Optogenetic Tools In The Molecular Spotlight

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Optogenetic Tools in the Molecular Spotlight

Author : Tilo Mathes
Publisher : Frontiers Media SA
ISBN 13 : 2889198995
Total Pages : 181 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Optogenetic Tools in the Molecular Spotlight by : Tilo Mathes

Download or read book Optogenetic Tools in the Molecular Spotlight written by Tilo Mathes and published by Frontiers Media SA. This book was released on 2016-08-09 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise of optogenetics as a standard technique to non-invasively probe and monitor biological function created an immense interest in the molecular function of photosensory proteins. These photoreceptors are usually protein/pigment complexes that translate light into biological information and have become essential tools in cell biology and neurobiology as their function is genetically encoded and can be conveniently delivered into a given cell. Like for fluorescent proteins that quickly became invaluable as genetically encodable reporters in microscopy and imaging, variants of photosensory proteins with customized sensitivity and functionality are nowadays in high demand. In this ebook we feature reviews and original research on molecular approaches from synthetic biology and molecular spectroscopy to computational molecular modelling that all aspire to elucidate the molecular prerequisites for the photosensory function of the given proteins. The principle property of changing activity of biological function simply by application of light is not only very attractive for cell biology, it also offers unique opportunities for molecular studies as excitation can be controlled with high time precision. Especially in spectroscopy the usually fully reversible photoactivation of photosensory proteins allows researchers to to perform time resolved studies with up to femtosecond resolution. In addition, functional variants can be investigated and quickly screened in common biochemical experiments. The insights that are obtained by the here presented various yet complementary methods will ultimately allow us write the script for a molecular movie from excitation of the protein by a photon to activation of its biological function. Such deep understanding does not only provide unique insights into the dynamics of protein function, it will also ultimately enable us to rationally design novel optogenetic tools to be used in cell biology and therapy.

Optogenetic Tools in the Molecular Spotlight

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Optogenetic Tools in the Molecular Spotlight by :

Download or read book Optogenetic Tools in the Molecular Spotlight written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise of optogenetics as a standard technique to non-invasively probe and monitor biological function created an immense interest in the molecular function of photosensory proteins. These photoreceptors are usually protein/pigment complexes that translate light into biological information and have become essential tools in cell biology and neurobiology as their function is genetically encoded and can be conveniently delivered into a given cell. Like for fluorescent proteins that quickly became invaluable as genetically encodable reporters in microscopy and imaging, variants of photosensory proteins with customized sensitivity and functionality are nowadays in high demand. In this ebook we feature reviews and original research on molecular approaches from synthetic biology and molecular spectroscopy to computational molecular modelling that all aspire to elucidate the molecular prerequisites for the photosensory function of the given proteins. The principle property of changing activity of biological function simply by application of light is not only very attractive for cell biology, it also offers unique opportunities for molecular studies as excitation can be controlled with high time precision. Especially in spectroscopy the usually fully reversible photoactivation of photosensory proteins allows researchers to to perform time resolved studies with up to femtosecond resolution. In addition, functional variants can be investigated and quickly screened in common biochemical experiments. The insights that are obtained by the here presented various yet complementary methods will ultimately allow us write the script for a molecular movie from excitation of the protein by a photon to activation of its biological function. Such deep understanding does not only provide unique insights into the dynamics of protein function, it will also ultimately enable us to rationally design novel optogenetic tools to be used in cell biology and therapy.

The Advances and Applications of Optogenetics

Author : Elena G. Govorunova
Publisher : MDPI
ISBN 13 : 3039436732
Total Pages : 164 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis The Advances and Applications of Optogenetics by : Elena G. Govorunova

Download or read book The Advances and Applications of Optogenetics written by Elena G. Govorunova and published by MDPI. This book was released on 2020-12-28 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.

Optogenetics

Author :
Publisher : Elsevier
ISBN 13 : 0444594450
Total Pages : 289 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Optogenetics by :

Download or read book Optogenetics written by and published by Elsevier. This book was released on 2012-12-06 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Handbook of Neurophotonics

Author : Francesco S. Pavone
Publisher : CRC Press
ISBN 13 : 1498718760
Total Pages : 579 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Handbook of Neurophotonics by : Francesco S. Pavone

Download or read book Handbook of Neurophotonics written by Francesco S. Pavone and published by CRC Press. This book was released on 2020-05-10 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Handbook of in Vivo Neural Plasticity Techniques

Author :
Publisher : Academic Press
ISBN 13 : 0128120274
Total Pages : 576 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of in Vivo Neural Plasticity Techniques by :

Download or read book Handbook of in Vivo Neural Plasticity Techniques written by and published by Academic Press. This book was released on 2018-09-01 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of in Vivo Neural Plasticity Techniques, Volume 28: A Systems Neuroscience Approach to the Neural Basis of Memory and Cognition gives a comprehensive overview of the current methods and approaches that are used to study neural plasticity from a systems neuroscience perspective. In addition, the book offers in-depth methodological advice that provides the necessary foundation for researchers establishing methods and students who need to understand the theoretical and methodological bases of these approaches. This is the ideal resource for anyone new to the study of cognitive and behavioral neuroscience who seeks an introduction to state-of-the-art techniques. Offers a comprehensive overview of state-of-the-art approaches to studying neuroplasticity in vivo Combines discussions of theoretical underpinnings with the methodological and technical aspects necessary to guarantee success Arranged in a uniform format that clearly and concisely lays out descriptions, methods and the pitfalls of various techniques

Epigenetics to Optogenetics

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1838809937
Total Pages : 178 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Epigenetics to Optogenetics by :

Download or read book Epigenetics to Optogenetics written by and published by BoD – Books on Demand. This book was released on 2022-08-31 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one can be used to change or modify the other. The complexity of the techniques involved in these disciplines often leads to a lack of proper understanding by researchers from other disciplines and the scientific community at large. As such, this book provides simple and easy-to-follow explanations of some of the most exciting areas of research in these disciplines.

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

Author : George S. Baillie
Publisher : Frontiers Media SA
ISBN 13 : 2889198154
Total Pages : 193 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels by : George S. Baillie

Download or read book Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels written by George S. Baillie and published by Frontiers Media SA. This book was released on 2016-04-08 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

Neuroanatomical Tract-Tracing

Author : Laszlo Zaborszky
Publisher : Springer Science & Business Media
ISBN 13 : 0387289429
Total Pages : 703 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Neuroanatomical Tract-Tracing by : Laszlo Zaborszky

Download or read book Neuroanatomical Tract-Tracing written by Laszlo Zaborszky and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques.

Regenesis

Author : George M Church
Publisher : Basic Books
ISBN 13 : 0465038654
Total Pages : 305 pages
Book Rating : 4.4/5 (65 download)

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Book Synopsis Regenesis by : George M Church

Download or read book Regenesis written by George M Church and published by Basic Books. This book was released on 2014-04-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Optogenetics

Author : Hiromu Yawo
Publisher : Springer Nature
ISBN 13 : 9811587639
Total Pages : 648 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Optogenetics by : Hiromu Yawo

Download or read book Optogenetics written by Hiromu Yawo and published by Springer Nature. This book was released on 2021-01-05 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.

Lipid-mediated Protein Signaling

Author : Daniel G.S. Capelluto
Publisher : Springer Science & Business Media
ISBN 13 : 940076331X
Total Pages : 227 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Lipid-mediated Protein Signaling by : Daniel G.S. Capelluto

Download or read book Lipid-mediated Protein Signaling written by Daniel G.S. Capelluto and published by Springer Science & Business Media. This book was released on 2013-06-17 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.

Chronic Pain and Brain Abnormalities

Author : Carl Y. Saab
Publisher : Academic Press
ISBN 13 : 0124058965
Total Pages : 167 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Chronic Pain and Brain Abnormalities by : Carl Y. Saab

Download or read book Chronic Pain and Brain Abnormalities written by Carl Y. Saab and published by Academic Press. This book was released on 2013-06-28 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes. Philosophical and social concepts of pain; testimonials of chronic-pain patients Clinical data from pain patients’ brains Advances in noninvasive brain imaging for pain patients Combining theoretical and empirical approaches to the analysis of pain-related brain function Manipulation of brain function in animal models Emerging neurotechnology principles for pain diagnostics and therapeutics

Behavioral and Neural Genetics of Zebrafish

Author : Robert T. Gerlai
Publisher : Academic Press
ISBN 13 : 9780128175286
Total Pages : 800 pages
Book Rating : 4.1/5 (752 download)

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Book Synopsis Behavioral and Neural Genetics of Zebrafish by : Robert T. Gerlai

Download or read book Behavioral and Neural Genetics of Zebrafish written by Robert T. Gerlai and published by Academic Press. This book was released on 2020-04 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and increased investigation into the neurobiological basis of behavior using zebrafish. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, and conveniently small size and transparent embryology. Behavioral and Neural Genetics of Zebrafish assembles state of the art methodologies and the most current concepts pertinent to the neurobehavioral genetics of zebrafish. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and "big-data" related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes description of behavioral, genetic, and neural methods and concepts and adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Near-Infrared Spectroscopy

Author : Yukihiro Ozaki
Publisher : Springer Nature
ISBN 13 : 9811586489
Total Pages : 593 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Near-Infrared Spectroscopy by : Yukihiro Ozaki

Download or read book Near-Infrared Spectroscopy written by Yukihiro Ozaki and published by Springer Nature. This book was released on 2020-11-13 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides knowledge of the basic theory, spectral analysis methods, chemometrics, instrumentation, and applications of near-infrared (NIR) spectroscopy—not as a handbook but rather as a sourcebook of NIR spectroscopy. Thus, some emphasis is placed on the description of basic knowledge that is important in learning and using NIR spectroscopy. The book also deals with applications for a variety of research fields that are very useful for a wide range of readers from graduate students to scientists and engineers in both academia and industry. For readers who are novices in NIR spectroscopy, this book provides a good introduction, and for those who already are familiar with the field it affords an excellent means of strengthening their knowledge about NIR spectroscopy and keeping abreast of recent developments.

Genetics and Biotechnology

Author : J. Philipp Benz
Publisher : Springer Nature
ISBN 13 : 3030499243
Total Pages : 452 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Genetics and Biotechnology by : J. Philipp Benz

Download or read book Genetics and Biotechnology written by J. Philipp Benz and published by Springer Nature. This book was released on 2020-10-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised third edition includes up-to-date topics and developments in the field, which has made tremendous strides since the publication of the second edition in 2004. Many novel techniques based on Next Generation Sequencing have sped up the analysis of fungi and major advances have been made in genome editing, leading to a deeper understanding of the genetics underlying cellular processes as well as their applicability. At the same time, the relevance of fungi is unbroken, both due to the serious threats to human health and welfare posed by fungal pests and pathogens, and to the many benefits that fungal biotechnology can offer for diverse emerging markets and processes that form the basis of the modern bioeconomy. With regard to these advances, the first section of this volume, Genetics, illustrates the basic genetic processes underlying inheritance, cell biology, metabolism and “lifestyles” of fungi. The second section, Biotechnology, addresses the applied side of fungal genetics, ranging from new tools for synthetic biology to the biotechnological potential of fungi from diverse environments. Gathering chapters written by reputed scientists, the book represents an invaluable reference guide for fungal biologists, geneticists and biotechnologists alike.

Multivalency

Author : Jurriaan Huskens
Publisher : John Wiley & Sons
ISBN 13 : 1119143462
Total Pages : 434 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Multivalency by : Jurriaan Huskens

Download or read book Multivalency written by Jurriaan Huskens and published by John Wiley & Sons. This book was released on 2018-02-05 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.