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Author : Upjohn Company
Publisher :
ISBN 13 :
Total Pages : 616 pages
Book Rating : 4.3/5 (91 download)
Download or read book Oxy-radicals in Molecular Biology and Pathology written by Upjohn Company and published by . This book was released on 1988 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter A. Cerutti
Publisher : Wiley-Liss
ISBN 13 : 9780471501886
Total Pages : 606 pages
Book Rating : 4.5/5 (18 download)
Download or read book Oxy-Radicals in Molecular Biology and Pathology written by Peter A. Cerutti and published by Wiley-Liss. This book was released on 1988-09-22 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides in-depth coverage of recent advances in oxy-radical biology and medicine. Examines the deleterious effects of oxy-radicals at the tissue, cellular, and molecular levels; and application of ESR and spin-trapping to in vivo detection and identification of free radicals. Also covers biological sources of O2-, superoxide dismutases, the defensive role of glutathione peroxidase against oxygen toxicity, regulation of the GSHPx gene, and much more.
Author : Michael Simic
Publisher : Springer Science & Business Media
ISBN 13 : 1468455680
Total Pages : 1064 pages
Book Rating : 4.4/5 (684 download)
Download or read book Oxygen Radicals in Biology and Medicine written by Michael Simic and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.
Author : TARR,M.
Publisher : Springer Science & Business Media
ISBN 13 : 1461598400
Total Pages : 306 pages
Book Rating : 4.4/5 (615 download)
Download or read book Oxygen Free Radicals in Tissue Damage written by TARR,M. and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen free radicals and other reactive oxygen species are being postulated as causal agents in an increasing number of pathological conditions. Indeed, some investigators are suggesting that highly destructive reactive oxygen species are the final common path lead ing to tissue damage following a wide variety of insults including trauma, hypoxia, ischemia, hyperoxia, radiation, some toxins, and even strenuous athletic pursuits. But, as Robert Floyd points out, "Proof of the importance of oxygen free radicals and the oxidative damage they initiate depend on unequivocal evidence for the pres ence of free radicals and a clear association of their formation with the induction of the dysfunction of pathological conditions. " Since such proof does not come easily, there have been and will continue to be many controversies regarding the role played by reactive oxygen species in tissue damage. There have been many recent reviews of the chemistry and pos sible role of reactive oxygen species in many types of organ dys functions, tissue damage, degenerative diseases, and aging. This book is not such a review. Rather it presents for a diverse audience of physical-organic chemists, biochemists, medical researchers, and other investigators of pathophysiology, discussions of a variety of is sues important for understanding reactive oxygen species and their role in tissue damage.
Author : Val Vallyathan
Publisher : Springer Science & Business Media
ISBN 13 : 1461510872
Total Pages : 393 pages
Book Rating : 4.4/5 (615 download)
Download or read book Oxygen/Nitrogen Radicals: Cell Injury and Disease written by Val Vallyathan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.
Author : C.A. Rice-Evans
Publisher : Elsevier
ISBN 13 : 0080860885
Total Pages : 409 pages
Book Rating : 4.0/5 (88 download)
Download or read book Free Radical Damage and its Control written by C.A. Rice-Evans and published by Elsevier. This book was released on 1994-02-09 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.
Author : J.M. McCord
Publisher : Elsevier
ISBN 13 : 9780080877105
Total Pages : 188 pages
Book Rating : 4.8/5 (771 download)
Download or read book Oxyradicals in Medical Biology written by J.M. McCord and published by Elsevier. This book was released on 1998-04-23 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid expansion of the area of free radical biology in the last 25 years has occurred within a framework of assumptions and preconceived notions that has at times directed the course of this movement. The most dominant of these notions has been the view that free radical production is without exception a bad thing, and that the more efficient our elimination of these toxic substances, the better off we will be. The very important observation by Bernard Babior and colleagues in 1973 that activated phagocytes produce superoxide in order to kill micro organisms, served to illustrate that constructive roles are possible for free radicals. For many in the field, however, this merely underscored the deadly nature of oxygen-derived radicals, both from the microbe's point of view and from the host's as well. (Phagocyte-produced superoxide is responsible in part for the tissue injury manifested as inflammation. See Harris and Granger, Chapter 5, and Leff, Hybertson and Repine, Chapter 6.) Mother Nature, however, has a penchant for being able to make a silk purse from a sow's ear. If one is dealt a bad hand, one must simply make the best of it. After two decades of focusing on the destructive side of free radicals, the last few years have begun to reveal a new and finer perspective on free radical metabolism - a role in regulation of cellular function (see Schulze-Osthoff and Baeuerle, Chapter 2). Evidence from a number of sources suggests that an increase in the oxidative status of cell encourages that cell to grow and divide. Increasing the expression of mangnese superoxide dismutase can suppress the malignant phenotype of melanon cells (see Oberley and Oberley, Chapter 3). Oxidative stress beyond a certain poitosis (from the Greek, literally "to fall apart"). Is this suicide response an evolutionary fail-safe device to curtail tumorogenesis? Does oxidative stress-induced apoptosis account for the loss of immune cells in AIDS (see Flores and McCor Chapter 4)? This volume attempts to present the spectrum of roles, both good and bad played by active oxygen species as understood at this point in the evolution of this field of free radical biology.
Author : Barry Halliwell
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 568 pages
Book Rating : 4.:/5 (321 download)
Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell and published by Oxford University Press, USA. This book was released on 1989 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.
Author : Kunio Yagi
Publisher :
ISBN 13 :
Total Pages : 904 pages
Book Rating : 4.3/5 (91 download)
Download or read book Oxygen Radicals written by Kunio Yagi and published by . This book was released on 1992 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an increasing number of reports that suggest that oxygen radicals play a role in a wide variety of pathological conditions such as atherosclerosis, cancer, ischemia, inflammation, radiation injury, and environmental stress and that they may be important in the aging process. This publication comprises of poster presentations given at the 5th International Congress on Oxygen Radicals which was held on November 17-21, in Kyoto, Japan. Contributions to this volume describe the generation and reaction of oxygen radicals and lipid peroxides, and the pathophysiological effects of various radical species. Furthermore, presentations on the effect of antioxidants in preventing free radical injury were given. A summarized version of the contents is provided hereunder.
Author : R. V. Bensasson
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)
Download or read book Excited States and Free Radicals in Biology and Medicine written by R. V. Bensasson and published by . This book was released on 1993 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excited states and free radicals are involved in the normal physiology of living systems, in pathological processes (including lipid peroxidation, inflammation, Parkinson's disease, cancer, and aging), in the mechanisms of drug action, and in the photochemotherapies such as the PUVA therapy for skin diseases and PDT for cancer. This text introduces the reader to this rapidly expanding field, one that lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine. The authors explore in particular how time-resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems. Topics include the nature of excited states and free radicals and the techniques for their study, activated oxygen species, DNA, proteins, carotenoids and photosynthetic reaction centers, photodermatology and melanogenesis, and aspects of cancer related to radio-, chemo-, and photodynamic therapy. Researchers and graduate students in photochemistry, photobiology, photomedicine, radiation chemistry and biology, and cancer therapies will find this book to be of very significant interest.
Author : Igor B. Afanas'ev
Publisher : CRC Press
ISBN 13 : 1420073753
Total Pages : 230 pages
Book Rating : 4.4/5 (2 download)
Download or read book Signaling Mechanisms of Oxygen and Nitrogen Free Radicals written by Igor B. Afanas'ev and published by CRC Press. This book was released on 2009-06-18 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once the existence of free radicals was proven, an avalanche of studies on free radical-mediated biological processes ensued. The study of reactive oxygen and nitrogen species (ROS and RNS) is center stage in biological free radical investigations. Written by a biochemist, Signaling Mechanisms of Oxygen and Nitrogen Free Radicals discusses the regu
Author : Lester Packer
Publisher : Elsevier
ISBN 13 : 9780121821340
Total Pages : 758 pages
Book Rating : 4.8/5 (213 download)
Download or read book Oxygen Radicals in Biological Systems written by Lester Packer and published by Elsevier. This book was released on 1994 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since biological tissues are unstable in an oxygen atmosphere, a great deal of effort is expended by organisms to metabolically limit or repair oxidative tissue damage. This volume of Methods in Enzymology and its companion Volume 234 present methods developed to investigate the roles of oxygen radicals and antioxidants in disease. Key Features* Generation, detection, and characterization of oxygen radicals, chemistry, biochemistry, and intermediate states of reductio* Isolation, characterization, and assay of enzymes or substrates involved in formation or removal of oxygen radical* Methods for assessing molecular, cell, and tissue damage; assays and repair of oxidative damage.
Author : Wolf Bors
Publisher : de Gruyter
ISBN 13 :
Total Pages : 1060 pages
Book Rating : 4.:/5 (44 download)
Download or read book Oxygen Radicals in Chemistry and Biology written by Wolf Bors and published by de Gruyter. This book was released on 1984 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Oxygen Radicals in Chemistry and Biology".
Author : Wolf Bors
Publisher :
ISBN 13 : 9780899253916
Total Pages : 1029 pages
Book Rating : 4.2/5 (539 download)
Download or read book Oxygen Radicals in Chemistry and Biology written by Wolf Bors and published by . This book was released on 1984-03-01 with total page 1029 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rao M. Uppu
Publisher : Humana Press
ISBN 13 : 9781617796838
Total Pages : 480 pages
Book Rating : 4.7/5 (968 download)
Download or read book Free Radicals and Antioxidant Protocols written by Rao M. Uppu and published by Humana Press. This book was released on 2012-04-06 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge and updated book offers methods for the rapid detection of RONs and redox stress. It includes in-depth analysis of natural and synthetic antioxidants, and also of DNA oxidation, oxidative lipidomics, and biomarkers.
Author : C. J. Duncan
Publisher : Cambridge University Press
ISBN 13 : 0521380685
Total Pages : 238 pages
Book Rating : 4.5/5 (213 download)
Download or read book Calcium, Oxygen Radicals and Cellular Damage written by C. J. Duncan and published by Cambridge University Press. This book was released on 1991-11-21 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cellular events underlying rapid cellular damage in different organs are potentially of great medical importance, for example muscular dystrophy, liver damage and the preservation of kidneys for transplantation. Many hypotheses exist for the biochemical pathways involved in these damage processes. The roles of calcium and active oxygen metabolites are of particular interest. There is considerable literature on both these triggering agents and good evidence for their involvement in the genesis of damage, although little agreement on their precise roles. This volume records the proceedings of a meeting held by the Society for Experimental Biology that attempted to determine whether there are common mechanisms of cellular damage and to explore the ways in which calcium and oxygen radicals may interact to generate damage. The questions addressed, in particular, are whether there are any common biochemical pathways, and the specific and possibly interacting roles of calcium and active oxygen metabolites.
Author : Anne Pomeroy Autor
Publisher :
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.:/5 (321 download)
Download or read book Pathology of Oxygen written by Anne Pomeroy Autor and published by . This book was released on 1982 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has been designed to provide those interested in oxygen toxicity with a working knowledge of advancement in the field with the intention that the topics described in each chapter will be immediately useful. The book is divided into three general sections. The first and smallest section of the book explains the molecular and biochemical basis of our current understanding of oxygen radical toxicity as well as the means by which normal aerobic cells protect themselves from the toxic effects of oxygen radicals. The second and third sections of about equal length are concerned consecutively with in vivo and in vitro laboratory studies of oxygen toxicity in animals and with the results of clinical studies of patients.
