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Overview Of Tumor Promoters And Test Systems To Identify Promoters
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Book Synopsis Overview of Tumor Promoters and Test Systems to Identify Promoters by : Herman Autrup
Download or read book Overview of Tumor Promoters and Test Systems to Identify Promoters written by Herman Autrup and published by Nordic Council of Ministers. This book was released on 1987 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Elizabeth K. Weisburger Publisher :Springer Science & Business Media ISBN 13 :9400925263 Total Pages :210 pages Book Rating :4.4/5 (9 download)
Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger
Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Book Synopsis Drinking Water and Health, by : National Research Council
Download or read book Drinking Water and Health, written by National Research Council and published by National Academies Press. This book was released on 1986-02-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Naturally Occurring Antitumourigens by : Lars Ove Dragsted
Download or read book Naturally Occurring Antitumourigens written by Lars Ove Dragsted and published by Nordic Council of Ministers. This book was released on 1992 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Preclinical Safety Evaluation of Biopharmaceuticals by : Joy A. Cavagnaro
Download or read book Preclinical Safety Evaluation of Biopharmaceuticals written by Joy A. Cavagnaro and published by John Wiley & Sons. This book was released on 2013-03-07 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Mechanisms of Carcinogenesis in Risk Identification by : Harri Vainio
Download or read book Mechanisms of Carcinogenesis in Risk Identification written by Harri Vainio and published by . This book was released on 1992 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative volume includes a consensus document drawn up by a working group of international experts in various fields of carcinogenesis. It describes the multistage and multifactorial nature of carcinogenesis, the different mechanisms of action of carcinogens, epidemiological and laboratory means for their identification, and proposed principles and procedures for their possible use in the prediction and evaluation of carcinogenic risks to humans. Other chapters cover critical molecular targets in chemical carcinogenesis; mechanisms of carcinogenicity; animal carcinogenicity tests and their interpretations; biological markers in exposed humans; and data analysis and modelling. This work will be a valuable reference for cancer researchers and toxicologists.
Book Synopsis Cellular Interactions by Environmental Tumor Promoters by : Hirota Fujiki
Download or read book Cellular Interactions by Environmental Tumor Promoters written by Hirota Fujiki and published by VSP. This book was released on 1984-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable progress in our understanding of tumor promotion has been made by cancer researchers throughout the world. In addition, scientists in several other disciplines have made significant contributions in elucidating the pleiotropic effects of tumor promotion. This international symposium was specifically convened to review research progress in these areas and to consider the relevance of these findings to human cancer causation and prevention. The proceedings include the contributions of leading researchers from Europe, Japan and the USA. Several papers report the exciting progress made in understanding how tumor promoters act at the cellular and biochemical levels. Elsewhere attention is focused on tumor promotion as an important phase in the occurrence of certain human tumors. It is hoped that advances in the understanding of the mechanism of tumor promotion in experimental systems will lead to new and effective approaches to human cancer prevention. The proceedings will be of interest and value to researchers working in cancer research, biochemistry, molecular genetics, mutagenesis and cell biology.
Book Synopsis Anticancer Drug Development by : Bruce C. Baguley
Download or read book Anticancer Drug Development written by Bruce C. Baguley and published by Elsevier. This book was released on 2001-11-17 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. - One work that can be consulted for all aspects of anticancer drug development - Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts - A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death - Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products - Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques - Hundreds of references that allow the reader to access relevant scientific and medical literature - Clear illustrations, some in color, that provide both understanding of the field and material for teaching
Book Synopsis Precision Cancer Medicine by : Sameek Roychowdhury
Download or read book Precision Cancer Medicine written by Sameek Roychowdhury and published by Springer Nature. This book was released on 2020-01-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.
Book Synopsis An Introduction to Toxicogenomics by : Michael E. Burczynski
Download or read book An Introduction to Toxicogenomics written by Michael E. Burczynski and published by CRC Press. This book was released on 2003-03-26 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.
Book Synopsis Review of Current DHHS, DOE, and EPA Research Related to Toxicology by :
Download or read book Review of Current DHHS, DOE, and EPA Research Related to Toxicology written by and published by . This book was released on 1992 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Chemical Interactions by : Edward J. Calabrese
Download or read book Multiple Chemical Interactions written by Edward J. Calabrese and published by CRC Press. This book was released on 1990-12-19 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: This classic work on a vitally important and new topic contains over 1200 pages of complete information on chemical interactions as it pertains to environmental and medical concerns. It illustrates principles of interactions so you will have the conceptual basis for predicting responses to complex environmental mixtures-apply it to specific situations-theoretical and practical. To date, environmental standards regulate the effects of a single pollutant. Multiple Chemical Interactions is exhaustive coverage of how the multitude of chemicals in our world interact with human health. This book gives us critically new and complete data on an emerging field that will be of interest to all environmental scientists, environmental and public health professionals, toxicologists, industrial hygienists, regulators and libraries.
Book Synopsis The Molecular Basis of Cancer by : John Mendelsohn
Download or read book The Molecular Basis of Cancer written by John Mendelsohn and published by Elsevier Health Sciences. This book was released on 2008-04-01 with total page 1948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
Author :United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies Publisher : ISBN 13 : Total Pages :1092 pages Book Rating :4.0/5 (9 download)
Book Synopsis Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1985 by : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Download or read book Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1985 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 1984 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Tumors, An Issue of Surgical Pathology Clinics by : Lynette M. Sholl
Download or read book Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Tumors, An Issue of Surgical Pathology Clinics written by Lynette M. Sholl and published by Elsevier Health Sciences. This book was released on 2016-08-23 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Surgical Pathology Clinics entitled “Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Tumors is being edited by Dr. Lynette Sholl and will cover molecular pathology in a wide array of anatomic locations including, salivary gland, lung, bladder, glioma, endometrium, colon, pancreaticobiliary tract, sarcoma, myeloid neoplasams, and lymphomas.
