Organ Directed Toxicities Of Anticancer Drugs

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Organ Directed Toxicities of Anticancer Drugs

Author : Miles P. Hacker
Publisher : Springer Science & Business Media
ISBN 13 : 1461320232
Total Pages : 259 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Organ Directed Toxicities of Anticancer Drugs by : Miles P. Hacker

Download or read book Organ Directed Toxicities of Anticancer Drugs written by Miles P. Hacker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

Handbook of Cancer Treatment-Related Symptoms and Toxicities E-Book

Author : Vamsidhar Velcheti
Publisher : Elsevier Health Sciences
ISBN 13 : 032367299X
Total Pages : 355 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Handbook of Cancer Treatment-Related Symptoms and Toxicities E-Book by : Vamsidhar Velcheti

Download or read book Handbook of Cancer Treatment-Related Symptoms and Toxicities E-Book written by Vamsidhar Velcheti and published by Elsevier Health Sciences. This book was released on 2021-01-28 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice. - Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource. - Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis. - Overviews pharmacologic and non-pharmacologic approaches to symptom management. - Offers recommendations for mitigating toxicities in high-risk patients. - Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.

Superoxide Ion: Volume II (1991)

Author : Igor B. Afanas'ev
Publisher : CRC Press
ISBN 13 : 1351357441
Total Pages : 373 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Superoxide Ion: Volume II (1991) by : Igor B. Afanas'ev

Download or read book Superoxide Ion: Volume II (1991) written by Igor B. Afanas'ev and published by CRC Press. This book was released on 2017-11-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical properties of superoxide ion, its biological role, and the role of other oxygen radicals which arise as a result of its transformations are contained in this text. In Volume I the principal reactions of superoxide ion, including protonation reactions with proton donors, nucleophilic reactions with esters, alkyl halides and other compounds, electron transfer reactions with quinones and metal complexes, are described.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1068 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1988 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1060 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

The Anticancer Drugs

Author : William B. Pratt
Publisher :
ISBN 13 : 9780195067392
Total Pages : 366 pages
Book Rating : 4.0/5 (673 download)

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Book Synopsis The Anticancer Drugs by : William B. Pratt

Download or read book The Anticancer Drugs written by William B. Pratt and published by . This book was released on 1994 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.

Cancer Treatment Reports

Author :
Publisher :
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Cancer Treatment Reports by :

Download or read book Cancer Treatment Reports written by and published by . This book was released on 1986 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Resistance in Cancer Therapy

Author : Robert F. Ozols
Publisher : Springer Science & Business Media
ISBN 13 : 1461316014
Total Pages : 216 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Drug Resistance in Cancer Therapy by : Robert F. Ozols

Download or read book Drug Resistance in Cancer Therapy written by Robert F. Ozols and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung can cer, genitourinary cancer, and pediatric oncology; second, by asking emi nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Superoxide Ion

Author : Igor B. Afanas'ev
Publisher : CRC Press
ISBN 13 : 9780849354526
Total Pages : 232 pages
Book Rating : 4.3/5 (545 download)

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Book Synopsis Superoxide Ion by : Igor B. Afanas'ev

Download or read book Superoxide Ion written by Igor B. Afanas'ev and published by CRC Press. This book was released on 1991-04-23 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical properties of superoxide ion, its biological role, and the role of other oxygen radicals which arise as a result of its transformations are contained in this text. In Volume I the principal reactions of superoxide ion, including protonation reactions with proton donors, nucleophilic reactions with esters, alkyl halides and other compounds, electron transfer reactions with quinones and metal complexes, are described. Basic quantitative data including rate constants and yields for the reactions of superoxide ion of all types are given in tables. This volumecontains the mechanisms of the generation of oxygen radicals in cells and the interaction of superoxide ion with cell components. The role of superoxide ion in lipid peroxidation and destruction of proteins and nucleic acids is explained, as well as oxygen radicals in the mechanisms of toxic and therapeutic action of drugs, especially anticancer antibiotics. In addition, the action of superoxide ion and other oxygen radicals on plants, micro-, and macroorganisms is discussed, along with the role of oxygen radicals in normal metabolic and pathological processes.

Biochemical Pharmacology of Blood and Bloodforming Organs

Author : James W. Fisher
Publisher : Springer Science & Business Media
ISBN 13 : 3642758657
Total Pages : 598 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Biochemical Pharmacology of Blood and Bloodforming Organs by : James W. Fisher

Download or read book Biochemical Pharmacology of Blood and Bloodforming Organs written by James W. Fisher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of this volume is to review chemical agents which affect blood and blood-forming organs. Significant ad- vances made over the past several years in the purification of several hematopoietic growth factors, such as erythro- poietin and colony stimulating factor; the availability of several other growth factors, such as the interleukins which are important in regulating the production of red blood cells, leukocytes, megakaryocytes and platelets are discus- sed. Numerous toxic chemical substances are being produced in our environment which people are exposed todaily causing a suppression of erythropoiesis, myelopoiesis and megakaryo- cytopoiesis. Attempts to evaluate both the therapeutic role of some of the newer growth factors, such as erythropoietin in the anemia of end stage disease, as well as colony stimu- lating factors in somehematopoietic abnormalities are also covered in this volume. In addition, numerous chemical fac- tors in our environment which suppress major hematopoietic lineages stimulated by erythropoietin, macrophage colony stimulating factor, granulocyte colony stimulating factor, interleukin 1-alpha, 1-beta, 2,3,4,5,6, and 7 are also in- cluded. In addition, chapters on the use of erythropoietin in the treatment of anemia of end stage renal disease can provide the practicing hematologist and nephrologist with updated information on the use of erythropoietin for this disease. The book includes chapters on the fundamental con- trol of hematopoiesis and other mechanisms of action of erythropoietin, and finally an up-to-date overview of the chemotherapy of leukemia. This book will prove useful to in- vestigators in the fields of pharmacology, physiology, nephrology, urology, hematology, pathology, endocrinology, biochemistry, and molecular and cell biology.

Paclitaxel

Author : Mallappa Kumara Swamy
Publisher : Academic Press
ISBN 13 : 0323909523
Total Pages : 356 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Paclitaxel by : Mallappa Kumara Swamy

Download or read book Paclitaxel written by Mallappa Kumara Swamy and published by Academic Press. This book was released on 2021-10-08 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer. This is a valuable resource for cancer researchers, biotechnologists and members of biomedical field who are interested in the promising anticancer qualities of this antineoplastic drug and how to enhance them for better treatments. - Presents detailed information about Paclitaxel research, from its discovery to clinical uses and biotechnological routes of commercial production - Focuses on Paclitaxel development as an effective chemotherapeutic drug, along with its application in different types of cancers - Encompasses descriptive illustrations and workflows to help the reader fully understand the content and easily apply it to their research

Pharmacology

Author : Miles Hacker
Publisher : Academic Press
ISBN 13 : 0080919227
Total Pages : 607 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Pharmacology by : Miles Hacker

Download or read book Pharmacology written by Miles Hacker and published by Academic Press. This book was released on 2009-06-19 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. - Uses individual drugs to explain molecular actions - Full color art program explains molecular and chemical concepts graphically - Logical structure reflecting the current state of pharmacology and translational research - Covers such intricacies as drug resistance and cell death - Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Cancer and the Heart

Author : Michael S. Ewer
Publisher : PMPH-USA
ISBN 13 : 9781550092684
Total Pages : 414 pages
Book Rating : 4.0/5 (926 download)

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Book Synopsis Cancer and the Heart by : Michael S. Ewer

Download or read book Cancer and the Heart written by Michael S. Ewer and published by PMPH-USA. This book was released on 2006 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "complete text in searchable PDF format."--P. [4] of cover.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advanced Drug Delivery Systems in the Management of Cancer

Author : Kamal Dua
Publisher : Elsevier
ISBN 13 : 0323900798
Total Pages : 574 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua

Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. - Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer - Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers - Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Dermatologic Principles and Practice in Oncology

Author : Mario E. Lacouture
Publisher : John Wiley & Sons
ISBN 13 : 1118590600
Total Pages : 764 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Dermatologic Principles and Practice in Oncology by : Mario E. Lacouture

Download or read book Dermatologic Principles and Practice in Oncology written by Mario E. Lacouture and published by John Wiley & Sons. This book was released on 2013-11-26 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 290 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series