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Palladium Catalyzed Intramolec
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Book Synopsis Catalyzed Carbon-Heteroatom Bond Formation by : Andrei K. Yudin
Download or read book Catalyzed Carbon-Heteroatom Bond Formation written by Andrei K. Yudin and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an experienced editor widely acclaimed within the scientific community, this book covers everything fromo9xygen to nitrogen functionalities. From the contents: Palladium-Catalyzed Syntheses of Five-Member Saturated Heterocyclic and of Aromatic Heterodynes Palladium-Catalysis for Oxidative 1, 2-Difunctionalization of Alkenes Rhodium-Catalyzed Amination of C-H-Bonds Carbon-Heteroatom Bond Formation by RH(I)-Catalyzed Ring-Opening Reactions Transition Metal-Catalyzed Synthesis of Lactones and of Monocyclic and Fused Five-Membered Aromatic heterocycles the Formation of Carbon-Sulfur and Carbon-Selenium bonds by Substitution and Addition reactions catalyzed by Transition Metal Complexes New Reactions of Copper Acetylides Gold Catalyzed Addition of Nitrogen, Sulfur and Oxygen Nucleophiles to C-C Multiple Bonds. The result is an indispensable source of information for the Strategic Planning of the Synthetic routes for organic, catalytic and medicinal chemists, as well as chemists in industry.
Book Synopsis Palladium-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes for Synthesis of Nitrogen-Containing Heterocycles by : Liu Ye
Download or read book Palladium-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes for Synthesis of Nitrogen-Containing Heterocycles written by Liu Ye and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Palladium-catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes for Synthesis of Nitrogen-containing Heterocycles" by Liu, Ye, 葉柳, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Palladium-catalyzed carboamination (simultaneous formation of C-N and C-C bonds from an olefin) has emerged as an efficient protocol for the synthesis of diversely functionalized N-heterocycles, which are widely displayed in natural products and pharmaceuticals. Compared with the well-documented aminoarylation, aminovinylation and aminoalkynylation, analogous aminoalkylation remains a challenge. This project aims at developing innovative strategies for aminoalkylation to construct a broad array of N-containing heterocycles. An efficient and general palladium-catalyzed intramolecular aminoalkylation of alkenyl aromatic α-halo acetamides with a wide substrate scope under mild conditions has been developed, yielding diverse dihydropyrroloindole derivatives of pharmaceutical interest. Preliminary mechanistic studies suggest that the reaction involves a Pd(0)/Pd(II) catalytic cycle, initiated by oxidative addition of α-halogen of amide with Pd(0) complex. The formation of an unprecedented four-membered-ring Pd(alkyl)amido complex is also supported by ESI-MS analysis. The synthetic utility of this aminoalkylation has been demonstrated by the synthesis of bioactive compounds A, B and C. Then the aminoalkylation reaction has been expanded to the more challenging alkenyl aliphatic α-halo acetamide substrates. This transformation features no requirement for air and moisture sensitive phosphine ligands and provides a straightforward access to a variety of bicyclic pyrrolizidine derivatives. Detailed mechanism studies support the hypothesis that the formation of a four-coordinate intermediate 3-IV is crucial for the realization of this transformation. An isotopic labeling experiment indicates that the aminopalladation proceeds through syn-insertion of alkene into Pd-N bond. The application of this aminoalkylation reaction to construct bicyclic isoxazolidines from α-halo oxy-acetamides has been explored. The reaction proceeds well at room temperature for α-iodo substrates. In addition, α-bromo and α-chloro substrates are also compatible, affording the desired products in good yields with moderate diastereoselectivity. The observation of different effects from externally added phosphine ligands indicates a distinct catalytic cycle, which may involve an initial aminopalladation followed by bimetallic transmetallation or oxidative addition. This tandem cyclization may offer a novel route to natural products and bioactive compounds containing this core. Finally, the enantioselective intramolecular aminoalkylation for the construction of chiral bicyclic isoxazolidines has been attempted. After screening of a variety of reaction parameters and a series of SPINOL-based ligands, a catalytic system has been disclosed, which utilizes 7 mol% Pd(TFA)2, 20 mol% (R)-Siphos-PE, 300 mol% sodium bromide and 100 mol% sodium carbonate. The desired product can be obtained in 70% yield with 60% enantiomeric excess. A general structure-activity-relationship (SAR) for SPINOL-based ligands is obtained, which provides a platform for further modification. DOI: 10.5353/th_b5610939 Subjects: Heterocyclic compounds - Synthesis Transition metal catalysts
Book Synopsis Organometallic Chemistry in Industry by : Thomas J. Colacot
Download or read book Organometallic Chemistry in Industry written by Thomas J. Colacot and published by John Wiley & Sons. This book was released on 2020-05-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.
Book Synopsis Palladium-catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes for Synthesis of Nitrogen-containing Heterocycles by : 葉柳
Download or read book Palladium-catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes for Synthesis of Nitrogen-containing Heterocycles written by 葉柳 and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Organopalladium Chemistry for Organic Synthesis by : Ei-ichi Negishi
Download or read book Handbook of Organopalladium Chemistry for Organic Synthesis written by Ei-ichi Negishi and published by John Wiley & Sons. This book was released on 2003-11-24 with total page 1657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Book Synopsis Development of Palladium Catalyzed Intramolecular Allylic C-H Amination and Oxidation Towards Pharmacological Motifs by :
Download or read book Development of Palladium Catalyzed Intramolecular Allylic C-H Amination and Oxidation Towards Pharmacological Motifs written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Practical Medicinal Chemistry with Macrocycles by : Eric Marsault
Download or read book Practical Medicinal Chemistry with Macrocycles written by Eric Marsault and published by John Wiley & Sons. This book was released on 2017-09-12 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Book Synopsis Rhodium Catalysis by : Carmen Claver
Download or read book Rhodium Catalysis written by Carmen Claver and published by Springer. This book was released on 2017-12-15 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbrev iated as Top Organomet Chem and cited as a journal.
Book Synopsis Solvents as Reagents in Organic Synthesis by : Xiao-Feng Wu
Download or read book Solvents as Reagents in Organic Synthesis written by Xiao-Feng Wu and published by John Wiley & Sons. This book was released on 2018-01-03 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by highly renowned and experienced authors, this is the only reference on the application of solvents as reagents. Clearly structured, the text describes various methods for the activation and reaction of these small molecules, highlighting the synthetic opportunities as well as process-oriented advantages. To this end, all relevant types of solvents are covered separately and emphasized with numerous synthetic examples, while taking care to explain applications so as to avoid undesired side reactions. The result is a unique resource for every synthetic chemist and reaction engineer in industry and academia working on the methodical optimization of synthetic transformations.
Book Synopsis Handbook of Palladium-Catalysed Organic Reactions by : J. C. Fiaud
Download or read book Handbook of Palladium-Catalysed Organic Reactions written by J. C. Fiaud and published by Elsevier. This book was released on 1997-02-18 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook will be an indispensable research tool for chemists. Handbook of Palladium Catalysed Organic Reactions provides a synoptic description of the main types of reactions which are catalyzed by Palladium and the mechanism which causes these reactions. Each reaction is presented in graphical form and classified according to the type of transformation involved. Other books covering the use of Palladium complexes as catalysts have been written, but the Handbook is the only to offer a synoptic view, showing the catalytic cycle of each reaction. This complete coverage provides the reader with a good understanding of the parameters involved. The tables included can be viewed from the point of view of the reagents, the product of the reaction, or the mechanism involved. The Handbook is a companion to the Database of Palladium Chemistry: Reactions andCatalytic Cycles, published on CD-ROM. Begins with explicit instructions from the authors, facilitating use of the Handbook Details the associated catalytic cycle for each class of reactions Offers a choice of references, allowing the reader to find the closest example for solving a given problem 84 types of mechanism covered, plus over 2500 references Presents graphical abstracts for all reactions described, making it easy to search a type of reaction Comb-bound for easy reference Free demo disk included for the Database of Palladium Chemistry A versatile tool for chemists in the academic community, this handbook will be an invaluable tool in the laboratory
Book Synopsis Palladium(II) Catalyzed Intramolecular Hydroamination of 1,3-dienes by : Justin M. Pierson
Download or read book Palladium(II) Catalyzed Intramolecular Hydroamination of 1,3-dienes written by Justin M. Pierson and published by . This book was released on 2012 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly regioselective palladium catalyzed intramolecular hydroamination of substituted 1,3-dienes was achieved to create diverse nitrogen containing heterocycles. Hydroamination of 1,3-dienes goes in high yields, is selective for 1,2 addition and is suitable for a wide variety of nitrogen protecting groups. Insight to the mechanism of 1,3-diene hydroamination was accomplished by isolating a crucial palladium allyl complex.
Book Synopsis Peptide Macrocycles by : Matthew B. Coppock
Download or read book Peptide Macrocycles written by Matthew B. Coppock and published by Humana. This book was released on 2021-11-02 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.
Book Synopsis Palladium Assisted Synthesis of Heterocycles by : Navjeet Kaur
Download or read book Palladium Assisted Synthesis of Heterocycles written by Navjeet Kaur and published by CRC Press. This book was released on 2019-05-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.
Book Synopsis Intramolecular Palladium Catalyzed Trimethylenemethane Cycloadditions by : Timothy Alan Grese
Download or read book Intramolecular Palladium Catalyzed Trimethylenemethane Cycloadditions written by Timothy Alan Grese and published by . This book was released on 1990 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Palladium in Organic Synthesis by : Jiro Tsuji
Download or read book Palladium in Organic Synthesis written by Jiro Tsuji and published by Springer Science & Business Media. This book was released on 2005-07-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts
Book Synopsis C-X Bond Formation by : Arkadi Vigalok
Download or read book C-X Bond Formation written by Arkadi Vigalok and published by Springer. This book was released on 2010-06-30 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.
Download or read book Time Under the Sea written by Kathryn Lay and published by ABDO. This book was released on 2016-12-15 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Travel through time with Luis, Casey, Tyler, and robot cat Steel! Using Tesla's Time Twister, the friends travel into the future and under the sea! Adventure in a city below the waves awaits. Yet with sea monsters on the attack, can they finally get Uncle Cyrus unstuck in time? Aligned to Common Core standards and correlated to state standards. Calico is an imprint of Magic Wagon, a division of ABDO.
