based nanoparticles Nanotechnology is becoming increasingly important for products used in our daily lives. Nanometer-sized titanium dioxide (TiO2) are widely used in industry for different purposes, such as painting, sunscreen, printing, cosmetics, biomedicine, and so on. This book summarizes the advances of TiO2 based nanobiotechnology and nanomedicine, covering materials properties, toxicological research, and biomedical application, such as antibacter, biosensing, and cancer theranostics. It uniquely integrates the TiO2 applications from physical properties, toxicology to various biomedical applications, and includes black TiO2 based cancer theranostics. Beginning with a comprehensive introduction to the properties and applications of nanoparticles, TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine offers chapters on: Toxicity of TiO2 Nanoparticles; Antibacterial Applications of TiO2 Nanoparticles; Surface Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate); TiO2 as Inorganic Photosensitizer for Photodynamic Therapy; Cancer Theranostics of Black TiO2 Nanoparticles; and Neurodegenerative Disease Diagnostics and Therapy of TiO2-Based Nanoparticles. This title: -Blends the physical properties, toxicology of TiO2 nanoparticles to the many biomedical applications -Includes black TiO2 based cancer theranostics in its coverage -Appeals to a broad audience of researchers in academia and industry working on nanomaterials-based biosensing, drug delivery, nanomedicine TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine is an ideal book for medicinal chemists, analytical chemists, biochemists, materials scientists, toxicologists, and those in the pharmaceutical industry.
Download or read book Nanozymology written by Xiyun Yan and published by Springer Nature. This book was released on 2020-01-30 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for industry. It is of interest to university researchers, R&D engineers, as well as graduate students in nanoscience and technology, and biology wishing to learn the core principles, methods, and the corresponding applications of “nanozyme”.
Book Synopsis Iron Oxide Nanoparticles for Targeted Cellular Imaging and Drug Delivery by : Mike Jeon
Download or read book Iron Oxide Nanoparticles for Targeted Cellular Imaging and Drug Delivery written by Mike Jeon and published by . This book was released on 2019 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxide nanoparticles (IONPs) have drawn significant interest in the field of biomedicine due to their intrinsic magnetic properties that allow contrast under magnetic resonance imaging (MRI). With proven biocompatibility, biodegradability, and flexible surface chemistry for a variety of applications, IONPs have been used as theranostic agents, combining therapy and diagnosis in a single formulation. Despite their potential, few IONPs have transitioned to the clinic due to the challenges of achieving high drug loading while maintaining proper size and stability to bypass biological barriers, minimizing off-target drug release to prevent side effects, and increasing specificity to minimize non-specific uptake for increased efficacy. Many strategies can overcome these limitations. To increase specificity, incorporating active targeting by conjugating targeting agents onto IONPs can specifically bind and label intended sites. This approach can open up labeling and imaging of novel sites, such as neurons, when using MRI for diagnostic purposes. For drug delivery purposes, chemotherapeutics can be loaded onto IONPs with controlled release to prevent drug leakage and the consequent side effects. Incorporating targeting agents can further reduce off-target drug release. While IONPs have historically seen great utility as T2 contrast agents, these applications could be further expanded by designing IONPs for T1 contrast enhancement. This dissertation documents the development of iron oxide nanoparticle systems intended to overcome the shortcomings of various iron oxide nanoparticle applications with novel applications. First, we used IONPs conjugated with a dopaminergic neurolabeler to actively target the dopamine transporter to label and image dopaminergic neurons under MRI. The neurolabeler enhanced targeting and uptake of IONPs 3-fold over control IONPs. Labeling and imaging the brain using PET/SPECT is a tool to diagnose neurological disorders, such as Parkinson's disease. By using IONPs, this technique can be expanded to MRI to improve upon the shortcomings of PET/SPECT. Next, IONPs were loaded with paclitaxel to treat breast cancer cells. Due to their severe hydrophobicity, paclitaxel were bound close to the core of the IONP via an acid-cleavable ester bond, with longer chain PEG providing steric stabilization and hydrophilicity to stabilize the IONP. The paclitaxel loaded IONPs were further modified with folic acid, used as a targeting agent to bind to the folate receptors that are commonly over-expressed in breast cancer cells. The folic acid labeled and paclitaxel loaded IONP enhanced uptake by 2-fold, demonstrated controlled release of paclitaxel, and produced significantly higher cytotoxicity in breast cancer cells compared to free paclitaxel. Despite their proven efficacy as T2 contrast agents, IONPs have been hindered in their translation to clinical imaging applications due to the inherent limitations of T2 contrast agents. The benefits of T1 contrast has led to gadolinium-based contrast agents (GBCAs) serving as the dominant contrast agents in the clinic, while their severe side effects have highlighted the need for a biocompatible alternative. IONPs have the ability to serve as an alternative T1 contrast agent to GBCAs, but their potential has not been fully explored. Using the fundamentals of T1 contrast, we developed and characterized a T1 IONP. It demonstrated excellent physiological properties ideal for biological applications, with T1 contrast capabilities confirmed through phantom MR imaging. Finally, with clinical translation in mind, we investigated optimization of freeze-drying methods to prolong the stability of IONPs. Aqueous solutions can hydrolyze and degrade NPs, prohibiting long-term stability in solutions. Freeze-drying offers means of removing water to prevent degradation, yet freeze-drying stresses can cause irreversible damage to NPs. Cryoprotectants have been used to minimize or rid these freeze-drying stresses, yet their effects on IONPs have not been explored. A variety of cryoprotectants were tested for their effects on maintaining size, stability, zeta potential, and magnetic properties after freeze-drying on IONPs produced by the Zhang group and commercially available IONPs. Sucrose was the most effective cryoprotectant, with 10 wt.% sucrose offering IONPs great stability up to 6 months while preserving size, zeta potential, and magnetic properties.
Book Synopsis Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices by : Kalim Deshmukh
Download or read book Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices written by Kalim Deshmukh and published by Elsevier. This book was released on 2024-01-22 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices: Current and Emerging Research Trends explores the various aspects of functionalization of magnetic nanosystems in great detail, providing a thorough review of the associated benefits and challenges. The book begins with an overview of each key pillar for the design and application of functionalized magnetic nanosystems, from the synthesis, processing methods, and characterization techniques, to biocompatibility and toxicity considerations. Later chapters focus on specific nanomaterials and targeted biomedical applications, including point-of-care diagnosis, cancer therapy, medical imaging, biosensing and more. Importance is given to the safety considerations; environmental, legal and ethical implications, and commercial aspects of functionalized magnetic nanosystems - providing guidance relevant for advancing research into clinical practice. Provides an overview of fundamentals in the design and application of magnetic nanosystems, from synthesis and processing to functionalization and toxicity assessment Explores research in industry and clinical practice, providing insights into ethical, environmental, legal, and commercial aspects Covers a wide range of diagnostic applications for functionalized magnetic nanosystems, such as in medical imaging, drug detection, tissue engineering, and more
Book Synopsis Cancer Theranostics by : Xiaoyuan Chen
Download or read book Cancer Theranostics written by Xiaoyuan Chen and published by Academic Press. This book was released on 2014-03-20 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management
Book Synopsis Diverse Use of Iron Oxide Nanoparticles for Anticancer Therapy by : Gayani Sandeepa Abayaweera
Download or read book Diverse Use of Iron Oxide Nanoparticles for Anticancer Therapy written by Gayani Sandeepa Abayaweera and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent development of a variety of superparamagnetic and ferromagnetic iron/iron oxide (Fe/Fe3O4) nanoparticles with different surface chemistry have been widely studied for numerous biological applications such as drug delivery, as diagnostics, hyperthermia and magnetic resonance imaging. The wide applications of Fe/Fe3O4 nanoparticles are possible since they exhibit favorable properties as high magnetization ability, are smaller than 100 nm in size, they can be coated with several ligands which allow drug delivery at a specific site and are biocompatible. By using Fe/Fe3O4 nanoparticles as drug delivery agents treatment costs and side effects can be reduced, however treatment efficacy can be increased. We have demonstrated that Fe/Fe3O4 nanoparticles can be utilized in different methods depending on their properties, to be used as therapeutic agents for cancer treatment. In one method we have taken advantage of the Fe/Fe3O4 nanoparticles magnetic ability to produce hyperthermia (heat) in cancer cells when subjected to an alternative magnetic field. Here we use the cell based delivery system since the size of the nanoparticles are small they can be taken up by monocyte/ macrophage like cells for systemic transportation to the inflamed cancer cite. The hyperthermia study was conducted in mice with pancreatic cancer. This study demonstrated that the life expectancy of the mice increased by 31%. In the next method we took the advantage of the surface chemistry of the Fe/Fe3O4 nanoparticles and changed it with dopamine-peptide and dopamine-thiosemicarbazone ligands. The advantage of the peptide is to deliver the nanoparticle to its target site and the thiosemicarbazone analogue is used as an iron chelator that would initiate apoptosis in cancer cells. This nanoplatform was tested in 4T1 breast cancer cell line and normal fibroblast cell line and demonstrated that it was effective towards the cancer cell line than the normal cell line at a ratio of 5:1 of thiosemicarbazone analogue : dopamine on the nanoparticle. However further studies are needed to be done to clarify the effectiveness of this nanosystem.
Book Synopsis Magnetic Nanoparticles in Biosensing and Medicine by : Nicholas J. Darton
Download or read book Magnetic Nanoparticles in Biosensing and Medicine written by Nicholas J. Darton and published by Cambridge University Press. This book was released on 2019-02-14 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing together topics from a wide range of disciplines, and featuring up-to-date examples of clinical usage and research applications, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine.
