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Oncogenes As Transcriptional Regulators
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Book Synopsis Oncogenes as Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Birkhäuser. This book was released on 2013-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.
Book Synopsis Oncogenes As Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes As Transcriptional Regulators written by Moshe Yaniv and published by Springer Science & Business Media. This book was released on 1997 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 E2Fs and the Retinoblastoma Protein Family.- 2 Signalling to the C-terminus of p53.- 3 Chromosome Translocations Generating Chimeric Transcription Factors, Unique Genetic Events with Pleiotropic Cellular Consequences.- 4 The Runt Domain Transcription Factor, PEBP2/CBF, and its Involvement in Human Leukemia.- 5 EBNA2: A Viral Transcription Factor Essential for the Immortalization of Human B Lymphocytes by the Epstein-Barr Virus (EBV).
Book Synopsis Oncogenes as Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Birkhäuser. This book was released on 2013-11-27 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.
Download or read book Retroviral Oncogenes written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oncogenes as Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Birkhäuser. This book was released on 1997-07-15 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the molecular events leading to cellular transformation and cancer has progressed enormously in the last decade. It has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic program of the cell. Transcription factors can behave either as oncogenes or as tumor suppressor genes. To date only a very limited number of transcription factors have been associated with cancer. Volume 1 deals with several transcription factor families that were first identified in oncogenic retroviruses. Volume 2 brings up-to-date molecular information on several onco- genes, tumor suppressor genes or chromosomal translocations. Each chapter contains a comprehensive description of the structure of such transcription factors, the nature of target genes, the regulation of their activities and a plausible explanation of how they can deregulate cell growth and differentiation. These volumes are addressed both to the specialized scientist and to an advanced student.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Oncogenes as Transcriptional Regulators: Retroviral oncogenes by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators: Retroviral oncogenes written by Moshe Yaniv and published by Birkhauser. This book was released on 1997 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Frank J. III Rauscher Publisher :Springer Science & Business Media ISBN 13 :364260479X Total Pages :173 pages Book Rating :4.6/5 (426 download)
Book Synopsis Chromosomal Translocations and Oncogenic Transcription Factors by : Frank J. III Rauscher
Download or read book Chromosomal Translocations and Oncogenic Transcription Factors written by Frank J. III Rauscher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.
Download or read book Oncogenes written by Geoffrey M. Cooper and published by Jones & Bartlett Learning. This book was released on 1995 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and scientists by examining the current state of oncogene study and where future research may lead.
Book Synopsis Transcriptional and Post-transcriptional Regulation of Oncogenes and Tumor-suppressor Genes and Their Role in Solid Cancer Metastasis by : Giridhar Mudduluru
Download or read book Transcriptional and Post-transcriptional Regulation of Oncogenes and Tumor-suppressor Genes and Their Role in Solid Cancer Metastasis written by Giridhar Mudduluru and published by . This book was released on 2012 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional Regulation by the Oncogene V-Src by : Eric John Martens
Download or read book Transcriptional Regulation by the Oncogene V-Src written by Eric John Martens and published by . This book was released on 2004 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oncogenes as Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Springer Science & Business Media. This book was released on 1997 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Myc Structure and Function.- 2 The ETS Family of Transcriptional Regulators.- 3 myb Proto-Oncogene Product as a Transcriptional Regulator.- 4 The v-erbA Oncogene.- 5 Rel Proteins and Their Inhibitors: A Balancing Act.- 6 Structure/Function and Oncogenic Conversion of Fos and Jun.
Book Synopsis Oncogenes and Growth Control by : Patricia Kahn
Download or read book Oncogenes and Growth Control written by Patricia Kahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.
Book Synopsis Oncogene and Cancer by : Yahwardiah Siregar
Download or read book Oncogene and Cancer written by Yahwardiah Siregar and published by Inst za onkologiju i radiol. This book was released on 2013-01-24 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors
Book Synopsis Zinc-finger Proteins in Oncogenesis by : Mels Sluyser
Download or read book Zinc-finger Proteins in Oncogenesis written by Mels Sluyser and published by . This book was released on 1993 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Devoted to the role zinc-finger proteins play in the regulation of transcription and oncogenesis, this book includes material on functional domains of DNA-binding zinc-finger proteins, structure and function of zinc fingers, zinc-finger protein mutants, transcription activation mechanisms, and control and loss of gene transcription.
Book Synopsis The Myc/Max/Mad Transcription Factor Network by : Robert N. Eisenman
Download or read book The Myc/Max/Mad Transcription Factor Network written by Robert N. Eisenman and published by Springer Science & Business Media. This book was released on 2006-05-28 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be interested in the “big picture” and excessive zeal in pursuit of a single pixel might seem to border on an obsession that is likely to yield only details. However as this volume of Current Topics in Microbiology and Immunology demonstrates, this is certainly not the case for myc. Intense study of this en- matic proto-oncogene over the last twenty years has only broadened our view of its functions and led to insights into mechanisms relating to transcriptional regulation as well as to cell growth, proliferation, differentiation, apoptosis and organismal development. The myc gene originally came to light as a retroviral oncogene (v-myc) associated with a wide range of acute neoplasms. It was later shown to be a virally transduced cellular gene (c-myc) which is a member of family of on- genes (c-myc,N-myc,L-myc). These family members are themselves subject to a bewildering assortment of genetic rearrangements associated with many different types of tumors derived from many different types of cells. These rearrangements (including chromosomal translocation, viral integration, and gene ampli?cation) act to uncouple expression of the myc family genes from their normal physiological regulators. The chapter by LIU and LEVENS - scribes the key pathways leading to regulation of myc expression, showing that such regulation occurs at several different levels and through multiple mechanisms.
Book Synopsis Transcription Factors and Human Disease by : Gregg L. Semenza
Download or read book Transcription Factors and Human Disease written by Gregg L. Semenza and published by Oxford Monographs on Medical G. This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.
