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P 450 And Chemical Carcinogenesis
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Book Synopsis P-450 and Chemical Carcinogenesis by : Yusaku Tagashira
Download or read book P-450 and Chemical Carcinogenesis written by Yusaku Tagashira and published by Springer. This book was released on 2013-05-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is one of a GANN Monograph on Cancer Research series and is based on a Japanese Cancer Association-sponsored symposium entitled "Multiplicity of Chemical Carcinogen-Activating Enzymes· with Particular Emphasis on Cytochrome P-450" which was held in Tokyo on November 21, 1983. The principal role of microsomal cytochrome P-450 in the metabolic activation of various chemical carcinogens in animal cells has been well established. The activated chemical carcinogens induce mutations of the cells, which is an essential part of the initiation of chemical carcinogenesis. Since microsomal cytochrome P-450 in various animal tissues includes multiple molecular species with different substrate specificities and different responses to chemical inducers, knowledge of the molecular and catalytic properties and the inducibilities of those cytochrome P-450 forms is surely a most important base from which to elucidate the mechanism of chemical carcinogenesis. The focus of the symposium was this area of molecular diversity and inducibility of microsomal cytochrome P-450 in animal tissues. The mechanism of activation of various types of chemical carcinogens by cytochrome P-450 and related enzymes was another main topic. The editors, who were also the symposium organizers, hope these summaries of current research in this field in Japan will stimulate future development of studies on the mechanism of chemical carcinogenesis.
Book Synopsis Mechanisms of Chemical Carcinogenesis by : D. E. Hathway
Download or read book Mechanisms of Chemical Carcinogenesis written by D. E. Hathway and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.
Book Synopsis Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 by : Minor Coon
Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Book Synopsis Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 by : Minor Coon
Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Book Synopsis Chemical Carcinogenesis and Mutagenesis I by :
Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Book Synopsis Cytochromes P450 by : Costas Ioannides
Download or read book Cytochromes P450 written by Costas Ioannides and published by CRC Press. This book was released on 1996-09-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to: Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicity Anticipate drug interactions Modify doses to fit the needs of patients Contributions from internationally acknowledged experts are organized into three sections. The first section provides an overview, the next profiles each of the cytochrome P450 families and subfamilies involved in chemical metabolism, and the last section discusses new issues and developments of current interest. This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.
Book Synopsis Biochemistry of Chemical Carcinogenesis by : R. Colin Garner
Download or read book Biochemistry of Chemical Carcinogenesis written by R. Colin Garner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Encyclopedic Reference of Cancer by : Manfred Schwab
Download or read book Encyclopedic Reference of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2001-10-15 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
Book Synopsis Cytochromes P450 by : Costas Ioannides
Download or read book Cytochromes P450 written by Costas Ioannides and published by Royal Society of Chemistry. This book was released on 2008-06-27 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.
Book Synopsis Chemical Carcinogenesis by : Francisco Feo
Download or read book Chemical Carcinogenesis written by Francisco Feo and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
Book Synopsis Cytochrome P450 Protocols by : Ian R. Phillips
Download or read book Cytochrome P450 Protocols written by Ian R. Phillips and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source.
Book Synopsis Combination Effects in Chemical Carcinogenesis by : Dietrich Schmähl
Download or read book Combination Effects in Chemical Carcinogenesis written by Dietrich Schmähl and published by John Wiley & Sons. This book was released on 1988 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microsomes, Drug Oxidations, and Chemical Carcinogenesis by : Minor Jesser Coon
Download or read book Microsomes, Drug Oxidations, and Chemical Carcinogenesis written by Minor Jesser Coon and published by . This book was released on 1980 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer by :
Download or read book Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer written by and published by Academic Press. This book was released on 2015-07-23 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer. Contains contributions from the best authors in the field Ideal reference for those conducting research in cancer, inflammation, cytochrome P450, metabolism, liver disease, and oxidative stress Provides an essential resource for pharmacologists, immunologists, and biochemists
Book Synopsis Genetic Epidemiology of Cancer by : Henry T. Lynch
Download or read book Genetic Epidemiology of Cancer written by Henry T. Lynch and published by CRC Press. This book was released on 1989-06-30 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.
Book Synopsis Chemical Carcinogens by : Charles E. Searle
Download or read book Chemical Carcinogens written by Charles E. Searle and published by . This book was released on 1976 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer causing agents are now known to exist throughout the environment-in polluted air and tobacco smoke, in various plants and foods, and in many chemicals that are used in industry and laboratories. With the incidence of cancer apparently on the rise, there has been an even greater push to find the causes of this ancient disease. The increased worldwide research effort has produced a vast amount of data and new information which must be collated and interpreted. This monograph contains comprehensive accounts of the latest theories of cancer chemistry and biology and of the major hazards identified so far.
Book Synopsis Carcinogens, DNA Damage and Cancer Risk by : Miriam Christine Poirier
Download or read book Carcinogens, DNA Damage and Cancer Risk written by Miriam Christine Poirier and published by . This book was released on 2018 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt:
