Optimisation Therapeutique Des Classes Iii

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Optimization of Pharmaceutical R&D Programs and Portfolios

Author : Zoran Antonijevic
Publisher : Springer
ISBN 13 : 3319090755
Total Pages : 204 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Optimization of Pharmaceutical R&D Programs and Portfolios by : Zoran Antonijevic

Download or read book Optimization of Pharmaceutical R&D Programs and Portfolios written by Zoran Antonijevic and published by Springer. This book was released on 2014-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.

Antibiotic Optimization

Author : Robert C. Owens
Publisher : CRC Press
ISBN 13 : 0203996925
Total Pages : 684 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Antibiotic Optimization by : Robert C. Owens

Download or read book Antibiotic Optimization written by Robert C. Owens and published by CRC Press. This book was released on 2004-11-04 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi

Handbook on Optimizing Patient Care in Psychiatry

Author : Amresh Shrivastava
Publisher : Taylor & Francis
ISBN 13 : 0429638574
Total Pages : 843 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Handbook on Optimizing Patient Care in Psychiatry by : Amresh Shrivastava

Download or read book Handbook on Optimizing Patient Care in Psychiatry written by Amresh Shrivastava and published by Taylor & Francis. This book was released on 2022-11-21 with total page 843 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook examines current mental health research, challenges in patient care, and advances in clinical psychiatry with the aim of improving approaches toward the screening of at-risk individuals, facilitating access to care, and supervising rehabilitation. Combining evidence-based research with clinical case studies, international experts provide detailed, holistic insights into our understanding of mental disorders through biological, social, interpersonal, and economical lenses. Models of intervention, prevention, and treatment are provided, along with methods for continued care and patient advocacy. Finally, experts analyze the future of psychiatric research and mental health care. Readers will gain greater understanding of the finer nuances of handling psychiatric cases and a holistic perspective of optimizing patient care within this field. This innovative book contributes to the development of community management of various psychiatric disorders and will be of interest to case managers, mental health workers, doctors, nurses, and many more.

Antimicrobial Peptides: Molecular Design, Structure Function Relationship and Biosynthesis Optimization

Author : Jianhua Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889760812
Total Pages : 294 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Antimicrobial Peptides: Molecular Design, Structure Function Relationship and Biosynthesis Optimization by : Jianhua Wang

Download or read book Antimicrobial Peptides: Molecular Design, Structure Function Relationship and Biosynthesis Optimization written by Jianhua Wang and published by Frontiers Media SA. This book was released on 2022-05-04 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adult Audiologic Rehabilitation, Third Edition

Author : Joseph J. Montano
Publisher : Plural Publishing
ISBN 13 : 1635501377
Total Pages : 641 pages
Book Rating : 4.6/5 (355 download)

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Book Synopsis Adult Audiologic Rehabilitation, Third Edition by : Joseph J. Montano

Download or read book Adult Audiologic Rehabilitation, Third Edition written by Joseph J. Montano and published by Plural Publishing. This book was released on 2020-01-20 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult Audiologic Rehabilitation, Third Edition is an advanced textbook for doctoral level audiology students that focuses solely on adults with a completely international perspective. It is the only advanced text to meet the need for the high level of preparation required for doctoral level training. It is also an essential resource for practicing clinicians looking for a complete reference on the latest techniques and technologies. With ever changing technology and new methodologies in client care, the third edition of Adult Audiologic Rehabilitation is a critical resource to audiology education. The book covers definitions of audiologic rehabilitation, an overview of the area, psychosocial impact of hearing loss, assessment strategies, current technologies, treatment methodologies, e-technologies, research needs, and special issues in audiologic rehabilitation. It has been deliberately structured to move the reader from introduction, to specific details of the specialty of audiologic rehabilitation, to providing insights into characteristics of this patient population, and thence to a framework for assessment and treatment of the impact of hearing loss. New to the Third Edition: Thoroughly updated, this edition includes eight new chapters and revisions to nineteen chapters that include updated content, references, figures and tables. New topics include: * Hearing Health-Seeking Behavior * Social Factors in Hearing Aids * Improving Patient Adherence * Multimedia Educational Resources * Family-Centered Care * Patient Narratives in Audiology * E-health and M-health for Audiologic Rehabilitation * Community Outreach This edition welcomes contributions from new authors including: Abbey L. Berg, Melanie Ferguson, Stefan Launer, Alessia Paglialonga, Gabrielle Saunders, Nerina Scarinci, Gurjit Singh, Nancy Tye- Murray, Barbra Timmer, Emilie Zaslow, and a foreword by Arthur Boothroyd. Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.

Optimizing the Self

Author : Ole Jacob Madsen
Publisher : Routledge
ISBN 13 : 1317437772
Total Pages : 200 pages
Book Rating : 4.3/5 (174 download)

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Book Synopsis Optimizing the Self by : Ole Jacob Madsen

Download or read book Optimizing the Self written by Ole Jacob Madsen and published by Routledge. This book was released on 2015-06-19 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an analysis of the social representations of leading self-help genres, including neurolinguistic programming, cognitive self-help therapy, mindfulness, self-management, self-esteem, self-leadership and self-control. Exploring the globalised therapeutic culture of today, the book argues that psychology as ‘science’ is often abandoned to aid the individual pursuit for self-realization and self-optimization. Opposing the view that self-help culture is external to psychology, Madsen argues that it is firmly embedded within psychology, playing an important role in people’s lives. Each chapter traces and critically interprets a range of self-help philosophies and techniques, examining the claims of self-help literature to represent the most innovative psychological, medical or neurobiological research. Discussing each genre in turn, chapters examine key research alongside self-help literature to explore the effectiveness and impact of leading self-help genres in various social contexts and environments. The book offers a contemporary critical overview of issues concerning self-help, combining critical psychology with the theory of social representation to provide a broad perspective on self-help as a valid psychology. Optimizing the Self will be of interest to academics, researchers and postgraduate students in the fields of social representation, critical and cultural psychology and theory, clinical psychology, and the sociology of culture and science. The book will also be of use to critical and cultural psychologists and theorists, as well as clinical psychologists.

Lead Optimization for Medicinal Chemists

Author : Florencio Zaragoza Dörwald
Publisher : John Wiley & Sons
ISBN 13 : 3527645659
Total Pages : 627 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Lead Optimization for Medicinal Chemists by : Florencio Zaragoza Dörwald

Download or read book Lead Optimization for Medicinal Chemists written by Florencio Zaragoza Dörwald and published by John Wiley & Sons. This book was released on 2013-02-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.

The Third Histamine Receptor

Author : Divya Vohora
Publisher : CRC Press
ISBN 13 : 1000687368
Total Pages : 408 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis The Third Histamine Receptor by : Divya Vohora

Download or read book The Third Histamine Receptor written by Divya Vohora and published by CRC Press. This book was released on 2008-11-14 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and DisordersThe H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer's disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodege

Comprehensive Medicinal Chemistry III

Author :
Publisher : Elsevier
ISBN 13 : 0128032014
Total Pages : 4609 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Comprehensive Medicinal Chemistry III by :

Download or read book Comprehensive Medicinal Chemistry III written by and published by Elsevier. This book was released on 2017-06-03 with total page 4609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Optimizing Online English Language Learning and Teaching

Author : Maria-del-Mar Suárez
Publisher : Springer Nature
ISBN 13 : 3031278259
Total Pages : 385 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Optimizing Online English Language Learning and Teaching by : Maria-del-Mar Suárez

Download or read book Optimizing Online English Language Learning and Teaching written by Maria-del-Mar Suárez and published by Springer Nature. This book was released on 2023-04-14 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on English as a Foreign Language (EFL) and provides advice on how to approach EFL teaching in the online context. Coronavirus has accelerated e-learning significantly and has highlighted the need of appropriate web tools that will allow teachers to present their material either synchronously or asynchronously, while also adequately assess their students. At the same time, there is a need of tools that can engage the students and motivate them to actively participate in the lesson. With e-learning being a rather new challenge for both teachers and students, this book provides research- and practice- based chapters with strategies, techniques, approaches, and methods which have proven to be successful in e-learning environments, maximizing their impact . Apart from presenting research results with strong pedagogical implications on online or blended English language learning and teaching, the book also trains educators on utilizing online tools and managing online learning environments and platforms.

Novel Diagnostic and Therapeutic Strategies in the Management of Cerebral Gliomas

Author : Valeria Barresi
Publisher : Frontiers Media SA
ISBN 13 : 2832554407
Total Pages : 624 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Novel Diagnostic and Therapeutic Strategies in the Management of Cerebral Gliomas by : Valeria Barresi

Download or read book Novel Diagnostic and Therapeutic Strategies in the Management of Cerebral Gliomas written by Valeria Barresi and published by Frontiers Media SA. This book was released on 2024-10-29 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral gliomas account for 45% of all primary central nervous system (CNS) tumors. The median survival after the initial diagnosis of glioblastoma (GBM) is only 15 months, and less than 10% of patients survive three years post-diagnosis. Surgical treatment followed by adjuvant therapies such as radiotherapy and chemotherapy represents the classical strategy in glioma management. The revised WHO 2016 classification now distinguishes the oligodendrogliomas with 1p19q codeletion and IDH mutation from the astrocytomas with or without IDH mutations, thereby creating homogenous and pathologically distinct subgroups. While the status of gene expression and mutations define components of GBM subtypes, it was also found that response to therapies was different for each subtype, suggesting that personalized treatment based on genomic alterations could lead to a more favorable outcome for this disease.

Emerging Therapeutic Approaches for Cystic Fibrosis

Author : Miquéias Lopes-Pacheco
Publisher : Frontiers Media SA
ISBN 13 : 2889633675
Total Pages : 281 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Emerging Therapeutic Approaches for Cystic Fibrosis by : Miquéias Lopes-Pacheco

Download or read book Emerging Therapeutic Approaches for Cystic Fibrosis written by Miquéias Lopes-Pacheco and published by Frontiers Media SA. This book was released on 2020-01-27 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg?

Author : Leonor Kremer
Publisher : Frontiers Media SA
ISBN 13 : 2889454622
Total Pages : 305 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg? by : Leonor Kremer

Download or read book Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg? written by Leonor Kremer and published by Frontiers Media SA. This book was released on 2018-03-27 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high effectiveness of antibodies as anti-tumor therapeutic agents has led to a burst of research aiming to increase their therapeutic applications by the use of antibodies against new targets, new antibody formats or new combinations. In this e-book we present relevant research depicting the current efforts in the field.

Journal of the House of Representatives of the United States

Author : United States. Congress. House
Publisher :
ISBN 13 :
Total Pages : 1884 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Journal of the House of Representatives of the United States by : United States. Congress. House

Download or read book Journal of the House of Representatives of the United States written by United States. Congress. House and published by . This book was released on 2005 with total page 1884 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some vols. include supplemental journals of "such proceedings of the sessions, as, during the time they were depending, were ordered to be kept secret, and respecting which the injunction of secrecy was afterwards taken off by the order of the House."

Blood-Brain Barrier in Drug Discovery

Author : Li Di
Publisher : John Wiley & Sons
ISBN 13 : 1118788354
Total Pages : 604 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Blood-Brain Barrier in Drug Discovery by : Li Di

Download or read book Blood-Brain Barrier in Drug Discovery written by Li Di and published by John Wiley & Sons. This book was released on 2015-02-02 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Antibiotics - Therapeutic Spectrum and Limitations

Author : Amal Kumar Dhara
Publisher : Elsevier
ISBN 13 : 0323957862
Total Pages : 742 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Antibiotics - Therapeutic Spectrum and Limitations by : Amal Kumar Dhara

Download or read book Antibiotics - Therapeutic Spectrum and Limitations written by Amal Kumar Dhara and published by Elsevier. This book was released on 2023-07-13 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics: Therapeutic Spectrum and Limitations provides up-to-date information on managing microbial infections, the development and types of antibiotics, the rationale for utilizing antibiotics, toxicity considerations, and the control of antibiotic resistance in one single resource. This book also aims to provide comprehensive insights and current trends on antibiotic therapies to treat microbial infections, their mechanisms of action, and the role of modern drug delivery in improving their efficacy. Written by leading experts from around the globe, the chapters in the book covers important aspects of microbial infections including hospital acquired infections and community acquired infections and adult sepsis, examines the various types of antibiotics with different mechanisms and therapeutic uses, the global challenge of antibiotic resistance, and clinical trials, regulatory considerations, and market overview of antibiotics. Furthermore, the chapters include updated literature reviews of the relevant key topics, high-quality illustrations, chemical structures, flowcharts, and well-organized tables, all of which enable better understanding by the readers. - Provides in-depth and updated information and analyses on microbial infections, antibiotics and therapeutics, the consequences of antibiotic resistance, and the role of modern drug delivery in improving efficacy - Discusses different types of antibiotics and their mechanisms as well as traditional medicine, herbal drugs, and postbiotics in the treatment and prevention of microbial infections and management of antibiotic resistance - Contributed by global leaders and experts from academia, industry, research institutes, and regulatory agencies

Anticancer Drug Development

Author : Bruce C. Baguley
Publisher : Elsevier
ISBN 13 : 0080490441
Total Pages : 411 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Anticancer Drug Development by : Bruce C. Baguley

Download or read book Anticancer Drug Development written by Bruce C. Baguley and published by Elsevier. This book was released on 2001-11-17 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. - One work that can be consulted for all aspects of anticancer drug development - Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts - A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death - Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products - Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques - Hundreds of references that allow the reader to access relevant scientific and medical literature - Clear illustrations, some in color, that provide both understanding of the field and material for teaching