High-Dimensional Data Analysis in Cancer Research

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Publisher : Springer Science & Business Media
ISBN 13 : 0387697659
Total Pages : 164 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis High-Dimensional Data Analysis in Cancer Research by : Xiaochun Li

Download or read book High-Dimensional Data Analysis in Cancer Research written by Xiaochun Li and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.

Comprehensive Chemometrics

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Publisher : Elsevier
ISBN 13 : 0444641661
Total Pages : 2948 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Comprehensive Chemometrics by : Steven Brown

Download or read book Comprehensive Chemometrics written by Steven Brown and published by Elsevier. This book was released on 2020-05-26 with total page 2948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Chemometrics, Second Edition, Four Volume Set features expanded and updated coverage, along with new content that covers advances in the field since the previous edition published in 2009. Subject of note include updates in the fields of multidimensional and megavariate data analysis, omics data analysis, big chemical and biochemical data analysis, data fusion and sparse methods. The book follows a similar structure to the previous edition, using the same section titles to frame articles. Many chapters from the previous edition are updated, but there are also many new chapters on the latest developments. Presents integrated reviews of each chemical and biological method, examining their merits and limitations through practical examples and extensive visuals Bridges a gap in knowledge, covering developments in the field since the first edition published in 2009 Meticulously organized, with articles split into 4 sections and 12 sub-sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Written by academics and practitioners from various fields and regions to ensure that the knowledge within is easily understood and applicable to a large audience Presents integrated reviews of each chemical and biological method, examining their merits and limitations through practical examples and extensive visuals Bridges a gap in knowledge, covering developments in the field since the first edition published in 2009 Meticulously organized, with articles split into 4 sections and 12 sub-sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Written by academics and practitioners from various fields and regions to ensure that the knowledge within is easily understood and applicable to a large audience

Statistical Learning with Sparsity

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Publisher : CRC Press
ISBN 13 : 1498712177
Total Pages : 354 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Statistical Learning with Sparsity by : Trevor Hastie

Download or read book Statistical Learning with Sparsity written by Trevor Hastie and published by CRC Press. This book was released on 2015-05-07 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover New Methods for Dealing with High-Dimensional DataA sparse statistical model has only a small number of nonzero parameters or weights; therefore, it is much easier to estimate and interpret than a dense model. Statistical Learning with Sparsity: The Lasso and Generalizations presents methods that exploit sparsity to help recover the underl

Chemometrics in Chromatography

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Publisher : CRC Press
ISBN 13 : 1498772544
Total Pages : 506 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Chemometrics in Chromatography by : Łukasz Komsta

Download or read book Chemometrics in Chromatography written by Łukasz Komsta and published by CRC Press. This book was released on 2018-02-02 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemometrics uses advanced mathematical and statistical algorithms to provide maximum chemical information by analyzing chemical data, and obtain knowledge of chemical systems. Chemometrics significantly extends the possibilities of chromatography and with the technological advances of the personal computer and continuous development of open-source software, many laboratories are interested in incorporating chemometrics into their chromatographic methods. This book is an up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

Comprehensive Chemometrics

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Publisher : Elsevier
ISBN 13 : 044452701X
Total Pages : 2880 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Comprehensive Chemometrics by :

Download or read book Comprehensive Chemometrics written by and published by Elsevier. This book was released on 2009-03-09 with total page 2880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to serve as the first point of reference on the subject, Comprehensive Chemometrics presents an integrated summary of the present state of chemical and biochemical data analysis and manipulation. The work covers all major areas ranging from statistics to data acquisition, analysis, and applications. This major reference work provides broad-ranging, validated summaries of the major topics in chemometrics—with chapter introductions and advanced reviews for each area. The level of material is appropriate for graduate students as well as active researchers seeking a ready reference on obtaining and analyzing scientific data. Features the contributions of leading experts from 21 countries, under the guidance of the Editors-in-Chief and a team of specialist Section Editors: L. Buydens; D. Coomans; P. Van Espen; A. De Juan; J.H. Kalivas; B.K. Lavine; R. Leardi; R. Phan-Tan-Luu; L.A. Sarabia; and J. Trygg Examines the merits and limitations of each technique through practical examples and extensive visuals: 368 tables and more than 1,300 illustrations (750 in full color) Integrates coverage of chemical and biological methods, allowing readers to consider and test a range of techniques Consists of 2,200 pages and more than 90 review articles, making it the most comprehensive work of its kind Offers print and online purchase options, the latter of which delivers flexibility, accessibility, and usability through the search tools and other productivity-enhancing features of ScienceDirect

Mixed Effects Models for Complex Data

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Publisher : CRC Press
ISBN 13 : 9781420074086
Total Pages : 431 pages
Book Rating : 4.0/5 (74 download)

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Book Synopsis Mixed Effects Models for Complex Data by : Lang Wu

Download or read book Mixed Effects Models for Complex Data written by Lang Wu and published by CRC Press. This book was released on 2009-11-11 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.

Statistical Foundations of Data Science

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Publisher : CRC Press
ISBN 13 : 0429527616
Total Pages : 942 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Statistical Foundations of Data Science by : Jianqing Fan

Download or read book Statistical Foundations of Data Science written by Jianqing Fan and published by CRC Press. This book was released on 2020-09-21 with total page 942 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Foundations of Data Science gives a thorough introduction to commonly used statistical models, contemporary statistical machine learning techniques and algorithms, along with their mathematical insights and statistical theories. It aims to serve as a graduate-level textbook and a research monograph on high-dimensional statistics, sparsity and covariance learning, machine learning, and statistical inference. It includes ample exercises that involve both theoretical studies as well as empirical applications. The book begins with an introduction to the stylized features of big data and their impacts on statistical analysis. It then introduces multiple linear regression and expands the techniques of model building via nonparametric regression and kernel tricks. It provides a comprehensive account on sparsity explorations and model selections for multiple regression, generalized linear models, quantile regression, robust regression, hazards regression, among others. High-dimensional inference is also thoroughly addressed and so is feature screening. The book also provides a comprehensive account on high-dimensional covariance estimation, learning latent factors and hidden structures, as well as their applications to statistical estimation, inference, prediction and machine learning problems. It also introduces thoroughly statistical machine learning theory and methods for classification, clustering, and prediction. These include CART, random forests, boosting, support vector machines, clustering algorithms, sparse PCA, and deep learning.

Gentle Introduction To Support Vector Machines In Biomedicine, A - Volume 2: Case Studies And Benchmarks

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Publisher : World Scientific Publishing Company
ISBN 13 : 9814518506
Total Pages : 210 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Gentle Introduction To Support Vector Machines In Biomedicine, A - Volume 2: Case Studies And Benchmarks by : Alexander Statnikov

Download or read book Gentle Introduction To Support Vector Machines In Biomedicine, A - Volume 2: Case Studies And Benchmarks written by Alexander Statnikov and published by World Scientific Publishing Company. This book was released on 2013-03-21 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Support Vector Machines (SVMs) are among the most important recent developments in pattern recognition and statistical machine learning. They have found a great range of applications in various fields including biology and medicine. However, biomedical researchers often experience difficulties grasping both the theory and applications of these important methods because of lack of technical background. The purpose of this book is to introduce SVMs and their extensions and allow biomedical researchers to understand and apply them in real-life research in a very easy manner. The book is to consist of two volumes: theory and methods (Volume 1) and case studies (Volume 2).

Regression Modeling with Actuarial and Financial Applications

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Publisher : Cambridge University Press
ISBN 13 : 0521760119
Total Pages : 585 pages
Book Rating : 4.5/5 (217 download)

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Book Synopsis Regression Modeling with Actuarial and Financial Applications by : Edward W. Frees

Download or read book Regression Modeling with Actuarial and Financial Applications written by Edward W. Frees and published by Cambridge University Press. This book was released on 2010 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book teaches multiple regression and time series and how to use these to analyze real data in risk management and finance.

Generalized Additive Models

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Publisher : CRC Press
ISBN 13 : 1584884746
Total Pages : 412 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Generalized Additive Models by : Simon Wood

Download or read book Generalized Additive Models written by Simon Wood and published by CRC Press. This book was released on 2006-02-27 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in widespread use, generalized additive models (GAMs) have evolved into a standard statistical methodology of considerable flexibility. While Hastie and Tibshirani's outstanding 1990 research monograph on GAMs is largely responsible for this, there has been a long-standing need for an accessible introductory treatment of the subject that also emphasizes recent penalized regression spline approaches to GAMs and the mixed model extensions of these models. Generalized Additive Models: An Introduction with R imparts a thorough understanding of the theory and practical applications of GAMs and related advanced models, enabling informed use of these very flexible tools. The author bases his approach on a framework of penalized regression splines, and builds a well-grounded foundation through motivating chapters on linear and generalized linear models. While firmly focused on the practical aspects of GAMs, discussions include fairly full explanations of the theory underlying the methods. Use of the freely available R software helps explain the theory and illustrates the practicalities of linear, generalized linear, and generalized additive models, as well as their mixed effect extensions. The treatment is rich with practical examples, and it includes an entire chapter on the analysis of real data sets using R and the author's add-on package mgcv. Each chapter includes exercises, for which complete solutions are provided in an appendix. Concise, comprehensive, and essentially self-contained, Generalized Additive Models: An Introduction with R prepares readers with the practical skills and the theoretical background needed to use and understand GAMs and to move on to other GAM-related methods and models, such as SS-ANOVA, P-splines, backfitting and Bayesian approaches to smoothing and additive modelling.

Regression Modeling Strategies

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Publisher : Springer Science & Business Media
ISBN 13 : 147573462X
Total Pages : 583 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Regression Modeling Strategies by : Frank E. Harrell

Download or read book Regression Modeling Strategies written by Frank E. Harrell and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".

U-MIDAS

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Publisher :
ISBN 13 : 9783865587817
Total Pages : 0 pages
Book Rating : 4.5/5 (878 download)

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Book Synopsis U-MIDAS by : Claudia Foroni

Download or read book U-MIDAS written by Claudia Foroni and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Scientific and Technical Aerospace Reports

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Publisher :
ISBN 13 :
Total Pages : 1282 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Scientific and Technical Aerospace Reports by :

Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1982 with total page 1282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.

Linear Regression Analysis

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Publisher : World Scientific
ISBN 13 : 9812834109
Total Pages : 349 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Linear Regression Analysis by : Xin Yan

Download or read book Linear Regression Analysis written by Xin Yan and published by World Scientific. This book was released on 2009 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume presents in detail the fundamental theories of linear regression analysis and diagnosis, as well as the relevant statistical computing techniques so that readers are able to actually model the data using the techniques described in the book. This book is suitable for graduate students who are either majoring in statistics/biostatistics or using linear regression analysis substantially in their subject area." --Book Jacket.

Data Science and Machine Learning

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Publisher : CRC Press
ISBN 13 : 1000730778
Total Pages : 538 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Data Science and Machine Learning by : Dirk P. Kroese

Download or read book Data Science and Machine Learning written by Dirk P. Kroese and published by CRC Press. This book was released on 2019-11-20 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on mathematical understanding Presentation is self-contained, accessible, and comprehensive Full color throughout Extensive list of exercises and worked-out examples Many concrete algorithms with actual code

Applied Predictive Modeling

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Publisher : Springer Science & Business Media
ISBN 13 : 1461468493
Total Pages : 595 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Applied Predictive Modeling by : Max Kuhn

Download or read book Applied Predictive Modeling written by Max Kuhn and published by Springer Science & Business Media. This book was released on 2013-05-17 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Predictive Modeling covers the overall predictive modeling process, beginning with the crucial steps of data preprocessing, data splitting and foundations of model tuning. The text then provides intuitive explanations of numerous common and modern regression and classification techniques, always with an emphasis on illustrating and solving real data problems. The text illustrates all parts of the modeling process through many hands-on, real-life examples, and every chapter contains extensive R code for each step of the process. This multi-purpose text can be used as an introduction to predictive models and the overall modeling process, a practitioner’s reference handbook, or as a text for advanced undergraduate or graduate level predictive modeling courses. To that end, each chapter contains problem sets to help solidify the covered concepts and uses data available in the book’s R package. This text is intended for a broad audience as both an introduction to predictive models as well as a guide to applying them. Non-mathematical readers will appreciate the intuitive explanations of the techniques while an emphasis on problem-solving with real data across a wide variety of applications will aid practitioners who wish to extend their expertise. Readers should have knowledge of basic statistical ideas, such as correlation and linear regression analysis. While the text is biased against complex equations, a mathematical background is needed for advanced topics.

Cumulated Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1792 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1792 pages. Available in PDF, EPUB and Kindle. Book excerpt: